Slightly Deleterious Mutant Substitutions in Evolution
DOI 10.1038/246096a0
Cited by (1,000)
Items 201–300 of 1,000
- Proportion of Solvent-Exposed Amino Acids in a Protein and Rate of Protein EvolutionYeong‐Shin Lin, Wei-Lun Hsu, Jenn-Kang Hwang, Wen‐Hsiung Li · 2007 · Molecular Biology and Evolution
- Beneficial Mutations, Hitchhiking and the Evolution of Mutation Rates in Sexual PopulationsToby Johnson · 1999 · Genetics
- Anticancer drug discovery in the future: an evolutionary perspectiveXianghui Ma, Zhiwen Wang · 2009 · Drug Discovery Today
- Quantifying how constraints limit the diversity of viable routes to adaptationSam Yeaman, Aleeza C. Gerstein, Kathryn A. Hodgins, Michael C. Whitlock · 2018 · PLoS Genetics
- Molecular phylogeny of Arthrotardigrada (Tardigrada)Aslak Jørgensen, Søren Faurby, Jesper Hansen, Nadja Møbjerg, Reinhardt Møbjerg Kristensen · 2009 · Molecular Phylogenetics and Evolution
- Directional mutational pressure affects the amino acid composition and hydrophobicity of proteins in bacteria.Xun Gu, David Hewett‐Emmett, Wen‐Hsiung Li · 1998 · PubMed
- The genomic basis of adaptation in plantsPádraic J. Flood, Angela M. Hancock · 2017 · Current Opinion in Plant Biology
- Genome-wide maps of ribosomal occupancy provide insights into adaptive evolution and regulatory roles of uORFs during Drosophila developmentHong Zhang, Shengqian Dou, Feng He, Junjie Luo, Liping Wei, Jian Lü · 2018 · PLoS Biology
- Constructive Neutral Evolution 20 Years LaterSergio A. Muñoz-Gómez, Gaurav Bilolikar, Jeremy G. Wideman, Kerry Geiler‐Samerotte · 2021 · Journal of Molecular Evolution
- Population dynamics of PIWI-interacting RNAs (piRNAs) and their targets in DrosophilaJian Lü, Andrew G. Clark · 2009 · Genome Research
- Effective Population Size Is Positively Correlated with Levels of Adaptive Divergence among Annual SunflowersJared L. Strasburg, Nolan C. Kane, Andrew R. Raduski, Aurélie Bonin, Richard W. Michelmore, Loren H. Rieseberg · 2010 · Molecular Biology and Evolution
- Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 FunctionParul Mishra, Julia M. Flynn, Tyler N. Starr, Daniel N. A. Bolon · 2016 · Cell Reports
- Molecular Basis of Adaptive Convergence in Experimental Populations of RNA VirusesJosé M. Cuevas, Santiago F. Elena, Andrés Moyá · 2002 · Genetics
- Recent insights into the genotype–phenotype relationship from massively parallel genetic assaysHarry E Kemble, Philippe Nghe, Olivier Tenaillon · 2019 · Evolutionary Applications
- Purging of deleterious burden in the endangered Iberian lynxDaniel Kleinman‐Ruiz, María Lucena-Pérez, Beatriz Villanueva, Jesús Fernández, Alexander P. Saveljev, Mirosław Ratkiewicz, Krzysztof Schmidt, Nicolas Galtier, Aurora García‐Dorado, José A. Godoy · 2022 · Proceedings of the National Academy of Sciences
- JOINT RECONSTRUCTION OF DIVERGENCE TIMES AND LIFE-HISTORY EVOLUTION IN PLACENTAL MAMMALS USING A PHYLOGENETIC COVARIANCE MODELNicolas Lartillot, Frédéric Delsuc · 2011 · Evolution
- The Evolution of the Heat-Shock Protein GroEL from Buchnera, the Primary Endosymbiont of Aphids, Is Governed by Positive SelectionMario A. Fares, Eladio Barrio, Beatriz Sabater‐Muñoz, Andrés Moyá · 2002 · Molecular Biology and Evolution
- Why Do Paralogs Persist? Molecular Evolution of CYCLOIDEA and Related Floral Symmetry Genes in Antirrhineae (Veronicaceae)Lena C. Hileman · 2003 · Molecular Biology and Evolution
- Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population geneticsAdrian W.R. Serohijos, Eugene I. Shakhnovich · 2014 · Current Opinion in Structural Biology
- Statistical analysis of DNA polymorphism.Fumio Tajima · 1993 · The Japanese Journal of Genetics
- Leafing through the genomes of our major crop plants: strategies for capturing unique informationAndrew H. Paterson · 2006 · Nature Reviews Genetics
- Evidence for Abundant Slightly Deleterious Polymorphisms in Bacterial PopulationsAustin L. Hughes · 2004 · Genetics
- Phylogeny and comparative biogeography of Pionopsitta parrots and Pteroglossus toucansJessica R. Eberhard, Eldredge Bermingham · 2005 · Molecular Phylogenetics and Evolution
- An Evolutionary Classification of Genomic FunctionDan Graur, Yichen Zheng, Ricardo B. R. Azevedo · 2015 · Genome Biology and Evolution
- Endosymbiosis: Lessons in Conflict ResolutionJennifer J. Wernegreen · 2004 · PLoS Biology
- MtDNA Phylogeography and Recent Intra-island Diversification among Canary Island Calathus BeetlesBrent C. Emerson, Pedro Oromı́, Godfrey M. Hewitt · 1999 · Molecular Phylogenetics and Evolution
- Molecular Mechanisms of Poxvirus EvolutionGreg Brennan, Ana M. M. Stoian, Huibin Yu, M. Julhasur Rahman, Shefali Banerjee, Jeannine N. Stroup, Chorong Park, Loubna Tazi, Stefan Rothenburg · 2022 · mBio
- Role of positive selection in the retention of duplicate genes in mammalian genomesShin‐Han Shiu, Jake Byrnes, Runsun Pan, Peng Zhang, Wen‐Hsiung Li · 2006 · Proceedings of the National Academy of Sciences
- Mutation and selection at silent and replacement sites in the evolution of animal mitochondrial DNADavid M. Rand, Lisa M. Kann · 1998 · Genetica
- Characteristics of Neutral and Deleterious Protein-Coding Variation among Individuals and PopulationsWenqing Fu, Rachel M. Gittelman, Michael J. Bamshad, Joshua M. Akey · 2014 · The American Journal of Human Genetics
- Unifying ecology and macroevolution with individual‐based theoryJames Rosindell, Luke J. Harmon, Rampal S. Etienne · 2015 · Ecology Letters
- Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiaeZhenglong Gu, Lior David, Dmitri A. Petrov, Ted Jones, Ronald Wayne Davis, Lars Michael Steinmetz · 2005 · Proceedings of the National Academy of Sciences
- Nucleotide polymorphism in the acidic chitinase locus (ChiA) region of the wild plant Arabidopsis thalianaAkira Kawabe, Hideki Innan, Ryohei Terauchi, Naohiko T. Miyashita · 1997 · Molecular Biology and Evolution
- Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rateChungang Feng, Mats E. Pettersson, Sangeet Lamichhaney, Carl‐Johan Rubin, Nima Rafati, Michele Casini, Arild Folkvord, Leif Andersson · 2017 · eLife
- Evolutionary history of the Asr gene familyNicolás Frankel, Fernando O. Carrari, Esteban Hasson, Norberto Daniel Iusem · 2006 · Gene
- The neutral theory is dead. The current significance and standing of neutral and nearly neutral theoriesTomoko Ohta · 1996 · BioEssays
- Demography and mating system shape the genome-wide impact of purifying selection in Arabis alpinaBenjamin Laenen, Andrew Tedder, Michael D. Nowak, Per Toräng, Jörg Wunder, Stefan Wötzel, Kim A. Steige, Yiannis A. I. Kourmpetis, Thomas Lapaka Odong, Andreas D. Drouzas et al. · 2018 · Proceedings of the National Academy of Sciences
- Comparative analysis of protein coding sequences from human, mouse and the domesticated pigFrank Grønlund Jørgensen, Asger Hobolth, Henrik Hornshøj, Christian Bendixen, Merete Fredholm, Mikkel Heide Schierup · 2005 · BMC Biology
- Quantifying Homologous Replacement of Loci between Haloarchaeal SpeciesDavid F. Williams, Johann Peter Gogarten, R. Thane Papke · 2012 · Genome Biology and Evolution
- MITOCHONDRIAL DNA INGASTEROSTEUSAND PLEISTOCENE GLACIAL REFUGIUM ON THE QUEEN CHARLOTTE ISLANDS, BRITISH COLUMBIAPatrick T O'Reilly, Thomas Edward Reimchen, Robin N. Beech, Curtis Strobeck · 1993 · Evolution
- Evidence for Widespread Positive and Purifying Selection Across the European Rabbit (Oryctolagus cuniculus) GenomeMiguel Carneiro, Frank Wolfgang Albert, José Melo‐Ferreira, Nicolas Galtier, Philippe Gayral, José Blanco, Rafael Villafuerte, Michael W. Nachman, Nuno Ferrand · 2012 · Molecular Biology and Evolution
- Amino acid substitution at the Adh locus of Drosophila is facilitated by small population size.T Ohta · 1993 · Proceedings of the National Academy of Sciences
- Patterns of Neutral Diversity Under General Models of Selective SweepsGraham Coop, Peter L. Ralph · 2012 · Genetics
- Biology of Fungi and Their Bacterial EndosymbiontsTeresa E. Pawlowska, Maria Laura Gaspar, Olga A. Lastovetsky, Stephen James Mondo, Imperio Real-Ramírez, Evaniya Shakya, Paola Bonfante · 2018 · Annual Review of Phytopathology
- The Role of Population Size in Molecular EvolutionJohn H. Gillespie · 1999 · Theoretical Population Biology
- The contribution of Neanderthal introgression to modern human traitsPatrick F. Reilly, Audrey Tjahjadi, Samantha L. Miller, Joshua M. Akey, Serena Tucci · 2022 · Current Biology
- Faster-X Evolution of Gene Expression in DrosophilaRichard P. Meisel, John H. Malone, Andrew G. Clark · 2012 · PLoS Genetics
- Genetic Correlations Greatly Increase Mutational Robustness and Can Both Reduce and Enhance EvolvabilitySam F. Greenbury, Steffen Schaper, Sebastian E. Ahnert, Ard A. Louis · 2016 · PLoS Computational Biology
- Comparative Analyses of Selection Operating on Nontranslated Intergenic Regions of Diverse Bacterial SpeciesHarry A. Thorpe, Sion Bayliss, Laurence D. Hurst, Edward J. Feil · 2017 · Genetics
- Higher rates of amino acid substitution in rodents than in humansXun Gu, Wen‐Hsiung Li · 1992 · Molecular Phylogenetics and Evolution
- Aquatic Adaptation and Depleted Diversity: A Deep Dive into the Genomes of the Sea Otter and Giant OtterAnnabel C. Beichman, Klaus‐Peter Koepfli, Gang Li, William J. Murphy, Pasha Dobrynin, Sergei F. Kliver, Martin Tim Tinker, Michael J. Murray, Jeremy Johnson, Kerstin Lindblad‐Toh et al. · 2019 · Molecular Biology and Evolution
- Symbiosis of Thioautotrophic Bacteria with Riftia pachyptilaFrank J. Stewart, Colleen M. Cavanaugh · 2005 · Progress in molecular and subcellular biology
- Adaptive Evolution and Effective Population Size in Wild House MiceMegan Phifer‐Rixey, François Bonhomme, Pierre Boursot, Gary A. Churchill, Jaroslav Piálek, Priscilla K. Tucker, Michael W. Nachman · 2012 · Molecular Biology and Evolution
- The type of bottleneck matters: Insights into the deleterious variation landscape of small managed populationsChiara Bortoluzzi, Mirte Bosse, Martijn F. L. Derks, Richard P. M. A. Crooijmans, Martien A. M. Groenen, Hendrik‐Jan Megens · 2019 · Evolutionary Applications
- Quantification of ortholog losses in insects and vertebratesStefan Wyder, Evgenia V. Kriventseva, Reinhard Schröder, Tatsuhiko Kadowaki, Evgeny M. Zdobnov · 2007 · Genome biology
- Evolutionary genetics of the mitochondrial genome: insights from DrosophilaDamian K. Dowling, Jonci N. Wolff · 2023 · Genetics
- Molecular hyperdiversity and evolution in very large populationsAsher D. Cutter, Richard Jovelin, Alivia Dey · 2013 · Molecular Ecology
- The Temporal Dynamics of Slightly Deleterious Mutations in Escherichia coli and Shigella spp.Kevin Jon Balbi, Eduardo P. C. Rocha, Edward J. Feil · 2008 · Molecular Biology and Evolution
- The Evolution of Control and Distribution of Adaptive Mutations in a Metabolic PathwayKevin M. Wright, Mark D. Rausher · 2009 · Genetics
- Consanguineous Marriage and Human EvolutionAlan Holland Bittles, Michael L. Black · 2010 · Annual Review of Anthropology
- Uncovering the rules of microbial community invasionsJean C. C. Vila, Matt Lloyd Jones, Matishalin Patel, Thomas Bell, James Rosindell · 2019 · Nature Ecology & Evolution
- Transitions, transversions, and the molecular evolutionary clockThomas H. Jukes · 1987 · Journal of Molecular Evolution
- Genomic evolution of MHC class I region in primatesKaoru Fukami-Kobayashi, Takashi Shiina, Tatsuya Anzai, Kazumi Sano, Masaaki Yamazaki, Hidetoshi Inoko, Yoshio Tateno · 2005 · Proceedings of the National Academy of Sciences
- High levels of genetic variation in natural populations of marine lower invertebratesAntonio Mateo Solé-Cava, J. P. Thorpe · 1991 · Biological Journal of the Linnean Society
- Genetics and the evolutionary processMichel Veuille · 2000 · Comptes Rendus de l Académie des Sciences - Series III - Sciences de la Vie
- Shifts in the intensity of purifying selection: An analysis of genome-wide polymorphism data from two closely related yeast speciesEyal Elyashiv, Kevin Bullaughey, Shmuel Sattath, Yosef Rinott, Molly Przeworski, Guy Sella · 2010 · Genome Research
- Towards a theory of evolutionary adaptationDaniel L. Hartl, Clifford Henry Taubes · 1998 · Genetica
- Roles of mutation and recombination in the evolution of protein thermodynamicsYu Xia, Michael Levitt · 2002 · Proceedings of the National Academy of Sciences
- Deleterious Passengers in Adapting PopulationsBenjamin H. Good, Michael M. Desai · 2014 · Genetics
- Reconstructing the Phylogenetic History of Long-Term Effective Population Size and Life-History Traits Using Patterns of Amino Acid Replacement in Mitochondrial Genomes of Mammals and BirdsBenoît Nabholz, Nicole Uwimana, Nicolas Lartillot · 2013 · Genome Biology and Evolution
- Selection Conflicts, Gene Expression, and Codon Usage Trends in YeastRichard M. Kliman, Naheelah Irving, Maria Santiago · 2003 · Journal of Molecular Evolution
- Comparative mitochondrial genomics within and among species of killifishAndrew Whitehead · 2009 · BMC Evolutionary Biology
- Domestication Process of the Goat Revealed by an Analysis of the Nearly Complete Mitochondrial Protein-Encoding GenesKoh Nomura, Takahiro Yonezawa, Shuhei Mano, Shigehisa Kawakami, Andrew M. Shedlock, Masami Hasegawa, Takashi Amano · 2013 · PLoS ONE
- Weighing the evidence for adaptation at the molecular levelJustin C. Fay · 2011 · Trends in Genetics
- Molecular evolution of the duplicated Amy locus in the Drosophila melanogaster species subgroup: concerted evolution only in the coding region and an excess of nonsynonymous substitutions in speciation.Hiroki Shibata, T Yamazaki · 1995 · Genetics
- An analysis of the gene complement of a marsupial,Monodelphis domestica: Evolution of lineage-specific genes and giant chromosomesGoodstadt, Leo, Heger, Andreas, Webber, Caleb, Ponting, Chris P. · 2007 · Genome Research
- Functional and Evolutionary Analysis of the Genome of an Obligate Fungal SymbiontKevin J. Vogel, Nancy A. Moran · 2013 · Genome Biology and Evolution
- Phylogenetic relationships in the honeybee (Genus Apis) as determined by the sequence of the cytochrome oxidase II region of mitochondrial DNALeslie G. Willis, Mark L. Winston, Barry M. Honda · 1992 · Molecular Phylogenetics and Evolution
- Effective Population Size and the Efficacy of Selection on the X Chromosomes of Two Closely Related Drosophila SpeciesPeter Andolfatto, Karen M. Wong, Doris Bachtrog · 2010 · Genome Biology and Evolution
- A Model for Damage Load and Its Implications for the Evolution of Bacterial AgingLin Chao · 2010 · PLoS Genetics
- Molecular Structure and Protein Variation within and among PopulationsRichard K. Koehn, Walter F. Eanes · 1978 · Springer eBooks
- Fast and Robust Characterization of Time-Heterogeneous Sequence Evolutionary Processes Using Substitution MappingJonathan Romiguier, Emeric Figuet, Nicolas Galtier, Emmanuel Douzery, Bastien Boussau, Julien Yann Dutheil, Vincent Ranwez · 2012 · PLoS ONE
- K r /K c but not d N /d S correlates positively with body mass in birds, raising implications for inferring lineage-specific selectionClaudia C. Weber, Benoît Nabholz, Jonathan Romiguier, Hans Ellegren · 2014 · Genome biology
- The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic InuitCasper‐Emil Tingskov Pedersen, Kirk E. Lohmueller, Niels Grarup, Peter Bjerregaard, Torben F. Hansen, HANS REDLEF SIEGISMUND, Ida Moltke, Anders Albrechtsen · 2016 · Genetics
- Horizontal and Vertical Gene Transfer: The Life History of PathogensJeffrey G. Lawrence · 2004 · KARGER eBooks
- NORTH AMERICAN ORIGIN AND RECENT EUROPEAN ESTABLISHMENTS OF THE AMPHI-ATLANTIC PEAT MOSS SPHAGNUM ANGERMANICUMHans K. Stenøien, A. Jonathan Shaw, Blanka Shaw, Kristian Hassel, Urban Gunnarsson · 2010 · Evolution
- Understanding the Hidden Complexity of Latin American Population IsolatesJazlyn A. Mooney, Christian D. Huber, Susan K. Service, Jae Hoon Sul, Clare D. Marsden, Zhongyang Zhang, Chiara Sabatti, Andrés Ruiz‐Linares, Gabriel Bedoya, Nelson B. Freimer et al. · 2018 · The American Journal of Human Genetics
- Directional mutational pressure affects the amino acid composition and hydrophobicity of proteins in bacteriaXun Gu, David Hewett‐Emmett, Wen‐Hsiung Li · 1998 · Genetica
- Inference of Positive and Negative Selection on the 5′ Regulatory Regions of Drosophila GenesMichael H. Kohn, Shu Fang, Chung‐I Wu · 2004 · Molecular Biology and Evolution
- Genetic studies on the Ticuna, an eniǵmatic tribe of Central AmazonasJames V. Neel, H. Gershowitz, Harvey W. Mohrenweiser, Bernard D. Amos, Donna D. Kostyu, Francisco M. Salzano, Moacyr Antônio Mestriner, Dale N. Lawrence, AGUINALDO L. SIMOTES, Peter E. Smouse et al. · 1980 · Annals of Human Genetics
- New thoughts on an old riddle: What determines genetic diversity within and between species?Shi Huang · 2016 · Genomics
- Selective constraint in protein polymorphism: Study of the effectively neutral mutation model by using an improved pseudosampling methodMotoo Kimura, Naoyuki Takahata · 1983 · Proceedings of the National Academy of Sciences
- Mutations within lncRNAs are effectively selected against in fruitfly but not in humanWilfried Haerty, Chris P. Ponting · 2013 · Genome biology
- Genomic Flux: Genome Evolution by Gene Loss and AcquisitionJeffrey G. Lawrence, John R. Roth · 2014 · ASM Press eBooks
- Optimizing Epochal Evolutionary Search: Population-Size Dependent TheoryErik van Nimwegen, James P. Crutchfield · 2001 · Machine Learning
- A Conservative Test of Genetic Drift in the Endosymbiotic Bacterium Buchnera: Slightly Deleterious Mutations in the Chaperonin groELHerbeck, Joshua T, Funk, Daniel J, Degnan, Patrick H, Wernegreen, Jennifer J · 2003 · Genetics
- The Age of Nonsynonymous and Synonymous Mutations in Animal mtDNA and Implications for the Mildly Deleterious TheoryRasmus Nielsen, Daniel M. Weinreich · 1999 · Genetics
- Rapid Evolution of the Sex-Determining Gene, transformer: Structural Diversity and Rate Heterogeneity Among Sibling Species of DrosophilaRob J. Kulathinal · 2003 · Molecular Biology and Evolution
- The insect molecular clockSimon Y. W. Ho, Nathan C. Lo · 2013 · Australian Journal of Entomology
- Genetic diversity and models of viral evolution for the hepatitis C virusMichael P. H. Stumpf, Oliver G. Pybus · 2002 · FEMS Microbiology Letters