Orgel, Leslie E.

Evolution of the genetic apparatus

Orgel, L. E. (1968) · Journal of Molecular Biology

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 996

Synthesis of long prebiotic oligomers on mineral surfaces.

Ferris, J. P., Hill, A. R., Liu, R., & Orgel, L. E. (1996) · Nature

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 865

Molecular replication

Orgel, L. E. (1992) · Nature

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 535

Carbonyl Sulfide-Mediated Prebiotic Formation of Peptides

Leman, L., Orgel, L., & Ghadiri, M. R. (2004) · Science

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 428

Chiral selection in poly(C)-directed synthesis of oligo(G)

Joyce, G. F., Visser, G. M., van Boeckel, C. A. A., van Boom, J. H., Orgel, L. E., & van Westrenen, J. (1984) · Nature

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 398

The case for an ancestral genetic system involving simple analogues of the nucleotides.

Joyce, G. F., Schwartz, A. W., Miller, S. L., & Orgel, L. E. (1987) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 387

Autocatalytic synthesis of a tetranucleotide analogue

Zielinski, W. S., & Orgel, L. E. (1987) · Nature

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 310

Studies in prebiotic synthesis

Fuller, W. D., Sanchez, R. A., & Orgel, L. E. (1972) · Journal of Molecular Biology

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 280

The Implausibility of Metabolic Cycles on the Prebiotic Earth

Orgel, L. E. (2008) · PLoS Biology

Origins and Evolution of LifeEarth Systems and Cosmic Evolution

Cited by 271

Cyanoacetylene in Prebiotic Synthesis

Sanchez, R. A., Ferris, J. P., & Orgel, L. E. (1966) · Science

Origins and Evolution of LifeAstrophysics and Star Formation Studies

Cited by 270

Prebiotic chemistry and nucleic acid replication

Orgel, L. E., & Lohrmann, R. (1974) · Accounts of Chemical Research

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 247

Urea-Inorganic Phosphate Mixtures as Prebiotic Phosphorylating Agents

Lohrmann, R., & Orgel, L. E. (1971) · Science

Origins and Evolution of LifeOrganophosphorus compounds synthesis

Cited by 245

Oligomerization of (guanosine 5′-phosphor)-2-methylimidazolide on poly(C)

Inoue, T., & Orgel, L. E. (1982) · Journal of Molecular Biology

DNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

Cited by 209

Derivatization of unprotected polynucleotides

Chu, B. C. F., Wahl, G. M., & Orgel, L. E. (1983) · Nucleic Acids Research

DNA and Nucleic Acid ChemistryOrganophosphorus compounds synthesis

Cited by 182

Non-enzymatic template-directed synthesis on RNA random copolymers

Joyce, G. F., Inoue, T., & Orgel, L. E. (1984) · Journal of Molecular Biology

DNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

Cited by 178

Template-Directed Synthesis with Adenosine-5′-phosphorimidazolide

Weimann, B. J., Lohrmann, R., Orgel, L. E., Schneider-Bernloehr, H., & Sulston, J. E. (1968) · Science

DNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

Cited by 166

Prebiotic activation processes

LOHRMANN, R., & ORGEL, L. E. (1973) · Nature

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 154

Nonenzymatic synthesis of oligoadenylates on a polyuridylic acid template.

Sulston, J., Lohrmann, R., Orgel, L. E., & Miles, H. T. (1968) · Proceedings of the National Academy of Sciences

DNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

Cited by 149

Catalysts for the self-polymerization of adenosine cyclic 2′,3′-phosphate

Verlander, M. S., Lohrmann, R., & Orgel, L. E. (1973) · Journal of Molecular Evolution

Origins and Evolution of LifeDNA and Nucleic Acid Chemistry

Cited by 142

Some consequences of the RNA world hypothesis

Orgel, L. E. (2003) · Origins of life and evolution of the biosphere

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 124

Substituent control of the poly(C)-directed oligomerization of guanosine 5'-phosphoroimidazolide

Inoue, T., & Orgel, L. E. (1981) · Journal of the American Chemical Society

DNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

Cited by 120

Nonenzymatic template-directed synthesis on hairpin oligonucleotides. 3. Incorporation of adenosine and uridine residues.

Wu, T., & Orgel, L. E. (1992) · Journal of the American Chemical Society

DNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

Cited by 103

The limits of template-directed synthesis with nucleoside-5′-phosphoro(2-methyl)imidazolides

Hill, A. R., Orgel, L. E., & Wu, T. (1993) · Origins of life and evolution of the biosphere

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 92

Amino Acid Dependent Formation of Phosphate Anhydrides in Water Mediated by Carbonyl Sulfide

Leman, L. J., Orgel, L. E., & Ghadiri, M. R. (2006) · Journal of the American Chemical Society

Origins and Evolution of LifeOrganophosphorus compounds synthesis

Cited by 87