Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat.
Abstract
Male rats display a conditioned preference to ejaculate with a female bearing an odor paired previously with copulation to ejaculation. The present study examined the role of endogenous opioid and dopamine systems in this preference. Male rats received saline, the opioid receptor antagonist naloxone, or the dopamine receptor antagonist flupenthixol prior to 10 conditioning trials in a pacing chamber with an almond-scented female. On the final test, all males were injected with saline and given access to 2 females, 1 scented and the other unscented, in an open field. Only males injected with naloxone during training failed to manifest a conditioned ejaculatory preference. These findings suggest that activation of opioid, but not dopamine, systems during sexual interaction are necessary for conditioned ejaculatory preference in male rats.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
When rats mate, they associate ejaculation reward with non-social cues and can form preferences for location or non-social odors.
“Instead, when rats mate, they associate the reward from ejaculation with non-social cues and can form preferences for the location or for non-social odors (Miller and Baum 1987; Mehrara and Baum 1990; Ismail et al 2009).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Ismail et al 2009
Cites
The Physiology of Reproduction
Legendre, M., & Jalabert, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-2-176_1 · Cited by 7,879 · see citing works
Editorial Office (1997) · Obesity Surgery · doi:10.1381/096089297765555359 · Cited by 3,917 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307 · see citing works
“Instead, when rats mate, they associate the reward from ejaculation with nonsocial cues and can form preferences for the location or for nonsocial odors (Miller and Baum 1987; Mehrara and Baum 1990; Ismail et al. 2009).”
Pfaus, J. G., Kippin, T. E., Coria-Avila, G. A., Gelez, H., Afonso, V. M., Ismail, N., & Parada, M. (2012) · Archives of Sexual Behavior · doi:10.1007/s10508-012-9935-5 · Cited by 215 · see citing works
Self-citationResendez, S. L., Dome, M., Gormley, G., Franco, D., Nevárez, N., Hamid, A. A., & Aragona, B. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4123-12.2013 · Cited by 93 · see citing works
- Authors
- Ismail, N., Girard-Bériault, F., Nakanishi, S., & Pfaus, J. G.
- Affiliations
- Concordia University (CA)
- Venue
- Behavioral Neuroscience
- Published
- 2009
- Volume
- 123
- Issue
- 5
- Pages
- 992-999
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2003674988
- Cited by
- 33
- References
- 2
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 5 · 2012: 5
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP-74563)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- naloxone, flupenthixol, opioid system, dopaminergic system, opioid antagonists, dopamine antagonists, male sexual behavior, copulation
- MeSH terms
- Analysis of Variance, Animals, Association Learning, Choice Behavior, Copulation, Dopamine, Ejaculation, Female, Flupenthixol, Injections, Subcutaneous, Male, Naloxone, Narcotic Antagonists, Odorants, Receptors, Dopamine, Receptors, Opioid, Smell, Dopamine Antagonists, Opioid Peptides, Rats, Long-Evans, Recognition, Psychology, Rats, Mating Preference, Animal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
