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Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160
Open accessAbstract
THE development of a vaccine to provide protective immunity to human immunodeficiency virus type 1 (HIV-1), the virus causing AIDS, would be the most practical method to control its spread. Subunit vaccines consisting of virus envelope glycoproteins, produced by recombinant DNA technology, are effective in preventing viral infections1. We have now used this approach in the development of a candidate AIDS vaccine. Chimpanzees were immunized with recombinant forms of the HIV-1 glycoproteins gp120 and gp160 produced in Chinese hamster ovary cells, and then challenged with HIV-1. The control and the two animals immunized with the gp160 variant became infected within 7 weeks of challenge. The two animals immunized with the gp120 variant have shown no signs of infection after more than 6 months. These studies demonstrate that recombinant gp120, formulated in an adjuvant approved for human use, can elicit protective immunity against a homologous strain of HIV-1.
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Cited by
Thali, M., Moore, J. P., Furman, C., Charles, M., Ho, D. D., Robinson, J., & Sodroski, J. (1993) · Journal of Virology · doi:10.1128/jvi.67.7.3978-3988.1993 · Cited by 616
Moore, J. P., Cao, Y., Qing, L., Sattentau, Q. J., Pyati, J., Koduri, R., Robinson, J., Barbas, C. F., Burton, D. R., & Ho, D. D. (1995) · Journal of Virology · doi:10.1128/jvi.69.1.101-109.1995 · Cited by 401
Gilbert, P. B., Peterson, M. L., Follmann, D., Hudgens, M. G., Francis, D. P., Gurwith, M., Heyward, W. L., Jobes, D. V., Popovic, V., Self, S. G., et al. (2005) · The Journal of Infectious Diseases · doi:10.1086/428405 · Cited by 355
Self-citationControl of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine
Cafaro, A., Caputo, A., Fracasso, C., Maggiorella, M. T., Goletti, D., Baroncelli, S., Pace, M., Sernicola, L., Koanga-Mogtomo, M. L., Betti, M., et al. (1999) · Nature Medicine · doi:10.1038/9488 · Cited by 276
An Assessment of the Role of Chimpanzees in AIDS Vaccine Research
Bailey, J. (2008) · Alternatives to Laboratory Animals · doi:10.1177/026119290803600403 · Cited by 49
Metadata
- Authors
- Berman, P. W., Gregory, T. J., Riddle, L., Nakamura, G. R., Champe, M. A., Porter, J. P., Wurm, F. M., Hershberg, R. D., Cobb, E. K., & Eichberg, J. W.
- Venue
- Nature
- Published
- 1990-06-14
- Volume
- 345
- Issue
- 6276
- Pages
- 622-625
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2049836668
- Cited by
- 590
- References
- 0
- FWCI
- 22.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Berman, P. W., Gregory, T. J., Riddle, L., Nakamura, G. R., Champe, M. A., Porter, J. P., Wurm, F. M., Hershberg, R. D., Cobb, E. K., & Eichberg, J. W. (1990). Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160. Nature. https://doi.org/10.1038/345622a0
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