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Designing CD4 immunoadhesins for AIDS therapy
Open accessAbstract
A newly-constructed antibody-like molecule containing the gp!20-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic use.
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Citations
Cited by
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Carter, P., Presta, L., Gorman, C. M., Ridgway, J. B., Henner, D., Wong, W. L., Rowland, A. M., Kotts, C., Carver, M. E., & Shepard, H. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4285 · Cited by 1,918
Shields, R. L., Namenuk, A. K., Hong, K., Meng, Y. G., Rae, J., Briggs, J., Xie, D., Lai, J., Stadlen, A., Li, B., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009483200 · Cited by 1,161
Antibody Pharmacokinetics and Pharmacodynamics
Lobo, E. D., Hansen, R. J., & Balthasar, J. P. (2004) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20178 · Cited by 909
Wyatt, R., Moore, J., Accola, M., Desjardin, E., Robinson, J., & Sodroski, J. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5723-5733.1995 · Cited by 417
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Somorjai, G. A. (1996) · Chemical Reviews · doi:10.1021/cr950234e · Cited by 310
Metadata
- Authors
- Capon, D. J., Chamow, S. M., Mordenti, J., Marsters, S. A., Gregory, T., Mitsuya, H., Byrn, R. A., Lucas, C., Wurm, F. M., Groopman, J. E., Broder, S., & Smith, D. H.
- Venue
- Nature
- Published
- 1989-02
- Volume
- 337
- Issue
- 6207
- Pages
- 525-531
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2074969682
- Cited by
- 615
- References
- 0
- FWCI
- 18.09
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Designing CD4 immunoadhesins for AIDS therapy. https://app.cochat.ai/papers/10.1038/337525a0
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- Capon, D. J., Chamow, S. M., Mordenti, J., Marsters, S. A., Gregory, T., Mitsuya, H., Byrn, R. A., Lucas, C., Wurm, F. M., Groopman, J. E., Broder, S., & Smith, D. H. (1989). Designing CD4 immunoadhesins for AIDS therapy. Nature. https://doi.org/10.1038/337525a0
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
