Cited by 1,208Ion channel regulation and functionPancreatic function and diabetesIon Transport and Channel Regulation

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Intracellular ATP directly blocks K+ channels in pancreatic B-cells

Cook, Daniel L., Hales, Nicholas·1984·Nature

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Abstract

It is known that glucose-induced depolarization of pancreatic B-cells is due to reduced membrane K+-permeability and is coupled to an increase in the rate of glycolysis, but there has been no direct evidence linking specific metabolic processes or products to the closing of membrane K+ channels. During patch-clamp studies of proton inhibition of Ca2+-activated K+ channels [GK(Ca)] in B-cells, we identified a second K+-selective channel which is rapidly and reversibly inhibited by ATP applied to the cytoplasmic surface of the membrane. This channel is spontaneously active in excised patches and frequently coexists with GK(Ca) channels yet is insensitive to membrane potential and to intracellular free Ca2+ and pH. Blocking of the channel is ATP-specific and appears not to require metabolism of the ATP. This ATP-sensitive K+ channel [GK(ATP)] may be a link between metabolism and membrane K+-permeability in pancreatic B-cells.

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Background
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Background
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Background
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Background
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Background
Ligand-dependent Linkage of the ATP Site to Inhibition Gate Closure in the KATP Channel
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Background
Evidence for modulation of cell‐to‐cell electrical coupling by cAMP in mouse islets of Langerhans
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Self-citation
Verapamil corrects abnormal metabolism of pancreatic islets and insulin secretion in phosphate depletion.
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Authors: Cook, D. L., & Hales, N.
Affiliations: United States Department of Veterans Affairs (US)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1984-09
Volume: 311
Issue: 5983
Pages: 271-273
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/311271a0
OpenAlex: W1985770721
Cited by: 1,208
References: 24
Citations by year: 2026: 11 · 2025: 16 · 2024: 12 · 2023: 22 · 2022: 14 · 2021: 21 · 2020: 12 · 2019: 19 · 2018: 13 · 2017: 9 · 2016: 15 · 2015: 21 · 2014: 34 · 2013: 14 · 2012: 29
FWCI: 13.20
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: ATP-sensitive potassium channels, pancreatic beta cells, intracellular ATP, potassium channel inhibition, glycolysis, proton inhibition, calcium-activated potassium channels
MeSH terms: Adenosine Triphosphate, Animals, Cell Membrane Permeability, Cells, Cultured, Cytoplasm, Electric Conductivity, Ion Channels, Islets of Langerhans, Potassium, Rats

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Intracellular ATP directly blocks K+ channels in pancreatic B-cells

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