Memory modulation.
Open accessAbstract
Our memories are not all created equally strong: Some experiences are well remembered while others are remembered poorly, if at all. Research on memory modulation investigates the neurobiological processes and systems that contribute to such differences in the strength of our memories. Extensive evidence from both animal and human research indicates that emotionally significant experiences activate hormonal and brain systems that regulate the consolidation of newly acquired memories. These effects are integrated through noradrenergic activation of the basolateral amygdala that regulates memory consolidation via interactions with many other brain regions involved in consolidating memories of recent experiences. Modulatory systems not only influence neurobiological processes underlying the consolidation of new information, but also affect other mnemonic processes, including memory extinction, memory recall, and working memory. In contrast to their enhancing effects on consolidation, adrenal stress hormones impair memory retrieval and working memory. Such effects, as with memory consolidation, require noradrenergic activation of the basolateral amygdala and interactions with other brain regions.
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Increased serotonin and catecholamine levels induced by antidepressant intake might compensate for the memory-impairing effects of REM-sleep suppression.
“On the other hand, the increase in sero-tonin and catecholamine levels induced by antidepressant intake might compensate for the memory-impairing effects of REM-sleep suppression, as these neurotransmitters have been implicated in memory consolidation processes (815, 842, 1011).”
From About Sleep's Role in Memory (2013) · cites this paper as [1011]
The ‘Other Neuromodulatory Systems’ section links catecholamine-acting drugs to enhanced memory consolidation. The paper mentions serotonin in its ‘Memory Retrieval’ section, but not as evidence for serotonin’s role in consolidation. It does not test the citing authors’ proposed compensation for REM-sleep suppression. (LLM, conf=0.86)
Experimental — accuracy not yet measuredNeurobiology literature indicates that memory performance for information encoded under stress tends to be superior to memory performance for neutral information.
“Contrary to eyewitness identification laboratory studies, the empirical literature from the field of neurobiology indicates that memory performance for information encoded under stress tends to be superior to memory performance for neutral information (see LaBar & Cabeza, 2006 for a review; Roozendaal & McGaugh, 2011).”
From Stress, stress-induced cortisol responses, and eyewitness identification performance (2016) · cites this paper as Roozendaal & McGaugh, 2011
The process by which emotionally-aversive memories become consolidated is recognized to be an interaction between glucocorticoid hormones and norepinephrine, both of which are released in response to stress.
“The process by which emotionally-aversive memories become consolidated is recognized to be an interaction between glucocorticoid hormones and norepinephrine, both of which are released in response to stress2.”
From Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: A positron emission tomography study (2013) · cites this paper as [2]
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References 351 · Cited by 445
Research works printed but not linked: 15
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- Authors
- Roozendaal, B., & McGaugh, J. L.
- Affiliations
- University Medical Center Groningen (NL)
- University of California, Irvine (US)
- ORCID
- Roozendaal, Benno
- Venue
- Behavioral Neuroscience
- Published
- 2011-12
- Volume
- 125
- Issue
- 6
- Pages
- 797-824
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- PMC
- PMC3236701
- OpenAlex
- W4210955994
- Cited by
- 445
- References
- 351
- Citations by year
- 2026: 25 · 2025: 22 · 2024: 14 · 2023: 22 · 2022: 34 · 2021: 39 · 2020: 32 · 2019: 26 · 2018: 38 · 2017: 31 · 2016: 44 · 2015: 33 · 2014: 31 · 2013: 38 · 2012: 15
- FWCI
- 13.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- US PHS (MH12526)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- memory modulation, memory consolidation, emotional arousal, noradrenergic activation, basolateral amygdala, memory extinction, memory retrieval, working memory
- MeSH terms
- Amygdala, Animals, Glucocorticoids, Humans, Memory, Memory, Short-Term, Nerve Net, Norepinephrine, Mental Recall, Retention, Psychology, Signal Transduction
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