Circadian rhythms and addiction: Mechanistic insights and future directions.
Open accessAbstract
Circadian rhythms are prominent in many physiological and behavioral functions. Circadian disruptions either by environmental or molecular perturbation can have profound health consequences, including the development and progression of addiction. Both animal and humans studies indicate extensive bidirectional relationships between the circadian system and drugs of abuse. Addicted individuals display disrupted rhythms, and chronic disruption or particular chronotypes may increase the risk for substance abuse and relapse. Moreover, polymorphisms in circadian genes and an evening chronotype have been linked to mood and addiction disorders, and recent efforts suggest an association with the function of reward neurocircuitry. Animal studies are beginning to determine how altered circadian gene function results in drug-induced neuroplasticity and behaviors. Many studies suggest a critical role for circadian rhythms in reward-related pathways in the brain and indicate that drugs of abuse directly affect the central circadian pacemaker. In this review, we highlight key findings demonstrating the importance of circadian rhythms in addiction and how future studies will reveal important mechanistic insights into the involvement of circadian rhythms in drug addiction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chronic exposure to drugs of abuse can lead to epigenetic changes affecting the molecular clock that may then alter function of the reward circuitry for long periods of time, creating more vulnerability for future drug abuse.
“Chronic exposure to drugs of abuse can lead to epigenetic changes affecting the molecular clock that may then alter function of the reward circuitry for long periods of time, creating more vulnerability for future drug abuse176.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [176]
An emerging literature links mutations in circadian genes (e.g., Period and Clock) to human alcohol involvement, consistent with findings in the animal literature.
“An emerging literature also links mutations in circadian genes (e.g., Period and Clock) to human alcohol involvement, consistent with findings in the more substantive animal literature (reviewed in Logan, Williams, & McClung, 2014).”
From Sleep and circadian contributions to adolescent alcohol use disorder (2015) · cites this paper as Logan et al., 2014
Disruptions to the function of circadian genes are associated with corresponding disruptions to key elements of the reward system in animal models.
“Animal models (see Logan et al., 2014 for review) have demonstrated that disruptions to the function of circadian genes are associated with corresponding disruptions to key elements of the reward system.”
From Sleep and circadian contributions to adolescent alcohol use disorder (2015) · cites this paper as Logan et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 345 · Cited by 142
Research works printed but not linked: 1
- Spencer S Falcon E Kumar J Krishnan V Mukherjee S Birnbaum SG McClung CA 2013 Circadian genes Period 1 and Period 2 in the nucleus accumbens regulate anxiety-related behavior The European journal of neuroscience 37 2 242 250 10.1111/ejn.12010 23039899 PMC3711746 · DOI · Paper page
- Authors
- Logan, R. W., Williams, W. P., & McClung, C. A.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Behavioral Neuroscience
- Published
- 2014
- Volume
- 128
- Issue
- 3
- Pages
- 387-412
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- PMC
- PMC4041815
- OpenAlex
- W2164482113
- Cited by
- 142
- References
- 345
- Citations by year
- 2026: 14 · 2025: 7 · 2024: 13 · 2023: 7 · 2022: 14 · 2021: 21 · 2020: 12 · 2019: 13 · 2018: 8 · 2017: 13 · 2016: 4 · 2015: 11 · 2014: 5
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse
- National Institute of Mental Health
- National Institute on Neurological Disorders and Stroke
- McKnight Foundation
- Brain and Behavior Research Foundation
- International Mental Health Research Organization
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- circadian rhythm, addiction, circadian rhythm disruption, chronotype, evening chronotype, circadian genes, genetic polymorphism, substance abuse, relapse, circadian pacemaker, mood disorders
- MeSH terms
- Animals, Brain, Humans, Mutation, Reward, Illicit Drugs, Substance-Related Disorders, Chronobiology Disorders, Circadian Rhythm Signaling Peptides and Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
