The DOI matches its Crossref record; 0 of the 1 references it cites were found in a registry or an index.
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Abstract
Bacterial infection of the mammalian bloodstream can lead to overwhelming sepsis, a potentially fatal syndrome of irreversible cardiovascular collapse (shock) and critical organ failure. Cachectin, also known as tumour necrosis factor, is a macrophage-derived peptide hormone released in response to bacterial lipopolysaccharide, and it has been implicated as a principal mediator of endotoxic shock, although its function in bacterial sepsis is not known. Anaesthetized baboons were passively immunized against endogenous cachectin and subsequently infused with an LD100 dose of live Escherichia coli. Control animals (not immunized against cachectin) developed hypotension followed by lethal renal and pulmonary failure. Neutralizing monoclonal anti-cachectin antibody fragments (F(ab')2) administered to baboons only one hour before bacterial challenge protected against shock, but did not prevent critical organ failure. Complete protection against shock, vital organ dysfunction, persistent stress hormone release and death was conferred by administration of antibodies 2 h before bacterial infusion. These results indicate that cachectin is a mediator of fatal bacteraemic shock, and suggest that antibodies against cachectin offer a potential therapy of life-threatening infection.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“TNF is produced during Gram-negative bacteria-induced acute septic shock (3).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [3]
In the citing paper
“Consider as one example the case of TNF, a cytokine implicated as a necessary and sufficient mediator of lethal septic shock caused by infection with Gram-negative bacteria.”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [3]
Citations
Cites
1. Kreger, B. E. W., Craven, D. E. & McCabe, W. R. Am. J. Med. 68, 344-355 (1980). 2. Ziegler, E. J. el al New Engl. J. Med, 307, 1225-1230 (1982). 3. Gilbert, R. P. Physiol. Rev. 40, 245-279 (1960). 4. Beutler, B. & Cerami, A. Nature 320, 584-588 (1986). 5. Beutler, B. & Cerami, A. New Engl. J. Med
(n.d.)
Unresolved
Flagged first, then by citations
1 of the 1 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 401–500 of 1,001
Inflammatory serum markers in patients with multiple trauma
Giannoudis, P. V., Hildebrand, F., & Pape, H. (2004) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.86b3.15035 · Cited by 147
van der Poll, T., Coyle, S. M., Levi, M. M., Jansen, P. M., Dentener, M. A., Barbosa, K., Buurman, W. A., Hack, C. E., ten Cate, J. W., Agosti, J. M., et al. (1997) · PubMed · doi:10.1182/blood.v89.10.3727 · Cited by 147
Self-citationA multicenter trial to compare blood culture with polymerase chain reaction in severe human sepsis
Bloos, F., Hinder, F., Becker, K., Sachse, S., Dessap, A. M., Straube, E., Cattoir, V., Brun‐Buisson, C., Reinhart, K., Peters, G., et al. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1705-z · Cited by 139
Anti-inflammatory therapies in sepsis and septic shock
Freeman, B. D., & Natanson, C. (2000) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.9.7.1651 · Cited by 146
“, glucocorticoids, anti-endotoxin antibodies and inhibitors of specific host pro-inflammatory mediators such as TNF-α or IL-1, ameliorated inflammatory response and improved the outcome in animal models of sepsis [12-27].”
BackgroundLantz, M., Thysell, H., Nilsson, E., & Olsson, I. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115530 · Cited by 143
RetractedAllan, C. K., Newburger, J. W., McGrath, E. A., Elder, J., Psoinos, C. M., Laussen, P. C., del Nido, P. J., Wypij, D., & McGowan, F. X. J. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181f333aa · Cited by 144
CYTOKINES IN NECROTIZING ENTEROCOLITIS
Markel, T. A., Crisostomo, P. R., Wairiuko, G. M., Pitcher, J. M., Tsai, B. M., & Meldrum, D. R. (2006) · Shock · doi:10.1097/01.shk.0000192126.33823.87 · Cited by 144
Redl, H. R., Dinges, H. P., Buurman, W. A., et al. (1991) · PubMed · Cited by 145
Tumor Necrosis Factor and Severe Malaria
Shaffer, N., Grau, G. E., Hedberg, K., Davachi, F., Lyamba, B., Hightower, A. W., Breman, J. G., & Nguyen-Dinh, P. (1991) · The Journal of Infectious Diseases · doi:10.1093/infdis/163.1.96 · Cited by 143
“Among its wide range of systemic effects, it acts as an endogenous pyrogen [4] and has been found to mediate endotoxic shock [5].”
BackgroundArmstrong, L., Jordan, N., & Millar, A. (1996) · Thorax · doi:10.1136/thx.51.2.143 · Cited by 144
A diet containing glycine improves survival in endotoxin shock in the rat
Ikejima, K., Iimuro, Y., Forman, D. T., & Thurman, R. G. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.271.1.g97 · Cited by 144
Doxorubicin sensitizes human bladder carcinoma cells to Fas-mediated cytotoxicity
Mizutani, Y., Okada, Y., Yoshida, O., Fukumoto, M., & Bonavida, B. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970315)79:6 · Cited by 80
Wan, W., Janz, L., Vriend, C. Y., Sorensen, C. M., Greenberg, A. H., & Nance, D. M. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90158-8 · Cited by 143
Abandon the Mouse Research Ship? Not Just Yet!
Osuchowski, M. F., Remick, D. G., Lederer, J. A., Lang, C. H., Aasen, A. O., Aibiki, M., Azevedo, L. C. P., Bahrami, S., Boros, M., Cooney, R. N., et al. (2014) · Shock · doi:10.1097/shk.0000000000000153 · Cited by 148
“, against circulating cytokines or endotoxins) in the mouse (98), rat (102), rabbit (103), dog (104) and non-human primates (105), the striking failure of similar anti-inflammatory therapeutic protocols in septic patients has brought a painful realization that injecting mice and other species with a lethal dose of bac…”
Targeting HMGB1 in the treatment of sepsis
Wang, H., Ward, M. F., & Sama, A. E. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.863876 · Cited by 144
“For instance, neutralizing antibodies against an early cytokine, TNF [17], reduce lethality in animal models of endotoxemic/bacteremic shock.”
BackgroundInfluentialCortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia
González‐Rey, E., Chorny, A., Robledo, G., & Delgado, M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052017 · Cited by 142
Interleukin 1 induces ferritin heavy chain in human muscle cells
Wei, Y., Miller, S. C., Tsuji, Y., Torti, S. V., & Torti, F. M. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91466-6 · Cited by 142
Gray, P. W., Barrett, K., Chantry, D., Turner, M., & Feldmann, M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7380 · Cited by 141
Tumor necrosis factor in mediating experimental Haemophilus influenzae type B meningitis.
Mustafa, M. M., Ramilo, O., Olsen, K. D., Franklin, P., Hansen, E. J., Beutler, B., & McCracken, G. H. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114292 · Cited by 141
Lambert, J. C., Zhou, Z., Wang, L., Song, Z., McClain, C. J., & Kang, Y. J. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.047852 · Cited by 143
“Injection of anti-TNF antibodies as well as pentoxifylline, an inhibitor of TNF- secretion, into animals has been shown to protect the liver (Tracey et al., 1987; Bachmann et al., 1992).”
BackgroundChorny, A., Anderson, P. O., González‐Rey, E., & Delgado, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.8369 · Cited by 141
DEVELOPMENT OF IMMUNE FUNCTION IN THE INTESTINE AND ITS ROLE IN NEONATAL DISEASES
Insoft, R. M., Sanderson, I. R., & Walker, W. A. (1996) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(05)70420-x · Cited by 141
Concanavalin A—induced T-cell—mediated hepatic injury in mice: The role of tumor necrosis factor
Gantner, F., Leist, M., Lohse, A. W., Germann, P., & Tiegs, G. (1995) · Hepatology · doi:10.1002/hep.1840210131 · Cited by 140
Guy, G. R., Cao, X., Chua, S. P., & Tan, Y. H. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46024-3 · Cited by 133
Mintz, M. (1989) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1989.02150190021012 · Cited by 140
Identification of a brainstem locus that inhibits tumor necrosis factor
Kressel, A. M., Tsaava, T., Levine, Y. A., Chang, E. H., Addorisio, M. E., Chang, Q., Burbach, B. J., Carnevale, D., Lembo, G., Zador, A. M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008213117 · Cited by 133
Self-citationInflammatory Stress and Idiosyncratic Hepatotoxicity: Hints from Animal Models
Deng, X., Luyendyk, J. P., Ganey, P. E., & Roth, R. A. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001727 · Cited by 139
“Administration of TNF -neutralizing antibodies to baboons protects them from lethal bacteremia triggered by infusion of live Escherichia coli (Tracey et al., 1987).”
BackgroundThe role of tumor necrosis factor in sepsis
Spooner, C. E., Markowitz, N. P., & Saravolatz, L. D. (1992) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(92)90036-n · Cited by 138
Acute respiratory distress syndrome heterogeneity and the septic ARDS subgroup
Xu, H., Sheng, S., Luo, W., Xu, X.-F., & Zhang, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1277161 · Cited by 157
Group A Streptococcal Bacteremia: The Role of Tumor Necrosis Factor in Shock and Organ Failure
Stevens, D. L., Bryant, A. E., Hackett, S. P., et al. (1996) · The Journal of Infectious Diseases · doi:10.1093/infdis/173.3.619 · Cited by 138
Santucci, L., Fiorucci, S., Matteo, F. M. D., & Morelli, A. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90065-9 · Cited by 138
Endocan Elicits Severe Vascular Inflammatory Responses In Vitro and In Vivo
Lee, W., Ku, S., Kim, S., & Bae, J. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24485 · Cited by 139
Tumour necrosis factor in infectious disease
Waters, J. P., Pober, J. S., & Bradley, J. R. (2013) · The Journal of Pathology · doi:10.1002/path.4187 · Cited by 136
The Inflammatory Reflex and the Role of Complementary and Alternative Medical Therapies
Oke, S. L., & Tracey, K. J. (2009) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1393.013 · Cited by 139
Self-citationO’Connor, K., Hansen, M. K., Pugh, C., Deak, M. M., Biedenkapp, J. C., Milligan, E. D., Johnson, J. D., Wang, H., Maier, S. F., Tracey, K. J., et al. (2003) · Cytokine · doi:10.1016/j.cyto.2003.08.001 · Cited by 138
Self-citationCorral, L. G., Muller, G. W., Moreira, A. L., Chen, Y., Wu, M., Stirling, D., & Kaplan, G. (1996) · PubMed Central · Cited by 137
Tumor Necrosis Factor-α Induces a Biphasic Effect on Myocardial Contractility in Conscious Dogs
Murray, D. R. P., & Freeman, G. L. (1996) · Circulation Research · doi:10.1161/01.res.78.1.154 · Cited by 137
Steeland, S., Libert, C., & Vandenbroucke, R. E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051442 · Cited by 145
Kalechman, Y., Gafter, U., Gal, R., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.384 · Cited by 136
“administration of high doses of bacteria or bacterial products such as endotoxin, excessive production of proinflammatory cytokines significantly contributes to organ failure and death, as reflected by findings that neutralization of either TNF or IL-1 activity markedly reduced mortality in these systemic challenge mo…”
BackgroundAnti-inflammatory Effects of Aronia Extract on Rat Endotoxin-Induced Uveitis
Ohgami, K., Ilieva, I. B., Shiratori, K., Koyama, Y., Jin, X.-H., Yoshida, K., Kase, S., Kitaichi, N., Suzuki, Y., Tanaka, T., et al. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0715 · Cited by 136
“In particular, as suggested by the protective effects afforded by TNF- –neutralizing antibodies, increased plasma TNF- levels during endotoxemia and Gram-negative sepsis contributes to lethality.(25) Three types of nitric oxide synthase (NOS) isoforms have been identified in cells.”
BackgroundThe history, properties, and biological effects of cachectin
Beutler, B., & Cerami, A. (1988) · Biochemistry · doi:10.1021/bi00420a001 · Cited by 131
Self-citationWolf, H., Fischer, M. B., Pühringer, H., Samstag, A., Vogel, E., & Eibl, M. M. (1994) · Blood · doi:10.1182/blood.v83.5.1278.1278 · Cited by 138
Zamir, O. (1992) · Archives of Surgery · doi:10.1001/archsurg.1992.01420020052008 · Cited by 133
Tuberculosis as a Primary Cause of Respiratory Failure Requiring Mechanical Ventilation
Penner, C., ROBERTS, D. E., Kunimoto, D. Y., Manfreda, J., & Long, R. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/151.3_pt_1.867 · Cited by 138
Warren, H. S., Amato, S. F., Fitting, C., Black, K. M., Loiselle, P. M., Pasternack, M. S., & Cavaillon, J. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.1.89 · Cited by 128
“-1 and TNF are felt to be important in the pathogenesis of septic shock (45-50), and plasma levels of TNF and Ib6 have been reported to correlate with the outcome of patients with sepsis (51-54).”
Inflection points in sepsis biology: from local defense to systemic organ injury
Seeley, E. J., Matthay, M. A., & Wolters, P. J. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00069.2012 · Cited by 135
Johnson, E. O., Kamilaris, T. C., Carter, C. S., Calogero, A. E., Gold, P. W., & Chrousos, G. P. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00397-5 · Cited by 132
Vascular leak in sepsis: physiological basis and potential therapeutic advances
McMullan, R. R., McAuley, D. F., O’Kane, C. M., & Silversides, J. A. (2024) · Critical Care · doi:10.1186/s13054-024-04875-6 · Cited by 147
“Moreover, it has been demonstrated that the administration of anti-TNF antibodies could prevent shock, organ dysfunction and death in a baboon Escherichia coli model of sepsis [45].”
BackgroundInsulin Attenuates the Systemic Inflammatory Response to Thermal Trauma
Jeschke, M. G., Einspanier, R., Klein, D., & Jauch, K. (2002) · Molecular Medicine · doi:10.1007/bf03402024 · Cited by 130
Wurfel, M. M., Park, W. Y., Radella, F., Ruzinski, J., Sandstrom, A., Strout, J., Bumgarner, R. E., & Martin, T. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2570 · Cited by 130
Negussie, Y., Remick, D. G., DeForge, L. E., Kunkel, S. L., Eynon, A., & Griffin, G. E. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.5.1207 · Cited by 131
DNA fragmentation in mouse organs during endotoxic shock.
Bohlinger, I., Leist, M., Gantner, F., Angermüller, S., Tiegs, G., & Wendel, A. (1996) · Europe PMC (PubMed Central) · Cited by 128
Posttraumatic Multisystem Organ Failure
DeCamp, M. M. (1988) · JAMA · doi:10.1001/jama.1988.03410040102037 · Cited by 130
Marsden, P. A., & Ballermann, B. J. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1843 · Cited by 129
Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone.
Bianchi, M., Bloom, O., Raabe, T. D., Cohen, P. S., Chesney, J. A., Sherry, B. A., Schmidtmayerova, H., Calandra, T., Zhang, X., Bukrinsky, M., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.3.927 · Cited by 127
Self-citationComplexity of complement activation in sepsis
Markiewski, M. M., DeAngelis, R. A., & Lambris, J. D. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00504.x · Cited by 133
Nakane, A., Okamoto, M., Asano, M., Kohanawa, M., & Minagawa, T. (1995) · Infection and Immunity · doi:10.1128/iai.63.4.1165-1172.1995 · Cited by 125
“In contrast, TNF has been identified as an essential mediator in septic shock induced by gram-negative bacteria (3, 54).”
BackgroundSuperantigen Mediated Shock: A Cytokine Release Syndrome
Miethke, T., Wahl, C., Regele, D., et al. (1993) · Immunobiology · doi:10.1016/s0171-2985(11)80362-1 · Cited by 127
Rijneveld, A. W., Florquin, S., Branger, J., Speelman, P., van Deventer, S. J. H., & van der Poll, T. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.5240 · Cited by 126
“administration of high doses of bacteria (12, 13).”
BackgroundRevisiting the Role of Tumor Necrosis Factor α and the Response to Surgical Injury and Inflammation
Ksontini, R. (1998) · Archives of Surgery · doi:10.1001/archsurg.133.5.558 · Cited by 127
Baue, A. E. (1997) · Archives of Surgery · doi:10.1001/archsurg.1997.01430310017002 · Cited by 126
NOVEL HMGB1-INHIBITING THERAPEUTIC AGENTS FOR EXPERIMENTAL SEPSIS
Wang, H., Ward, M. F., & Sama, A. E. (2009) · Shock · doi:10.1097/shk.0b013e3181a551bd · Cited by 125
“However, the early kinetics of systemic TNF accumulation makes it difficult to target in a clinical setting (17), prompting a search for other late proinflammatory mediators that may offer a wider therapeutic window (Fig.”
BackgroundVielhauer, V., & Mayadas, T. N. (2007) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2007.02.004 · Cited by 125
Critical illness polyneuromyopathy after artificial respiration
de Coul, A. A. W. O., Verheul, G. A. M., Leyten, A. C. M., et al. (1991) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(91)90005-a · Cited by 125
Adjunctive Therapy for Septic Shock: A Review of Experimental Approaches
Lynn, W. A., & Cohen, J. B. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.1.143 · Cited by 125
“Antibodies o TNF-a are protective in some animal models of endotoxmia and gram-negative bacteremia [59-61].”
BackgroundTumor necrosis factor alpha has a protective role in a murine model of systemic candidiasis
Louie, A., Baltch, A. L., Smith, R. P., Franke, M. A., Ritz, W. J., Singh, J. K., & Gordon, M. A. (1994) · Infection and Immunity · doi:10.1128/iai.62.7.2761-2772.1994 · Cited by 120
“In contrast, the higher TNF-a levels that are measurable in animals challenged with large bacterial inocula (27, 28, 54), and in patients with overwhelming bacterial infections (22, 58), initiate biochemical and physiologic reactions that result in end-organ failure and, perhaps, septic shock (27, 28, 53, 54).”
BackgroundKristiansson, M., Soop, M., Saraste, L., et al. (1996) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.1996.tb04475.x · Cited by 124
Pharmacotherapy of Acute Lung Injury and Acute Respiratory Distress Syndrome
Raghavendran, K., Pryhuber, G., Chess, P. R., Davidson, B. A., Knight, P. R., & Notter, R. H. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708785132942 · Cited by 124
Stephens, S., Emtage, S., Vetterlein, O. M., Chaplin, L. C., Bebbington, C. R., Nesbitt, A. M., Sopwith, M., Athwal, D., Novak, C., & Bodmer, M. (1995) · PubMed Central · Cited by 124
Roles of tumour necrosis factor in the illness and pathology of malaria
Clark, I. A., Chaudhri, G., & Cowden, W. B. (1989) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(89)90240-x · Cited by 123
Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein.
Wispé, J. R., Clark, J. C., Warner, B. B., Fajardo, D., Hull, W. E., Holtzman, R. B., & Whitsett, J. A. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114929 · Cited by 123
Vandenabeele, P., Declercq, W., Vercammen, D., de Craen, M. V., Grooten, J., Loetscher, H., Brockhaus, M., Lesslauer, W., & Fiers, W. C. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.4.1015 · Cited by 122
Yamamoto, S., Tanabe, M., Wakabayashi, G., Shimazu, M., Matsumoto, K., & Kitajima, M. (2001) · Journal of Surgical Research · doi:10.1006/jsre.2001.6106 · Cited by 123
Regulation by C5a of Neutrophil Activation during Sepsis
Riedemann, N. C., Guo, R., Bernacki, K. D., Reuben, J. S., Laudes, I. J., Neff, T. A., Gao, H., Speyer, C. L., Sarma, V. J., Zetoune, F. S., et al. (2003) · Immunity · doi:10.1016/s1074-7613(03)00206-1 · Cited by 121
Endotoxin Tolerance Is Associated With Reduced Secretion of Tumor Necrosis Factor
Sánchez-Cantú, L. (1989) · Archives of Surgery · doi:10.1001/archsurg.1989.01410120082016 · Cited by 123
Opal, S. M., Cross, A. S., Kelly, N. M., SADOFF, J. C., Bodmer, M., Palardy, J., & Victor, G. (1990) · The Journal of Infectious Diseases · doi:10.1093/infdis/161.6.1148 · Cited by 123
Zhao, Y. X., He, W., Jing, X. H., Liu, J. L., Rong, P. J., Ben, H., Liu, K., & Zhu, B. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/627023 · Cited by 122
“Several potent cytokines including tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), and transforming growth factor-beta (TGF-β) are produced by activated macrophages and other immune cells, as necessary and sufficient mediators involved in local and system…”
Lehner, M. D., Ittner, J., Bundschuh, D. S., et al. (2001) · Infection and Immunity · doi:10.1128/iai.69.1.463-471.2001 · Cited by 122
“In these models, the crucial role of the proinflammatory cytokines TNF-a, IL-1, and IFN-g as distal mediators of LPS toxicity leading to shock and death is well documented (4, 31, 42 ).”
BackgroundSelection of Novel Analogs of Thalidomide with Enhanced Tumor Necrosis Factor α Inhibitory Activity
Corral, L. G., Muller, G. W., Moreira, A. L., Chen, Y., Wu, M., Stirling, D., & Kaplan, G. (1996) · Molecular Medicine · doi:10.1007/bf03401909 · Cited by 121
Spengler, R. N., Spengler, M. L., Lincoln, P., Remick, D. G., Strieter, R. M., & Kunkel, S. L. (1989) · Infection and Immunity · doi:10.1128/iai.57.9.2837-2841.1989 · Cited by 119
“(16), who observed that the lethality of E.”
BackgroundLíénard, D., Lejeune, F. J., & Ewalenko, P. (1992) · World Journal of Surgery · doi:10.1007/bf02071526 · Cited by 122
Novel Therapies for Sepsis: A Review
Deans, K. J., Haley, M., Natanson, C., Eichacker, P. Q., & Minneci, P. C. (2005) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000158244.69179.94 · Cited by 122
Dual roles for HMGB1: DNA binding and cytokine
Czura, C. J., Wang, H., & Tracey, K. J. (2001) · Journal of Endotoxin Research · doi:10.1177/09680519010070041401 · Cited by 122
Self-citationMetabolic Responses to Cachectin/TNF
Tracey, K. J., & Cerami, A. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb00173.x · Cited by 120
Self-citationSepsis Syndrome, the Adult Respiratory Distress Syndrome, and Nosocomial Pneumonia
Niederman, M. S., & Fein, A. M. (1990) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(21)00760-7 · Cited by 119
van der Poll, T., Jansen, J., van Leenen, D., von der Mohlen, M., Levi, M. M., Cate, H. T., Gallati, H., ten Cate, J. W., & van Deventer, S. J. H. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/168.4.955 · Cited by 116
“Massive induction of TNF synthesis, resulting in high concentrations of the protein in the circulation, is a prerequisite for the development of shock and multiple organ failure in experimental sepsis in animals [2].”
BackgroundNovel Insights for Systemic Inflammation in Sepsis and Hemorrhage
Cai, B., Deitch, E. A., & Ulloa, L. (2010) · Mediators of Inflammation · doi:10.1155/2010/642462 · Cited by 120
“Here, we review the new insights on the mentions.”
BackgroundVacchelli, E., Galluzzi, L., Eggermont, A. M. M., Galon, J., Tartour, É., Zitvogel, L., & Kroemer, G. (2012) · OncoImmunology · doi:10.4161/onci.20459 · Cited by 122
Luo, G., Niesel, D. W., Shaban, R. A., Grimm, E. A., & Klimpel, G. R. (1993) · Infection and Immunity · doi:10.1128/iai.61.3.830-835.1993 · Cited by 119
“not only in host defense (11, 15, 18) but also in some of the pathological sequelae associated with different bacterial infections (7, 13, 30).”
BackgroundGlauser, M. P. (1996) · Drugs · doi:10.2165/00003495-199600522-00004 · Cited by 119
Toll-like receptor 4-mediated signaling by epithelial surfaces: necessity or threat?
Bäckhed, F., & Hornef, M. W. (2003) · Microbes and Infection · doi:10.1016/s1286-4579(03)00189-8 · Cited by 119
Pathogenesis and Treatment of the Adult Respiratory Distress Syndrome
Fulkerson, W. J. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440010035006 · Cited by 122
Miethke, T., Duschek, K., Wahl, C., Heeg, K., & Wagner, H. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230715 · Cited by 118
Bianchi, M., Ulrich, P. C., Bloom, O., Meistrell, M. E., Zimmerman, G. A., Schmidtmayerova, H., Bukrinsky, M., Donnelley, T., Bucala, R., Sherry, B. A., et al. (1995) · Molecular Medicine · doi:10.1007/bf03401550 · Cited by 116
Self-citationPRECLINICAL MODELS OF SHOCK AND SEPSIS: WHAT CAN THEY TELL US?
Marshall, J. C., Deitch, E. A., Moldawer, L. L., Opal, S. M., Redl, H. R., & van der Poll, T. (2005) · Shock · doi:10.1097/01.shk.0000191383.34066.4b · Cited by 117
“TNF—originally described as an endogenous protein that could induce the death of tumor cells—was subsequently shown to be a cardinal mediator of the early inflammatory response to endotoxin or bacterial challenge (5, 6).”
BackgroundMetabolism of Sepsis and Multiple Organ Failure
MICHIE, H. R. (1996) · World Journal of Surgery · doi:10.1007/s002689900072 · Cited by 118
Spittler, A., Razenberger, M., Küpper, H., Kaul, M., Hackl, W. O., Boltz‐Nitulescu, G., Függer, R., & Roth, E. (2000) · Clinical Infectious Diseases · doi:10.1086/317499 · Cited by 115
Netea, M. G., van Tits, L. J. H., Curfs, J. H. A. J., Amiot, F., Meis, J. F. G. M., van der Meer, J. W. M., & Kullberg, B. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.3.1498 · Cited by 157
Metadata
- Authors
- Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A.
- Affiliations
- Cornell University (US)
- Rockefeller University (US)
- Venue
- Nature
- Published
- 1987-12
- Volume
- 330
- Issue
- 6149
- Pages
- 662-664
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2038434279
- Cited by
- 2,448
- References
- 1
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 19 · 2023: 17 · 2022: 13 · 2021: 24 · 2020: 24 · 2019: 32 · 2018: 31 · 2017: 24 · 2016: 40 · 2015: 33 · 2014: 44 · 2013: 43 · 2012: 46
- FWCI
- 95.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- TNF-α, septic shock, bacteremia, Escherichia coli, passive immunization, neutralizing monoclonal antibodies, F(ab')2 fragments, endotoxic shock, organ failure, renal failure, respiratory failure, stress hormones, baboons, sepsis treatment
- MeSH terms
- Animals, Antibodies, Monoclonal, Blood Pressure, Cardiac Output, Catecholamines, Glucagon, Immunization, Passive, Immunologic Techniques, Leukocyte Count, Papio, Shock, Septic, Tumor Necrosis Factor-alpha, Sepsis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
