The DOI matches its Crossref record; 132 of the 133 references it cites were found in a registry or an index.
Neurocognition in first-episode schizophrenia: A meta-analytic review.
Abstract
Compromised neurocognition is a core feature of schizophrenia. Following Heinrichs and Zakzanis's (1998) seminal meta-analysis of middle-aged and predominantly chronic schizophrenia samples, the aim of this study is to provide a meta-analysis of neurocognitive findings from 47 studies of first-episode (FE) schizophrenia published through October 2007. The meta-analysis uses 43 separate samples of 2,204 FE patients with a mean age of 25.5 and 2,775 largely age- and gender-matched control participants. FE samples demonstrated medium-to-large impairments across 10 neurocognitive domains (mean effect sizes from -0.64 to -1.20). Findings indicate that impairments are reliably and broadly present by the FE, approach or match the degree of deficit shown in well-established illness, and are maximal in immediate verbal memory and processing speed. Larger IQ impairments in the FE compared to the premorbid period, but comparable to later phases of illness suggests deterioration between premorbid and FE phases followed by deficit stability at the group level. Considerable heterogeneity of effect sizes across studies, however, underscores variability in manifestations of the illness and a need for improved reporting of sample characteristics to support moderator variable analyses.
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“High rates of cognitive impairment in individuals experiencing psychosis have been found across multiple cognitive domains (Bokat & Goldberg, 2003;Dickinson et al., 2007;Mesholam-Gately et al., 2009).”
From Mindfulness for voices: An experimental analogue study of the effect of manipulating response style to simulated voices in a non‐clinical population. (2023) · cites this paper as Mesholam-Gately et al., 2009
In the citing paper
“Schizophrenia is associated with deficits in cognitive domains of executive functioning, processing speed, memory and attention (Mesholam-Gately et al., 2009; Keefe and Harvey, 2012).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Mesholam-Gately et al., 2009
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Sirichitr, L. C., & Moldestad, T. (2012) · NORA - Norwegian Open Research Archives
Metadata
- Authors
- Mesholam-Gately, R. I., Giuliano, A. J., Goff, K. P., Faraone, S. V., & Seidman, L. J.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- SUNY Upstate Medical University (US)
- Venue
- Neuropsychology
- Published
- 2009
- Volume
- 23
- Issue
- 3
- Pages
- 315-336
- ISSN
- 0894-4105 (ISSN-L)
- 1931-1559
- OpenAlex
- W1987834520
- Semantic Scholar
- 1f5bc4062ee07501c7114895394d11f0b51016c3
- Cited by
- 1,130
- References
- 133
- Citations by year
- 2026: 29 · 2025: 43 · 2024: 52 · 2023: 54 · 2022: 56 · 2021: 73 · 2020: 74 · 2019: 103 · 2018: 88 · 2017: 79 · 2016: 66 · 2015: 88 · 2014: 74 · 2013: 84 · 2012: 66
- FWCI
- 34.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institute of Mental Health (P50MH080272, MH 43518; MH 63951; MH 65562)
- Department of Mental Health Research
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- first-episode schizophrenia, neurocognitive function, cognitive impairment, verbal memory, processing speed, IQ decline, premorbid intelligence, effect size heterogeneity
- MeSH terms
- Adult, Cognition Disorders, Humans, Intelligence, Memory, Neuropsychological Tests, Schizophrenia, Schizophrenic Psychology, Time Factors, Verbal Learning
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