The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding
Open accessAbstract
Interaction with the CD4 receptor enhances the exposure on the human immunodeficiency type 1 gp120 exterior envelope glycoprotein of conserved, conformation-dependent epitopes recognized by the 17b and 48d neutralizing monoclonal antibodies. The 17b and 48d antibodies compete with anti-CD4 binding antibodies such as 15e or 21h, which recognize discontinuous gp120 sequences near the CD4 binding region. To characterize the 17b and 48d epitopes, a panel of human immunodeficiency virus type 1 gp120 mutants was tested for recognition by these antibodies in the absence or presence of soluble CD4. Single amino acid changes in five discontinuous, conserved, and generally hydrophobic regions of the gp120 glycoprotein resulted in decreased recognition and neutralization by the 17b and 48d antibodies. Some of these regions overlap those previously shown to be important for binding of the 15e and 21h antibodies or for CD4 binding. These results suggest that discontinuous, conserved epitopes proximal to the binding sites for both CD4 and anti-CD4 binding antibodies become better exposed upon CD4 binding and can serve as targets for neutralizing antibodies.
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The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
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T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
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The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
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Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1
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Cited by
Structural definition of a conserved neutralization epitope on HIV-1 gp120
Zhou, T., Xu, L., Dey, B., Hessell, A. J., Van Ryk, D., Xiang, S.-H., Yang, X., Zhang, M.-Y., Zwick, M. B., Arthos, J., et al. (2007) · Nature · doi:10.1038/nature05580 · Cited by 770
Self-citationWyatt, R., Moore, J., Accola, M., Desjardin, E., Robinson, J., & Sodroski, J. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5723-5733.1995 · Cited by 417
Self-citationLabrijn, A. F., Poignard, P., Raja, A., Zwick, M. B., Delgado, K., Franti, M., Binley, J., Vivona, V., Grundner, C., Huang, C.-C., et al. (2003) · Journal of Virology · doi:10.1128/jvi.77.19.10557-10565.2003 · Cited by 357
Self-citationJette, C. A., Barnes, C. O., Kirk, S. M., Melillo, B., Smith, A. B., & Bjorkman, P. J. (2021) · Nature Communications · doi:10.1038/s41467-021-21816-x · Cited by 38
Nguyen, H. T., Wang, Q., Anang, S., & Sodroski, J. G. (2023) · Journal of Virology · doi:10.1128/jvi.01857-22 · Cited by 19
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Metadata
- Authors
- Thali, M., Moore, J. P., Furman, C., Charles, M., Ho, D. D., Robinson, J., & Sodroski, J.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1993-07
- Volume
- 67
- Issue
- 7
- Pages
- 3978-3988
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2131903471
- Cited by
- 616
- References
- 68
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Thali, M., Moore, J. P., Furman, C., Charles, M., Ho, D. D., Robinson, J., & Sodroski, J. (1993). Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding. Journal of Virology. https://doi.org/10.1128/jvi.67.7.3978-3988.1993
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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