The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Mechanism of Testosterone Action in Erythropoiesis
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“For example, administration of graded doses of testosterone to healthy young and older men, whose endogenous testosterone production was suppressed by administration of a long-acting gonadotropin releasing hormone agonist, dose dependently increased hemoglobin and hematocrit but did not change EPO levels consistently after 20 weeks even at supraphysiologic doses of testosterone (4).”
From Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point (2014) · cites this paper as [4]
In the citing paper
“especially in older men, who experience greater increments in hemoglobin and hematocrit in response to testosterone administration than young men (4).”
From Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point (2014) · cites this paper as [4]
In the citing paper
“In the case of testosterone therapy or supplementation, this new set point appears become established after 3 months of treatment (4,10).”
From Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point (2014) · cites this paper as [4]
Citations
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“Testosterone is an important regulator of erythropoiesis in men and women (Mirand et al., 1965; Bhasin et al., 2010).”
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Erythrocytosis Following Testosterone Therapy
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“Androgenic steroids [10,39,40], anabolic steroids [41], and cobaltous chloride [9] stimulate EPO production by an unknown mechanism.”
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Self-citationThe vulnerable man: impact of testosterone deficiency on the uraemic phenotype
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“Although the exact mechanism(s) by which testosterone stimulates erythropoiesis are not evident, it seems that testosterone does stimulate erythropoietin production and erythroid progenitor cells [28].”
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Changes in blood cell composition of the brown trout, Salmo trutta L., during the spawning season
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Efficacy of Testosterone Replacement Therapy in Correcting Anemia in Men With Hypogonadism
Pencina, K. M., Travison, T. G., Artz, A. S., Lincoff, A. M., Nissen, S. E., Flevaris, P., Chan, A., Li, X., Diegel, S. A., Wannemuehler, K. A., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.40030 · Cited by 69
THE MECHANISM OF ACTION OF ANDROGENS ON ERYTHROPOIESIS*
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The Effect of Testosterone on Erythropoietin Levels in Anemic Patients
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Haematology of the Japanese quail (coturnix coturnix japonica)1
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ANDROGEN ACTIONS ON ERYTHROPOIESIS*
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Self-citationTestosterone Therapy for Anaemia in Maintenance Dialysis
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Virus-Induced Erythropoiesis in Hypertransfused-Polycythemic Mice
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“In human cell cultures, T exerts a direct role on bone marrow erythroblasts and red cell precursor survival [28, 43, 44],”
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Oxymetholone Treatment for the Anemia of Bone Marrow Failure
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“The proposed mechanisms by which testosterone stimulates erythropoiesis include stimulation of erythroid progenitor cells and EPO secretion (49, 51, 58, 59), although some studies have not shown stimulation of EPO levels with testosterone administration (19, 36, 67).”
BackgroundAndrogens, angiogenesis and cardiovascular regeneration
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Self-citationTestosterone Regulates the Haemoglobin Concentration in Male Puberty
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The Effect of Testosterone on Erythropoiesis
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Hepcidin is not essential for mediating testosterone's effects on erythropoiesis
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“erythroid progenitors, alterations in ferrokinetics, and increased red cell survival (Mirand et al., 1965; Mirand & Murphy, 1971; Moriyama & Fisher, 1975; Beran et al., 1982; Bachman et al., 2010, 2014; Guo et al., 2013, 2014); however, the evidence supporting these hypotheses is inconclusive.”
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Effects of androgenic steroids on erythropoiesis
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EXTRA‐RENAL AND RENAL CONTROL OF ERYTHROPOIETIN PRODUCTION*
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Self-citationHematologic Complications of Chronic Renal Failure
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“stimulating erythropoises is well established (Mirand et al., 1965).”
Assessment of Red Blood Cell and Coagulation Laboratory Data
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Self-citationTHE EFFECT OF TESTOSTERONE ON THE UPTAKE OF TRITIATED THYMIDINE BY THE BONE MARROW OF CHILDREN*
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Studies on the erythropoietic stimulating factor in the plasma of mice after receiving testosterone.
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Androgen therapy for anemia in elderly uremic patients
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Self-citationSimultaneous quantification of total and free testosterone in human serum by LC–MS/MS
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Effect of testosterone formulations on hematocrit in transgender individuals: A systematic review
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“4,7 Bachman et al. proposed a multifactorial mechanism in which testosterone induces erythropoiesis by stimulating EPO and recalibrating the set point of EPO in relation to hemoglobin, along with increasing iron utilization for erythropoiesis.”
Vatsalya, V., & Arora, K. L. (2012) · International Journal of Poultry Science · doi:10.3923/ijps.2012.251.258 · Cited by 10
“An increase of PCV is an indication of enhanced erythropoiesis (Mirand et al., 1965) due to increased secretion of gonadotropins and testosterone.”
BackgroundNissen, C., de Planque, M. M., Würsch, A., Moser, Y., Carbonare, V. D., & SPECK, B. (1988) · British Journal of Haematology · doi:10.1111/j.1365-2141.1988.tb02381.x · Cited by 10
Current Status of Erythropoietin
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Hematologic abnormalities in chronic renal failure
Fried, W. I. (1981) · Seminars in Nephrology · doi:10.5555/uri:pii:0270929581900401 · Cited by 10
Erythropoietin and Erythropoiesis
Gurney, C. W. (1966) · Annals of Internal Medicine · doi:10.7326/0003-4819-65-2-377 · Cited by 9
The Effect of Some Erythropoietic Agents on the ‘Tissue’ Tension of Oxygen
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OBSERVATIONS ON THE EFFECT OF TESTOSTERONE AND HYDROCORTISONE ON ERYTHROPOIESIS*
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Stimulation of Erythropoietin by Androgen in the Human
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“Some authors reported stimulation of mammalian erythropoiesis by testosterone ( Mirand et al. 1965; Naets and Wittek 1966; Gordon et al. 1970; Ohno and Fischer 1978).”
BackgroundMethodAssociation of subcutaneous testosterone pellet therapy with developing secondary polycythemia
Rotker, K. L., Alavian, M. R., Nelson, B. T., Baird, G., Miner, M. M., Sigman, M., & Hwang, K. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_51_17 · Cited by 9
Hemopoietic response to male hormone in the chequered water-snake, Natrix piscator
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Effects of androgens on burst forming units (BFU-E) in normal rabbit bone marrows
Ohno, Y., & Fisher, J. W. (1978) · Life Sciences · doi:10.1016/0024-3205(78)90550-7 · Cited by 8
THE FRACTIONATION OF ERYTHROPOIETIN FROM ANEMIC AND NORMAL HUMAN URINE*
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Scala, A., Gender Incongruence Interdisciplinary Group, Graziani, A., Vianello, F., Ferlin, A., & Garolla, A. (2024) · Minerva Endocrinology · doi:10.23736/s2724-6507.24.04171-x · Cited by 7
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The Hematologic Effects of Androgens
Gurney, C. W. (1976) · Springer eBooks · doi:10.1007/978-3-642-66353-6_15 · Cited by 7
Androgens and particularly, a Metabolite of Testosterone, 5α-Dihydrotestosterone
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Talbott, K. M., & Ketterson, E. D. (2023) · Scientific Reports · doi:10.1038/s41598-023-38438-6 · Cited by 6
“Although we detected no differences in max T between birds with and without chronic infections, it is possible that the chronically infected birds generally have higher levels of circulating testosterone, which is known to support hematopoiesis 64 .”
BackgroundOyewale, J. O., Ebute, C. P., Ogunsanmi, A. O., Olayemi, F. O., & Durotoye, L. A. (1998) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1111/j.1439-0442.1998.tb00864.x · Cited by 6
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“…regulate blood oxygen levels in animals, by promoting myoglobin and overall red blood cell production (Bachman et al., 2014; Mänttäri et al., 2008; Mirand et al., 1965), which as previously mentioned allows for longer foraging durations in this species (Villegas- Amtmann & Costa, 2010; Villegas-…”
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Metadata
- Authors
- MIRAND, E. A., GORDON, A. S., & WENIG, J.
- Affiliations
- Roswell Park Comprehensive Cancer Center (US)
- New York University (US)
- Venue
- Nature
- Published
- 1965-04
- Volume
- 206
- Issue
- 4981
- Pages
- 270-272
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2095110446
- Cited by
- 145
- References
- 27
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 1 · 2021: 1 · 2020: 7 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 1 · 2013: 2 · 2012: 3
- FWCI
- 15.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- testosterone, erythropoiesis, erythropoietin, androgen action
- MeSH terms
- Animals, Blood, Erythropoiesis, Iron, Iron Isotopes, Rabbits, Rodentia, Testosterone, Mice, Rats, In Vitro Techniques
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