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Single Na+ channel currents observed in cultured rat muscle cells
Open accessAbstract
The voltage- and time-dependent conductance of membrane Na+ channels is responsible for the propagation of action potentials in nerve and muscle cells. In voltage-step-clamp experiments on neurone preparations containing 104–107 Na+ channels the membrane conductance shows smooth variations in time, but analysis of fluctuations1,2 and other evidence3 suggest that the underlying single-channel conductance changes are stochastic, rapid transitions between ‘closed’ and ‘Open’ states as seen in other channel types. We report here the first observations of currents through individual Na+ channels under physiological conditions using an improved version of the extracellular patch-clamp technique4–6 on cultured rat muscle cells. Our observations support earlier inferences about channel gating and show a single-channel conductance of approximately 18 pS.
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Cited by
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Self-citationSodium and calcium channels in bovine chromaffin cells
Fenwick, E. M., Marty, A., & Neher, E. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014394 · Cited by 961
Self-citationOn the stochastic properties of bursts of single ion channel openings and of clusters of bursts
Colquhoun, D., & Hawkes, A. G. (1982) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1982.0156 · Cited by 567
Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture
Pallotta, B. S., Magleby, K. L., & Barrett, J. N. (1981) · Nature · doi:10.1038/293471a0 · Cited by 414
Mendonça, P. R., Vargas-Caballero, M., Erdélyi, F., Szabó, G., Paulsen, O., & Robinson, H. P. (2016) · eLife · doi:10.7554/elife.16475 · Cited by 37
Metadata
- Authors
- Sigworth, F. J., & Neher, E.
- Venue
- Nature
- Published
- 1980-10
- Volume
- 287
- Issue
- 5781
- Pages
- 447-449
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2066914900
- Cited by
- 461
- References
- 0
- FWCI
- 14.81
- Type
- journal article
- Language
- en
- Open access
- green
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