Cited by 1,248Virus-based gene therapy researchViral-associated cancers and disordersCancer-related Molecular Pathways

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

Ruley, H. Earl·1983·Nature

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Abstract

The polyoma virus middle-T and the T24 Harvey ras1 genes are individually unable to transform primary baby rat kidney cells. Adenovirus early region 1A provides functions required by these genes to transform primary cells following DNA-mediated gene transfer. These results suggest that separate establishment and transforming functions are required for oncogenic transformation of primary cells in culture.

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Detection of specific sequences among DNA fragments separated by gel electrophoresis
Southern, E. M. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80083-0 · Cited by 32,245
Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I
Rigby, P. W. J., Dieckmann, M., Rhodes, C., & Berg, P. R. (1977) · Journal of Molecular Biology · doi:10.1016/0022-2836(77)90052-3 · Cited by 11,400
A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide Gels
Bonner, W. M., & Laskey, R. A. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03599.x · Cited by 8,589
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
Thomas, P. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5201 · Cited by 7,937
Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose
Aviv, H., & Leder, P. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1408 · Cited by 6,636
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Transformation of mammalian cells with genes from procaryotes and eucaryotes
Wigler, M. H., Sweet, R. W., Sim, G.-K., Wold, B. J., Pellicer, À., Lacy, E., Maniatis, T., Silverstein, S. J., & Axel, R. (1979) · Cell · doi:10.1016/0092-8674(79)90093-x · Cited by 1,407
Mechanism of activation of a human oncogene
Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., & Chang, E. H. (1982) · Nature · doi:10.1038/300143a0 · Cited by 1,393
A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene
Reddy, E. P., Reynolds, R. K., Santos, E., & Barbacid, M. (1982) · Nature · doi:10.1038/300149a0 · Cited by 1,391

Show all 31 references

Research works printed but not linked: 3

Tooze, J. (ed.) Molecular Biology of Tumor Viruses Pt 2 (revised) (Cold Spring Harbor Laboratory, New York, 1981).
Rassoulzadegan, M. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning (Cold Spring Harbor Laboratory, New York, 1982).

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Jenkins, J. R., Rudge, K., & Currie, G. A. (1984) · Nature · doi:10.1038/312651a0 · Cited by 543
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Kovesdi, I., Reichel, R. R., & Nevins, J. R. (1986) · Cell · doi:10.1016/0092-8674(86)90386-7 · Cited by 530
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Fleischman, L. F., Chahwala, S. B., & Cantley, L. C. (1986) · Science · doi:10.1126/science.3001936 · Cited by 422
Cyclin D1/bcl‐1 cooperates with myc genes in the generation of B‐cell lymphoma in transgenic mice.
Lovec, H., Grzeschiczek, A., Kowalski, M., & Möröy, T. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06655.x · Cited by 411
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Wolf, D., & Rotter, V. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.3.790 · Cited by 411
Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.
Bernard, O., Cory, S., Gerondakis, S., Webb, E., & Adams, J. M. (1983) · The EMBO Journal · doi:10.1002/j.1460-2075.1983.tb01749.x · Cited by 409
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Borrelli, E., Hen, R., & Chambon, P. (1984) · Nature · doi:10.1038/312608a0 · Cited by 404
In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA
Titomirov, A. V., Sukharev, S., & Kistanova, E. K. (1991) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(91)90162-f · Cited by 403
Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype
Ray, R., Lagging, M., Meyer, K., & Ray, R. (1996) · Journal of Virology · doi:10.1128/jvi.70.7.4438-4443.1996 · Cited by 403
Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies
Drebin, J. A., Link, V. C., Stern, D. F., Weinberg, R. A., & Greene, M. I. (1985) · Cell · doi:10.1016/s0092-8674(85)80050-7 · Cited by 398
Introduction of a Normal Human Chromosome 11 into a Wilms' Tumor Cell Line Controls Its Tumorigenic Expression
Weissman, B. E., Saxon, P. J., Pasquale, S. R., Jones, G. R., Geiser, A. G., & Stanbridge, E. J. (1987) · Science · doi:10.1126/science.3031816 · Cited by 395
Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors
Serasinghe, M. N., Wieder, S. Y., Renault, T. T., Elkholi, R., Asciolla, J. J., Yao, J. L., Jabado, O., Hoehn, K. L., Kageyama, Y., Sesaki, H., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.01.003 · Cited by 400
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Sakamuro, D., Elliott, K. J., Wechsler-Reya, R., & Prendergast, G. C. (1996) · Nature Genetics · doi:10.1038/ng0996-69 · Cited by 387
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Balmain, A., & Brown, K. (1988) · Advances in cancer research · doi:10.1016/s0065-230x(08)60222-5 · Cited by 384
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Sklar, J., & Longtine, J. (1992) · Cancer · doi:10.1002/1097-0142(19920915)70:4+ · Cited by 22
The molecular role of Myc in growth and transformation: recent discoveries lead to new insights
Facchini, L. M., & Penn, L. Z. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.9.633 · Cited by 381
Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus
Berk, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1209040 · Cited by 386
Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products
Harlow, E., Franza, B. R., & Schley, C. (1985) · Journal of Virology · doi:10.1128/jvi.55.3.533-546.1985 · Cited by 376
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Ananthaswamy, H. N., & Pierceall, W. E. (1990) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1990.tb08452.x · Cited by 374
Association of Adenovirus Early-Region 1A Proteins with Cellular Polypeptides
Harlow, E., Whyte, P., Franza, B. R., & Schley, C. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.5.1579 · Cited by 369
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White, E., Sabbatini, P., Debbas, M. E., Wold, W. S. M., Kusher, D. I., & Gooding, L. R. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2570 · Cited by 368
Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease
Butel, J. S. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.405 · Cited by 368
Establishment and characterization of multipotent neural cell lines using retrovirus vector‐mediated oncogene transfer
Ryder, E. F., Snyder, E. Y., & Cepko, C. L. (1990) · Journal of Neurobiology · doi:10.1002/neu.480210209 · Cited by 365
Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation
Julius, D. J., Livelli, T. J., Jessell, T. M., & Axel, R. (1989) · Science · doi:10.1126/science.2727693 · Cited by 361
GROWTH FACTORS AND CANCER
Burgess, A. W. (1985) · Australian and New Zealand Journal of Surgery · doi:10.1111/j.1445-2197.1985.tb00868.x · Cited by 353
Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ
Thompson, T. C., Southgate, J., Kitchener, G., & Land, H. (1989) · Cell · doi:10.1016/0092-8674(89)90625-9 · Cited by 349
Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.
Matlashewski, G., Schneider, J., Banks, L., Jones, N., Murray, A., & Crawford, L. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02426.x · Cited by 345
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Yadav, V. R., Prasad, S., Sung, B., & Aggarwal, B. B. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.12.006 · Cited by 348
TGF-β inhibition of endothelial cell proliferation: Alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression
Takehara, K., LeRoy, E. C., & Grotendorst, G. R. (1987) · Cell · doi:10.1016/0092-8674(87)90294-7 · Cited by 342
Degradation of nuclear oncoproteins by the ubiquitin system in vitro.
Ciechanover, A. J., DiGiuseppe, J. A., Bercovich, B., Orian, A., Richter, J. D., Schwartz, A. L., & Brodeur, G. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.1.139 · Cited by 336
The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.Preprint
Li, Y., Graham, C., Lacy, S., Duncan, A. M. V., & Whyte, P. (1993) · Genes & Development · doi:10.1101/gad.7.12a.2366 · Cited by 334
Characterization of the Human p53 Gene
Lamb, P., & Crawford, L. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.5.1379 · Cited by 335
Role of epidermal growth factor in carcinogenesis.
Stoscheck, C. M., & King, L. E. (1986) · PubMed · Cited by 325
Adenovirus E1a proteins repress transcription from the SV40 early promoter
Velcich, A., & Ziff, E. B. (1985) · Cell · doi:10.1016/0092-8674(85)90219-3 · Cited by 325
Common Control of the Heat Shock Gene and Early Adenovirus Genes: Evidence for a Cellular E1A-like Activity
Imperiale, M. J., Kao, H., Feldman, L. T., Nevins, J. R., & Strickland, S. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.5.867 · Cited by 324
E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.Preprint
Beijersbergen, R. L., Kerkhoven, R. M., Zhu, L., Carlée, L., Voorhoeve, P. M., & Bernards, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2680 · Cited by 321
Regulation of gamma‐glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells
Roux, F. S., Durieu-Trautmann, O., Chaverot, N., Claire, M., Mailly, P., Bourre, J. M., Strosberg, A. D., & Couraud, P. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041590114 · Cited by 326
Cell Lines Established by a Temperature-Sensitive Simian Virus 40 Large-T-Antigen Gene Are Growth Restricted at the Nonpermissive Temperature
Jat, P., & Sharp, P. A. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.4.1672 · Cited by 317
An adenovirus E1a protein region required for transformation and transcriptional repression
Lillie, J. W., Green, M. R., & Green, M. R. (1986) · Cell · doi:10.1016/0092-8674(86)90704-x · Cited by 308
Adenovirus-5 E1A: paradox and paradigm
Frisch, S. M., & Mymryk, J. S. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm827 · Cited by 318
Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product
Rustgi, A. K., Dyson, N. J., & Bernards, R. (1991) · Nature · doi:10.1038/352541a0 · Cited by 307
Expression of human HSP70 during the synthetic phase of the cell cycle.
Milarski, K. L., & Morimoto, R. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9517 · Cited by 304
N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma
Bernards, R., Dessain, S. K., & Weinberg, R. A. (1986) · Cell · doi:10.1016/0092-8674(86)90509-x · Cited by 303

Authors: Ruley, H. E.
Affiliations: Cold Spring Harbor Laboratory (US)
Corresponding author: Ruley, H. Earl
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1983-08
Volume: 304
Issue: 5927
Pages: 602-606
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/304602a0
OpenAlex: W2117079180
Cited by: 1,248
References: 31
Citations by year: 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 8 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 12 · 2014: 8 · 2013: 5 · 2012: 13
FWCI: 102.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: polyomavirus middle T antigen, oncogenic transformation, primary cells, DNA-mediated gene transfer
MeSH terms: Adenoviridae, Animals, Antigens, Viral, Antigens, Viral, Tumor, Cell Transformation, Viral, Cells, Cultured, Cloning, Molecular, Gene Expression Regulation, Genes, Viral, Oncogenes, Plasmids, Polyomavirus, Transfection, Transformation, Genetic, Rats

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

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