The DOI matches its Crossref record; 0 of the 1 references it cites were found in a registry or an index.
Autocatalytic synthesis of a tetranucleotide analogue
Abstract
As an approach to the study of the kind of chemical process that might have contributed to the origin of life, attempts have been made to develop purely chemical systems in which oligonucleotides self-replicate. Although performed oligonucleotides have been shown to facilitate the formation of their complements from activated mononucleotides, only a restricted range of oligomers are efficient templates and it will clearly be difficult to find a pair of complementary oligomers each of which will facilitate the formation of the other. Many of the difficulties facing the development of a self-replicating system could be overcome by using a pair of complementary substrate molecules that condense together more easily than ribonucleotides. It would also be helpful if each substrate molecule contained equal numbers of purine and pyrimidine bases as, otherwise, there is a tendency for purines to be overrepresented in the products. We have therefore explored the chemistry of 3'-amino-3'-deoxynucleotides and their dimers. We report here that the tetranucleoside triphosphoramidate GNHpCNHpGNHpCN3 acts as a template to catalyse the condensation of GNHpCNH2 and pGNHpCN3, forming further molecules of the template. The system is therefore autocatalytic, and in accordance with elementary theory the amount of product made increases with the square root of the template concentration.
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1. Inoue, T. & Orgel, L. E. Science 219, 859–862 (1983). 2. Haertle, T. & Orgel, L. E. / molec. EvoL 23, 108–112 (1986). 3. Zielinski, W. S. & Orgel, L. E. Nucleic Acids Res. 13, 2469–2484 (1985). 4. Zielinski, W. S. & Orgel, L. E. Nucleic Acids Res. 15, 1699–1715 (1987). 5. Von Kiedrowski, G. Angew
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Paczkó, M., Szathmáry, E., & Szilágyi, A. (2024) · eLife · doi:10.7554/elife.93208.2
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Radakovic, A., Todisco, M., Mishra, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.26.620442
Highly Effective Chemical Ligation of DNA and l ‐aTNA
Okita, H., Murayama, K., & Asanuma, H. (2025) · Current Protocols · doi:10.1002/cpz1.70140
Simple Diaminonucleoside-Mediated Nonenzymatic Ligation of Oligonucleotides
Capperauld, M. J., Valluru, K. K., Saraya, J. S., Zakaria, E., Wong, C. E., & O’Flaherty, D. K. (2025) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5c00090
Model Syntheses of Oligo- and Polynucleotides
Kricheldorf, H. R. (2025) · Springer eBooks · doi:10.1007/978-3-662-70752-4_7
Energetic processes driving potential peptide protometabolisms at the origin of living systems
Ajram, G. (2018) · theses.fr (ABES) · doi:10.70675/d95ee480z7b27z430fz8d7dzd9cfb7c120ff
Fayolle, D. (2020) · theses.fr (ABES) · doi:10.70675/6e174fe2z79a7z4a7fzae6cz837cb04a065b
The ecology and evolution of sub-exponential replicators
Kovács, B., Barabás, G., Meszéna, G., Szathmáry, E., & Szilágyi, A. (2026) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1014247
tinyRNA-seq: An optimized approach to sequencing tiny RNAs and primitive RNA genomesPreprint
Colville, B. W. F., Zhao, J., Hade, L., & Szostak, J. W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.06.743385
Rauchfuss, H., & Mitchell, T. N. (2008) · Springer eBooks · doi:10.1007/978-3-540-78823-2_6
Metadata
- Authors
- Zielinski, W. S., & Orgel, L. E.
- Affiliations
- Salk Institute for Biological Studies (US)
- Venue
- Nature
- Published
- 1987-05
- Volume
- 327
- Issue
- 6120
- Pages
- 346-347
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1967935039
- Cited by
- 310
- References
- 1
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 14 · 2023: 9 · 2022: 14 · 2021: 11 · 2020: 8 · 2019: 9 · 2018: 8 · 2017: 3 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 12 · 2012: 5
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- origin of life, chemical evolution
- MeSH terms
- Catalysis, Chemistry, Oligodeoxyribonucleotides, Templates, Genetic, Macromolecular Substances, Chemical Phenomena
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