Mechanisms of fear extinction

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292 · see citing works

A model for Pavlovian learning: Variations in the effectiveness of conditioned but not of unconditioned stimuli.

Pearce, J. M., & Hall, G. (1980) · Psychological Review · doi:10.1037/0033-295x.87.6.532 · Cited by 3,023 · see citing works

Habituation: a model phenomenon for the study of neuronal substrates of behavior

Thompson, R. F., & Spencer, W. A. (1966) · Psychological Review · doi:10.1037/h0022681 · Cited by 2,608 · see citing works

Modality-Specific Retrograde Amnesia of Fear

Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483 · see citing works

Neurons in medial prefrontal cortex signal memory for fear extinction

Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · see citing works

Extinction Learning in Humans

Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753 · see citing works

The endogenous cannabinoid system controls extinction of aversive memories

Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728 · see citing works

Probability of shock in the presence and absence of cs in fear conditioning.

Rescorla, R. A. (1968) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0025984 · Cited by 1,067 · see citing works

Cognitive Enhancers as Adjuncts to Psychotherapy: Use of D-Cycloserine in Phobic Individuals to Facilitate Extinctionof Fear

Ressler, K. J., Rothbaum, B. O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., Hodges, L., & Davis, M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1136 · Cited by 1,063 · see citing works

The role of ventromedial prefrontal cortex in the recovery of extinguished fear

Quirk, G. J., Russo, G. K., Barron, J. L., & Lebron, K. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06225.2000 · Cited by 957 · see citing works

Behavioral and Neural Analysis of Extinction

Myers, K. M., & Davis, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01064-4 · Cited by 918 · see citing works

Extinction of emotional learning: contribution of medial prefrontal cortex

Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90241-c · Cited by 897 · see citing works

Retrograde Amnesia Produced by Electroconvulsive Shock after Reactivation of a Consolidated Memory Trace

Misanin, J. R., Miller, R. R., & Lewis, D. J. (1968) · Science · doi:10.1126/science.160.3827.554 · Cited by 872 · see citing works

New Vistas on Amygdala Networks in Conditioned Fear

Paré, D., Quirk, G. J., & Ledoux, J. E. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00153.2004 · Cited by 841 · see citing works

Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala

Falls, W., Miserendino, M., & Davis, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00854.1992 · Cited by 673 · see citing works

Augmentation of Exposure Therapy With D-Cycloserine for Social Anxiety Disorder

Hofmann, S. G., Meuret, A. E., Smits, J. A. J., Simon, N. M., Pollack, M. H., Eisenmenger, K., Shiekh, M., & Otto, M. W. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.298 · Cited by 560 · see citing works

Molecular mechanisms underlying emotional learning and memory in the lateral amygdala

Rodrigues, S. M., Schafe, G. E., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.014 · Cited by 491 · see citing works

Hippocampal Inactivation Disrupts Contextual Retrieval of Fear Memory after Extinction

Corcoran, K. A., & Maren, S. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01720.2001 · Cited by 455 · see citing works

Protein Synthesis Subserves Reconsolidation or Extinction Depending on Reminder Duration

Pedreira, M. E., & Maldonado, H. (2003) · Neuron · doi:10.1016/s0896-6273(03)00352-0 · Cited by 406 · see citing works

Effects of D-cycloserine on extinction of conditioned freezing.

Ledgerwood, L., Richardson, R., & Cranney, J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.341 · Cited by 388 · see citing works

Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli.

Muller, J., Corodimas, K. P., Fridel, Z., & LeDoux, J. E. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.4.683 · Cited by 382 · see citing works

Prefrontal Control of the Amygdala

Likhtik, E., Pelletier, J. G., Paz, R., & Paré, D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2314-05.2005 · Cited by 361 · see citing works

Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery

Quirk, G. J. (2002) · Learning & Memory · doi:10.1101/lm.49602 · Cited by 360 · see citing works

Human orbitofrontal cortex mediates extinction learning while accessing conditioned representations of value

Gottfried, J. A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1314 · Cited by 353 · see citing works

Different mechanisms of fear extinction dependent on length of time since fear acquisition

Myers, K. M., Ressler, K. J., & Davis, M. (2006) · Learning & Memory · doi:10.1101/lm.119806 · Cited by 334 · see citing works

Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A

Tronson, N. C., Wiseman, S. L., Olausson, P., & Taylor, J. R. (2006) · Nature Neuroscience · doi:10.1038/nn1628 · Cited by 264 · see citing works

Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling

Azad, S. C., Monory, K., Marsicano, G., Cravatt, B. F., Lutz, B., Zieglgänsberger, W., & Rammes, G. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2134-04.2004 · Cited by 263 · see citing works

Amygdala and hippocampal activity during acquisition and extinction of human fear conditioning

Knight, D. C., Smith, C. N., Cheng, D. T., Stein, E. A., & Helmstetter, F. J. (2004) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.4.3.317 · Cited by 249 · see citing works

Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP

Wang, H., Ferguson, G. D., Pineda, V. V., Cundiff, P. E., & Storm, D. R. (2004) · Nature Neuroscience · doi:10.1038/nn1248 · Cited by 244 · see citing works

Lesions of the Basal Amygdala Block Expression of Conditioned Fear But Not Extinction

Anglada-Figueroa, D., & Quirk, G. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2600-05.2005 · Cited by 238 · see citing works

The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear

Szapiro, G., Vianna, M. R. M., McGaugh, J. L., Medina, J. H., & Izquierdo, I. (2003) · Hippocampus · doi:10.1002/hipo.10043 · Cited by 221 · see citing works

Activation of the cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdala of the mouse

Azad, S. C., Eder, M., Marsicano, G., Lutz, B., Zieglgänsberger, W., & Rammes, G. (2003) · Learning & Memory · doi:10.1101/lm.53303 · Cited by 220 · see citing works

Adrenergic transmission facilitates extinction of conditional fear in mice

Cain, C. K., Blouin, A. M., & Barad, M. (2004) · Learning & Memory · doi:10.1101/lm.71504 · Cited by 215 · see citing works

Extinction Learning Before Trauma and Subsequent Posttraumatic Stress

Guthrie, R. M., & Bryant, R. A. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000208629.67653.cc · Cited by 198 · see citing works

Recent fear is resistant to extinction

Maren, S., & Chang, C.-H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608398103 · Cited by 184 · see citing works

Effects of bed nucleus of the stria terminalis lesions on conditioned anxiety: Aversive conditioning with long-duration conditional stimuli and reinstatement of extinguished fear.

Waddell, J., Morris, R. W., & Bouton, M. E. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.2.324 · Cited by 183 · see citing works

The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.

Baker, J. D., & Azorlosa, J. L. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.3.618 · Cited by 179 · see citing works

Localization of the CB1 type cannabinoid receptor in the rat basolateral amygdala: high concentrations in a subpopulation of cholecystokinin-containing interneurons

McDonald, A. J., & Mascagni, F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00380-3 · Cited by 157 · see citing works

L-type voltage-gated calcium channels are required for extinction, but not for acquisition or expression, of conditional fear in mice

Cain, C. K., Blouin, A. M., & Barad, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09113.2002 · Cited by 130 · see citing works

Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle

Lin, H.-C., Mao, S.-C., & Gean, P.-W. (2006) · Learning & Memory · doi:10.1101/lm.217006 · Cited by 107 · see citing works

Evidence for differential modulation of conditioned aversion and fear‐conditioned analgesia by CB ₁ receptors

Finn, D. P., Beckett, S. R. G., Richardson, D., Kendall, D. A., Marsden, C. A., & Chapman, V. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03509.x · Cited by 66 · see citing works

Behavioral and paired-pulse facilitation analyses of long-lasting depression at excitatory synapses in the medial prefrontal cortex in mice

Herry, C., & Garcia, R. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.017 · Cited by 41 · see citing works

How does mindfulness meditation work? Proposing mechanisms of action from a conceptual and neural perspective

Hölzel, B. K., Lazar, S. W., Gard, T., Schuman-Olivier, Z., Vago, D. R., & Ott, U. (2011) · Perspectives on Psychological Science · doi:10.1177/1745691611419671 · Cited by 3,024 · see citing works

Maximizing exposure therapy: An inhibitory learning approach

Craske, M. G., Treanor, M., Conway, C. C., Zbozinek, T., & Vervliet, B. (2014) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.04.006 · Cited by 2,339 · see citing works

Neuronal circuits for fear and anxiety

Tovote, P., Fadok, J. P., & Lüthi, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3945 · Cited by 1,786 · see citing works

Mechanisms of attentional biases towards threat in anxiety disorders: An integrative review

Cisler, J. M., & Koster, E. H. W. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.11.003 · Cited by 1,753 · see citing works

Neural Mechanisms of Extinction Learning and Retrieval

Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645 · see citing works

Optimizing inhibitory learning during exposure therapy

Craske, M. G., Kircanski, K., Zelikowsky, M., Mystkowski, J., Chowdhury, N., & Baker, A. (2008) · Behaviour Research and Therapy · doi:10.1016/j.brat.2007.10.003 · Cited by 1,607 · see citing works

Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder

Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N. B., Zeidan, M. A., Handwerger, K., Orr, S. P., & Rauch, S. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.026 · Cited by 1,339 · see citing works

Memory engrams: Recalling the past and imagining the future

Josselyn, S. A., & Tonegawa, S. (2020) · Science · doi:10.1126/science.aaw4325 · Cited by 1,087 · see citing works

Molecular mechanisms of fear learning and memory

Johansen, J. P., Cain, C. K., Ostroff, L. E., & LeDoux, J. E. (2011) · Cell · doi:10.1016/j.cell.2011.10.009 · Cited by 1,012 · see citing works

Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear

Pape, H.-C., & Pare, D. (2010) · Physiological Reviews · doi:10.1152/physrev.00037.2009 · Cited by 994 · see citing works

Switching on and off fear by distinct neuronal circuits

Herry, C., Ciocchi, S., Senn, V., Demmou, L., Müller, C., & Lüthi, A. (2008) · Nature · doi:10.1038/nature07166 · Cited by 950 · see citing works

Amygdala inhibitory circuits and the control of fear memory

Ehrlich, I., Humeau, Y., Grenier, F., Ciocchi, S., Herry, C., & Lüthi, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.026 · Cited by 878 · see citing works

Don’t fear “fear conditioning”: Methodological considerations for the design and analysis of studies on human fear acquisition, extinction, and return of fear

Lonsdorf, T. B., Menz, M. M., Andreatta, M., Fullana, M. A., Golkar, A., Haaker, J., Heitland, I., Hermann, A., Kuhn, M., Kruse, O., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.026 · Cited by 837 · see citing works

Perineuronal Nets Protect Fear Memories from Erasure

Gogolla, N., Caroni, P., Lüthi, A., & Herry, C. (2009) · Science · doi:10.1126/science.1174146 · Cited by 760 · see citing works

Extinction circuits for fear and addiction overlap in prefrontal cortex

Peters, J., Kalivas, P. W., & Quirk, G. J. (2009) · Learning & Memory · doi:10.1101/lm.1041309 · Cited by 736 · see citing works

Amygdala Microcircuits Controlling Learned Fear

Duvarci, S., & Pare, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.042 · Cited by 751 · see citing works

Acceptance and mindfulness-based therapy: New wave or old hat?

Hofmann, S. G., & Asmundson, G. J. G. (2008) · Clinical Psychology Review · doi:10.1016/j.cpr.2007.09.003 · Cited by 665 · see citing works

Emotion regulation and the anxiety disorders: An integrative review

Cisler, J. M., Olatunji, B. O., Feldner, M. T., & Forsyth, J. P. (2010) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-009-9161-1 · Cited by 607 · see citing works

Targeted electrode-based modulation of neural circuits for depression.

Mayberg, H. S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38454 · Cited by 542 · see citing works

Long-range connectivity defines behavioral specificity of amygdala neurons

Senn, V., Wolff, S. B. E., Herry, C., Grenier, F., Ehrlich, I., Gründemann, J., Fadok, J. P., Müller, C., Letzkus, J. J., & Lüthi, A. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.006 · Cited by 522 · see citing works

The endocannabinoid system in guarding against fear, anxiety and stress

Lutz, B., Marsicano, G., Maldonado, R., & Hillard, C. J. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4036 · Cited by 506 · see citing works

Impaired safety signal learning may be a biomarker of PTSD

Jovanovic, T., Kazama, A., Bachevalier, J., & Davis, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.023 · Cited by 473 · see citing works

Neuronal circuits of fear extinction

Herry, C., Ferraguti, F., Singewald, N., Letzkus, J. J., Ehrlich, I., & Lüthi, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07101.x · Cited by 484 · see citing works

Amygdala intercalated neurons are required for expression of fear extinction

Likhtik, E., Popa, D., Apergis-Schoute, J., Fidacaro, G. A., & Paré, D. (2008) · Nature · doi:10.1038/nature07167 · Cited by 474 · see citing works

Fear memory

Izquierdo, I., Furini, C. R. G., & Myskiw, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00018.2015 · Cited by 453 · see citing works

Mindfulness and Behavior Change

Schuman-Olivier, Z., Trombka, M., Lovas, D. A., Brewer, J. A., Vago, D. R., Gawande, R., Dunne, J. P., Lazar, S. W., Loucks, E. B., & Fulwiler, C. (2020) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000277 · Cited by 435 · see citing works

From Fear to Safety and Back: Reversal of Fear in the Human Brain

Schiller, D., Levy, I., Niv, Y., LeDoux, J. E., & Phelps, E. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2265-08.2008 · Cited by 429 · see citing works

Neural and cellular mechanisms of fear and extinction memory formation

Orsini, C. A., & Maren, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.014 · Cited by 429 · see citing works

Estrous cycle phase and gonadal hormones influence conditioned fear extinction

Milad, M. R., Igoe, S. A., Lebron-Milad, K., & Novales, J. E. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.09.011 · Cited by 417 · see citing works

Fear is only as deep as the mind allows

Diekhof, E. K., Geier, K., Falkai, P., & Gruber, O. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.05.073 · Cited by 413 · see citing works

Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390 · see citing works

The Study of Fear Extinction: Implications for Anxiety Disorders

Graham, B. M., & Milad, M. R. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11040557 · Cited by 387 · see citing works

Opposite effects of fear conditioning and extinction on dendritic spine remodelling.

Lai, C. S. W., Franke, T. F., & Gan, W.-B. (2012) · Nature · doi:10.1038/nature10792 · Cited by 392 · see citing works

A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder

O'Doherty, D. C. M., Chitty, K. M., Saddiqui, S., Bennett, M. R., & Lagopoulos, J. (2015) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2015.01.002 · Cited by 375 · see citing works

Bifidobacteria modulate cognitive processes in an anxious mouse strain

Savignac, H. M., Tramullas, M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.044 · Cited by 365 · see citing works

Estradiol Modulates Medial Prefrontal Cortex and Amygdala Activity During Fear Extinction in Women and Female Rats

Zeidan, M. A., Igoe, S. A., Linnman, C., Vitalo, A., Levine, J. B., Klibanski, A., Goldstein, J. M., & Milad, M. R. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.016 · Cited by 354 · see citing works

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

Kimura, R., & Ohno, M. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.10.006 · Cited by 333 · see citing works

Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction

Laurent, V., & Westbrook, R. F. (2009) · Learning & Memory · doi:10.1101/lm.1474609 · Cited by 311 · see citing works

Posttraumatic stress disorder may be associated with impaired fear inhibition: Relation to symptom severity

Jovanovic, T., Norrholm, S. D., Fennell, J. E., Keyes, M., Fiallos, A. M., Myers, K. M., Davis, M., & Duncan, E. J. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2007.12.014 · Cited by 315 · see citing works

Distinct hippocampal engrams control extinction and relapse of fear memory

Lacagnina, A. F., Brockway, E. T., Crovetti, C. R., Shue, F., McCarty, M. J., Sattler, K. P., Lim, S. C., Santos, S. L., Denny, C. A., & Drew, M. R. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0361-z · Cited by 311 · see citing works

Overlapping neural systems mediating extinction, reversal and regulation of fear

Schiller, D., & Delgado, M. R. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.04.002 · Cited by 294 · see citing works

Neuropeptide S-Mediated Control of Fear Expression and Extinction: Role of Intercalated GABAergic Neurons in the Amygdala

Jüngling, K., Seidenbecher, T., Sosulina, L., Lesting, J., Sangha, S., Clark, S. D., Okamura, N., Duangdao, D. M., Xu, Y.-L., Reinscheid, R. K., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.002 · Cited by 299 · see citing works

Patterns of Coupled Theta Activity in Amygdala-Hippocampal-Prefrontal Cortical Circuits during Fear Extinction

Lesting, J., Narayanan, R. T., Kluge, C., Sangha, S., Seidenbecher, T., & Pape, H.-C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021714 · Cited by 275 · see citing works

Neural systems underlying approach and avoidance in anxiety disorders

Robin L., A., & Martin, P. P. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.4/raupperle · Cited by 227 · see citing works

Effects of sleep on memory for conditioned fear and fear extinction.

Pace-Schott, E. F., Germain, A., & Milad, M. R. (2015) · Psychological Bulletin · doi:10.1037/bul0000014 · Cited by 218 · see citing works

Oxytocin facilitates the extinction of conditioned fear in humans

Eckstein, M., Becker, B., Scheele, D., Scholz, C., Preckel, K., Schlaepfer, T. E., Grinevich, V., Kendrick, K. M., Maier, W., & Hurlemann, R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.015 · Cited by 210 · see citing works

First-line Treatment: A Critical Appraisal of Cognitive Behavioral Therapy Developments and Alternatives.

Arch, J. J., & Craske, M. G. (2009) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.05.001 · Cited by 208 · see citing works

D-cycloserine does not enhance exposure-response prevention therapy in obsessive-compulsive disorder

Storch, E. A., Merlo, L. J., Bengtson, M., Murphy, T. K., Lewis, M. H., Yang, M. C., Jacob, M. L., Larson, M., Hirsh, A., Fernandez, M., et al. (2007) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e32819f8480 · Cited by 200 · see citing works

Exercise augmentation of exposure therapy for PTSD: rationale and pilot efficacy data

Powers, M. B., Medina, J. L., Burns, S., Kauffman, B. Y., Monfils, M., Asmundson, G. J. G., Diamond, A., McIntyre, C., & Smits, J. A. J. (2015) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2015.1012740 · Cited by 194 · see citing works

Pathological circuit function underlying addiction and anxiety disorders

Lüthi, A., & Lüscher, C. (2014) · Nature Neuroscience · doi:10.1038/nn.3849 · Cited by 192 · see citing works

New findings on extinction of conditioned fear early in development: theoretical and clinical implications

Kim, J. H., & Richardson, R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.003 · Cited by 189 · see citing works

Inhibitory learning approaches to exposure therapy: a critical review and translation to obsessive-compulsive disorder

Jacoby, R. J., & Abramowitz, J. S. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.07.001 · Cited by 188 · see citing works

Remediation of childhood math anxiety and associated neural circuits through cognitive tutoring

Supekar, K., Iuculano, T., Chen, L., & Menon, V. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0786-15.2015 · Cited by 187 · see citing works

Extracellular matrix abnormalities in schizophrenia

Berretta, S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.010 · Cited by 179 · see citing works

Cannabinoids and anxiety

Moreira, F. A., & Wotjak, C. T. (2009) · Current topics in behavioral neurosciences · doi:10.1007/7854_2009_16 · Cited by 177 · see citing works

Prefrontal cortex executive processes affected by stress in health and disease

Girotti, M., Adler, S. M., Bulin, S. E., Fucich, E. A., Paredes, D., & Morilak, D. A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.004 · Cited by 176 · see citing works

Cannabinoid receptor activation in the basolateral amygdala blocks the effects of stress on the conditioning and extinction of inhibitory avoidance

Ganon-Elazar, E., & Akirav, I. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1223-09.2009 · Cited by 173 · see citing works

Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex

Lang, S., Kroll, A., Lipinski, S. J., Wessa, M., Ridder, S., Christmann, C., Schad, L. R., & Flor, H. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06624.x · Cited by 171 · see citing works

Extinction memory is impaired in schizophrenia

Holt, D. J., Lebron-Milad, K., Milad, M. R., Rauch, S. L., Pitman, R. K., Orr, S. P., Cassidy, B. S., Walsh, J. P., & Goff, D. C. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.017 · Cited by 170 · see citing works

Anxiety, stress, and fear response in mice with reduced endocannabinoid levels

Jenniches, I., Ternes, S., Albayram, O., Otte, D. M., Bach, K., Bindila, L., Michel, K., Lutz, B., Bilkei-Gorzo, A., & Zimmer, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.033 · Cited by 169 · see citing works

Reactivation of recall-induced neurons contributes to remote fear memory attenuation

Khalaf, O., Resch, S., Dixsaut, L., Gorden, V., Glauser, L., & Gräff, J. (2018) · Science · doi:10.1126/science.aas9875 · Cited by 146 · see citing works

Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y

Bowers, M. E., Choi, D. C., & Ressler, K. J. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.03.004 · Cited by 155 · see citing works

Fear Extinction across Development: The Involvement of the Medial Prefrontal Cortex as Assessed by Temporary Inactivation and Immunohistochemistry

Kim, J. H., Hamlin, A. S., & Richardson, R. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0596-09.2009 · Cited by 154 · see citing works

Is aversive learning a marker of risk for anxiety disorders in children?

Craske, M. G., Waters, A. M., Lindsey Bergman, R., Naliboff, B., Lipp, O. V., Negoro, H., & Ornitz, E. M. (2008) · Behaviour Research and Therapy · doi:10.1016/j.brat.2008.04.011 · Cited by 146 · see citing works

Immunohistochemical Analyses of Long-Term Extinction of Conditioned Fear in Adolescent Rats

Kim, J. H., Li, S., & Richardson, R. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq116 · Cited by 149 · see citing works

Oxytocin׳s role in anxiety: A critical appraisal

MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139 · see citing works

Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction

de Oliveira Alvares, L., Pasqualini Genro, B., Diehl, F., Molina, V. A., & Quillfeldt, J. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.005 · Cited by 143 · see citing works

The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample

Acheson, D., Feifel, D., de Wilde, S., Mckinney, R., Lohr, J., & Risbrough, V. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3099-4 · Cited by 141 · see citing works

Pavlovian fear memory circuits and phenotype models of PTSD

Johnson, L. R., McGuire, J., Lazarus, R., & Palmer, A. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.004 · Cited by 140 · see citing works

Does attention bias modification improve attentional control? A double-blind randomized experiment with individuals with social anxiety disorder

Heeren, A., Mogoaşe, C., McNally, R. J., Schmitz, A., & Philippot, P. (2015) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2014.10.007 · Cited by 134 · see citing works

Cannabinoid facilitation of fear extinction memory recall in humans

Rabinak, C. A., Angstadt, M., Sripada, C. S., Abelson, J. L., Liberzon, I., Milad, M. R., & Phan, K. L. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.063 · Cited by 163 · see citing works

A psychobiological rationale for oxytocin in the treatment of posttraumatic stress disorder

Olff, M., Langeland, W., Witteveen, A., & Denys, D. (2010) · CNS Spectrums · doi:10.1017/s109285290000047x · Cited by 135 · see citing works

The potential impact of mindfulness on exposure and extinction learning in anxiety disorders

Treanor, M. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2011.02.003 · Cited by 134 · see citing works

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity

Fendt, M., Schmid, S., Thakker, D. R., Jacobson, L. H., Yamamoto, R., Mitsukawa, K., Maier, R., Natt, F., Hüsken, D., Kelly, P. H., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002073 · Cited by 135 · see citing works

NMDA receptor antagonism in the basolateral but not central amygdala blocks the extinction of Pavlovian fear conditioning in rats

Zimmerman, J. M., & Maren, S. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07223.x · Cited by 127 · see citing works

Exposure therapy in eating disorders revisited

Koskina, A., Campbell, I. C., & Schmidt, U. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.11.010 · Cited by 127 · see citing works

Training‐induced changes in the expression of GABA_A‐associated genes in the amygdala after the acquisition and extinction of Pavlovian fear

Heldt, S. A., & Ressler, K. J. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05970.x · Cited by 125 · see citing works

Updating fearful memories with extinction training during reconsolidation: a human study using auditory aversive stimuli

Oyarzún, J. P., Lopez-Barroso, D., Fuentemilla, L., Cucurell, D., Pedraza, C., Rodriguez-Fornells, A., & de Diego-Balaguer, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038849 · Cited by 125 · see citing works

The learning of fear extinction

Furini, C., Myskiw, J., & Izquierdo, I. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.016 · Cited by 124 · see citing works

Microinfusion of the D1 receptor antagonist, SCH23390 into the IL but not the BLA impairs consolidation of extinction of auditory fear conditioning

Hikind, N., & Maroun, M. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.03.003 · Cited by 124 · see citing works

Optimizing exposure therapy for anxiety disorders: an inhibitory learning and inhibitory regulation approach

Craske, M. (2015) · Verhaltenstherapie · doi:10.1159/000381574 · Cited by 124 · see citing works

Mitigation of post‐traumatic stress symptoms by <i>Cannabis</i> resin: A review of the clinical and neurobiological evidence

Passie, T., Emrich, H. M., Karst, M., Brandt, S. D., & Halpern, J. H. (2012) · Drug Testing and Analysis · doi:10.1002/dta.1377 · Cited by 117 · see citing works

Ex vivo dissection of optogenetically activated mPFC and hippocampal inputs to neurons in the basolateral amygdala: implications for fear and emotional memory

Hübner, C., Bosch, D., Gall, A., Lüthi, A., & Ehrlich, I. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00064 · Cited by 115 · see citing works

REM Sleep Is Causal to Successful Consolidation of Dangerous and Safety Stimuli and Reduces Return of Fear after Extinction

Menz, M. M., Rihm, J. S., & Büchel, C. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.3083-15.2016 · Cited by 99 · see citing works

Developmental rodent models of fear and anxiety: from neurobiology to pharmacology

Ganella, D. E., & Kim, J. H. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12643 · Cited by 107 · see citing works

Translating Across Circuits and Genetics Toward Progress in Fear- and Anxiety-Related Disorders

Ressler, K. J. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20010055 · Cited by 104 · see citing works

Directional Theta Coherence in Prefrontal Cortical to Amygdalo-Hippocampal Pathways Signals Fear Extinction

Lesting, J., Daldrup, T., Narayanan, V., Himpe, C., Seidenbecher, T., & Pape, H.-C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077707 · Cited by 105 · see citing works

Functional reorganization of neural networks during repeated exposure to the traumatic memory in posttraumatic stress disorder: an exploratory fMRI study

Cisler, J. M., Steele, J. S., Lenow, J. K., Smitherman, S., Everett, B., Messias, E., & Kilts, C. D. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.09.013 · Cited by 100 · see citing works

How could MDMA (ecstasy) help anxiety disorders? A neurobiological rationale

Johansen, P., & Krebs, T. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109102787 · Cited by 96 · see citing works

Long-term expression of human contextual fear and extinction memories involves amygdala, hippocampus and ventromedial prefrontal cortex: a reinstatement study in two independent samples

Lonsdorf, T. B., Haaker, J., & Kalisch, R. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu018 · Cited by 89 · see citing works

Acute stress impairs the retrieval of extinction memory in humans

Raio, C. M., Brignoni-Perez, E., Goldman, R., & Phelps, E. A. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.01.015 · Cited by 90 · see citing works

Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process

Inserra, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00330 · Cited by 91 · see citing works

360° Video virtual reality exposure therapy for public speaking anxiety: a randomized controlled trial

Reeves, R., Elliott, A., Curran, D., Dyer, K., & Hanna, D. (2021) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2021.102451 · Cited by 82 · see citing works

Amygdala-Prefrontal Synchronization Underlies Resistance to Extinction of Aversive Memories

Livneh, U., & Paz, R. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.016 · Cited by 87 · see citing works

Social modeling of conditioned fear in mice by non-fearful conspecifics

Guzmán, Y. F., Tronson, N. C., Guedea, A., Huh, K. H., Gao, C., & Radulovic, J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.02.024 · Cited by 85 · see citing works

Fear extinction deficits following acute stress associate with increased spine density and dendritic retraction in basolateral amygdala neurons

Maroun, M., Ioannides, P. J., Bergman, K. L., Kavushansky, A., Holmes, A., & Wellman, C. L. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12259 · Cited by 86 · see citing works

Resting heart rate variability is associated with inhibition of conditioned fear

Wendt, J., Neubert, J., Koenig, J., Thayer, J. F., & Hamm, A. O. (2015) · Psychophysiology · doi:10.1111/psyp.12456 · Cited by 85 · see citing works

Effective behavioural strategies for reducing disgust in contamination-related OCD: a review

Ludvik, D., Boschen, M. J., & Neumann, D. L. (2015) · Clinical Psychology Review · doi:10.1016/j.cpr.2015.07.001 · Cited by 84 · see citing works

Sex differences in the functional connectivity of the amygdalae in association with cortisol

Kogler, L., Müller, V. I., Seidel, E.-M., Boubela, R., Kalcher, K., Moser, E., Habel, U., Gur, R. C., Eickhoff, S. B., & Derntl, B. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.03.064 · Cited by 78 · see citing works

Hippocampal network oscillations at the interplay between innate anxiety and learned fear

Çalışkan, G., & Stork, O. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5109-z · Cited by 72 · see citing works