Slightly Deleterious Mutant Substitutions in Evolution

Animal Species and Evolution

Mayr, E. (1963) · doi:10.4159/harvard.9780674865327 · Cited by 10,175 · see citing works

Evolutionary Rate at the Molecular Level

KIMURA, M. (1968) · Nature · doi:10.1038/217624a0 · Cited by 3,747 · see citing works

THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION

Kimura, M., & Crow, J. F. (1964) · Genetics · doi:10.1093/genetics/49.4.725 · Cited by 2,690 · see citing works

Atlas of Protein Sequence and Structure, 1972.

Fitch, W. M., & Dayhoff, M. O. (1973) · Systematic Zoology · doi:10.2307/2412105 · Cited by 2,458 · see citing works

The sampling theory of selectively neutral alleles

Ewens, W. J. (1972) · Theoretical Population Biology · doi:10.1016/0040-5809(72)90035-4 · Cited by 2,178 · see citing works

Non-Darwinian Evolution

King, J. L., & Jukes, T. H. (1969) · Science · doi:10.1126/science.164.3881.788 · Cited by 1,776 · see citing works

ON THE PROBABILITY OF FIXATION OF MUTANT GENES IN A POPULATION

Kimura, M. (1962) · Genetics · doi:10.1093/genetics/47.6.713 · Cited by 1,228 · see citing works

An improved method for determining codon variability in a gene and its application to the rate of fixation of mutations in evolution

Fitch, W. M., & Markowitz, E. (1970) · Biochemical Genetics · doi:10.1007/bf00486096 · Cited by 464 · see citing works

On the constancy of the evolutionary rate of cistrons

Ohta, T., & Kimura, M. (1971) · Journal of Molecular Evolution · doi:10.1007/bf01659391 · Cited by 322 · see citing works

Population size and rate of evolution

Ohta, T. (1972) · Journal of Molecular Evolution · doi:10.1007/bf01653959 · Cited by 212 · see citing works

Actin in the Mitotic Spindle

Gawadi, N. (1971) · Nature · doi:10.1038/234410a0 · Cited by 99 · see citing works

Linkage Disequilibrium in a Local Population of Drosophila melanogaster

Mukai, T., Mettler, L. E., & Chigusa, S. I. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.5.1065 · Cited by 87 · see citing works

Evolutionary rate of cistrons and DNA divergence

Ohta, T. (1972) · Journal of Molecular Evolution · doi:10.1007/bf01659161 · Cited by 78 · see citing works

Evolution of Ribonuclease in Relation to Polypeptide Folding Mechanisms

Barnard, E. A., COHEN, M. S., GOLD, M. H., & KIM, J.-K. (1972) · Nature · doi:10.1038/240395a0 · Cited by 53 · see citing works

Protein Polymorphism

Bulmer, M. G. (1971) · Nature · doi:10.1038/234410b0 · Cited by 31 · see citing works

Evidence that Enzyme Polymorphisms are not Selectively Neutral

Johnson, G. B. (1972) · Nature New Biology · doi:10.1038/newbio237170a0 · Cited by 25 · see citing works

Indications for a common evolutionary origin shown in the primary structure of three transfer RNAs

Jukes, T. H. (1966) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(66)90388-3 · Cited by 16 · see citing works

Protein Polymorphism

Smith, J. M. (1972) · Nature New Biology · doi:10.1038/newbio237031a0 · Cited by 13 · see citing works

The α-Glycerophosphate Cycle in Drosophila melanogaster. III. Relative Viability of "Null" Mutants at the α-Glycerophosphate Dehydrogenase-1 Locus

O’Brien, S. J., Wallace, B. B., & MacIntyre, R. (1972) · The American Naturalist · doi:10.1086/282811 · Cited by 10 · see citing works

Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.

Tajima, F. (1989) · Genetics · doi:10.1093/genetics/123.3.585 · Cited by 13,991 · see citing works

Initial sequence of the chimpanzee genome and comparison with the human genome

The Chimpanzee Sequencing and Analysis Consortium (2005) · Nature · doi:10.1038/nature04072 · Cited by 2,459 · see citing works

The incomplete natural history of mitochondria

Ballard, J. W. O., & Whitlock, M. C. (2003) · Molecular Ecology · doi:10.1046/j.1365-294x.2003.02063.x · Cited by 2,289 · see citing works

Statistical tests of selective neutrality in the age of genomics

Nielsen, R. (2001) · Heredity · doi:10.1046/j.1365-2540.2001.00895.x · Cited by 1,911 · see citing works

Statistical methods for detecting molecular adaptation

Yang, Z., & Bielawski, J. P. (2000) · Trends in Ecology & Evolution · doi:10.1016/s0169-5347(00)01994-7 · Cited by 1,807 · see citing works

Cancer as an evolutionary and ecological process

Merlo, L. M. F., Pepper, J. W., Reid, B. J., & Maley, C. C. (2006) · Nature reviews. Cancer · doi:10.1038/nrc2013 · Cited by 1,690 · see citing works

The origins of genome complexity

Lynch, M., & Conery, J. S. (2003) · Science · doi:10.1126/science.1089370 · Cited by 1,698 · see citing works

The Drosophila melanogaster Genetic Reference Panel

Mackay, T., Richards, S., Stone, E. A., Barbadilla, A., Ayroles, J., Zhu, D., Casillas, S., Han, Y., Magwire, M., Cridland, J., et al. (2012) · Nature · doi:10.1038/nature10811 · Cited by 1,686 · see citing works

Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene

Nielsen, R., & Yang, Z. (1998) · Genetics · doi:10.1093/genetics/148.3.929 · Cited by 1,622 · see citing works

Computational Molecular Evolution

Yang, Z. (2006) · doi:10.1093/acprof:oso/9780198567028.001.0001 · Cited by 1,143 · see citing works

Identification of deleterious mutations within three human genomesPreprint

Chun, S., & Fay, J. C. (2009) · Genome Research · doi:10.1101/gr.092619.109 · Cited by 1,101 · see citing works

Time dependency of molecular rate estimates and systematic overestimation of recent divergence times.

Ho, S., Phillips, M., Cooper, A., & Drummond, A. (2005) · Molecular biology and evolution · doi:10.1093/molbev/msi145 · Cited by 1,065 · see citing works

The Nearly Neutral Theory of Molecular Evolution

Ohta, T. (1992) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.23.110192.001403 · Cited by 1,149 · see citing works

Cartesian Genetic Programming

Miller, J. F., & Thomson, P. (2000) · Lecture notes in computer science · doi:10.1007/978-3-540-46239-2_9 · Cited by 960 · see citing works

Non-coding RNA: what is functional and what is junk?

Palazzo, A. F., & Lee, E. S. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00002 · Cited by 891 · see citing works

A complex journey: transmission of microbial symbionts.

Bright, M., & Bulgheresi, S. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2262 · Cited by 894 · see citing works

Determinants of genetic diversity

Ellegren, H., & Galtier, N. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.58 · Cited by 887 · see citing works

Mechanism of action of insecticidal secondary metabolites of plant origin

Rattan, R. S. (2010) · Crop Protection · doi:10.1016/j.cropro.2010.05.008 · Cited by 845 · see citing works

The frailty of adaptive hypotheses for the origins of organismal complexity

Lynch, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702207104 · Cited by 804 · see citing works

Genome analysis of the platypus reveals unique signatures of evolution

paper, A. L. O. A. A. T. A. A. A. T. E. O. T. (2008) · Nature · doi:10.1038/nature06936 · Cited by 719 · see citing works

Assessing the evolutionary impact of amino acid mutations in the human genome.

Boyko, A. R., Williamson, S. H., Indap, A. R., Degenhardt, J. D., Hernandez, R. D., Lohmueller, K. E., Adams, M. D., Schmidt, S., Sninsky, J. J., Sunyaev, S. R., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000083 · Cited by 628 · see citing works

An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people

Nelson, M. R., Wegmann, D., Ehm, M. G., Kessner, D., St. Jean, P., Verzilli, C., Shen, J., Tang, Z., Bacanu, S.-A., Fraser, D., et al. (2012) · Science · doi:10.1126/science.1217876 · Cited by 647 · see citing works

Comparative population genomics in animals uncovers the determinants of genetic diversity

Romiguier, J., Gayral, P., Ballenghien, M., Bernard, A., Cahais, V., Chenuil, A., Chiari, Y., Dernat, R., Duret, L., Faivre, N., et al. (2014) · Nature · doi:10.1038/nature13685 · Cited by 661 · see citing works

Population genetics of polymorphism and divergence.

Sawyer, S. A., & Hartl, D. L. (1992) · Genetics · doi:10.1093/genetics/132.4.1161 · Cited by 592 · see citing works

Local fitness landscape of the green fluorescent protein

Sarkisyan, K. S., Bolotin, D. A., Meer, M. V., Usmanova, D. R., Mishin, A. S., Sharonov, G. V., Ivankov, D. N., Bozhanova, N. G., Baranov, M. S., Soylemez, O., et al. (2016) · Nature · doi:10.1038/nature17995 · Cited by 591 · see citing works

Revisiting an Old Riddle: What Determines Genetic Diversity Levels within Species?

Leffler, E. M., Bullaughey, K., Matute, D. R., Meyer, W. K., Ségurel, L., Venkat, A., Andolfatto, P., & Przeworski, M. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001388 · Cited by 577 · see citing works

Molecular spandrels: tests of adaptation at the genetic level

Barrett, R. D. H., & Hoekstra, H. E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3015 · Cited by 562 · see citing works

Time-dependent rates of molecular evolution

Ho, S. Y. W., Lanfear, R., Bromham, L. D., Phillips, M. J., Soubrier, J., Rodrigo, A. G., & Cooper, A. (2011) · Molecular Ecology · doi:10.1111/j.1365-294x.2011.05178.x · Cited by 566 · see citing works

Inferring weak selection from patterns of polymorphism and divergence at "silent" sites in Drosophila DNA.

Akashi, H. D. (1995) · Genetics · doi:10.1093/genetics/139.2.1067 · Cited by 559 · see citing works

On Some Principles Governing Molecular Evolution

Kimura, M., & Ohta, T. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.7.2848 · Cited by 503 · see citing works

Targeted Retrieval and Analysis of Five Neandertal mtDNA Genomes

Briggs, A. W., Good, J. M., Green, R. E., Krause, J., Maričić, T., Stenzel, U., Lalueza‐Fox, C., Rudan, P., Brajković, D., Kućan, Ž., et al. (2009) · Science · doi:10.1126/science.1174462 · Cited by 501 · see citing works

Predicting the clinical impact of human mutation with deep neural networks

Sundaram, L., Gao, H., Padigepati, S. R., McRae, J. F., Li, Y., Kosmicki, J. A., Fritzilas, N., Hakenberg, J., Dutta, A., Shon, J. C., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0167-z · Cited by 482 · see citing works

Genome evolution in bacterial endosymbionts of insects

Wernegreen, J. J. (2002) · Nature Reviews Genetics · doi:10.1038/nrg931 · Cited by 487 · see citing works

Genomic insights into positive selection

Biswas, S., & Akey, J. M. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.06.005 · Cited by 476 · see citing works

The Genetic Cost of Neanderthal Introgression

Harris, K., & Nielsen, R. (2016) · Genetics · doi:10.1534/genetics.116.186890 · Cited by 419 · see citing works

The application of statistical physics to evolutionary biology

Sella, G., & Hirsh, A. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501865102 · Cited by 457 · see citing works

Mutation rate variation in multicellular eukaryotes: causes and consequences

Baer, C. F., Miyamoto, M. M., & Denver, D. R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2158 · Cited by 458 · see citing works

An evaluation of the molecular clock hypothesis using mammalian DNA sequences

Li, W., Tanimura, M., & Sharp, P. M. (1987) · Journal of Molecular Evolution · doi:10.1007/bf02603118 · Cited by 450 · see citing works

Why prokaryotes have pangenomes

McInerney, J. O., McNally, A., & O’Connell, M. J. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.40 · Cited by 403 · see citing works

Selectionism and Neutralism in Molecular Evolution

Nei, M. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi242 · Cited by 415 · see citing works

Protein dispensability and rate of evolution

Hirsh, A. E., & Fraser, H. B. (2001) · Nature · doi:10.1038/35082561 · Cited by 413 · see citing works

The Origins of Eukaryotic Gene Structure

Lynch, M. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msj050 · Cited by 391 · see citing works

BOTTLENECK EFFECTS ON AVERAGE HETEROZYGOSITY AND GENETIC DISTANCE WITH THE STEPWISE MUTATION MODEL

Chakraborty, R., & Nei, M. (1977) · Evolution · doi:10.1111/j.1558-5646.1977.tb01017.x · Cited by 395 · see citing works

Proportionally more deleterious genetic variation in European than in African populations

Lohmueller, K. E., Indap, A. R., Schmidt, S., Boyko, A. R., Hernandez, R. D., Hubisz, M. J., Sninsky, J. J., White, T. J., Sunyaev, S. R., Nielsen, R., et al. (2008) · Nature · doi:10.1038/nature06611 · Cited by 374 · see citing works

The Population Genetics of the Origin and Divergence of the Drosophila simulans Complex Species

Kliman, R. M., Andolfatto, P., Coyne, J. A., Depaulis, F., Kreitman, M., Berry, A. J., McCarter, J. P., Wakeley, J., & Hey, J. (2000) · Genetics · doi:10.1093/genetics/156.4.1913 · Cited by 363 · see citing works

Testing the neutral theory of molecular evolution with genomic data from Drosophila

Fay, J. C., Wyckoff, G. J., & Wu, C. (2002) · Nature · doi:10.1038/4151024a · Cited by 357 · see citing works

Evolution of primate gene expression

Khaitovich, P., Enard, W., Lachmann, M., & Pääbo, S. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1940 · Cited by 341 · see citing works

Experimental illumination of a fitness landscape

Hietpas, R. T., Jensen, J. D., & Bolon, D. N. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016024108 · Cited by 336 · see citing works

Pervasive Natural Selection in the Drosophila Genome?

Sella, G., Petrov, D. A., Przeworski, M., & Andolfatto, P. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000495 · Cited by 336 · see citing works

Pattern of polymorphism after strong artificial selection in a domestication event

Innan, H., & Kim, Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401720101 · Cited by 332 · see citing works

Simultaneous inference of selection and population growth from patterns of variation in the human genome

Williamson, S., Hernandez, R. D., Fledel-Alon, A., Zhu, L., Nielsen, R., & Bustamante, C. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502300102 · Cited by 325 · see citing works

Genetic Properties Influencing the Evolvability of Gene Expression

Landry, C. R., Lemos, B., Rifkin, S. A., Dickinson, W. J., & Hartl, D. L. (2007) · Science · doi:10.1126/science.1140247 · Cited by 319 · see citing works

Genetic load: genomic estimates and applications in non-model animals

Bertorelle, G., Raffini, F., Bosse, M., Bortoluzzi, C., Iannucci, A., Trucchi, E., Morales, H. E., & van Oosterhout, C. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00448-x · Cited by 306 · see citing works

Synonymous and nonsynonymous substitutions in mammalian genes and the nearly neutral theory

Ohta, T. (1995) · Journal of Molecular Evolution · doi:10.1007/bf00166595 · Cited by 304 · see citing works

IS THE POPULATION SIZE OF A SPECIES RELEVANT TO ITS EVOLUTION?

Gillespie, J. H. (2001) · Evolution · doi:10.1554/0014-3820(2001)055[2161:itpsoa]2.0.co;2 · Cited by 297 · see citing works

Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications

Kapusta, A., & Feschotte, C. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.08.004 · Cited by 291 · see citing works

Sequence Divergence, Functional Constraint, and Selection in Protein Evolution

Fay, J. C., & Wu, C. (2003) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.4.020303.162528 · Cited by 293 · see citing works

Genetic and non-genetic clonal diversity in cancer evolution

Black, J. R., & McGranahan, N. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00336-2 · Cited by 287 · see citing works

The Case for Junk DNA

Palazzo, A. F., & Gregory, T. R. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004351 · Cited by 282 · see citing works

Development of Neutral and Nearly Neutral Theories

Ohta, T., & Gillespie, J. H. (1996) · Theoretical Population Biology · doi:10.1006/tpbi.1996.0007 · Cited by 281 · see citing works

Mechanisms of molecular evolution

Ohta, T. (2000) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0724 · Cited by 281 · see citing works

Estimating the mutation load in human genomes

Henn, B. M., Botigué, L. R., Bustamante, C. D., Clark, A. G., & Gravel, S. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3931 · Cited by 281 · see citing works

ACCELERATED EVOLUTION OF LAND SNAILS MANDARINA IN THE OCEANIC BONIN ISLANDS: EVIDENCE FROM MITOCHONDRIAL DNA SEQUENCES

Chiba, S. (1999) · Evolution · doi:10.1111/j.1558-5646.1999.tb03781.x · Cited by 276 · see citing works

The role of compensatory neutral mutations in molecular evolution

Kimura, M. (1985) · Journal of Genetics · doi:10.1007/bf02923549 · Cited by 275 · see citing works

Functional genomic analysis of the rates of protein evolution

Wall, D. P., Hirsh, A. E., Fraser, H. B., Kumm, J., Giaever, G. N., Eisen, M. B., & Feldman, M. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501761102 · Cited by 265 · see citing works

Molecular Evolution

Yang, Z. (2014) · doi:10.1093/acprof:oso/9780199602605.001.0001 · Cited by 273 · see citing works

Distance from sub-Saharan Africa predicts mutational load in diverse human genomes

Henn, B. M., Botigué, L. R., Peischl, S., Dupanloup, I., Lipatov, M., Maples, B. K., Martin, A. R., Musharoff, S. A., Cann, H. M., Snyder, M. P., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510805112 · Cited by 257 · see citing works

Model of effectively neutral mutations in which selective constraint is incorporated

Kimura, M. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.7.3440 · Cited by 254 · see citing works

Bias of Selection on Human Copy-Number Variants

Nguyen, D.-Q., Webber, C., & Ponting, C. P. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020020 · Cited by 255 · see citing works

The road from Santa Rosalia: A faster tempo of evolution in tropical climates

Wright, S. D., Keeling, J., & Gillman, L. N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510383103 · Cited by 246 · see citing works

A phylogenetic model for investigating correlated evolution of substitution rates and continuous phenotypic characters

Lartillot, N., & Poujol, R. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msq244 · Cited by 243 · see citing works

A Catalog of Neutral and Deleterious Polymorphism in Yeast

Doniger, S. W., Kim, H. S., Swain-Lenz, D., Corcuera, D., Williams, M., Yang, S., & Fay, J. C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000183 · Cited by 238 · see citing works

Looking for Darwin in all the wrong places: the misguided quest for positive selection at the nucleotide sequence level

Hughes, A. L. (2007) · Heredity · doi:10.1038/sj.hdy.6801031 · Cited by 239 · see citing works

Maximum-Likelihood Analysis of Molecular Adaptation in Abalone Sperm Lysin Reveals Variable Selective Pressures Among Lineages and Sites

Yang, Z., Swanson, W. J., & Vacquier, V. D. (2000) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a026245 · Cited by 239 · see citing works

Animal Mitochondrial DNA as We Do Not Know It: mt-Genome Organization and Evolution in Nonbilaterian Lineages

Lavrov, D. V., & Pett, W. (2016) · Genome Biology and Evolution · doi:10.1093/gbe/evw195 · Cited by 234 · see citing works

Paired sequence difference in ribosomal RNAs: evolutionary and phylogenetic implications.

(1988) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040480 · Cited by 234 · see citing works

Structural and functional constraints in the evolution of protein families

Worth, C. L., Gong, S., & Blundell, T. L. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2762 · Cited by 230 · see citing works

Biophysics of protein evolution and evolutionary protein biophysics

Sikosek, T., & Chan, H. S. (2014) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.0419 · Cited by 220 · see citing works

Copy number variation and evolution in humans and chimpanzeesPreprint

Perry, G. H., Yang, F., Marquès‐Bonet, T., Murphy, C., Fitzgerald, T. W., Lee, A. S., Hyland, C., Stone, A. C., Hurles, M. E., Tyler‐Smith, C., et al. (2008) · Genome Research · doi:10.1101/gr.082016.108 · Cited by 220 · see citing works

Unraveling selection in the mitochondrial genome of Drosophila.

Ballard, J. W. O., & Kreitman, M. (1994) · Genetics · doi:10.1093/genetics/138.3.757 · Cited by 219 · see citing works

Nonneutral Mitochondrial DNA Variation in Humans and Chimpanzees

Nachman, M. W., Brown, W. M., Stoneking, M., & Aquadro, C. F. (1996) · Genetics · doi:10.1093/genetics/142.3.953 · Cited by 211 · see citing works

Some Structural Aspects of Language Are More Stable than Others: A Comparison of Seven Methods

Dediu, D., & Cysouw, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055009 · Cited by 218 · see citing works

Molecular Changes At Speciation

Harrison, R. G. (1991) · Annual Review of Ecology and Systematics · doi:10.1146/annurev.es.22.110191.001433 · Cited by 218 · see citing works

Comparative analysis of encephalization in mammals reveals relaxed constraints on anthropoid primate and cetacean brain scaling

BODDY, A. M., McGOWEN, M. R., SHERWOOD, C. C., GROSSMAN, L. I., GOODMAN, M., & WILDMAN, D. E. (2012) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2012.02491.x · Cited by 207 · see citing works

Adaptive evolution: evaluating empirical support for theoretical predictions

Olson-Manning, C. F., Wagner, M. R., & Mitchell‐Olds, T. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3322 · Cited by 214 · see citing works

The genome as a life-history character: why rate of molecular evolution varies between mammal species

Bromham, L. D. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0014 · Cited by 211 · see citing works

A global catalog of whole-genome diversity from 233 primate species

Kuderna, L. F. K., Gao, H. C., Janiak, M. C., Kuhlwilm, M., Orkin, J. D., Bataillon, T. M., Manu, S., Valenzuela, A., Bergman, J., Rousselle, M. M. C., et al. (2023) · Science · doi:10.1126/science.abn7829 · Cited by 206 · see citing works

The Ecological Niche: History and Recent Controversies

Pocheville, A. (2014) · Springer eBooks · doi:10.1007/978-94-017-9014-7_26 · Cited by 212 · see citing works

Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution

Eyre‐Walker, A., Keightley, P. D., Smith, N. G. C., & Gaffney, D. J. (2002) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a004039 · Cited by 209 · see citing works

Mitochondrial–Nuclear Interactions and Accelerated Compensatory Evolution: Evidence from the Primate Cytochrome c Oxidase Complex

Osada, N., & Akashi, H. D. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr211 · Cited by 204 · see citing works

Evidence for Widespread Degradation of Gene Control Regions in Hominid Genomes

Keightley, P. D., Lercher, M. J., & Eyre‐Walker, A. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030042 · Cited by 198 · see citing works

EFFECTIVE POPULATION SIZE AND THE FASTER-X EFFECT: AN EXTENDED MODEL

Viçoso, B., & Charlesworth, B. (2009) · Evolution · doi:10.1111/j.1558-5646.2009.00719.x · Cited by 202 · see citing works

Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen

MacLean, O. A., Lytras, S., Weaver, S., Singer, J. B., Boni, M. F., Lemey, P., Pond, S. L. K., & Robertson, D. L. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001115 · Cited by 215 · see citing works

Role of very slightly deleterious mutations in molecular evolution and polymorphism

Ohta, T. (1976) · Theoretical Population Biology · doi:10.1016/0040-5809(76)90019-8 · Cited by 196 · see citing works

The importance of the Neutral Theory in 1968 and 50 years on: A response to Kern and Hahn 2018

Jensen, J. D., Payseur, B. A., Stephan, W., Aquadro, C. F., Lynch, M., Charlesworth, D., & Charlesworth, B. (2018) · Evolution · doi:10.1111/evo.13650 · Cited by 195 · see citing works

Comparative Genomics of Mitochondrial DNA in Members of the Drosophila melanogaster Subgroup

Ballard, J. W. O. (2000) · Journal of Molecular Evolution · doi:10.1007/s002390010066 · Cited by 186 · see citing works

The landscape of tolerated genetic variation in humans and primates

(2023) · doi:10.1126/science.abn8197 · Cited by 182 · see citing works

Modeling Evolution Using the Probability of Fixation: History and Implications

McCandlish, D. M., & Stoltzfus, A. (2014) · The Quarterly Review of Biology · doi:10.1086/677571 · Cited by 189 · see citing works

Evolution in the light of fitness landscape theory

Fragata, I., Blanckaert, A., Louro, M. A. D., Liberles, D. A., & Bank, C. (2018) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2018.10.009 · Cited by 175 · see citing works

Molecular evolutionary clock and the neutral theory

Kimura, M. (1987) · Journal of Molecular Evolution · doi:10.1007/bf02111279 · Cited by 183 · see citing works

Molecular Evolution: Patterns and Rates

Bromham, L. D. (2013) · Wiley eBooks · doi:10.1002/9780470015902.a0001799.pub4

Nearly Neutral Theory

Ohta, T. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-374984-0.01022-6 · Cited by 1 · see citing works

Population size and rate of evolution

Ohta, T. (1972) · Journal of Molecular Evolution · doi:10.1007/bf01653959 · Cited by 212 · see citing works

Theoretical study of near neutrality. I. Heterozygosity and rate of mutant substitution.

Ohta, T., & Tachida, H. (1990) · Genetics · doi:10.1093/genetics/126.1.219 · Cited by 131 · see citing works

Epistasis Increases the Rate of Conditionally Neutral Substitution in an Adapting Population

Draghi, J. A., Parsons, T. L., & Plotkin, J. B. (2011) · Genetics · doi:10.1534/genetics.110.125997 · Cited by 22 · see citing works