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Mycoplasma infection of cultured cells
Abstract
Mycoplasma contamination is tough to detect and even more difficult to eradicate. It is best to start over fresh from clean cell stocks, but several elimination options are available.
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“Mycoplasma contamination, in particular, can persist undetected in cell cultures for extended periods, resulting in substantial alterations in gene expression and cellular behavior.”
From Cell Immortality: In Vitro Effective Techniques to Achieve and Investigate Its Applications and Challenges (2024) · cites this paper as [161]
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Research works printed but not linked: 14
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- Marcus, M., Lavi, U., Nattenberg, A., Rottem, S., & Markowitz, O. Nature 285, 659–661 (1980). · DOI
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Cited by
Human cancer cell lines: fact and fantasy
Masters, J. R. W. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043102 · Cited by 352
Drexler, H. G., & Uphoff, C. C. (2002) · Cytotechnology · doi:10.1023/a:1022913015916 · Cited by 340
Detection of mycoplasma contamination in cell cultures by a mycoplasma group-specific PCR
van Kuppeveld, F. J., Johansson, K. E., Galama, J. M., Kissing, J., Bölske, G., van der Logt, J. T., & Melchers, W. J. (1994) · Applied and Environmental Microbiology · doi:10.1128/aem.60.1.149-152.1994 · Cited by 186
Tang, J., Hu, M., Lee, S., & Roblin, R. (2000) · Journal of Microbiological Methods · doi:10.1016/s0167-7012(99)00107-4 · Cited by 130
Chalak, M., Hesaraki, M., Mirbahari, S. N., Yeganeh, M., Abdi, S., Rajabi, S., & Hemmatzadeh, F. (2024) · Life · doi:10.3390/life14030417 · Cited by 66
Metadata
- Authors
- Hay, R. J., Macy, M. L., & Chen, T. R.
- Venue
- Nature
- Published
- 1989-06
- Volume
- 339
- Issue
- 6224
- Pages
- 487-488
- ISSN
- 0028-0836
- 1476-4687
- Cited by
- 111
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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- CoChat. (2026). Citation check: Mycoplasma infection of cultured cells. https://app.cochat.ai/papers/10.1038/339487a0
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- Hay, R. J., Macy, M. L., & Chen, T. R. (1989). Mycoplasma infection of cultured cells. Nature. https://doi.org/10.1038/339487a0