The DOI matches its Crossref record.
Relative memory deficits in recurrent versus first-episode major depression on a word-list learning task.
Abstract
Although memory deficits are associated with major depressive disorder, few studies have identified which patient characteristics predict impairment. Because recurrent depression appears related to more severe cerebral dysfunction, the present study tested whether recurrent depressed individuals have worse memory function than first-episode depressed individuals. Two groups of young-adult, nonpsychotic, depressed inpatients (20 single episode [SE] and 46 recurrent episode [RE]) were administered the California Verbal Learning Test within a broader battery of neuropsychological tests. The groups were equivalent in age, education, estimated IQ, severity of depression, and demographic composition. The RE group demonstrated memory deficits relative to both the SE group and published norms, but no other significant difference was found across the battery. Data indicate that abnormal memory performance is associated with recurrent depression, whereas memory deficits are not prominent in first-episode depressed individuals.
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“Cognitive symptoms are seen in first-episode depression [6,8], persist beyond the symptoms of low mood [9-11], contribute to the risk of relapse [12], and worsen with repeated depressive episodes [13,14].”
From Wearable technology for high-frequency cognitive and mood assessment in major depressive disorder: longitudinal observational study (2019) · cites this paper as [13]
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Neurocognitive deficits and disability in major depressive disorder
Jaeger, J., Berns, S., Uzelac, S., & Davis-Conway, S. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2005.11.011 · Cited by 484
Cognitive impairment in major depression
Marazziti, D., Consoli, G., Picchetti, M., Carlini, M., & Faravelli, L. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.08.046 · Cited by 448
The role of cognitive impairment in general functioning in major depression
Baune, B. T., Miller, R., McAfoose, J., Johnson, M., Quirk, F., & Mitchell, D. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2008.12.001 · Cited by 378
Systematic review of the neural basis of social cognition in patients with mood disorders
Cusi, A. M., Nazarov, A., Holshausen, K., MacQueen, G. M., & McKinnon, M. C. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100179 · Cited by 278
Naismith, S. L., Norrie, L. M., Mowszowski, L., & Hickie, I. B. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.009 · Cited by 282
Metadata
- Authors
- Basso, M. R., & Bornstein, R. A.
- Affiliations
- University of Tulsa (US)
- ORCID
- Basso, Michael R.
- Venue
- Neuropsychology
- Published
- 1999
- Volume
- 13
- Issue
- 4
- Pages
- 557-563
- ISSN
- 0894-4105 (ISSN-L)
- 1931-1559
- OpenAlex
- W2050904569
- Cited by
- 141
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 9 · 2012: 9
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- recurrent depression, first-episode depression, major depressive disorder, memory impairment, word list learning, California Verbal Learning Test, neuropsychological assessment, cognitive impairment in depression
- MeSH terms
- Acute Disease, Adult, Analysis of Variance, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Memory Disorders, Neuropsychological Tests, Recurrence, Reference Values, Verbal Learning, Confounding Factors, Epidemiologic
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