The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
D-Cycloserine and the Facilitation of Extinction of Conditioned Fear: Consequences for Reinstatement.
Abstract
Several recent studies have reported that D-cycloserine (DCS), a partial N-methyl-D-aspartate agonist, facilitates extinction of learned fear in rats. Other studies have shown that representation of the unconditioned stimulus (US) can reinstate learned fear after extinction. This study examined whether this reinstatement effect occurs in Sprague-Dawley rats given DCS at the time of extinction. Results showed that saline-treated rats exhibited the reinstatement effect but DCS-treated rats did not (Experiments 1 and 2). This lack of reinstatement in DCS-treated rats was not due to residual effects of DCS on either US or context processing (Experiment 3). Overall, these results (a) raise questions about the mechanisms underlying DCS facilitation of extinction and (b) suggest that DCS might have substantial practical benefit.
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Cites
A theory of attention: Variations in the associability of stimuli with reinforcement
Mackintosh, N. J. (1975) · Psychological Review · doi:10.1037/h0076778 · Cited by 2,733
Context, time, and memory retrieval in the interference paradigms of Pavlovian learning
Bouton, M. E. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.114.1.80 · Cited by 1,896
Behavioral and Neural Analysis of Extinction
Myers, K. M., & Davis, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01064-4 · Cited by 918 · cited 2×
“One thing that does seem to be clear, however, is that the N-methyl-D-aspartate (NMDA) receptor, an excitatory amino acid receptor subtype, plays a critical role in extinction of learned fear (Myers & Davis, 2002, provide an extensive review of this literature).”
BackgroundWalker, D. L., Ressler, K. J., Lu, K.-T., & Davis, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02343.2002 · Cited by 815
Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala
Falls, W., Miserendino, M., & Davis, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00854.1992 · Cited by 673
Effects of D-cycloserine on extinction of conditioned freezing.
Ledgerwood, L., Richardson, R., & Cranney, J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.341 · Cited by 388
Self-citationLand, C., & Riccio, D. C. (1999) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3897 · Cited by 61
Cited by
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277
Pape, H.-C., & Pare, D. (2010) · Physiological Reviews · doi:10.1152/physrev.00037.2009 · Cited by 994
Contextual and temporal modulation of extinction: behavioral and biological mechanisms
Bouton, M. E., Westbrook, R. F., Corcoran, K. A., & Maren, S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.015 · Cited by 671
Treatment of specific phobia in adults
Choy, Y., Fyer, A. J., & Lipsitz, J. D. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.10.002 · Cited by 571
An Update on Memory Reconsolidation Updating
Lee, J. L. C., Nader, K., & Schiller, D. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.04.006 · Cited by 557
Metadata
- Authors
- Ledgerwood, L., Richardson, R., & Cranney, J.
- Venue
- Behavioral Neuroscience
- Published
- 2004
- Volume
- 118
- Issue
- 3
- Pages
- 505-513
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2103001237
- Cited by
- 190
- References
- 7
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ledgerwood, L., Richardson, R., & Cranney, J. (2004). D-Cycloserine and the Facilitation of Extinction of Conditioned Fear: Consequences for Reinstatement. Behavioral Neuroscience. https://doi.org/10.1037/0735-7044.118.3.505
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