Szostak, Jack W.

The double-strand-break repair model for recombination

Szostak, J. W., Orr-Weaver, T. L., Rothstein, R. J., & Stahl, F. W. (1983) · Cell

DNA Repair MechanismsFungal and yeast genetics research

Cited by 2,437

Synthesizing life

Szostak, J. W., Bartel, D. P., & Luisi, P. L. (2001) · Nature

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 1,681

Isolation of New Ribozymes from a Large Pool of Random Sequences

Bartel, D. P., & Szostak, J. W. (1993) · Science

RNA and protein synthesis mechanismsEvolution and Genetic Dynamics

Cited by 900

Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division

Hanczyc, M. M., Fujikawa, S. M., & Szostak, J. W. (2003) · Science

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 848

Template-directed synthesis of a genetic polymer in a model protocell

Mansy, S. S., Schrum, J. P., Krishnamurthy, M., Tobé, S., Treco, D. A., & Szostak, J. W. (2008) · Nature

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 684

DNA sequences of telomeres maintained in yeast

Shampay, J., Szostak, J. W., & Blackburn, E. H. (1984) · Nature

Telomeres, Telomerase, and SenescenceChromosomal and Genetic Variations

Cited by 551

Coupled Growth and Division of Model Protocell Membranes

Zhu, T. F., & Szostak, J. W. (2009) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 496

The Emergence of Competition Between Model Protocells

Chen, I. A., Roberts, R. W., & Szostak, J. W. (2004) · Science

Origins and Evolution of LifeEvolution and Genetic Dynamics

Cited by 435

Structurally Complex and Highly Active RNA Ligases Derived from Random RNA Sequences

Ekland, E. H., Szostak, J. W., & Bartel, D. P. (1995) · Science

RNA and protein synthesis mechanismsRNA regulation and disease

Cited by 422

Nonenzymatic template-directed RNA synthesis inside model protocells

Adamala, K., & Szostak, J. W. (2013) · Science

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 367

The eightfold path to non-enzymatic RNA replication

Szostak, J. W. (2012) · Journal of Systems Chemistry

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 359

Protocells and RNA Self-Replication

Joyce, G. F., & Szostak, J. W. (2018) · Cold Spring Harbor Perspectives in Biology

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 308

Competition between model protocells driven by an encapsulated catalyst

Adamala, K., & Szostak, J. W. (2013) · Nature Chemistry

Origins and Evolution of LifeEvolution and Genetic Dynamics

Cited by 300

Physical effects underlying the transition from primitive to modern cell membranes

Budin, I., & Szostak, J. W. (2011) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifeLipid Membrane Structure and Behavior

Cited by 289

RNA Catalysis in Model Protocell Vesicles

Chen, I. A., Salehi-Ashtiani, K., & Szostak, J. W. (2005) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 257

The Origins of Cellular Life

Schrum, J. P., Zhu, T. F., & Szostak, J. W. (2010) · Cold Spring Harbor Perspectives in Biology

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 255

A kinetic study of the growth of fatty acid vesicles

Chen, I. A., & Szostak, J. W. (2004) · Biophysical Journal

Origins and Evolution of LifeLipid Membrane Structure and Behavior

Cited by 251

Thermostability of model protocell membranes

Mansy, S. S., & Szostak, J. W. (2008) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 186

In vitro evolution suggests multiple origins for the hammerhead ribozyme

Salehi-Ashtiani, K., & Szostak, J. W. (2001) · Nature

RNA and protein synthesis mechanismsEvolution and Genetic Dynamics

Cited by 183

Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides

Li, L., Prywes, N., Tam, C. P., O’Flaherty, D. K., Lelyveld, V. S., Izgu, E. C., Pal, A., & Szostak, J. W. (2017) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 176

The Narrow Road to the Deep Past: In Search of the Chemistry of the Origin of Life

Szostak, J. W. (2017) · Angewandte Chemie International Edition

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 174

Expanding roles for diverse physical phenomena during the origin of life

Budin, I., & Szostak, J. W. (2010) · Annual Review of Biophysics

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 171

Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles

Chen, I. A., & Szostak, J. W. (2004) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifeLipid Membrane Structure and Behavior

Cited by 164

UV-light-driven prebiotic synthesis of iron-sulfur clusters

Bonfio, C., Valer, L., Scintilla, S., Shah, S., Evans, D. J., Jin, L., Szostak, J. W., Sasselov, D. D., Sutherland, J. D., & Mansy, S. S. (2017) · Nature Chemistry

Origins and Evolution of LifeMetalloenzymes and iron-sulfur proteins

Cited by 158