Cited by 664Memory and Neural MechanismsStress Responses and CortisolNeuroscience and Neuropharmacology Research

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Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy

Conrad, Cheryl D., Magariños, Ana María, LeDoux, Joseph E., McEwen, Bruce S.·1999·Behavioral Neuroscience

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Abstract

This study investigated whether 21 days of restraint stress (6 hr/day) and the subsequent hippocampal dendritic atrophy would affect fear conditioning, a memory task with hippocampal-dependent and hippocampal-independent components. Restraint-stressed rats were injected daily (21 days) with tianeptine (10 mg/kg; to prevent hippocampal atrophy) or vehicle then tested on fear conditioning (Days 23-25, with 2 tone-shock pairings) and open field (Day 25). Restraint stress enhanced freezing to context (hippocampal-dependent behavior) and tone (hippocampal-independent) and decreased open-field exploration, irrespective of whether tianeptine was given. Results confirmed that stress produced CA3 dendritic atrophy and tianeptine prevented it. Moreover, CA3 dendritic atrophy was not permanent but reversed to control levels by 10 days after the cessation of restraint stress. These data argue that different neural substrates underlie spatial recognition memory and fear conditioning.

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Authors: Conrad, C. D., Magariños, A. M., LeDoux, J. E., & McEwen, B. S.
Affiliations: Arizona State University (US)
ORCID: Conrad, Cheryl D.
LeDoux, Joseph E.
McEwen, Bruce S.
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 1999
Volume: 113
Issue: 5
Pages: 902-913
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/0735-7044.113.5.902
OpenAlex: W2018546099
Cited by: 664
References: 0
Citations by year: 2026: 4 · 2025: 12 · 2024: 10 · 2023: 14 · 2022: 15 · 2021: 22 · 2020: 15 · 2019: 21 · 2018: 25 · 2017: 29 · 2016: 38 · 2015: 30 · 2014: 31 · 2013: 53 · 2012: 31
FWCI: 7.02
Type: journal article
Language: en
Open access: closed
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1f32mh011526-01)
National Institute of Mental Health (MH-41256, MH11526)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: restraint stress, fear conditioning, hippocampal CA3, dendritic atrophy, tianeptine, hippocampal-dependent memory, spatial recognition memory, freezing behavior, open field exploration
MeSH terms: Animals, Antidepressive Agents, Tricyclic, Conditioning, Psychological, Dendrites, Exploratory Behavior, Fear, Hippocampus, Male, Restraint, Physical, Stress, Physiological, Thiazepines, Rats, Sprague-Dawley, Pyramidal Cells, Cell Size, Rats

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Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy

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