Reactivation of hippocampal ensemble activity patterns in the aging rat.
Abstract
In young rats, the pattern of neuronal ensemble activity correlations expressed among hippocampal pyramidal cells during behavior persists during subsequent quiet wakefulness and slow-wave sleep, a process that may facilitate the consolidation of episodic memories. The present study explored the hypothesis that age-related changes in this process might contribute to memory impairments observed during normal aging. Neuronal activity was recorded from CA1 pyramidal cells, and in both young and old rats, there was a strong similarity between the resting epoch activity patterns and those from the preceding behavior epoch. This similarity was strongest during sharp-wave events. There were no detectable differences in the reactivation process or the decay rate between the young and old age groups. Thus, age differences in spatial memory do not appear to be explainable by differences in the spontaneous reactivation of familiar patterns within the hippocampus during the immediate postbehavior period.
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Spontaneous memory reactivations during sleep correlate with later memory performance.
“and that spontaneous memory reactivations during sleep correlate with later memory performance (335, 448, 449).”
From About Sleep's Role in Memory (2013) · cites this paper as [449]
Simple reactivation patterns in CA1 cell ensembles, not taking into account the relative temporal order of cell-pair firing, were comparable between aged and young rats.
“Interestingly, simple reactivation patterns in CA1 cell ensembles, not taking into account the relative temporal order of cell-pair firing, was comparable between aged and young rats (449).”
From About Sleep's Role in Memory (2013) · cites this paper as [449]
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References 100 · Cited by 35
- Authors
- Gerrard, J. L., Kudrimoti, H., McNaughton, B. L., & Barnes, C. A.
- Affiliations
- University of Arizona (US)
- Venue
- Behavioral Neuroscience
- Published
- 2001
- Volume
- 115
- Issue
- 6
- Pages
- 1180-1192
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2071718136
- Cited by
- 35
- References
- 100
- Citations by year
- 2025: 1 · 2024: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 0.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k05mh001565-02)
- National Institute on Aging (AG12619)
- National Institute of Mental Health (MH01565, MH 46823)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- spontaneous reactivation, aging, CA1 pyramidal neurons, memory consolidation, episodic memory, spatial memory, slow-wave sleep, quiet wakefulness, memory impairment
- MeSH terms
- Aging, Animals, Hippocampus, Male, Memory Disorders, Rats, Inbred F344, Sleep, Pyramidal Cells, Rats
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