Sustained attention in the mouse: A study of the relationship with the cerebellum.
Abstract
To explore the role of the cerebellum in sustained attention, the authors tested lurcher, wildtype, and lurcher chimeric mice with zero, normal, and variable numbers of Purkinje cells, respectively, in a previously validated task of sustained attention. Results indicate that lurcher mice had a deficit in performance likely related to their motor disability, whereas lurcher chimeras performed similarly to wildtype controls. Presentation of auditory or visual distracters caused deficits in the performance of all mice that were specific to either signal (auditory) or non-signal (visual) events. The authors' results do not support a role of the cerebellum in sustained attention, instead indicating that behavioral changes are an indirect result of motor deficits.
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No relationship was observed between Purkinje cell number and performance on a sustained attention task.
“No relationship was observed between Purkinje cell number and performance on a sustained attention task [286].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [286]
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- Authors
- Martin, L. A., Goldowitz, D., & Mittleman, G.
- Affiliations
- Azusa Pacific University (US)
- University of Tennessee Health Science Center (US)
- University of Memphis (US)
- Venue
- Behavioral Neuroscience
- Published
- 2006
- Volume
- 120
- Issue
- 2
- Pages
- 477-481
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2010226000
- Cited by
- 17
- References
- 20
- Citations by year
- 2020: 1 · 2019: 1 · 2016: 1 · 2014: 2 · 2012: 3
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cure Autism Now
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- sustained attention, cerebellum, Purkinje cells, chimeric mice, motor impairment, attention deficits
- MeSH terms
- Analysis of Variance, Animals, Attention, Behavior, Animal, Cell Count, Cerebellum, Chimera, Mice, Neurologic Mutants, Neuropsychological Tests, Purkinje Cells, Mice
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