Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation
Abstract
Mast cells have a central role in allergic diseases mediated by specific immunoglobulin E antibody responses to allergens. The binding of IgE to the high-affinity receptor for IgE (Fc epsilon R) on mast cells and basophils enables these cells to react specifically to allergens. Such contact leads to the activation of mast cells and the release of histamine and other pharmacological mediators, causing an immediate hypersensitivity and acute inflammatory reactions, accompanied by the development of allergic symptoms. Here we show that Fc epsilon R-mediated activation of murine mast cells results in the production of the haemopoietic growth factors granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3). IL-3 and GM-CSF, in addition to their role in bone marrow haemopoiesis, also influence inflammation as they have the capacity to recruit, prime and activate inflammatory cells such as neutrophils, macrophages and eosinophils. Secretion of these factors by mast cells in response to allergens may therefore have an important role in local tissue defense.
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Mast cells are sources of cytokines which play key roles in signal transduction and communication between immune cells.
“The more recent discovery that mast cells are sources of cytokines 26 which play key roles in signal transduction and communication between immune cells suggests that mast cell activation could influence the development of T and B cell responses.27”
From Expression of oestrogen and progesterone receptors by mast cells alone, but not lymphocytes, macrophages or other immune cells in human upper airways (2001) · cites this paper as [26]
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- Authors
- Wodnar-Filipowicz, A., Heusser, C. H., & Moroni, C.
- Affiliations
- University of Basel (CH)
- ORCID
- Moroni, Christoph
- Venue
- Nature
- Published
- 1989-05
- Volume
- 339
- Issue
- 6220
- Pages
- 150-152
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2028395097
- Cited by
- 480
- References
- 0
- Citations by year
- 2022: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 3 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 5
- FWCI
- 22.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- mast cells, GM-CSF, interleukin-3, FcεRI, allergic inflammation, hematopoietic growth factors, immediate hypersensitivity, eosinophils, neutrophils, macrophages
- MeSH terms
- Animals, Antigens, Differentiation, B-Lymphocyte, Cells, Cultured, Colony-Stimulating Factors, Growth Substances, Interleukin-3, Mast Cells, Mice, Inbred DBA, Receptors, Fc, Granulocyte-Macrophage Colony-Stimulating Factor, Receptors, IgE, Mice
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