The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
Abstract
The polyoma virus middle-T and the T24 Harvey ras1 genes are individually unable to transform primary baby rat kidney cells. Adenovirus early region 1A provides functions required by these genes to transform primary cells following DNA-mediated gene transfer. These results suggest that separate establishment and transforming functions are required for oncogenic transformation of primary cells in culture.
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“However, transformation of primary cells by ras requires either a cooperating oncogene or the inactivation of tumor suppressors such as p53 or p16.”
From Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a (1997) · cites this paper as Ruley 1983
In the citing paper
“ras cooperates, however, with certain other oncogenic alterations to transform primary rodent cells (Land et al. 1983; Ruley 1983), including overexpression of c-Myc, dominant negative p53, D-type cyclins, and Cdc25A and -B, and loss of p53, p16, or IRF-1”
From Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a (1997) · cites this paper as Ruley 1983
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Metadata
- Authors
- Ruley, H. E.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Corresponding author
- Ruley, H. Earl
- Venue
- Nature
- Published
- 1983-08
- Volume
- 304
- Issue
- 5927
- Pages
- 602-606
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2117079180
- Cited by
- 1,248
- References
- 31
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 8 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 12 · 2014: 8 · 2013: 5 · 2012: 13
- FWCI
- 102.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- polyomavirus middle T antigen, oncogenic transformation, primary cells, DNA-mediated gene transfer
- MeSH terms
- Adenoviridae, Animals, Antigens, Viral, Antigens, Viral, Tumor, Cell Transformation, Viral, Cells, Cultured, Cloning, Molecular, Gene Expression Regulation, Genes, Viral, Oncogenes, Plasmids, Polyomavirus, Transfection, Transformation, Genetic, Rats
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