Cited by 2,448Sepsis Diagnosis and TreatmentInflammation biomarkers and pathwaysImmune Response and Inflammation

The DOI matches its Crossref record; 0 of the 1 references it cites were found in a registry or an index.

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

Tracey, Kevin J., Fong, Yuman, Hesse, David G., Manogue, Kirk R., Lee, Annette T., Kuo, George C., Lowry, Stephen F., Cerami, Anthony·1987·Nature

DOI 10.1038/330662a0

Open this paper in CoChat — free account

Abstract

Bacterial infection of the mammalian bloodstream can lead to overwhelming sepsis, a potentially fatal syndrome of irreversible cardiovascular collapse (shock) and critical organ failure. Cachectin, also known as tumour necrosis factor, is a macrophage-derived peptide hormone released in response to bacterial lipopolysaccharide, and it has been implicated as a principal mediator of endotoxic shock, although its function in bacterial sepsis is not known. Anaesthetized baboons were passively immunized against endogenous cachectin and subsequently infused with an LD100 dose of live Escherichia coli. Control animals (not immunized against cachectin) developed hypotension followed by lethal renal and pulmonary failure. Neutralizing monoclonal anti-cachectin antibody fragments (F(ab')2) administered to baboons only one hour before bacterial challenge protected against shock, but did not prevent critical organ failure. Complete protection against shock, vital organ dysfunction, persistent stress hormone release and death was conferred by administration of antibodies 2 h before bacterial infusion. These results indicate that cachectin is a mediator of fatal bacteraemic shock, and suggest that antibodies against cachectin offer a potential therapy of life-threatening infection.

Integrity signals

Registry

Crossref · 10.1038/330662a0

Cites

0 of 1 references verified0 citation errors · 1 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1. Kreger, B. E. W., Craven, D. E. & McCabe, W. R. Am. J. Med. 68, 344-355 (1980). 2. Ziegler, E. J. el al New Engl. J. Med, 307, 1225-1230 (1982). 3. Gilbert, R. P. Physiol. Rev. 40, 245-279 (1960). 4. Beutler, B. & Cerami, A. Nature 320, 584-588 (1986). 5. Beutler, B. & Cerami, A. New Engl. J. Med
(n.d.)
Unresolved

Flagged first, then by citations

Show all 1 references

1 of the 1 references couldn’t be matched to a known paper.

Sorted by citations

Items 201–300 of 1,001

Role of the neutrophil in adult respiratory distress syndrome
Windsor, A. C. J., Mullen, P. G., Fowler, A. A., & Sugerman, H. J. (1993) · British journal of surgery · doi:10.1002/bjs.1800800106 · Cited by 258
In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects.
Chensue, S. W., Terebuh, P., Remick, D. G., Scales, W. E., & Kunkel, S. L. (1991) · PubMed Central · Cited by 260
Modulation of Inflammation and Cytokine Production by Dietary (n-3) Fatty Acids
Blok, W. L., Katan, M., & van der Meer, J. W. M. (1996) · Journal of Nutrition · doi:10.1093/jn/126.6.1515 · Cited by 256
Immune dysregulation in sepsis: experiences, lessons and perspectives
Cao, M., Wang, G., & Xie, J. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01766-7 · Cited by 310
“Neutralizing monoclonal anti-cachectin/TNF α monoclonal antibodies injected only one hour before a bacterial attack in baboons prevented shock, while two hours prevented essential organ dysfunction and mortality [26].”
Background
Sepsis and serum cytokine concentrations
Damas, P., Canivet, J.-L., Groote, D. D., Vrindts, Y., Albert, A., Franchimont, P., & Lamy, M. (1997) · Critical Care Medicine · doi:10.1097/00003246-199703000-00006 · Cited by 252
Why immunomodulatory therapies have not worked in sepsis
Abraham, E. (1999) · Intensive Care Medicine · doi:10.1007/s001340050903 · Cited by 266
Sepsis and Septic Shock: A History
Funk, D. J., Parrillo, J. E., & Kumar, A. (2009) · Critical Care Clinics · doi:10.1016/j.ccc.2008.12.003 · Cited by 253
“A group of investigators including Tracey, Beutler, Lowry, Cerami and others elucidated a central role for tumor necrosis factor in septic shock and other systemic inflammatory states.(45,46) The discovery of the role that cytokines played in the activation of the immune system led clinicians to investigate these subs…”
Background
Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein.
Lee, J. D., Kato, K., Tobias, P. S., et al. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.6.1697 · Cited by 252
“In humans and experimental animals, it is well established that cytokines released from LPS-stimulated monocytes/macrophages (MO) 1 mediate many of the cellular changes that cause septic shock (1-5).”
Background
Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli.
Wakabayashi, G., Gelfand, J. A., Jung, W. K., Connolly, R. J., Burke, J. F., & Dinarello, C. A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115218 · Cited by 248
Antiendotoxin activity of cationic peptide antimicrobial agents
Gough, M., Hancock, R. E. W., & Kelly, N. M. (1996) · Infection and Immunity · doi:10.1128/iai.64.12.4922-4927.1996 · Cited by 246
“Experimental data have demonstrated that (i) circulating TNF can be detected in animals that have been administered lethal doses of endotoxin (4), (ii) injection of TNF into experimental animals recreates the symptoms of endotoxin injection (4, 5, 36), and (iii) treatment of laboratory animals with antiTNF antibodies…”
Background
Compartmentalization of Intraalveolar and Systemic Lipopolysaccharide-Induced Tumor Necrosis Factor and the Pulmonary Inflammatory Response
Nelson, S., Bagby, G. J., Bainton, B. G., Wilson, L. A., Thompson, J. J., & Summer, W. R. (1989) · The Journal of Infectious Diseases · doi:10.1093/infdis/159.2.189 · Cited by 244
TNF‐related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle‐wasting cytokine
Dogra, C., Changoua, H., Wedhas, N., Qin, X., Wergedal, J. E., & Kumar, A. (2007) · The FASEB Journal · doi:10.1096/fj.06-7537com · Cited by 248
Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice.
Waage, A., & Espevik, T. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.6.1987 · Cited by 242
Immunotherapy for the Adjunctive Treatment of Sepsis: From Immunosuppression to Immunostimulation. Time for a Paradigm Change?
Leentjens, J., Kox, M., van der Hoeven, J. G., Netea, M. G., & Pickkers, P. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201301-0036cp · Cited by 247
Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans
van der Poll, T., Romijn, J. A., Endert, E., Borm, J. J. J., Buller, H. R., & Sauerwein, H. P. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.261.4.e457 · Cited by 234
CECAL LIGATION AND PUNCTURE VERSUS COLON ASCENDENS STENT PERITONITIS: TWO DISTINCT ANIMAL MODELS FOR POLYMICROBIAL SEPSIS
Maier, S., Traeger, T., Entleutner, M., et al. (2004) · Shock · doi:10.1097/01.shk.0000126906.52367.dd · Cited by 240
Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway
Melero, I., Bach, N., Hellström, K. E., Aruffo, A. A., Mittler, R. S., & Chen, L. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199803)28:03 · Cited by 215
Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide‐induced lethality
Lesslauer, W., Tabuchi, H., Gentz, R., Brockhaus, M., Schlaeger, E. J., Grau, G. E., Piguet, P. F., Pointaire, P., VASSALLI, P., & Loetscher, H. (1991) · European Journal of Immunology · doi:10.1002/eji.1830211134 · Cited by 237
N-Acetylcysteine and glutathione as inhibitors of tumor necrosis factor production
Peristeris, P., Clark, B. D., Gatti, S., Faggioni, R., Mantovani, A., Mengozzi, M., Orencole, S. F., Sironi, M., & Ghezzi, P. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90205-4 · Cited by 236
Insulin Treatment Improves the Systemic Inflammatory Reaction to Severe Trauma
Jeschke, M. G., Klein, D., & Herndon, D. N. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000118569.10289.ad · Cited by 232
“showed that increased pro-inflammatory cytokine synthesis also contributes to hypermetabolism and catabolism.(9) There-”
Background
Lactoferrin regulates the release of tumour necrosis factor alpha and interleukin 6 in vivo.
Machnicki, M., Zimecki, M., & Zagulski, T. (1993) · Europe PMC (PubMed Central) · Cited by 232
Metabolic effects of cachectin/tumor necrosis factor are modified by site of production. Cachectin/tumor necrosis factor-secreting tumor in skeletal muscle induces chronic cachexia, while implantation in brain induces predominantly acute anorexia.
Tracey, K. J., Morgello, S., Koplin, B., Fahey, T. J., Fox, J., Aledo, A., Manogue, K. R., & Cerami, A. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114937 · Cited by 230
Self-citation
Tumor necrosis factor in the pathophysiology of infection and sepsis
Fong, Y., & Lowry, S. F. (1990) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(90)90094-7 · Cited by 230
Self-citation
The host response to endotoxin, antilipopolysaccharide strategies, and the management of severe sepsis
Opal, S. M. (2007) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2007.03.006 · Cited by 233
Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor‐immunoglobulin fusion proteins
Baker, D., Butler, D. M., Scallon, B. J., O'Neill, J. K., Turk, J. L., & Feldmann, M. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240916 · Cited by 230
The pathophysiology of falciparum malaria.
Clark, I., & Cowden, W. (2003) · Pharmacology and Therapeutics · doi:10.1016/s0163-7258(03)00060-3 · Cited by 258
The ATP-sensitive K+ channel mediates hypotension in endotoxemia and hypoxic lactic acidosis in dog.
Landry, D. W., & Oliver, J. A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115820 · Cited by 229
Preterm Birth and Cerebral Palsy: Is Tumor Necrosis Factor the Missing Link?
Leviton, A. (1993) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1993.tb11688.x · Cited by 227
Innate Immunity and Inflammation: A Transcriptional Paradigm
Hawiger, J. (2001) · Immunologic Research · doi:10.1385/ir:23:2-3:099 · Cited by 225
The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.
Giroir, B. P., Johnson, J. H., Brown, T., Allen, G. L., & Beutler, B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115939 · Cited by 224
Distribution and characterization of tumor necrosis factor‐α‐like immunoreactivity in the murine central nervous system
Breder, C. D., Tsujimoto, M., Terano, Y., Scott, D. W., & Saper, C. B. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903370403 · Cited by 226
The Circadian ClockPeriod 2Gene Regulates Gamma Interferon Production of NK Cells in Host Response to Lipopolysaccharide-Induced Endotoxic Shock
Liu, J., Mankani, G., Shi, X., Meyer, M., Cunningham-Runddles, S., Ma, X., & Sun, Z. S. (2006) · Infection and Immunity · doi:10.1128/iai.00287-06 · Cited by 231
“levels are well correlated with clinical septic shock, acute respiratory distress syndrome, renal failure, multiple organ system failure, and death (18, 24, 30).”
Background
Tumor Necrosis Factor a Inhibits the Hormonal Response of the Pituitary Gland to Hypothalamic Releasing Factors*
Gaillard, R. C., Turnill, D., Sappino, A. P., & Muller, A. F. (1990) · Endocrinology · doi:10.1210/endo-127-1-101 · Cited by 215
Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema
Schütte, H., Lohmeyer, J., Rosseau, S., Ziegler, S., Siebert, C., Kielisch, H., Pralle, H., Grimminger, F., Morr, H., & Seeger, W. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09091858 · Cited by 224
“Many features of septic shock [10–13] and ARDS [14, 15] have been ascribed to TNFα, but measurements of this cytokine under such clinical conditions (serum and lavage fluid) have produced inconsistent results [16–24].”
Result
Immunopathologic Alterations in Murine Models of Sepsis of Increasing Severity
Ebong, S., Call, D. R., Nemzek, J. A., Bolgos, G. L., Newcomb, D. E., & Remick, D. G. (1999) · Infection and Immunity · doi:10.1128/iai.67.12.6603-6610.1999 · Cited by 221
“With increasing understanding of the immunopathology of sepsis, innovative strategies targeting endotoxin and inflammatory mediators have been employed and have been effective in animal models (5, 36).”
Method
Cytokines, sepsis and immunomodulation
Molloy, R. G., Mannick, J. A., & Rodrick, M. L. (1993) · British journal of surgery · doi:10.1002/bjs.1800800308 · Cited by 216
The role of cytokines in cancer cachexia
Argilés, J. M. A., & López-Soriano, F. J. (1999) · Medicinal Research Reviews · doi:10.1002/(sici)1098-1128(199905)19:3 · Cited by 234
Administration of Anti-TNF Antibody Improves Left Ventricular Function in Septic Shock Patients
Vincent, J., Bakker, J., Marécaux, G., Schandené, L., Kahn, R. J., & Dupont, É. (1992) · CHEST Journal · doi:10.1378/chest.101.3.810 · Cited by 220
Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death.
Harris, H. W., Grünfeld, C., Feingold, K. R., Read, T. E., Kane, J. P., Jones, A. L., Eichbaum, E. B., Bland, G. F., & Rapp, J. H. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116259 · Cited by 214
Pituitary Cytokine and Growth Factor Expression and Action
Ray, D. W., & Melmed, S. K. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.2.0297 · Cited by 229
Molecular pathophysiology of bacterial meningitis: Current concepts and therapeutic implications
Sáez‐Llorens, X., Ramilo, O., Mustafa, M. M., Mertsold, J., & McCracken, G. H. (1990) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)82647-2 · Cited by 217
Characterization in vitro of a human tumor necrosis factor-binding protein. A soluble form of a tumor necrosis factor receptor.
Lantz, M., Gullberg, U., Nilsson, E., & Olsson, I. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114853 · Cited by 221
CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines.
Kim, J. J., Nottingham, L. K., Sin, J., Tsai, A., Morrison, L. D., Oh, J., Dang, K., Hu, Y., Kazahaya, K., Bennett, M., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3986 · Cited by 219
“TNF-a is also implicated in septic shock after infection by Gram-negative bacteria (44) and in rheumatoid arthritis (45).”
Background
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.
Kolls, J. K., Peppel, K., Silva, M., & Beutler, B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.215 · Cited by 214
Insulin Attenuates the Systemic Inflammatory Response in Endotoxemic Rats
Jeschke, M. G., Klein, D., Bolder, U., & Einspanier, R. (2004) · Endocrinology · doi:10.1210/en.2004-0592 · Cited by 220
Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon
Heinzel, F. P., Rerko, R. M., Ling, P., et al. (1994) · Infection and Immunity · doi:10.1128/iai.62.10.4244-4249.1994 · Cited by 217
Genomic polymorphisms in sepsis
Lin, M. T., & Albertson, T. E. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000110878.49476.42 · Cited by 217
Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide. Implications for cytokine production in normal and injured lungs.
Martin, T. R., Mathison, J. C., Tobias, P. S., Leturcq, D. J., Moriarty, A. M., Maunder, R. J., & Ulevitch, R. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116106 · Cited by 213
The natural interleukin-1 receptor antagonist prevents interleukin-l-induced preterm delivery in mice
Romero, R. J., & Tartakovsky, B. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(12)80035-4 · Cited by 214
Sepsis: mechanisms of bacterial injury to the patient
Minasyan, H. A. (2019) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-019-0596-4 · Cited by 235
Serum levels of cytokines in patients with colorectal cancer: Possible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis
Ueda, T., Shimada, E., & Urakawa, T. (1994) · Journal of Gastroenterology · doi:10.1007/bf02361238 · Cited by 215
Interferon gamma, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice.
Heremans, H., Damme, J. V., Dillen, C., Dijkmans, R., & Billiau, A. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.6.1853 · Cited by 214
Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice
Frebel, H., Nindl, V., Schuepbach, R. A., Braunschweiler, T., Richter, K., Vogel, J., Wagner, C. A., Loffing‐Cueni, D., Kurrer, M. O., Ludewig, B., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121015 · Cited by 218
“The important role of perforin-mediated cell lysis in vascular permeabilization is in contrast to pathologies with similar clinical pictures, for example, sepsis, where inflammatory mediators were found to drive pathogenesis (Tracey et al., 1987; Leon et al., 1998; Shresta et al., 2006).”
Background
Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections.
Netea, M. G., Demacker, P. N. M., Kullberg, B. J., Boerman, O. C., Verschueren, I., Stalenhoef, A. F. H., & van der Meer, J. W. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118556 · Cited by 207
Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture.
Kwiatkowski, D. P., Cannon, J. G., Manogue, K. R., et al. (1989) · PubMed · Cited by 210
Self-citation
Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.
Loetscher, H., Stueber, D., Banner, D. W., Mackay, F., & Lesslauer, W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74322-1 · Cited by 202
Citation classics in critical care medicine
Baltussen, A., & Kindler, C. H. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2195-7 · Cited by 205
Simultaneous or Delayed Administration of Hepatocyte Growth Factor Equally Represses the Fibrotic Changes in Murine Lung Injury Induced by Bleomycin
Yaekashiwa, M., Nakayama, S., OHNUMA, K., Sakai, T., Abé, T., Satoh, K., Matsumoto, K., Nakamura, T., TAKAHASHI, T., & Nukiwa, T. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.6.9611057 · Cited by 209
“Only prior and/or simultaneous administration of steroid hormones (32) or antibodies to cytokines such as anti-TNF-a antibody are capable of preventing damage (33, 34).”
Background
Essential Role of Gamma Interferon in Survival of Colon Ascendens Stent Peritonitis, a Novel Murine Model of Abdominal Sepsis
Zantl, N., Uebe, A., Neumann, B., Wagner, H., Siewert, J., Holzmann, B., Heidecke, C.-D., & Pfeffer, K. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.2300-2309.1998 · Cited by 206
“Thus, numerous studies identified cytokines as crucially involved in the pathogenesis of sepsis, and blockade of these cytokines was shown to ameliorate the challenge with bacterial endo- or exotoxins (41, 46, 47, 52, 55).”
Background
Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin-Thrombomodulin Complexes
Ito, T., Kawahara, K., Okamoto, K., Yamada, S., Yasuda, M., Imaizumi, H., Nawa, Y., Meng, X., Shrestha, B., Hashiguchi, T., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.150631 · Cited by 205
“exhibited decreased proinflammatory activity if sufficient thrombin to degrade HMGB1 was conjugated to the column; and (2) an abundant supply of TM (400 nmol/L) to HMGB1 samples from the control column did not cause a decrease in proinflammatory activity (relative expression of TNFmRNA in RAW 264.”
Background
Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages.
Mathison, J. C., Virca, G. D., Wolfson, E. B., Tobias, P. S., Glaser, K. B., & Ulevitch, R. J. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114542 · Cited by 203
“A key role for TNF has been established in models of shock induced by endotoxin (lipopolysaccharide, LPS) and gram-negative bacteria (1-3).”
Background
A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor α gene expression: Molecular cloning, sequencing, characterization, and chromosomal assignment
Myokai, F., Takashiba, S., Lebo, R. V., & Amar, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4518 · Cited by 204
Direct link between cytokine activity and a catalytic site for macrophage migration inhibitory factor
Swope, M., Sun, H., Blake, P. R., & Lolis, E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.13.3534 · Cited by 205
“This parallels results obtained with antibodies to other cytokines shown to be involved in sepsis (Tracey et al., 1987; McNamara et al., 1993).”
Result
Tumor necrosis factor participates in the pathogenesis of acute immune complex alveolitis in the rat.
Warren, J. S., Yabroff, K. R., Remick, D. G., Kunkel, S. L., Chensue, S. W., Kunkel, R. G., Johnson, K. J., & Ward, P. A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114374 · Cited by 203
Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase
Knotek, M., Rogachev, B. V., Wang, W., Ecder, T., Melnikov, V. G., Gengaro, P. E., Esson, M. L., Edelstein, C. L., Dinarello, C. A., & Schrier, R. W. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00740.x · Cited by 202
“Accordingly, passive immunization by an anti–TNF-a antibody protected against septic shock in baboon”
Background
Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model
Barton, B. E., & Jackson, J. V. (1993) · Infection and Immunity · doi:10.1128/iai.61.4.1496-1499.1993 · Cited by 200
“Passive administration of recombinant TNF was shown to induce shock in rats (20), while antibodies (Abs) to TNF protected mice against the lethal effects of TNF (5, 7, 10).”
Background
Amelioration of sepsis by TIE2 activation–induced vascular protection
Han, S., Lee, S.-J., Kim, K. E., Lee, H. S., Oh, N., Park, I., Ko, E., Oh, S. J., Lee, Y.-S., Kim, D., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad9260 · Cited by 203
“It would be interesting to test the combined effect of ABTAA with other immune modulatory agents/devices, including the Toll-like receptor 4 (TLR4) antagonist eritoran (48), HMGB1 blocker (49), TNF-a inhibitor (50), anticoagulants such as activated protein C (51), or an extracorporeal blood-cleansing device (52).”
Background
EVALUATION OF ENDOTOXIN MODELS FOR THE STUDY OF SEPSIS
Remick, D. G., & Ward, P. A. (2005) · Shock · doi:10.1097/01.shk.0000191384.34066.85 · Cited by 206
“The second line of evidence that TNFa was an important mediator in the pathogenesis of sepsis was found in the preclinical experiments that showed that blockade of TNFa would improve outcome in experimental animals given bolus injections of endotoxin or live bacteria (21, 23).”
Background
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activation polypeptide (PACAP) protect mice from lethal endotoxemia through the inhibition of TNF-alpha and IL-6.
Delgado, M., Martínez, C., Pozo, D., Calvo, J. R., Leceta, J., Ganea, D., & Gomariz, R. P. (1999) · PubMed · Cited by 201
Inflammatory cytokines
Cerami, A. (1992) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(92)90035-m · Cited by 199
Self-citation
Monoclonal antibody to TN F in severe septic shock
Exley, A., Cohen, J., Buurman, W. A., Owen, R., Lumley, J., Hanson, G. C., Aulakh, J. M., Bodmer, M., Stephens, S., Riddell, A., et al. (1990) · The Lancet · doi:10.1016/0140-6736(90)91337-a · Cited by 200
The role of mediators in the response to thermal injury
Youn, Y., Lalonde, C., & Demling, R. H. (1992) · World Journal of Surgery · doi:10.1007/bf02067111 · Cited by 197
“TNF has a number of actions primarily relating to the stress response [ 20-24 ] (Table 1). Immunologic responses include: 1) release of neutrophils from the bone marrow; 2) neutrophil rnargination and activation, including release of oxidants and Table 1. Actions of tumor necrosis factor.”
Background
Passive Immunization Against Tumor Necrosis Factor-Alpha Impairs Host Defense During Pneumococcal Pneumonia in Mice
van der Poll, T., Keogh, C. V., Buurman, W. A., & Lowry, S. F. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.2.9032201 · Cited by 199
Self-citation
Plasminogen Activator Inhibitor 1: A New Prognostic Marker in Septic Shock
Pralong, G., Calandra, T., Glausef, M.-P., Schellekens, J. F. P., Verhoef, J., Bachmann, F., & Kruithof, E. K. O. (1989) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646614 · Cited by 199
TUMOUR NECROSIS FACTOR IN BRONCHOPULMONARY SECRETIONS OF PATIENTS WITH ADULT RESPIRATORY DISTRESS SYNDROME
Millar, A., Singer, M., Meager, A., Foley, N. M., Johnson, N. M., & Rook, G. A. W. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90772-1 · Cited by 198
Tolerance to tumor necrosis factor in rats and the relationship to endotoxin tolerance and toxicity.
Fraker, D. L., Stovroff, M. C., Merino, M. J., & Norton, J. A. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.1.95 · Cited by 196
Endotoxin, septic shock and acute lung injury: Neutrophils, macrophages and inflammatory mediators
Welbourn, C. R. B., & Young, Y. (1992) · British journal of surgery · doi:10.1002/bjs.1800791006 · Cited by 195
Role of Alveolar Macrophages in Initiation and Regulation of Inflammation inPseudomonas aeruginosaPneumonia
Kooguchi, K., Hashimoto, S., Kobayashi, A., Kitamura, Y., Kudoh, I., Wiener-Kronish, J. P., & Sawa, T. (1998) · Infection and Immunity · doi:10.1128/iai.66.7.3164-3169.1998 · Cited by 199
“Recently, the use of various anti-inflammatory therapies has been proposed for acute inflammatory diseases (2, 20).”
Background
Prevention of Jarisch–Herxheimer Reactions by Treatment with Antibodies against Tumor Necrosis Factor α
Fekade, D., Knox, K., Hussein, K., Melka, A., Lalloo, D. G., Coxon, R. E., & Warrell, D. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199608013350503 · Cited by 195
Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAsPreprint
Lu, J., Sadri, N., & Schneider, R. J. (2006) · Genes & Development · doi:10.1101/gad.1467606 · Cited by 197
Cytokines and the immunomodulatory function of the vagus nerve
Johnston, G. R., & Webster, N. R. (2009) · British Journal of Anaesthesia · doi:10.1093/bja/aep037 · Cited by 205
Inflammation balance in skeletal muscle damage and repair
Tu, H., & Li, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1133355 · Cited by 226
Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells.
Ishida, H., Hastings, R., Kearney, J. F., & Howard, M. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.5.1213 · Cited by 196
Prophylactic and Therapeutic Effects of a Monoclonal Antibody to Tumor Necrosis Factor- in Experimental Gram-Negative Shock
Silva, A. T., Bayston, K. F., & Cohen, J. (1990) · The Journal of Infectious Diseases · doi:10.1093/infdis/162.2.421 · Cited by 195
“00 monoclonal anti-TNFa F(ab')2 fragment prevented shock and death after injection of a lethal dose (LD100) of live Escherichia coli [8].”
BackgroundResultInfluential
Expression of and Cytokine Activation byEscherichia coliCurli Fibers in Human Sepsis
Zhao, B., Brauner, A., Li, Y., & Normark, S. J. (2000) · The Journal of Infectious Diseases · doi:10.1086/315233 · Cited by 196
“TNF-a is considered a central mediator in septic shock, and it plays an important role in host defense against intracellular pathogens [41, 42].”
Background
Trial Watch
Galluzzi, L., Vacchelli, E., Eggermont, A. M. M., Fridman, W. H., Galon, J., Sautès‐Fridman, C., Tartour, É., Zitvogel, L., & Kroemer, G. (2012) · OncoImmunology · doi:10.4161/onci.20696 · Cited by 205
“Early clinical trials sought to determine the safety of LPS, with particular attention to the fact that circulating LPS might cause the sequential release into the circulation of large amounts of pro-inflammatory cytokines, a potentially lethal process that is known as endotoxic shock.(72,73) These studies determined…”
Proinflammatory cytokines and sepsis syndrome: not enough, or too much of a good thing?
Netea, M. G. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00079-6 · Cited by 195
Cerivastatin Improves Survival of Mice with Lipopolysaccharide-Induced Sepsis
Ando, H., Takamura, T., Ota, T., Nagai, Y., & Kobayashi, K. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39169-4 · Cited by 192
Differential induction of nitric oxide synthase in various organs of the mouse during endotoxaemia: role of TNF-alpha and IL-1-beta.
Cunha, F. Q., Assreuy, J., Moss, D. W., Rees, D. D., Leal, L. M. C. C., Moncada, S., CARRIER, M. J., O'Donnell, C. A., & Liew, F. Y. (1994) · PubMed Central · Cited by 192
The clinical significance of tumor necrosis factor-α plasma level in patients having chronic lymphocytic leukemia
Ferrajoli, A., Keating, M. J., Manshouri, T., Giles, F. J., Dey, A. L., Estrov, Z. E., Koller, C. A., Kurzrock, R., Thomas, D. A., Faderl, S. H., et al. (2002) · Blood · doi:10.1182/blood.v100.4.1215.h81602001215_1215_1219 · Cited by 192
Effect of cardiopulmonary bypass on systemic release of neutrophil elastase and tumor necrosis factor
Butler, J. M., Pillai, R. G., Rocker, G. M., Westaby, S., Parker, D., & Shale, D. J. (1993) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)33843-7 · Cited by 185
Tumor necrosis factor α and interleukin 6 plasma levels in infected cirrhotic patients
Byl, B., Roucloux, I., Crusiaux, A., Dupont, É., & Devière, J. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90361-f · Cited by 187
Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction
Chen, G., Chen, X., King, S., Cavassani, K. A., Cheng, J., Zheng, X., Cao, H., Yu, H., Qu, J., Fang, D., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1846 · Cited by 190
Apolipoprotein E Protects Against Bacterial Lipopolysaccharide-induced Lethality
Van Oosten, M., Rensen, P. C. N., Van Amersfoort, E. S., Van Eck, M., Van Dam, A.-M., Brevé, J. J. P., Vogel, T., Panet, A., Van Berkel, T. J. C., & Kuiper, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009915200 · Cited by 186
Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms
Chen, G., Li, J., Ochani, M., Rendon-Mitchell, B., Qiang, X., Susarla, S. M., Ulloa, L., Yang, H., Fan, S., Goyert, S. M., et al. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0404242 · Cited by 188
“TNF has been established as a causative mediator of endotoxemic shock but not septic shock, as anti-TNF antibodies improve survival in animal models of entotoxemic or bacteremic shock [10, 35] but actually worsen survival in animal models of sepsis [36].”
BackgroundSelf-citation
Evaluation of Definitions for Sepsis
Knaus, W. A., Sun, X., Nyström, P.-O., & Wagner, D. P. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1656 · Cited by 186
Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor
Czaja, M. J., Xu, J., & Alt, E. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90149-3 · Cited by 186
Production of interleukin-1 by bone marrow myeloma cells
Cozzolino, F., Torcia, M. G., Aldinucci, D., Rubartelli, A., Miliani, A., Shaw, A., Lansdorp, P., & Guglielmo, R. D. (1989) · Blood · doi:10.1182/blood.v74.1.380.380 · Cited by 184
Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins
Dimitriou, I. D., Clemenza, L., Scotter, A. J., Chen, G., Guerra, F. M., & Rottapel, R. K. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00659.x · Cited by 182
“LPS elicits a cascade of secondary mediators, including proinflammatory cytokines, and reactive oxygen and nitrogen species, following binding to TLR4 on the surface of macrophages and monocytes (40, 52, 53).”
Background
Historical review: Cytokines as therapeutics and targets of therapeutics
Vilček, J., & Feldmann, M. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.02.011 · Cited by 195

Authors: Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A.
Affiliations: Cornell University (US)
Rockefeller University (US)
ORCID: Tracey, Kevin J.
Fong, Yuman
Kuo, George C.
Cerami, Anthony
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1987-12
Volume: 330
Issue: 6149
Pages: 662-664
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/330662a0
OpenAlex: W2038434279
Cited by: 2,448
References: 1
Citations by year: 2026: 10 · 2025: 13 · 2024: 19 · 2023: 17 · 2022: 13 · 2021: 24 · 2020: 24 · 2019: 32 · 2018: 31 · 2017: 24 · 2016: 40 · 2015: 33 · 2014: 44 · 2013: 43 · 2012: 46
FWCI: 95.90
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: TNF-α, septic shock, bacteremia, Escherichia coli, passive immunization, neutralizing monoclonal antibodies, F(ab')2 fragments, endotoxic shock, organ failure, renal failure, respiratory failure, stress hormones, baboons, sepsis treatment
MeSH terms: Animals, Antibodies, Monoclonal, Blood Pressure, Cardiac Output, Catecholamines, Glucagon, Immunization, Passive, Immunologic Techniques, Leukocyte Count, Papio, Shock, Septic, Tumor Necrosis Factor-alpha, Sepsis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks