Differences in the Lactic Dehydrogenases of Primate Brains
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An evolutionary switch in the lactate dehydrogenase enzyme occurred among haplorhines from expression of an isozyme that predominantly supports anaerobic metabolism to one that predominantly supports oxidative metabolism.
“First, an evolutionary switch in the lactate dehydrogenase enzyme occurred among haplorhines from expression of an isozyme that predominantly supports anaerobic metabolism to one that predominantly supports oxidative metabolism (36).”
From Evolution of increased glia–neuron ratios in the human frontal cortex (2006) · cites this paper as [36]
The biochemical mechanism of generating energy has been under evolutionary selection going back at least to the anthropoid primate stem, presumably to fuel increases in brain size.
“Indeed, considerable evidence indicates that the biochemical mechanism of generating energy has been under evolutionary selection going back at least to the anthropoid primate stem, presumably to fuel increases in brain size.”
From Evolution of increased glia–neuron ratios in the human frontal cortex (2006) · cites this paper as [36]
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- Authors
- SYNER, F. N., & GOODMAN, M.
- Affiliations
- Wayne State University (US)
- Venue
- Nature
- Published
- 1966-01
- Volume
- 209
- Issue
- 5021
- Pages
- 426-428
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1971330606
- Cited by
- 26
- References
- 9
- Citations by year
- 2026: 1 · 2017: 1 · 2014: 2 · 2013: 2
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- lactate dehydrogenase, primate brain, isozymes, molecular forms, brain evolution, phylogenetic evolution, anaerobic metabolism, glycolysis, oxidative metabolism, comparative biochemistry
- MeSH terms
- Animals, Haplorhini, Blood Protein Electrophoresis, Brain Chemistry, Humans, L-Lactate Dehydrogenase, Muscles, Myocardium, Primates, Hominidae
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