Vasopressin in the lateral septum regulates pair bond formation in male prairie voles (Microtus ochrogaster)
Abstract
Male prairie voles (Microtus ochrogaster) form a pair bond with a female partner after mating, and this behavior is regulated by the neuropeptide vasopressin (AVP). The authors report that AVP in the lateral septum is important for pair bond formation. Administration of an AVP V1a receptor antagonist in the lateral septum blocked mating-induced pair bonding, whereas administration of AVP induced this behavior in the absence of mating. In addition, administration of an oxytocin (OT) receptor antagonist in the lateral septum also blocked pair bond formation induced by either mating or AVP administration, suggesting that the OT receptor blockade may have interfered with the AVP regulation of behavior. Together, these data provide evidence suggesting that AVP in the lateral septum regulates pair bond formation in male prairie voles and that this process requires access to both AVP and OT receptors.
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In male prairie voles, vasopressin injection into lateral septum induces partner preference.
“and of AVP into the lateral septum of males (8).”
From Oxytocin enhances brain reward system responses in men viewing the face of their female partner (2013) · cites this paper as [8]
ICV injections of OTR antagonist failed to inhibit partner preference in male prairie voles, but injections into the lateral septum did.
“In support, ICV injections of OTR antagonist failed to inhibit partner preference in male prairie voles (Winslow et al., 1993), but injections into the lateral septum did (Liu et al., 2001).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Liu et al., 2001
OTR antagonist administration in the LS blocked partner preference in male prairie voles.
“OTR antagonist administration in the LS blocked partner preference in male prairie voles”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Liu et al., 2001
Partner preference formation in prairie voles is modulated by the VP system acting in the LS and ventral pallidum and by the OT system acting in the NAc and prefrontal cortex.
“partner preference formation in prairie voles is modulated by the VP system acting in the LS and ventral pallidum (Liu et al., 2001; Pitkow et al., 2001; Lim & Young, 2004) and by the OT system acting in the NAc and prefrontal cortex (Young et al., 2001; Liu and Wang, 2003).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Liu et al., 2001
Blocking vasopressin V1a receptors in the ventral pallidum or lateral septum with antagonists prevents partner preference formation following mating.
“Specifically, blocking vasopressin V1a receptors (AVP1A) in the ventral pallidum or lateral septum with antagonists prevents partner preference formation following mating [20, 21].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [21]
Increased AVP signaling, especially in the ventral pallidum and lateral septum, is a prerequisite for partner preference formation and expression in male prairie voles.
“Increased arginine-vasopressin (AVP) signaling, especially in the ventral pallidum (VP) and lateral septum (Liu et al. 2001), is a prerequisite for partner preference formation and expression in male prairie voles”
From Oxytocin and Social Relationships: From Attachment to Bond Disruption (2017) · cites this paper as Liu et al. 2001
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References 54 · Cited by 282
- Authors
- Liu, Y., Curtis, J. T., & Wang, Z.
- Affiliations
- Florida State University (US)
- Venue
- Behavioral Neuroscience
- Published
- 2001-08
- Volume
- 115
- Issue
- 4
- Pages
- 910-919
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W4252654080
- Cited by
- 282
- References
- 54
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 33 · 2021: 10 · 2020: 7 · 2019: 12 · 2018: 13 · 2017: 18 · 2016: 18 · 2015: 13 · 2014: 12 · 2013: 18 · 2012: 14
- FWCI
- 14.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH R01-58616, MHR29-54554)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- vasopressin, lateral septum, pair bonding, Microtus ochrogaster, social bonding, neuropeptides, monogamy
- MeSH terms
- Animals, Arginine Vasopressin, Arvicolinae, Female, Male, Neuropeptides, Pair Bond, Sexual Behavior, Animal, Vasopressins, Receptors, Oxytocin, Septum of Brain, Antidiuretic Hormone Receptor Antagonists
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