The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
DNA sequences of telomeres maintained in yeast
Abstract
Telomeres, the ends of eukaryotic chromosomes, have long been recognized as specialized structures. Their stability compared with broken ends of chromosomes suggested that they have properties which protect them from fusion, degradation or recombination. Furthermore, a linear DNA molecule such as that of a eukaryotic chromosome must have a structure at its ends which allows its complete replication, as no known DNA polymerase can initiate synthesis without a primer. At the ends of the relatively short, multi-copy linear DNA molecules found naturally in the nuclei of several lower eukaryotes, there are simple tandemly repeated sequences with, in the cases analysed, a specific array of single-strand breaks, on both DNA strands, in the distal portion of the block of repeats. In general, however, direct analysis of chromosomal termini presents problems because of their very low abundance in nuclei. To circumvent this problem, we have previously cloned a chromosomal telomere of the yeast Saccharomyces cerevisiae on a linear DNA vector molecule. Here we show that yeast chromosomal telomeres terminate in a DNA sequence consisting of tandem irregular repeats of the general form C1-3A. The same repeat units are added to the ends of Tetrahymena telomeres, in an apparently non-template-directed manner, during their replication on linear plasmids in yeast. Such DNA addition may have a fundamental role in telomere replication.
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“The identification of telomeres rapidly led to the realization that some cells could elongate preexisting telomeres, implying the existence of telomere elongation mechanisms 49”
From The common biology of cancer and ageing (2007) · cites this paper as [49]
Citations
Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Molecular Cloning. A Laboratory Manual
Wood, E. (1983) · Biochemical Education · doi:10.1016/0307-4412(83)90068-7 · Cited by 29,534
[57] Sequencing end-labeled DNA with base-specific chemical cleavages
Maxam, A. M., & Gilbert, W. (1980) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(80)65059-9 · Cited by 13,943
Complete Nucleotide Sequence of the Escherichia coli Plasmid pBR322Preprint
Sutcliffe, J. G. (1979) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1979.043.01.013 · Cited by 1,728
WATSON, J. D. (1972) · Nature New Biology · doi:10.1038/newbio239197a0 · Cited by 1,632
THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS
McClintock, B. (1941) · Genetics · doi:10.1093/genetics/26.2.234 · Cited by 1,605
Yeast transformation: a model system for the study of recombination.
Orr‐Weaver, T. L., Szostak, J. W., & Rothstein, R. J. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.10.6354 · Cited by 1,501
Self-citationBlackburn, E. H., & Gall, J. G. (1978) · Journal of Molecular Biology · doi:10.1016/0022-2836(78)90294-2 · Cited by 1,023
Self-citationCloning yeast telomeres on linear plasmid vectors
Szostak, J. W., & Blackburn, E. H. (1982) · Cell · doi:10.1016/0092-8674(82)90109-x · Cited by 629
Self-citationMcClintock, B. (1938) · Genetics · doi:10.1093/genetics/23.4.315 · Cited by 474
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Research works printed but not linked: 2
- Muller, H. J. Collecting Net 13, 181–198 (1938).
- Blackburn, E. H. et al. UCLA Symp. Molec. Cell. Biol. 20 (in the press).
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Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596
Self-citationIdentification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400
Self-citationA telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
Greider, C. W., & Blackburn, E. H. (1989) · Nature · doi:10.1038/337331a0 · Cited by 1,643
Self-citationMorin, G. B. (1989) · Cell · doi:10.1016/0092-8674(89)90035-4 · Cited by 1,495
Metadata
- Authors
- Shampay, J., Szostak, J. W., & Blackburn, E. H.
- Affiliations
- University of California, Berkeley (US)
- Harvard University (US)
- Venue
- Nature
- Published
- 1984-07
- Volume
- 310
- Issue
- 5973
- Pages
- 154-157
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1972187528
- Cited by
- 551
- References
- 31
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 8 · 2023: 10 · 2022: 11 · 2021: 10 · 2020: 4 · 2019: 16 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 11 · 2014: 22 · 2013: 12 · 2012: 14
- FWCI
- 24.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- telomeres, Saccharomyces cerevisiae, Tetrahymena, tandem repeats, telomere replication, chromosome ends, linear plasmids, chromosome stability
- MeSH terms
- Base Sequence, Chromosomes, Cloning, Molecular, DNA Restriction Enzymes, DNA, Fungal, Molecular Weight, Nucleic Acid Hybridization, Plasmids, Saccharomyces cerevisiae
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