Effects of High Levels of Yeast Feeding on Uric Acid Metabolism of Young Men

EDOZIEN, J. C.; UDO, U. U.; YOUNG, V. R.; SCRIMSHAW, N. S.

doi:10.1038/228180a0

Cited by 111Gout, Hyperuricemia, Uric AcidDiet, Metabolism, and DiseaseFood Nutrient Composition and Product Development

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Effects of High Levels of Yeast Feeding on Uric Acid Metabolism of Young Men

EDOZIEN, J. C., UDO, U. U., YOUNG, V. R., SCRIMSHAW, N. S.·1970·Nature

DOI 10.1038/228180a0

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1038/228180a0

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The high level of RNA/nucleic acids in BSY is a major challenge and limits its use as a protein supplement in humans due to negative health effects caused by an excess of uric acid.
“A major challenge in the utilization of BSY in food for human consumption is the high level of RNA.”
From Brewer’s Spent Yeast (BSY), an Underutilized Brewing By-Product (2020) · cites this paper as [3]
If the intake of yeast is relatively high, for example in the case of protein supplementation, the increased purine content can result in increased uric acid levels in the blood, potentially leading to hyperuricemia and gout.
“If the intake of yeast is relatively high, for example in the case of protein supplementation, the increased purine content can result in an increased uric acid levels in the blood, potentially leading to hyperuricemia and gout [3].”
From Brewer’s Spent Yeast (BSY), an Underutilized Brewing By-Product (2020) · cites this paper as [3]

Uric acid nephrolithiasis
Gutman, A. B., & Yű, T.-F. (1968) · The American Journal of Medicine · doi:10.1016/0002-9343(68)90209-x · Cited by 312
Renal function in gout
Gutman, A. B., & Yű, T.-F. (1957) · The American Journal of Medicine · doi:10.1016/0002-9343(57)90231-0 · Cited by 263
Biochemistry of Uric Acid and Its Relation to Gout
Seegmiller, J. E., Laster, L., & Howell, R. R. (1963) · New England Journal of Medicine · doi:10.1056/nejm196303282681306 · Cited by 168
Uric Acid Production of Men Fed Graded Amounts of Egg Protein and Yeast Nucleic Acid
Waslien, C., Calloway, D. H., & Margen, S. (1968) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/21.9.892 · Cited by 87
New Process for Reducing the Nucleic Acid Content of Yeast
MAUL, S. B., Sinskey, A. J., & Tannenbaum, S. R. (1970) · Nature · doi:10.1038/228181a0 · Cited by 70
Diagnostic Significance of Hyperuricemia in Arthritis
Grayzel, A. I., Liddle, L., & Seegmiller, J. E. (1961) · New England Journal of Medicine · doi:10.1056/nejm196110192651601 · Cited by 50
The Uric Acid Concentration in Serum Determined by Enzymatic Spectrophotometry
GJØRUP, S., Poulsen, H. E., & Prætorius, E. (1955) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365515509134510 · Cited by 44
An Automated Method for Urine Creatinine Which Does Not Require a Dialyzer Module
Pino, S., Benotti, J. R., & Gardyna, H. (1965) · Clinical Chemistry · doi:10.1093/clinchem/11.6.664 · Cited by 37
THE NUTRITIVE VALUE OF YEAST, POLISHED RICE, AND WHITE BREAD, AS DETERMINED BY EXPERIMENTS ON MAN
Funk, C., Lyle, W. G., McCaskey, D., Joseph, C., & Joseph, P. (1916) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)86903-4 · Cited by 12
Controversial Aspects: Yeast in Human Nutrition
Loesecke, H. W. V. (1946) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(21)33553-2 · Cited by 12

Flagged first, then by citations

Research works printed but not linked: 7

Mateles, R. I., and Tannenbaum, S. R., (eds.), Single-Cell Protein (MIT Press, Cambridge, Massachusetts, and London, 1968).
Wintz, H., Munch. Med. Wschr., 63, 445 (1916).
Salomon, H., Munch. Med. Wschr., 63, 454 (1916).
Anderson, A. K., Penn. St. Univ. Agric. Exp. Stat. Bull., 367, 7 (1938).
Dirr, K., Biochem. Z., 312, 233 (1942).
Murlin, J. R., and Mattil, H. A., Amer. J. Physiol., 64, 275 (1923).
Liddle, L., Seegmiller, J. E., and Laster, L., J. Lab. Clin. Med., 54, 903 (1959).

Sorted by citations

Degradation of purines and pyrimidines by microorganisms
Vogels, G. D., & van der DRIFT, C. (1976) · Bacteriological Reviews · doi:10.1128/br.40.2.403-468.1976 · Cited by 607
The role of nucleotides in human nutrition
Carver, J. D., & Walker, W. A. (1995) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(94)00019-i · Cited by 401
A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice
Chiaro, T. R., Soto, R., Stephens, W. Z., Kubinak, J. L., Petersen, C., Gogokhia, L., Bell, R. S., Delgado, J. C., Cox, J. E., Voth, W. P., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf9044 · Cited by 237
High variability in nutritional value and safety of commercially available Chlorella and Spirulina biomass indicates the need for smart production strategies
Muys, M., Sui, Y., Schwaiger, B., Lesueur, C., Vandenheuvel, D., Vermeir, P., & Vlaeminck, S. E. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2018.12.059 · Cited by 175
Brewer’s Spent Yeast (BSY), an Underutilized Brewing By-Product
Jaeger, A., Arendt, E. K., Zannini, E., & Sahin, A. W. (2020) · Fermentation · doi:10.3390/fermentation6040123 · Cited by 172
“If the intake of yeast is relatively high, for example in the case of protein supplementation, the increased purine content can result in an increased uric acid levels in the blood, potentially leading to hyperuricemia and gout [3].”
BackgroundResult
Effect of Oral Purines on Serum and Urinary Uric Acid of Normal, Hyperuricemic and Gouty Humans
Clifford, A. J., Riumallo, J. A., Young, V. R., & Scrimshaw, N. S. (1976) · Journal of Nutrition · doi:10.1093/jn/106.3.428 · Cited by 158
Self-citation
Making the case for edible microorganisms as an integral part of a more sustainable and resilient food production system
Linder, T. (2019) · Food Security · doi:10.1007/s12571-019-00912-3 · Cited by 146
Levels of Purines in Foods and Their Metabolic Effects in Rats
Clifford, A. J., & Story, D. L. (1976) · Journal of Nutrition · doi:10.1093/jn/106.3.435 · Cited by 146
Uric acid in plants and microorganisms: Biological applications and genetics - A review
Hafez, R. M., Abdel-Rahman, T. M. A., & Naguib, R. M. (2017) · Journal of Advanced Research · doi:10.1016/j.jare.2017.05.003 · Cited by 115
Mycoprotein represents a bioavailable and insulinotropic non-animal-derived dietary protein source: a dose–response study
Dunlop, M. V., Kilroe, S. P., Bowtell, J. L., Finnigan, T. J. A., Salmon, D. L., & Wall, B. T. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517002409 · Cited by 105
Nitrogen cycling in Bioregenerative Life Support Systems: Challenges for waste refinery and food production processes
Clauwaert, P., Muys, M., Alloul, A., Paepe, J. D., Luther, A., Sun, X., Ilgrande, C., Christiaens, M. E. R., Hu, X., Zhang, D., et al. (2017) · Progress in Aerospace Sciences · doi:10.1016/j.paerosci.2017.04.002 · Cited by 89
Uric Acid Metabolism in Children
Baldree, L. A., & Stapleton, F. B. (1990) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)36876-6 · Cited by 82
Composition and nutritive value of single-cell protein (SCP)
Schulz, E., & Oslage, H. J. (1976) · Animal Feed Science and Technology · doi:10.1016/0377-8401(76)90003-1 · Cited by 80
A novel biological recovery approach for PHA employing selective digestion of bacterial biomass in animals
Ong, S. Y., Zainab‐L, I., Pyary, S., & Sudesh, K. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-8788-9 · Cited by 73
New Process for Reducing the Nucleic Acid Content of Yeast
MAUL, S. B., Sinskey, A. J., & Tannenbaum, S. R. (1970) · Nature · doi:10.1038/228181a0 · Cited by 70
Commensal fungi in intestinal health and disease
Ost, K. S., & Round, J. L. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00816-w · Cited by 68
Effect of Dietary Ribonucleotides on Infant Immune Status. Part 1: Humoral Responses
Schaller, J. P., Kuchan, M. J., Thomas, D. L., Cordle, C. T., Winship, T. R., Buck, R. H., Baggs, G. E., & Wheeler, J. G. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000145576.42115.5c · Cited by 65
Some methods for processing of single‐cell protein
Hedenskog, G., & Mogren, H. (1973) · Biotechnology and Bioengineering · doi:10.1002/bit.260150110 · Cited by 62
Single Cell Protein
Solomons, G. L., & Litchfield, J. H. (1983) · Critical Reviews in Biotechnology · doi:10.3109/07388558309082578 · Cited by 61
Single‐cell protein: Current status and future prospects
Tusé, D., & Miller, M. W. (1983) · C R C Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398409527379 · Cited by 59
Unusual sources of proteins for man
Waslien, C., & Oswald, W. J. (1975) · C R C Critical Reviews in Food Science and Nutrition · doi:10.1080/10408397509527186 · Cited by 55
Characterization of a Heat-Shock Process for Reduction of the Nucleic Acid Content of Candida utilis
Ohta, S., MAUL, S. B., Sinskey, A. J., & Tannenbaum, S. R. (1971) · Applied Microbiology · doi:10.1128/am.22.3.415-421.1971 · Cited by 52
Nutritive value of marine algae Laminaria japonica and Undaria pinnatifida
Jurković, N., Kolb, N., & Čolić, I. (1995) · Food / Nahrung · doi:10.1002/food.19950390108 · Cited by 48
The tolerance and nutritional value of two microfungal foods in human subjects
Udall, J. N., Lo, C.-C., Young, V. R., & Scrimshaw, N. S. (1984) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/40.2.285 · Cited by 46
Self-citation
Zur Verwendung von Mikroalgen f�r Ern�hrungszwecke
Soeder, C. J. (1976) · Die Naturwissenschaften · doi:10.1007/bf00600487 · Cited by 45
Reduction of the nucleic acid content of single‐cell protein concentrates
Hedenskog, G., & Ebbinghaus, L. (1972) · Biotechnology and Bioengineering · doi:10.1002/bit.260140313 · Cited by 43
A comprehensive analysis of the nutritional quality of edible mushroom Pleurotus sajor-caju grown in deproteinized whey medium
Mukhopadhyay, R., & Guha, A. K. (2015) · LWT · doi:10.1016/j.lwt.2014.12.055 · Cited by 41
Nutritional Profile of Food Yeast Kluyveromyces fragilis Biomass Grown on Whey
Paul, D., Mukhopadhyay, R., Chatterjee, B. P., & Guha, A. K. (2002) · Applied Biochemistry and Biotechnology · doi:10.1385/abab:97:3:209 · Cited by 41
Single-Cell Protein: Engineering, Economics, and Utilization in Foods
Cooney, C. L., Rha, C., & Tannenbaum, S. R. (1980) · Advances in food research · doi:10.1016/s0065-2628(08)60317-1 · Cited by 41
NH4OH-Based pretreatment for improving the nutritional quality of single-cell protein (SCP)
Parajó, J. C., Santos, V., Domı́nguez, H., & Vázquez, M. (1995) · Applied Biochemistry and Biotechnology · doi:10.1007/bf02783554 · Cited by 40
Serial fractionation of spent brewer's yeast protein hydrolysate by ultrafiltration: A peptide-rich product with low RNA content
Marson, G. V., Lacour, S., Hubinger, M. D., & Belleville, M. (2021) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2021.110737 · Cited by 39
The effect of different dietary levels of an‐paraffin‐grown yeast on the growth and food intake of broiler chicks
Shannon, D. W. F., & McNab, J. M. (1972) · British Poultry Science · doi:10.1080/00071667208415946 · Cited by 39
Hyperuricemia in Health and Disease
Fessel, W. J. (1972) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(78)90006-9 · Cited by 37
Beyond Agriculture─How Microorganisms Can Revolutionize Global Food Production
Linder, T. (2023) · ACS Food Science & Technology · doi:10.1021/acsfoodscitech.3c00099 · Cited by 35
Reduction of Nucleic Acid Content in Candida Yeast Cells by Bovine Pancreatic Ribonuclease A Treatment
Castro, A., Sinskey, A. J., & Tannenbaum, S. R. (1971) · Applied Microbiology · doi:10.1128/am.22.3.422-427.1971 · Cited by 35
Enzymatic RNA reduction in disintegrated cells of Saccharomyces cerevisiae
Lindblom, M., & Mogren, H. (1974) · Biotechnology and Bioengineering · doi:10.1002/bit.260160812 · Cited by 35
Umami: The Taste That Drives Purine Intake
Johnson, R. J., Nakagawa, T., Sánchez‐Lozada, L. G., Lanaspa, M. A., Tamura, Y., Tanabe, K., Ishimoto, T., Thomas, J. B., Inaba, S., KITAGAWA, W., et al. (2013) · The Journal of Rheumatology · doi:10.3899/jrheum.130531 · Cited by 35
Single cell protein as food and feed
Giec, A., & Skupin, J. (1988) · Food / Nahrung · doi:10.1002/food.19880320302 · Cited by 33
Chemical composition and evaluation of protein quality by amino acid score method of edible brown marine algae arame (eisenia bicyclis) and hijiki (hijikia fusiforme)
Kolb, N., Vallorani, L., & Stocchi, V. (1999) · Acta Alimentaria · doi:10.1556/aalim.28.1999.3.1 · Cited by 33
Nutritional quality of the blue‐green alga Spirulina platensis geitler
Narasimha, D. L. R., Venkataraman, G. S., Duggal, S. K., & Eggum, B. O. (1982) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2740330511 · Cited by 33
Valorisation of Brewer’s Spent Yeasts’ Hydrolysates as High-Value Bioactive Molecules
Martín, D. S., Ibarruri, J., Iñarra, B., Luengo, N., Ferrer, J., Alvarez-Ossorio, C., Bald, C., Gutierrez, M. A., & Zufía, J. (2021) · Sustainability · doi:10.3390/su13126520 · Cited by 32
Composition of Saccharomyces fragilis biomass grown on lactose permeate
Delaney, R. A. M., Kennedy, R., & Walley, B. D. (1975) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2740260816 · Cited by 31
The effect of RNA supplementation of rat diets on the composition of body fluids
HEAF, D. J., & DAVIES, J. I. (1976) · British Journal Of Nutrition · doi:10.1079/bjn19760094 · Cited by 30
Cyberlindnera jadinii yeast as a protein source for broiler chickens: effects on growth performance and digestive function from hatching to 30 days of age
Cruz, A., Sterten, H., Steinhoff, F. S., Mydland, L. T., & Øverland, M. (2020) · Poultry Science · doi:10.1016/j.psj.2020.01.023 · Cited by 26
Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout
Tatani, K., Hiratochi, M., Kikuchi, N., Kuramochi, Y., Watanabe, S., Yamauchi, Y., Itoh, F., Isaji, M., & Shuto, S. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01884 · Cited by 26
Thermal behavior and hydration properties of yeast proteins from Saccharomyces cerevisiae and Kluyveromyces fragilis
Otero, M. A., Wagner, J. R., Vasallo, M. C., Garcı́a, L., & Añón, M. C. (2000) · Food Chemistry · doi:10.1016/s0308-8146(99)00245-9 · Cited by 25
Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young Adults
Coelho, M. D. F. R., Monteyne, A. J., Kamalanathan, I. D., Najdanovic‐Visak, V., Finnigan, T. J. A., Stephens, F. B., & Wall, B. T. (2020) · Nutrients · doi:10.3390/nu12041115 · Cited by 25
On methods for reduction of nucleic acids content in a single-cell protein from gas oil
Abou‐Zeid, A. A., Khan, J. A., & Abulnaja, K. O. (1995) · Bioresource Technology · doi:10.1016/0960-8524(95)99782-q · Cited by 25
Iatrogenic hyperuricemia in children with cystic fibrosis
Davidson, G. P., Morad-Hassel, F., Crozier, D. N., Corey, M. L., & Forstner, G. (1978) · The Journal of Pediatrics · doi:10.1016/s0022-3476(78)81225-6 · Cited by 24
Effect of thiol reagents on extractability of protein from yeast
Shetty, K., & Kinsella, J. (1978) · Biotechnology and Bioengineering · doi:10.1002/bit.260200509 · Cited by 23
High dietary nucleotide consumption for one week increases circulating uric acid concentrations but does not compromise metabolic health: A randomised controlled trial
Coelho, M. D. F. R., Monteyne, A. J., Kamalanathan, I. D., Najdanovic‐Visak, V., Finnigan, T. J. A., Stephens, F. B., & Wall, B. T. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.04.022 · Cited by 20
Identifying Exogenous DNA in Liquid Foods by Gold Nanoparticles: Potential Applications in Traceability
Ding, S., Wang, L., He, Z., Sui, Z., Wang, G., Takarada, T., Maeda, M., & Liang, X. (2021) · ACS Food Science & Technology · doi:10.1021/acsfoodscitech.1c00048 · Cited by 19
Influence of Purine Intake on Uric Acid Excretion in Infants Fed Soy Infant Formulas
Kuchan, M. J., Ostrom, K. M., Smith, C., & Hu, P. E. (2000) · Journal of the American College of Nutrition · doi:10.1080/07315724.2000.10718909 · Cited by 19
Nucleic Acid Content of Bovine Bone Marrow, Muscle and Mechanically Deboned Beef
Arasu, P., Field, R. A., KRUGGEL, W. G., & Miller, G. J. (1981) · Journal of Food Science · doi:10.1111/j.1365-2621.1981.tb03003.x · Cited by 19
Chronic enteropathy and feeding in children: An update
Salvatore, S., Hauser, B., Devreker, T., Arrigo, S., & Vandenplas, Y. (2008) · Nutrition · doi:10.1016/j.nut.2008.04.011 · Cited by 18
Purine Availability and Metabolism in Dogs Fed Single-Cell Protein or RNA
Giesecke, D., Gaebler, S., & Tiemeyer, W. (1982) · Journal of Nutrition · doi:10.1093/jn/112.10.1822 · Cited by 17
Nucleic Acid, Fiber and Nutrient Composition of Inactive Dried Food Yeast Products
SARWAR, G., Shah, B. G., Mongeau, R., & Hoppner, K. (1985) · Journal of Food Science · doi:10.1111/j.1365-2621.1985.tb13400.x · Cited by 17
Protein concentrates from yeast cultured in wood hydrolysates
Parajó, J. C., Santos, V., Domı́nguez, H., Vázquez, M., & Álvarez, C. (1995) · Food Chemistry · doi:10.1016/0308-8146(95)90782-3 · Cited by 17
Phosphorylation of yeast protein: Reduction of ribonucleic acid and isolation of yeast protein concentrate
Huang, Y. ‐., & Kinsella, J. E. (1986) · Biotechnology and Bioengineering · doi:10.1002/bit.260281112 · Cited by 17
Growth and value of Chlorella salina grown on highly saline sewage effluent
Wong, P. K., & Chan, K. (1990) · Agriculture Ecosystems & Environment · doi:10.1016/0167-8809(90)90108-p · Cited by 16
Effects of Dietary Protein, Adenine, and Allopurinol on Growth and Metabolism of Rats
Story, D. L., Shrader, R. E., Theriault, L. L., Lumijarvi, D. L., Shenoy, T. S., Savaiano, D. A., Shaffer, R. H., Ho, C. Y., & Clifford, A. J. (1977) · Journal of Nutrition · doi:10.1093/jn/107.6.1044 · Cited by 15
Hydrolysis of nucleic acids in single-cell protein concentrates using immobilized benzonase
Moreno, J. M., Sanchez-Dmontero, J. M., Ballesteros, A. O., & Sinisterra, J. V. (1991) · Applied Biochemistry and Biotechnology · doi:10.1007/bf02922124 · Cited by 14
Industrial Biotechnology: Date Palm Fruit Applications
Aleid, S. M. (2011) · Springer eBooks · doi:10.1007/978-94-007-1318-5_32 · Cited by 14
The fungal etiology of gout and hyperuricemia: the antifungal mode of action of colchicine
Costantini, A. V. (1992) · Biomedical Reviews · doi:10.14748/bmr.v1.221 · Cited by 14
Brewing for the Future: Balancing Tradition and Sustainability
Serviss, M. T., Hout, D. V., Britton, S. J., & MacIntosh, A. J. (2025) · Journal of the American Society of Brewing Chemists · doi:10.1080/03610470.2025.2509059 · Cited by 13
Diet and gout – what is the role of purines?
Lockyer, S., & Stanner, S. A. (2016) · Nutrition Bulletin · doi:10.1111/nbu.12205 · Cited by 13
Some studies on Nigerian palm wine with special reference to yeasts
Enwefa, C., Uwajeh, R., & Oduh, M. (1992) · Acta Biotechnologica · doi:10.1002/abio.370120208 · Cited by 12
A comprehensive approach to the chemical analysis of fungal biomass – the pitfalls of nutritional standardization
Geerits, C. H. A., Haar, M. K., Knobel, K. C. C., Vincken, J., & Kabel, M. A. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145443 · Cited by 11
Energy requirements for single cell protein production
Lewis, C. W. (1976) · Journal of Applied Chemistry and Biotechnology · doi:10.1002/jctb.5020260180 · Cited by 11
Nutritive value and baking properties of bread supplemented with candida utilis
Yáñez, E., Wulf, H., Ballester, D., Fernández, N., Vivien Gattas, Z., & Mönckeberg, F. (1973) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2740240504 · Cited by 11
Preparation of succinylated yeast protein: Composition and solubility
Vananuvat, P., & Kinsella, J. (1978) · Biotechnology and Bioengineering · doi:10.1002/bit.260200903 · Cited by 10
Single-cell protein low in nucleic acids by alkaline treatment
Otero, M. A., & Cabello, A. (1980) · Biotechnology Letters · doi:10.1007/bf00144241 · Cited by 10
Blood Constituents of Yeast Fed Chicks
Saoud, N. B., & Daghir, N. J. (1980) · Poultry Science · doi:10.3382/ps.0591807 · Cited by 10
Food and Feed Yeast
Reed, G., & Nagodawithana, T. W. (1991) · Springer eBooks · doi:10.1007/978-94-011-9771-7_10 · Cited by 7
Effects of Dietary Probiotic on Performance, Noxious Gas Emission and Microflora Population on the Cecum in Broiler
Ko, Y. D., Sin, J. H., Kim, S. C., Kim, Y. M., Park, K. D., & Kim, J. H. (2003) · Journal of Animal Science and Technology · doi:10.5187/jast.2003.45.4.559 · Cited by 7
Fungalbionics: A New Concept of the Etiology of Gout, Hyperuricemia and their Related Diseases
Costantini, A. V. (1989) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5673-8_44 · Cited by 7
Adverse effects of low concentrations of dietary RNA addition on the growth, food intake and kidney weight of young chickens
Kubota, T., & Karasawa, Y. (1994) · British Poultry Science · doi:10.1080/00071669408417723 · Cited by 7
Acceptance of torula yeast for use as a food supplement
Weatherholtz, W. M., & Holsing, G. C. (1976) · Ecology of Food and Nutrition · doi:10.1080/03670244.1976.9990460 · Cited by 6
Microorganisms as Feed and Food Protein
Waldroup, P. W. (1981) · Elsevier eBooks · doi:10.1016/b978-0-12-054804-0.50015-9 · Cited by 6
EFFECT OF CONSUMING FOOD SUPPLEMENTED WITH SINGLE CELL PROTEIN ON URINE AND SERUM URIC ACID LEVELS
Kamel, B. S., & Kramer, A. (1979) · Journal of Food Quality · doi:10.1111/j.1745-4557.1979.tb00661.x · Cited by 5
The utility of a fungal bibonuclease for reducing the nucleic acid content of permeabilized yeast cells
Kunhi, A. A. M., & Rao, M. R. R. (1995) · Food Biotechnology · doi:10.1080/08905439509549882 · Cited by 5
A Short Assay for the Estimation of Dietary Purine Compounds, Using a Rat Model System with Inhibition of Uricase
Norrlind, B., & Kihlberg, R. (1973) · Journal of Nutrition · doi:10.1093/jn/103.9.1262 · Cited by 5
Effect of dietary RNA on growth and food intake of young chicks.
Karasawa, Y., & Kubota, T. (1990) · Japanese poultry science · doi:10.2141/jpsa.27.165 · Cited by 5
PROPERTIES AND COMPOSITION OP SINGLE-CELL PROTEIN, INFLUENCE OP PROCESSING
Hedenskog, G. (1978) · Elsevier eBooks · doi:10.1016/b978-0-08-022625-5.50014-5 · Cited by 4
Nucleic acid reduction from yeast activation of intracellular rnase
Bueno, G. E., Otero, M. A., Klibansky, M., & Gonzales, A. (1985) · Acta Biotechnologica · doi:10.1002/abio.370050116 · Cited by 4
Characterization of intracellular RNase in heat processed yeast cells
Bueno, G. E., Otero, M. A., & González, A. C. (1982) · Biotechnology Letters · doi:10.1007/bf00144314 · Cited by 4
Ribonuclease isolated from yeast (Saccharomyces carlsbergensis): Characterization and properties
Shetty, J. K., Weaver, R. C., & Kinsella, J. E. (1981) · Biotechnology and Bioengineering · doi:10.1002/bit.260230505 · Cited by 4
Food Technology and Industrial Mycology
Gray, W. D. (1981) · Elsevier eBooks · doi:10.1016/b978-0-12-179502-3.50015-7 · Cited by 4
DEGRADATION PRODUCTS OF NUCLEIC ACIDS IN WINES FERMENTED WITH DRIED AUTOLYSATE OF SEDIMENTED WINE YEAST
Pogorzelski, E., Laskowska, J., & Czyżowska, A. (2006) · Polish Journal of Food and Nutrition Sciences · Cited by 3
A Multi-Disciplinary Catalogue of Uric Acid Literature of Interest to Behavioural Scientists
Stevens, H. A. (1973) · Perceptual and Motor Skills · doi:10.2466/pms.1973.36.3.1007 · Cited by 3
Evaluating quality of novel alternative protein sources (microbial and insect proteins) using the INFOGEST in vitro digestion model
Graham, R., de Matos, A. M., Parr, T., & Brameld, J. M. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.147468 · Cited by 2
Valorizing plant biomass residues through edible mushroom mycelial fermentation: From bioconversion to bioactive recovery and direct mycelium utilization in novel foods
Chen, H., Mao, Y., Zhou, J., Zhang, C., & Du, J. (2026) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2026.105965 · Cited by 2
RNA removal from Candida utilis by chemical and thermal treatments
Otero, M. A., Bueno, G., Conde, J., & Gonzales, A. (1982) · Acta Biotechnologica · doi:10.1002/abio.370020205 · Cited by 2
Hava Bazlı Proteinin Alternatif Bir Protein Kaynağı Olarak Kullanım Olanaklarının İncelenmesi
Erdoğan, E., Orhan, K. A. Y. A., Derin, E., & Çakaloğlu, B. (2022) · International Journal of Life Sciences and Biotechnology · doi:10.38001/ijlsb.1096533 · Cited by 2
The Use of Brewery Yeast in Commercial Type Ration for Poultry
Vananuvat, P., & Chiraratananon, R. (1977) · World s Poultry Science Journal · doi:10.1079/wps19770008 · Cited by 2
Baker's Yeast as a Protein Supplement in Corn Meal Muffins1
Zabik, M. E., & Garrison, T. (1975) · Home Economics Research Journal · doi:10.1177/1077727x7500300303 · Cited by 1
Extraction of Protein from Brewer's Yeast with Aqueous NaOH Solution
Tu, C., Čavlović, K., & Tam, D. (1975) · Canadian Institute of Food Science and Technology Journal · doi:10.1016/s0315-5463(75)73771-9 · Cited by 1
Modification of Dietary Habits for Prevention of Gout in Japanese People: Gout and Diet
Koguchi, T. (2021) · American Journal of Health Research · doi:10.11648/j.ajhr.20210905.16 · Cited by 1
Xanthine Oxidase Inhibitory Activity on Selective Medicinal Plants
Rao, D. M. (2024) · International Journal of Recent Innovations in Medicine and Clinical Research · doi:10.18231/j.ijrimcr.2019.016 · Cited by 1
Einige Besonderheiten der Isolierung des Gesamteiweißes aus der Biomasse von Einzellern für Nahrungszwecke
Rogoshin, S. W., Sergejew, W. A., Mamzis, A. M., & Walkowski, D. G. (1975) · Food / Nahrung · doi:10.1002/food.19750190105 · Cited by 1

EFFECT OF CONSUMING FOOD SUPPLEMENTED WITH SINGLE CELL PROTEIN ON URINE AND SERUM URIC ACID LEVELS
Kamel, B. S., & Kramer, A. (1979) · Journal of Food Quality · doi:10.1111/j.1745-4557.1979.tb00661.x · Cited by 5
The Effect of Yeast Upon Metabolism.
Still, E. U., & Koch, E. M. (1928) · Experimental Biology and Medicine · doi:10.3181/00379727-25-3892 · Cited by 1
Dietary Protein Level and Uric Acid Metabolism in Normal Man ,
Bowering, J., Calloway, D. H., Margen, S., & KAUFMANN, N. A. (1970) · Journal of Nutrition · doi:10.1093/jn/100.2.249 · Cited by 65
Effect of high dietary concentrations of brewer's dried yeast on growth performance and liver uricase in rainbow trout (Oncorhynchus mykiss)
Rumsey, G. L., Kinsella, J. E., Shetty, K., & Hughes, S. G. (1991) · Animal Feed Science and Technology · doi:10.1016/0377-8401(91)90058-z · Cited by 143
Uric acid levels in men fed algae and yeast as protein sources
Calloway, D. H., Costa, F. G. P., Margen, S., & Waslien, C. (1968) · NASA Technical Reports Server (NASA)

Authors: EDOZIEN, J. C., UDO, U. U., YOUNG, V. R., & SCRIMSHAW, N. S.
Affiliations: Massachusetts Institute of Technology (US)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1970-10-10
Volume: 228
Issue: 5267
Pages: 180-180
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/228180a0
OpenAlex: W2026874053
Cited by: 110
References: 10
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 1 · 2013: 1
FWCI: 6.32
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Life Sciences › Agricultural and Biological Sciences › Food Science › Food Nutrient Composition and Product Development
Keywords: uric acid metabolism, urinary uric acid excretion, microbial protein, protein intake, hyperuricemia, young men
MeSH terms: Adolescent, Cryptococcus, Diet, DNA, Humans, Male, RNA, Uric Acid, Urinary Calculi

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of High Levels of Yeast Feeding on Uric Acid Metabolism of Young Men

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks