The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Sodium depletion enhances salt palatability in rats
Abstract
Sterotyped fixed action patterns (FAPs) are elicited in rats by oral infusions of taste solutions. These taste-elicited FAPs can be classified as either ingestive or aversive. They reflect the palatability of the taste and can be modified by learning and by the physiological state of the animal. These studies demonstrated that when the physiological state of the rat is altered by sodium depletion, the pattern of FAPs elicited by oral infusions of 0.5 M NaCl shifts from a mixture of ingestive and aversive components (while sodium replete) to exclusively ingestive ones (while sodium deplete). This shift in taste reactivity occurred the first time the rats were made sodium deplete. A similar shift was not observed to accompany infusions of 0.01 M HCl, a taste solution that also elicited mixed ingestive and aversive FAPs. This result suggests that the shift in response to NaCl is not due to a general change in ingestive bias or to a general taste deficit. On the basis of the change in FAPs, it is concluded that the palatability of highly concentrated salt solutions increases in sodium-deplete rats. Such a shift in salt palatability may be instrumental in directing the appetitive behavior of the animal.
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“Sodium depletion causes a robust and highly specific motivation to consume sodium, such that salt solutions that are negative/aversive in the replete state become preferred/rewarding in sodium-depleted animals”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [19]
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Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.014
Darwinian Hedonism and Unhealthy Behavior
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.023
The Evolutionary Function of Psychological Hedonism
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.020 · Cited by 1
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.011
Williams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.005
Salt Taste, Nutrition, and Health
(2020) · MDPI eBooks · doi:10.3390/books978-3-03936-466-4
Frank, G. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725600541.793558805
Endocrine and Behavioral Regulation of Water and Salt Intake in Vertebrates
Daniels, D., & Schulkin, J. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.20698-5
Self-citationWilliams, D. M. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316275047.034
(1990) · Elsevier eBooks · doi:10.1016/b978-0-12-304300-9.50015-0
Interoceptive inference and prediction in food-related disordersPreprint
Subramanian, M., & Thaiss, C. A. (2024) · Genes & Development · doi:10.1101/gad.352301.124 · Cited by 1
“…animals deprived of specific nutrients (both macronutrients and micronutrients) can rapidly select foods supplemented with those nutrients (Berridge et al. 1984; Beauchamp et al. 1990; White et al. 1992; Wallis de Vries and Schippers 1994; Provenza et al. 1998; Coelho et al. 2006;…”
BackgroundEndocrine and behavioral regulation of water and salt intake in vertebrates
Sortman, B. W., Schulkin, J. A., & Daniels, D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29068-8.00047-7
Self-citationSaenz, C., & Borgland, S. L. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-29867-7.00032-3 · Cited by 1
Possible role of brain angiotensin II in emotion as suggested by salt palatability
Junior, L. A. D. L., Zenatti, A. A., Pereira, E. D., Fernandes, N. A. R., Paula, P. M. D., Menani, J. V., & Andrade, C. A. F. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115069
Bed Nucleus of Stria Terminalis Enkephalin Neurons Contribute to Depletion-Induced Salt Appetite
Anversa, R. G., Teng, K. S.-L., Viden, A., et al. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.2290-25.2026
Rôle des stimuli sensoriels et de la palatabilité dans la prise orale de nicotine chez la souris
Tannous, S. (2019) · theses.fr (ABES) · doi:10.70675/eaa3d755ze7a1z4017z893dz1b7fd3cd4d8d
A microstructural analysis of sodium and water intake in male and female rats
Demieri, E., Mullane, E. L., Lamb, K. L., Edwards, A. A., Brooker, S. L., David, S. A., Daniels, D., Torregrossa, A., & Santollo, J. (2026) · Physiology & Behavior · doi:10.1016/j.physbeh.2026.115507
Metadata
- Authors
- Berridge, K. C., Flynn, F. W., Schulkin, J., & Grill, H. J.
- Venue
- Behavioral Neuroscience
- Published
- 1984
- Volume
- 98
- Issue
- 4
- Pages
- 652-660
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W4234619845
- Cited by
- 257
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 8 · 2019: 44 · 2018: 12 · 2017: 1 · 2016: 12 · 2015: 9 · 2014: 7 · 2013: 4 · 2012: 12
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- sodium depletion, sodium appetite, sodium chloride taste, taste preference
- MeSH terms
- Animals, Appetite, Humans, Male, Sodium Chloride, Stereotyped Behavior, Taste, Rats
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