Depletion of polysialic acid from neural cell adhesion molecule (PSA-NCAM) increases CA3 dendritic arborization and increases vulnerability to excitotoxicity
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Chronic immobilization stress (CIS) shortens apical dendritic trees of CA3 pyramidal neurons in the hippocampus of the male rat, and dendritic length may be a determinant of vulnerability to stress. Expression of the polysialylated form of neural cell adhesion molecule (PSA-NCAM) in the hippocampal formation is increased by stress, while PSA removal by Endo-neuraminidase-N (endo-N) is known to cause the mossy fibers to defasciculate and synapse ectopically in their CA3 target area. We show here that enzymatic removal of PSA produced a remarkable expansion of dendritic arbors of CA3 pyramidal neurons, with a lesser effect in CA1. This expansion eclipsed the CIS-induced shortening of CA3 dendrites, with the expanded dendrites of both no-stress-endo-N and CIS-endo-N rats being longer than those in no-stress-control rats and much longer than those in CIS-control rats. As predicted by the hypothesis that endo-N-induced dendritic expansion might increase vulnerability to excitotoxic challenge, systemic injection with kainic acid, showed markedly increased neuronal degeneration, as assessed by fluorojade B histochemistry, in rats that had been treated with endo-N compared to vehicle-treated rats throughout the entire hippocampal formation. PSA removal also exacerbated the CIS-induced reduction in body weight and abolished effects of CIS on NPY and NR2B mRNA levels. These findings support the hypothesis that CA3 arbor plasticity plays a protective role during prolonged stress and clarify the role of PSA-NCAM in stress-induced dendritic plasticity.
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The plasticity resulting from polysialic acid expression appears to be important for neuronal migration and for reorganization following injury.
“The ' plasticity ' resulting from polysialic acid expression appears to be important for neuronal migration as well as reorganization following injury (546 -554).”
From Biological roles of glycans (2017) · cites this paper as [553]
The References (page unavailable) cite studies linking polysialic acid to neuronal migration, and the Introduction (page unavailable) describes PSA-NCAM expression changing after ischemic injury. The paper also discusses PSA-dependent structural plasticity, but these passages do not establish that it is important for reorganization following injury. (LLM, conf=0.78)
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Effectiveness of mono and combined pharmacotherapy in patients with low back pain
Shmanko, V. V., Дзіх, І., & Shmanko, O. V. (2023) · Medicine Today and Tomorrow · doi:10.35339/msz.2023.92.4.sds
- Authors
- McCall, T., Weil, Z. M., Nacher, J., Bloss, E. B., El Maarouf, A., Rutishauser, U., & McEwen, B. S.
- Affiliations
- Rockefeller University (US)
- The Ohio State University Wexner Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Weil, Zachary M.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 241
- Pages
- 5-12
- ISSN
- 0014-4886 (ISSN-L)
- PMC
- PMC3570583
- OpenAlex
- W2089781305
- Cited by
- 34
- References
- 61
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 3 · 2013: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (MH41256)
- Spanish Ministry of Science and Innovation (MICINN-FEDER) BFU2009-12284/BFI, MICINN-PIM2010ERN-00577/NEUCONNECT)
- Generalitat Valenciana (ACOMP/2012/229)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- polysialic acid, CD56, chronic immobilization stress, CA3 pyramidal cells, excitotoxicity, kainic acid, dendritic plasticity, hippocampus, mossy fibers, neuropeptide Y, NR2B
- MeSH terms
- Analysis of Variance, Animals, Dendrites, Disease Models, Animal, Fluoresceins, Gene Expression Regulation, Kainic Acid, Male, Metalloendopeptidases, Nerve Degeneration, Organic Chemicals, Sialic Acids, Stress, Psychological, Body Mass Index, Receptors, N-Methyl-D-Aspartate, Silver Staining, Rats, Sprague-Dawley, Pyramidal Cells, Excitatory Amino Acid Agonists, Neural Cell Adhesion Molecules, Rats, CA3 Region, Hippocampal
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