Serum amyloid P component (not Serum Amyloid Protein)
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CPHPC efficiently binds to SAP, leading to the dissociation of SAP from bound amyloids and subsequent depletion of SAP levels in the body.
“This compound efficiently binds to SAP, leading to the dissociation of SAP from bound amyloids and subsequent depletion of SAP levels in the body24,62–68.”
From Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis (2025) · cites this paper as [67]
CPHPC (miridesap) at a concentration of 5 mg ml−1 in drinking water is an established dose for SAP depletion from the body.
“To examine the effects of CPHPC on age-associated bone changes, male and female mice aged 18 months were treated with CPHPC (miridesap) at a concentration of 5 mg ml−1 in drinking water, which is an established dose for SAP depletion from the body62–65,67,68,84.”
From Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis (2025) · cites this paper as [67]
Cites
Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene
Botto, M., Hawkins, P. N., Bickerstaff, M. C. M., Herbert, J., Bygrave, A. E., Mcbride, A., Hutchinson, W. L., Tennent, G. A., Walportz, M. J., & Pepys, M. B. (1997) · Nature Medicine · doi:10.1038/nm0897-855 · Cited by 266 · see citing works
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Reduction of Bleomycin-Induced Pulmonary Fibrosis by Serum Amyloid P
Pilling, D., Roife, D., Wang, M., Ronkainen, S. D., Crawford, J. R., Travis, E. L., & Gomer, R. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4035 · Cited by 230 · see citing works
“SAP is not related to serum amyloid A, serum amyloid protein, or amyloid precursor protein (15, 20, 22).”
BackgroundImmune Response Against Dying Tumor Cells
Zitvogel, L., Casares, N., Péquignot, M. O., Chaput, N., Albert, M. L., & Kroemer, G. (2004) · Advances in immunology · doi:10.1016/s0065-2776(04)84004-5 · Cited by 129 · see citing works
The Development of Serum Amyloid P as a Possible Therapeutic
Pilling, D., & Gomer, R. H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02328 · Cited by 92 · see citing works
“An early worker in the SAP field encountered this too, and published a letter in Nature entitled “Serum Amyloid P component (not Serum Amyloid Protein)” (118).”
BackgroundWang, T. G., Adcock, J., Kühtreiber, W., Qiang, D., Salleng, K., Trenary, I. A., & Williams, P. E. (2008) · Transplantation · doi:10.1097/tp.0b013e3181629c25 · Cited by 69 · see citing works
Encapsulated cell technology: from research to market.
Orive, G., Hernández, R., Gascón, A., Igartua, M., & Pedraz, J. (2002) · Trends in Biotechnology · doi:10.1016/s0167-7799(02)02037-1 · Cited by 63
Al-Mohanna, F., Parhar, R., & Kotwal, G. (2001) · Transplantation · doi:10.1097/00007890-200103270-00019 · Cited by 42 · see citing works
Haider, H., Jiang, S.-J., Ye, L., Aziz, S., Law, P., & Sim, E. (2004) · Transplantation Proceedings · doi:10.1016/j.transproceed.2003.11.001 · Cited by 19
Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis
Kumar, S., Song, K., Wang, J., Baghel, M. S., Zeng, Y., Shen, K., Zheng, J., Crane, J., Demehri, S., Gao, P., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00924-z · Cited by 16 · see citing works
“…with CPHPC (miridesap) at a concentration of 5 mg ml −1 in drinking water, which is an established dose for SAP depletion from the body 62–65, 67 , 68 Mice were kept under standard conditions with a 12-h light–dark cycle in a temperature-controlled room and provided with food and water ad…”
Harley, I. T. W., Allison, K., & Scofield, R. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.953439 · Cited by 14 · see citing works
Pharmacological Strategies for Neurodegeneration and Overview of Clinical Trials
Ley, L., & Herdegen, T. (2004) · Springer eBooks · doi:10.1007/1-4020-2541-6_39
- Authors
- Pepys, M. B.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Pepys, M.B.
- ORCID
- Pepys, M.B.
- Venue
- Nature Medicine
- Published
- 1999-08
- Volume
- 5
- Issue
- 8
- Pages
- 852-853
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1541704510
- Cited by
- 11
- References
- 0
- Citations by year
- 2025: 1 · 2022: 1 · 2018: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- serum amyloid P component, systemic lupus erythematosus, chromatin degradation, amyloid deposition, AA amyloidosis, autoantigens
- MeSH terms
- Serum Amyloid P-Component, Animals, Humans, Lupus Erythematosus, Systemic, Terminology as Topic, Mice, Knockout, Mice
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