Partial reinforcement effects in classical aversive conditioning in rabbits and human beings.
Abstract
The partial reinforcement extinction effect (the PREE) in classical aversive conditioning was investigated in 2 experiments. In the first, the nictitating membrane responses of 120 rabbits were conditioned at a 250-msec. interstimulus interval (ISI) under continuous reinforcement, partial reinforcement with the unconditioned stimulus (US) omitted (Group PO), or partial reinforcement with the US delayed to 1,500 msec. (Group PD). These 3 groups were factorially extinguished under US-Omitted, US-Unpaired, or US-Delayed extinction regimens. A significant PREE was obtained, but only for PO training and US-Omitted extinction. The second experiment, employing human subjects in a masked eye blink conditioning task, produced parallel results. A general discrimination view of the classical PREE seems applicable, but one in which neither cognitive factors nor intertrial conditioning of reinforcement aftereffects play a significant role.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Such effects may have occurred for the physiological measures during extinction because of the use of a partial reinforcement schedule during acquisition, which is known to slow down extinction.
“Such effects may have occurred for the physiological measures during extinction because of the use of a partial reinforcement schedule during acquisition, which is known to slow down extinction (Leonard 1975).”
From The Impact of Intolerance of Uncertainty and Cognitive Behavioural Instructions on Safety Learning (2020) · cites this paper as Leonard 1975
The time it takes participants to learn that a contingency change has occurred may differ depending on the reinforcement rate used during the prior acquisition phase.
“However, the time it takes participants to learn that a contingency change has occurred may differ depending on the reinforcement rate used during the prior acquisition phase (78,79).”
From I Doubt It Is Safe: A Meta-analysis of Self-reported Intolerance of Uncertainty and Threat Extinction Training (2021) · cites this paper as [79]
Cites
Amsel, A. (1962) · Psychological Review · doi:10.1037/h0046200 · Cited by 969 · see citing works
Partial reinforcement: A hypothesis of sequential effects.
Capaldi, E. J. (1966) · Psychological Review · doi:10.1037/h0023684 · Cited by 320 · see citing works
Rehearsal in animal conditioning.
Wagner, A. R., Rudy, J. W., & Whitlow, J. W. (1973) · Journal of Experimental Psychology · doi:10.1037/h0034136 · Cited by 260 · see citing works
The interstimulus interval and the latency of the conditioned eyelid response.
Boneau, C. A. (1958) · Journal of Experimental Psychology · doi:10.1037/h0044940 · Cited by 80 · see citing works
Extinction of conditioned fear as a function of percentage of reinforcement.
Wagner, A. R., Siegel, L. S., & Fein, G. G. (1967) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0024172 · Cited by 66 · see citing works
Partial reinforcement of the classically conditioned eyelid response in the rabbit.
Thomas, E., & Wagner, A. R. (1964) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0048811 · Cited by 41 · see citing works
Spence, K. W., Homzie, M. J., & Rutledge, E. F. (1964) · Journal of Experimental Psychology · doi:10.1037/h0048887 · Cited by 37 · see citing works
Effect of CS-US interval shift on classical conditioning of the nictitating membrane in the rabbit.
Leonard, D. W., & Theios, J. (1967) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0024373 · Cited by 29 · see citing works
Self-citationHartman, T. F., & Grant, D. A. (1962) · Journal of Experimental Psychology · doi:10.1037/h0038838 · Cited by 28 · see citing works
Hupka, R. B., Kwaterski, S. E., & Moore, J. W. (1970) · Journal of Experimental Psychology · doi:10.1037/h0028584 · Cited by 25 · see citing works
Leonard, D. W., & Theios, J. (1967) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0088043 · Cited by 18 · see citing works
Self-citationSpence, K. W., & Platt, J. R. (1967) · Journal of Experimental Psychology · doi:10.1037/h0024583 · Cited by 16 · see citing works
Papsdorf, J. D., & Kettlewell, N. M. (1968) · Psychonomic Science · doi:10.3758/bf03331465 · Cited by 15 · see citing works
Classical eyelid conditioning of the severely retarded: Partial reinforcement effects
Ross, L. E., Koski, C. H., & Yaeger, J. (1964) · Psychonomic Science · doi:10.3758/bf03342895 · Cited by 15 · see citing works
Hoehler, F. K., & Leonard, D. W. (1973) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0035037 · Cited by 10 · see citing works
Self-citationKettlewell, N. M., & Papsdorf, J. D. (1967) · Psychonomic Science · doi:10.3758/bf03332210 · Cited by 8 · see citing works
Salafia, W. R., & Papsdorf, J. D. (1968) · Psychonomic Science · doi:10.3758/bf03342473 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lonsdorf, T. B., Menz, M. M., Andreatta, M., Fullana, M. A., Golkar, A., Haaker, J., Heitland, I., Hermann, A., Kuhn, M., Kruse, O., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.026 · Cited by 837 · see citing works
Human Fear Conditioning and Extinction in Neuroimaging: A Systematic Review
Sehlmeyer, C., Schöning, S., Zwitserlood, P., Pfleiderer, B., Kircher, T., Arolt, V., & Konrad, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005865 · Cited by 543 · see citing works
Stress-induced recovery of fears and phobias.
Jacobs, W. J., & Nadel, L. (1985) · Psychological Review · doi:10.1037/0033-295x.92.4.512 · Cited by 322 · see citing works
Dunsmoor, J. E., Bandettini, P. A., & Knight, D. C. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.4.635 · Cited by 137 · see citing works
Morriss, J., Zuj, D. V., & Mertens, G. (2021) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2021.05.011 · Cited by 108 · see citing works
Hoehler, F. K., & Thompson, R. F. (1979) · Physiological Psychology · doi:10.3758/bf03326655 · Cited by 94 · see citing works
Bouton, M. E., Rosengard, C., Achenbach, G. G., Peck, C. A., & Brooks, D. C. (1993) · PubMed · Cited by 90 · see citing works
Amygdala-Prefrontal Synchronization Underlies Resistance to Extinction of Aversive Memories
Livneh, U., & Paz, R. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.016 · Cited by 87 · see citing works
Fundamental Behavioral Methods and Findings in Classical Conditioning
Kehoe, E. J., & Macrae, M. (2002) · Springer eBooks · doi:10.1007/978-1-4419-8558-3_6 · Cited by 80 · see citing works
Extinction after aversive conditioning: An associative or nonassociative process?
Frey, P. W., & Butler, C. S. (1977) · Learning and Motivation · doi:10.1016/0023-9690(77)90063-7 · Cited by 63 · see citing works
Morriss, J., Wake, S., Elizabeth, C., & van Reekum, C. M. (2021) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.05.011 · Cited by 52 · see citing works
“However, the time it takes participants to learn that a contingency change has occurred may differ depending on the reinforcement rate used during the prior acquisition phase (78,79).”
BackgroundMorriss, J., & van Reekum, C. M. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.03.004 · Cited by 46 · see citing works
Morriss, J., Saldarini, F., Chapman, C., Pollard, M. I., & van Reekum, C. M. (2019) · Journal of Experimental Psychopathology · doi:10.1177/2043808719834451 · Cited by 45 · see citing works
Garcia, K. S., Mauk, M. D., Weidemann, G., & Kehoe, E. J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.292 · Cited by 46 · see citing works
Kehoe, E. J., Morrow, L. D., & Holt, P. E. (1984) · Animal Learning & Behavior · doi:10.3758/bf03213131 · Cited by 41 · see citing works
The role of threat level and intolerance of uncertainty in extinction
Morriss, J., Saldarini, F., & van Reekum, C. M. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2019.05.013 · Cited by 39 · see citing works
Wake, S. J., Morriss, J., Johnstone, T., van Reekum, C. M., & Dodd, H. F. (2021) · Behaviour Research and Therapy · doi:10.1016/j.brat.2021.103818 · Cited by 33 · see citing works
The learning of prospective and retrospective cognitive maps within neural circuits
Namboodiri, V. M. K., & Stuber, G. D. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.034 · Cited by 31 · see citing works
Morriss, J., Wake, S., Lindner, M., McSorley, E., & Dodd, H. (2020) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2020.04.012 · Cited by 33 · see citing works
Sangha, S., McComb, C., Scheibenstock, A., Johannes, C., & Lukowiak, K. (2002) · Journal of Experimental Biology · doi:10.1242/jeb.205.8.1171 · Cited by 33 · see citing works
Allen, M. T., Myers, C. E., & Servatius, R. J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00347 · Cited by 29 · see citing works
Holloway, J. L., Allen, M. T., Myers, C. E., & Servatius, R. J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.041 · Cited by 26 · see citing works
Unpaired extinction: Implications for treating post-traumatic stress disorder
Schreurs, B. G., Smith‐Bell, C. A., & Burhans, L. B. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.10.010 · Cited by 24 · see citing works
The effect of social anxiety on the acquisition and extinction of low-cost avoidance
Wake, S., van Reekum, C. M., & Dodd, H. F. (2021) · Behaviour Research and Therapy · doi:10.1016/j.brat.2021.103967 · Cited by 19 · see citing works
The Impact of Intolerance of Uncertainty and Cognitive Behavioural Instructions on Safety Learning
Wake, S., van Reekum, C. M., Dodd, H., & Morriss, J. (2020) · Cognitive Therapy and Research · doi:10.1007/s10608-020-10113-4 · Cited by 20 · see citing works
Pavlovian safety learning: An integrative theoretical review
Laing, P., Vervliet, B., Dunsmoor, J., & Harrison, B. J. (2024) · Psychonomic Bulletin & Review · doi:10.3758/s13423-024-02559-4 · Cited by 23 · see citing works
The scent of salience — Is there olfactory-trigeminal conditioning in humans?
Moessnang, C., Pauly, K. D., Kellermann, T., Krämer, J., Finkelmeyer, A. E., Hummel, T. R., Siegel, S. J., Schneider, F. W., & Habel, U. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.03.049 · Cited by 21 · see citing works
Uncertainty-Dependent Extinction of Fear Memory in an Amygdala-mPFC Neural Circuit Model
Li, Y., Nakae, K., Ishii, S., & Naoki, H. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005099 · Cited by 18 · see citing works
Allen, M., Myers, C., Beck, K., Pang, K., & Servatius, R. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00496 · Cited by 16 · see citing works
An Amygdala-Inspired Classical Conditioning Model Implemented on an FPGA for Home Service Robots
Tanaka, Y., Morie, T., & Tamukoh, H. (2020) · IEEE Access · doi:10.1109/access.2020.3038161 · Cited by 16 · see citing works
Fan, M., Zhang, D., Zhao, S., Xie, Q., Chen, W., Jie, J., Wang, Y., & Zheng, X. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104201 · Cited by 14 · see citing works
Eyeblink classical conditioning and post-traumatic stress disorder – a model systems approach
Schreurs, B. G. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00050 · Cited by 14 · see citing works
McSweeney, F. K., Swindell, S., & Weatherly, J. N. (1999) · Learning and Motivation · doi:10.1006/lmot.1999.1032 · Cited by 14 · see citing works
Zhao, S., Chen, W., Jie, J., Fan, M., Li, J., Rong, M., Yang, Z., & Zheng, X. (2022) · Learning and Motivation · doi:10.1016/j.lmot.2022.101812 · Cited by 12 · see citing works
Coutanche, M. N., & Thompson‐Schill, S. L. (2012) · Perspectives on Psychological Science · doi:10.1177/1745691611434211 · Cited by 12 · see citing works
Allen, M., Handy, J., Miller, D. P., & Servatius, R. (2019) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.003 · Cited by 12 · see citing works
Classical Conditioning: Contingency and Contiguity
LoLordo, V. M. (1979) · Springer eBooks · doi:10.1007/978-1-4684-3387-6_3 · Cited by 7 · see citing works
Oristaglio, J., Romano, A. G., & Harvey, J. A. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.02.007 · Cited by 5 · see citing works
Electrocortical Responses in Anticipation of Avoidable and Inevitable Threats: A Multisite Study
Stegmann, Y., Teigeler, J., Mirifar, A., Keil, A., & Gamer, M. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0575-24.2024 · Cited by 6 · see citing works
Project DyAdd: classical eyeblink conditioning in adults with dyslexia and ADHD
Laasonen, M. R., Kauppinen, J., Leppämäki, S., Tani, P., Harno, H., Hokkanen, L., & Wikgren, J. (2012) · Experimental Brain Research · doi:10.1007/s00221-012-3237-y · Cited by 4 · see citing works
Attenuation and reacquisition of foraging behavior in a patchy environment
Mitchell, K. G., Calton, J. L., Threlkeld, R. C., & Schachtman, T. R. (1996) · Behavioural Processes · doi:10.1016/0376-6357(95)00034-8 · Cited by 3 · see citing works
Weaker situations: Uncertainty reveals individual differences in learning: Implications for PTSD
Allen, M. T. (2023) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-023-01077-5 · Cited by 2 · see citing works
Miller, D. P., Allen, M. T., & Servatius, R. J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00848 · Cited by 3 · see citing works
Morriss, J., Wake, S. J., elizabeth, C., & van Reekum, C. M. (2021) · doi:10.31234/osf.io/nrqv6 · Cited by 7 · see citing works
Reconciling Translational Disparities Between Empirical Approaches to Better Understand PTSD
Norrholm, S. D., Cilley, T., & Jovanović, T. (2023) · Neuromethods · doi:10.1007/978-1-0716-3218-5_6 · Cited by 2 · see citing works
Song, Y., Zhao, S., Rong, M., Liu, Y., Gao, Y., Chen, W., Zhang, D., & Zheng, X. (2024) · Behavioral Sciences · doi:10.3390/bs14080630 · Cited by 2 · see citing works
Finke, J. B., Schippers, A. M., & Klucken, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-05350-0 · Cited by 1 · see citing works
Holloway, J. L., Allen, M. T., Myers, C. E., & Servatius, R. J. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.016 · Cited by 1 · see citing works
No effect of partial reinforcement on fear extinction learning and memory in C57BL/6J micePreprint
Su, A. C. J., Fukunaga, Y., Penna, S. R., & Cazares, V. A. (2025) · Learning & Memory · doi:10.1101/lm.054033.124 · Cited by 1 · see citing works
Battaglia, S. (2020) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/9085
(1975) · Bulletin of the Psychonomic Society · doi:10.3758/bf03333271
No effect of partial reinforcement on fear extinction learning and memory in C57BL/6J micePreprint
Su, A. C. J., Fukunaga, Y., Penna, S., & Cazares, V. A. (2024) · doi:10.31234/osf.io/8udn5
Wang, J., Zixin, Y. U. A. N., Wikgren, J., Gan, X., Becker, B., Zhou, Y., & Lei, Y. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121901
Sridhar, S., Biagi, N., & Wake, S. (2026) · Behaviour Research and Therapy · doi:10.1016/j.brat.2026.105088
Concept of Unpaired Extinction for Treating PTSD
Schreurs, B. G., & Burhans, L. B. (2016) · Springer eBooks · doi:10.1007/978-3-319-08359-9_18
Early life threat and caregiver-related fear learning in early childhood
Murgueitio, N., McLaughlin, K., Machlin, L., Haughey, C., Sokolik, M., Swarna, P., Patel, K. K., Propper, C. B., Sullivan, R. M., & Sheridan, M. A. (2026) · Neurobiology of Stress · doi:10.1016/j.ynstr.2026.100859
Concept of Unpaired Extinction for Treating PTSD
Schreurs, B. G., & Burhans, L. B. (2015) · Springer eBooks · doi:10.1007/978-3-319-08613-2_18-1
- Authors
- Leonard, D. W.
- Corresponding author
- Leonard, Dale W.
- Venue
- Journal of Comparative and Physiological Psychology
- Published
- 1975
- Volume
- 88
- Issue
- 2
- Pages
- 596-608
- ISSN
- 0021-9940 (ISSN-L)
- OpenAlex
- W2008238339
- Cited by
- 58
- References
- 17
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 5 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Comparative and Physiological Psychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- partial reinforcement extinction effect, nictitating membrane response, eyeblink conditioning, extinction, discrimination learning, rabbits, research participants, interstimulus interval
- MeSH terms
- Acoustic Stimulation, Animals, Avoidance Learning, Conditioning, Classical, Conditioning, Eyelid, Discrimination Learning, Electroshock, Extinction, Psychological, Humans, Perceptual Masking, Rabbits, Reaction Time, Reinforcement, Psychology, Reinforcement Schedule, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review