Anxiety sensitivity and intolerance of uncertainty facilitate associations between generalized Pavlovian fear and maladaptive avoidance decisions.
Abstract
Generalization of Pavlovian fear to safe stimuli resembling conditioned-danger cues (CS+) is a widely accepted conditioning correlate of clinical anxiety. Though much of the pathogenic influence of such generalization may lie in the associated avoidance, few studies have assessed maladaptive avoidance decisions associated with Pavlovian generalization. Lab-based assessments of this process, here referred to as aversive Pavlovian-instrumental covariation during generalization (APIC-G), have recently begun. The current study represents a next step in this line of work by conducting the first examination of anxiety-related dimensions of personality that may exacerbate APIC-G. Specifically, we test anxiety sensitivity (AS) and intolerance of uncertainty (IU) as moderators of relations between Pavlovian generalization and maladaptive avoidance decisions in 102 undergraduate students with wide-ranging levels of IU and AS. Results indicate a facilitative effect of AS on this APIC-G process, with AS strengthening relations between Pavlovian generalization and maladaptive generalized avoidance whether operationalizing Pavlovian generalization with psychophysiological (fear-potentiated startle) or behavioral measures. Additionally, IU was found to facilitate APIC-G when indexing Pavlovian generalization with behavioral but not fear-potentiated startle measures. Moderating effects of AS were most pronounced for stimulus classes bearing the highest resemblance to CS+, whereas effects of…
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Once acquired, extinguished, or recovered, it is feasible to expect that avoidance may readily spread or generalize via relational learning to seemingly innocuous stimuli.
“Once acquired, extinguished, or recovered, it is feasible to expect that avoidance may readily spread or generalize via relational learning to seemingly innocuous stimuli (Dymond et al., 2018; Dymond, Dunsmoor, Vervliet, Roche, & Hermans, 2015; Hunt, Cooper, Hartnell, & Lissek, 2019).”
From Relapse of anxiety-related fear and avoidance: Conceptual analysis of treatment with acceptance and commitment therapy (2020) · cites this paper as Hunt, Cooper, Hartnell, & Lissek, 2019
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UNCERTAINTY AND ANXIETY; EVOLUTION AND NEUROBIOLOGY.
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- Authors
- Hunt, C., Cooper, S. E., Hartnell, M. P., & Lissek, S.
- Affiliations
- University of Minnesota (US)
- Venue
- Journal of Abnormal Psychology
- Published
- 2019-05
- Volume
- 128
- Issue
- 4
- Pages
- 315-326
- ISSN
- 0021-843X (ISSN-L)
- 1939-1846
- OpenAlex
- W2919942905
- Cited by
- 71
- References
- 0
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 8 · 2023: 9 · 2022: 18 · 2021: 14 · 2020: 11 · 2019: 2
- FWCI
- 13.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Abnormal Psychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- anxiety sensitivity, intolerance of uncertainty, fear-potentiated startle, clinical anxiety
- MeSH terms
- Correlation of Data, Adult, Anxiety, Arousal, Avoidance Learning, Character, Conditioning, Classical, Cues, Decision Making, Fear, Female, Generalization, Stimulus, Humans, Male, Prospective Studies, Reflex, Startle, Transfer, Psychology, Uncertainty, Young Adult
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