Cited by 1,208Ion channel regulation and functionPancreatic function and diabetesIon Transport and Channel Regulation

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Intracellular ATP directly blocks K+ channels in pancreatic B-cells

Cook, Daniel L., Hales, Nicholas·1984·Nature

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Abstract

It is known that glucose-induced depolarization of pancreatic B-cells is due to reduced membrane K+-permeability and is coupled to an increase in the rate of glycolysis, but there has been no direct evidence linking specific metabolic processes or products to the closing of membrane K+ channels. During patch-clamp studies of proton inhibition of Ca2+-activated K+ channels [GK(Ca)] in B-cells, we identified a second K+-selective channel which is rapidly and reversibly inhibited by ATP applied to the cytoplasmic surface of the membrane. This channel is spontaneously active in excised patches and frequently coexists with GK(Ca) channels yet is insensitive to membrane potential and to intracellular free Ca2+ and pH. Blocking of the channel is ATP-specific and appears not to require metabolism of the ATP. This ATP-sensitive K+ channel [GK(ATP)] may be a link between metabolism and membrane K+-permeability in pancreatic B-cells.

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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Lowering of pHi inhibits Ca2+-activated K+ channels in pancreatic B-cells
Cook, D. L., Ikeuchi, M., & Fujimoto, W. Y. (1984) · Nature · doi:10.1038/311269a0 · Cited by 264
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Meissner, H. P., Henquin, J.-C. & Preissler, M. FEBS Lett. 94, 87–89 (1978). · DOI
Meissner, H. P. J. Physiol., Lond. 72, 757–767 (1976).
Dean, P. M. and Matthews, E. K. J. Physiol., Lond. 210, 255–264 (1970). · DOI
Atwater, I., Ribalet, B. & Rojas, E. J. Physiol., Lond. 288, 561–567 (1979). · DOI
Atwater, I., Ribalet, B. & Rojas, E. J. Physiol., Lond. 278, 117–139 (1978). · DOI
Henquin, J.-C. Nature 271, 271–273 (1978). · DOI
Sehlin, J. & Taljedal, I.-B. Nature 253, 635–636 (1975). · DOI
Sehlin, J. & Freinkel, N. Diabetes 32, 820–823 (1983). · DOI
Henquin, J.-C. Biochem. J. 186, 541–550 (1980). · DOI
Burnstock, G. Cell Membrane Receptors for Drugs and Hormones: A Multidisciplinary Approach (eds Straub, R. W. & Bolis, L.) 107–117 (Raven, New York, 1978).
Noma, A. Nature 305, 147–148 (1983). · DOI
Atwater, L., Dawson, C. M., Ribalet, B. & Rojas, E. J. Physiol., Lond. 288, 575–588 (1979). · DOI
Henquin, J.-C. Biochem. biophys. Res. Commun. 77, 551–556 (1977). · DOI
Meissner, H. P., Preissler, M. & Henquin, J.-C. Proc. 10th Congr. Diabetes Federation (Excerpta Medica, Amsterdam, 1979) 166–171, (ed. Waldhausl, W. K.).
Henquin, J.-C. Endocrinology 110, 1325–1332 (1982). · DOI
Marty, A. and Neher, E. Single Channel Recording, (eds Sakmann, B. & Neher, E.) 117 (Plenum, New York, 1983).
Malaisse, W. J. et al. Diabetologia 16, 331–341 (1979). · DOI
Ashcroft, S. J. H., Chatra, C., Weersinghe, C. & Randle, P. J. Biochem. J. 132, 223–231 (1973). · DOI
Fujimoto, W. Proc. Soc. exp. Biol. Med. 162, 241–244 (1979). · DOI
Ikeuchi, M. & Yagi, K. Jap. J. Physiol. 32, 873–878 (1982). · DOI
Baskin, D. G., Gorray, K. C. & Fukimoto, W. Y. J. Histochem. Cytochem. 29, 567–571 (1981). · DOI
Yellen, G. Nature 296, 357–359 (1982). · DOI

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Background
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“A number of other nucleotides apart from ATP ( Cook & Hales, 1984; Findlay, Dunne & Petersen, 1985a; Findlay & Dunne, 1986) are able to influence the gating of these channels, including adenosine 5' diphosphate (ADP) (Dunne & Petersen, 1986a; Kakei et al., 1986) and the guanosine- (Dunne & Petersen, 1986b) and pyridin…”
Background
Calcium-activated K-channels ofAmphiuma early distal tubule: inhibition by ATP
Hunter, M., & Giebisch, G. (1988) · Pflügers Archiv · doi:10.1007/bf00582517 · Cited by 27
New aspects of the physiological significance of NAD, poly ADP-ribose and cyclic ADP-ribose.
Okamoto, H., Takasawa, S., & Tohgo, A. (1995) · Biochimie · doi:10.1016/0300-9084(96)88146-6 · Cited by 27
Chloride transporters and channels in β-cell physiology: revisiting a 40-year-old model
Fulvio, M. D., & Aguilar‐Bryan, L. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190513 · Cited by 30
CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients
Venkategowda, S., Verma, M. K., Oommen, A. M., Sadasivuni, M., Singh, J. K., Vijayraghav, D. N., Chandravanshi, B., Shetty, J., Biswas, S., Dandu, A., et al. (2014) · BMC Pharmacology and Toxicology · doi:10.1186/2050-6511-15-19 · Cited by 23
“The acute phase of insulin release observed in the first 10 min following oral glucose stimulation in the n-STZ-CNX-01167 rats on day 0 is attributable to mechanisms such as enhanced mitochondrial [Ca], glucose metabolism and ATP synthesis, that together trigger exocytosis of a small number of insulin granules from th…”
Method
Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane KATPchannels
Geng, X., Li, L., Bottino, R., Balamurugan, A. N., Bertera, S., Densmore, E., Su, A.-J. A., Chang, Y., Trucco, M., & Drain, P. F. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00016.2007 · Cited by 21
K channels “vingt ans après”: ATG to PDB to Mechanism
Babenko, A. P. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.12.004 · Cited by 28
Dihydroxyacetone-induced Oscillations in Cytoplasmic Free Ca2+ and the ATP/ADP Ratio in Pancreatic β-Cells at Substimulatory Glucose*
Juntti-Berggren, L., Webb, D.-L., Arkhammar, P., Schultz, V., Schweda, E. K., Tornheim, K., & Berggren, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308248200 · Cited by 26
Excitability of neurons in the ventromedial nucleus in rat hypothalamic slices: modulation by amino acids at cerebrospinal fluid levels.
Nishimura, F., Nishihara, M., Mori, M., Torii, K., & Takahashi, M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00719-7 · Cited by 26
Interaction of tolbutamide and cytosolic nucleotides in controlling the ATP‐sensitive K+ channel in mouse β‐cells
Schwanstecher, C., Dickel, C., & Panten, U. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb14060.x · Cited by 26
Relationships between energy level and insulin secretion in isolated rat islets of langerhans
Mitsuaki, O., NELSON, D. S., Nelson, J., Meglasson, M. D., & Erecińska, M. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90322-v · Cited by 24
Specificity of tetraethylammonium and quinine for three K channels in insulin-secreting cells
Fatherazi, S., & Cook, D. L. (1991) · The Journal of Membrane Biology · doi:10.1007/bf01872393 · Cited by 56
“K(ATP) channels with single-channel conductances of 50-65 pS in symmetrical 140 mM K + were first described in cardiac muscle (Noma, 1983), and subsequently in neonatal rat pancreatic B cells ( Cook & Hales, 1984 ), mouse B cells (Ashcroft et al., 1984), RINm5F cells (Findlay, Dunne & Petersen, 1985a; Ashford et al.,…”
BackgroundMethodInfluentialSelf-citation
KATP channels in focus: Progress toward a structural understanding of ligand regulation
Martin, G. M., Patton, B. L., & Shyng, S. (2023) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2023.102541 · Cited by 29
A Novel Gene Prognostic Signature Based on Differential DNA Methylation in Breast Cancer
Zhu, C., Zhang, S., Liu, D., Wang, Q., Yang, N., Zheng, Z., Wu, Q., & Zhou, Y. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.742578 · Cited by 33
“KCNJ11 played a key role in glucosestimulated insulin secretion (Cook and Hales, 1984).”
Background
MicroRNA miR-7 Regulates Secretion of Insulin-Like Peptides
Agbu, P., Cassidy, J. J., Braverman, J., Jacobson, A., & Carthew, R. W. (2019) · Endocrinology · doi:10.1210/endocr/bqz040 · Cited by 24
Pharmacological chaperones of ATP-sensitive potassium channels: mechanistic insight from cryoEM structures
Martin, G. M., Sung, M.-W., & Shyng, S. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110667 · Cited by 25
Synthesis of new arylsulfonylspiroimidazolidine-2ʹ,4ʹ-diones and study of their effect on stimulation of insulin release from MIN6 cell line, inhibition of human aldose reductase, sorbitol accumulations in various tissues and oxidative stress
Iqbal, Z., Morahan, G., Arooj, M., Sobolev, A. N., & Hameed, S. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.02.036 · Cited by 28
Cellular biophysical dynamics and ion channel activities detected by AFM-based nanorobotic manipulator in insulinoma β-cells
Yang, R.-G., Xi, N., Lai, K., Patterson, K. C., Chen, H.-Z., Song, B., Qu, C., Zhong, B., & Wang, D. H. (2012) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2012.10.011 · Cited by 25
“The closure of KATP channels causes the increase in plasma membrane (PM) potential [4] and cellular depolarization, a process leading to activation of voltage-dependent calcium channels (VDCC).”
Background
Patents related to therapeutic activation of KATPand K2Ppotassium channels for neuroprotection: ischemic/hypoxic/anoxic injury and general anesthetics
Judge, S. I. V., & Smith, P. J. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770902765151 · Cited by 23
“First biophysically and pharmacologically characterized in cardiac cells [8-10] and pancreatic β-cells [11-13], followed by CNS neurons [14-15], among various other tissues, KATP channels have since proven to be important metabolic regulators linking cellular metabolism to insulin secretion and to electrical activity…”
Background
Arrhythmia susceptibility and premature death in transgenic mice overexpressing both SUR1 and Kir6.2[ΔN30,K185Q] in the heart
Flagg, T. P., Patton, B. L., Masia, R., Mansfield, C., Lopatin, A. N., Yamada, K. A., & Nichols, C. G. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00011.2007 · Cited by 27
“ATP-SENSITIVE POTASSIUM (KATP) channels are expressed in a diverse set of tissues, including the heart (30) and the pancreas (8).”
Background
Troglitazone but not pioglitazone affects ATP-sensitive K(+) channel activity.
Sunaga, Y., Inagaki, N., Gonoi, T., Yamada, Y., Ishida, H., Seino, Y., & Seino, S. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00539-7 · Cited by 25
Membrane-Delimited Phosphorylation Enables the Activation of the Outward-Rectifying K Channels in Motor Cell Protoplasts of Samanea saman
Moran, N. (1996) · Plant Physiology · doi:10.1104/pp.111.4.1281 · Cited by 25
Short-term exposure of rat pancreatic islets to human interleukin-1 beta increases cellular uptake of calcium.
Borg, L., & Eizirik, D. (1990) · Immunology Letters · doi:10.1016/0165-2478(90)90155-j · Cited by 25
Diazoxide unmasks glucose inhibition of insulin release by counteracting entry of Ca2+
Bergsten, P., Gylfe, E., Wesslén, N., & Hellman, B. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.4.e422 · Cited by 22
Failure of beta-cell adaptation in type 2 diabetes: Lessons from animal models
Kaiser, N. (2009) · Frontiers in bioscience · doi:10.2741/3296 · Cited by 26
“The increase in the cytosolic ATP/ADP ratio causes depolarization of the plasma membrane by closure of ATP-sensitive K channels with subsequent opening of voltage-sensitive calcium channels (10, 11).”
Background
Glucose Evokes Rapid Ca2+ and Cyclic AMP Signals by Activating the Cell-Surface Glucose-Sensing Receptor in Pancreatic β-Cells
Nakagawa, Y., Nagasawa, M., Medina, J., & Kojima, I. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144053 · Cited by 25
“Closure of the KATP channel leads to gradual depolarization to a threshold, at which action potential driven by Ca is initiated [4, 5, 7, 8].”
Background
The microtubule associated protein syntabulin is required for glucose‐stimulated and cAMP‐potentiated insulin secretion
Ying, Y., Li, L., Cao, W., Yan, D., Zeng, Q., Kong, X.-C., Lu, L., Yan, M., Xu, X., Qu, J.-L., et al. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.08.025 · Cited by 24
Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells
Huypens, P., Huang, M., & Joseph, J. W. (2012) · Islets · doi:10.4161/isl.18338 · Cited by 23
ATP-Sensitive Potassium Channel-Deficient Mice Show Hyperphagia but Are Resistant to Obesity
Park, Y. B., Choi, Y. J., Park, S., Kim, J. Y., Kim, S. H., Song, D. K., Won, K. C., & Kim, Y. W. (2011) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2011.35.3.219 · Cited by 21
“KATP channels were first identified in the heart and have been extensively studied in both cardiac myocytes and pancreatic β-cells [16-18].”
Background
Reduced Cytochrome c Is an Essential Regulator of Sustained Insulin Secretion by Pancreatic Islets*
Jung, S.-R., Kuok, I. T., Couron, D., Rizzo, N. O., Margineantu, D., Hockenbery, D., Kim, F., & Sweet, I. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202820 · Cited by 24
The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes
Light, P. E. (2010) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s6969 · Cited by 22
“As elevations in cytosolic calcium are the primary trigger for insulin granule exocytosis, insulin secretion is suppressed when plasma glucose levels are low (Figure 1A).(19,20) When plasma glucose levels rise, glucose enters the β-cells via the glucose transporter 2.”
The physiology of rodent beta‐cells in pancreas slices
Rupnik, M. S. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01927.x · Cited by 26
“ATP binding closes KATP channels and depolarizes the plasma membrane (Ashcroft et al. 1984, Cook & Hales 1984).”
BackgroundMethod
Regulation of insulin secretion and proinsulin biosynthesis by succinate.
Attali, V., Parnes, M., Ariav, Y., Cerasi, E., Kaiser, N., & Leibowitz, G. (2006) · Endocrinology · doi:10.1210/en.2006-0496 · Cited by 24
“The ATP-sensitive K (K -ATP) channels are key players in the triggering pathway (2, 3).”
Background
Substrate Control of Insulin Release
Newgard, C. B., & Matschinsky, F. M. (2001) · Comprehensive physiology · doi:10.1002/j.2040-4603.2001.tb01451.x
“First, the conductance of ATP-sensitive K+ channels (K,,, channels) is regulated by the cytosolic ATP4-and MgADP-levels, with ATP4-serving as an inhibitor and MgADP-as an activator of the channel (4, 5, 22, 113, 114).”
ω-Conotoxin inhibits glucose- and arachidonic acid-induced rises in intracellular [Ca2+] in rat pancreatic islet β-cells
Ramanadham, S., & Turk, J. (1994) · Cell Calcium · doi:10.1016/0143-4160(94)90065-5 · Cited by 24
ATP sensitive K+ conductance in pancreatic zymogen granules: Block by glyburide and activation by diazoxide
Th�venod, F., Chathadi, K., Jiang, B., & Hopfer, U. (1992) · The Journal of Membrane Biology · doi:10.1007/bf00232907 · Cited by 44
“…conductance has characteristics of ATP-sensitive channels found in the plasma membrane of cardiac and skeletal muscle, neurons, pancreatic B-cells, smooth muscle and renal cells (Noma, 1983; Cook & Hales, 1984; Spruce et al., 1985; Standen et al., 1989; Ashford et al., 1990; Wang & Giebisch, 1991).”
Background

Authors: Cook, D. L., & Hales, N.
Affiliations: United States Department of Veterans Affairs (US)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1984-09
Volume: 311
Issue: 5983
Pages: 271-273
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/311271a0
OpenAlex: W1985770721
Cited by: 1,208
References: 24
Citations by year: 2026: 11 · 2025: 16 · 2024: 12 · 2023: 22 · 2022: 14 · 2021: 21 · 2020: 12 · 2019: 19 · 2018: 13 · 2017: 9 · 2016: 15 · 2015: 21 · 2014: 34 · 2013: 14 · 2012: 29
FWCI: 13.20
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: ATP-sensitive potassium channels, pancreatic beta cells, intracellular ATP, potassium channel inhibition, glycolysis, proton inhibition, calcium-activated potassium channels
MeSH terms: Adenosine Triphosphate, Animals, Cell Membrane Permeability, Cells, Cultured, Cytoplasm, Electric Conductivity, Ion Channels, Islets of Langerhans, Potassium, Rats

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Intracellular ATP directly blocks K+ channels in pancreatic B-cells

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