The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells
Open accessAbstract
RETINOIC acid has been implicated as a natural morphogen in chicken1–4 and frog5 embryogenesis, and is presumed to act through the gene regulatory activity of a family of nuclear receptors6–10. Homeobox genes, which specify positional information in Drosophila and possibly in vertebrate embryogenesis11–21, are among the candidate responsive genes4,5,14. We previously reported that retinoic acid specifically induces human homeobox gene (HOX) expression in the embryonal carcinoma cell line NT2/D1 (ref. 22). We now show that the nine genes of the HOX2 cluster are differentially activated in NT2/D1 cells exposed to retinoic acid concentrations ranging from 10–8 to 10–5 M. Genes located in the 3' half of the cluster are induced at peak levels by 10–8 M retinoic acid, whereas a concentration of 10–6 to 10–5 M is required to fully activate 5' genes. At both high and low retinoic acid concentrations, HOX2 genes are sequentially activated in embryonal carcinoma cells in the 3' to 5' direction.
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Cites
A human retinoic acid receptor which belongs to the family of nuclear receptors
Petkovich, M., Brand, N. J., Krust, A., & Chambon, P. (1987) · Nature · doi:10.1038/330444a0 · Cited by 2,214
Identification of a receptor for the morphogen retinoic acid
Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965
Cited by
Homeobox genes and axial patterning
McGinnis, W., & Krumlauf, R. (1992) · Cell · doi:10.1016/0092-8674(92)90471-n · Cited by 2,674
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H., & Helin, K. (2006) · Genes & Development · doi:10.1101/gad.381706 · Cited by 1,257
Retinoic Acid Synthesis and Signaling during Early Organogenesis
Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098
Smith, M. A., Parkinson, D. R., Cheson, B. D., & Friedman, M. A. (1992) · Journal of Clinical Oncology · doi:10.1200/jco.1992.10.5.839 · Cited by 486
Surface antigens of human embryonic stem cells: changes upon differentiation in culture*
Draper, J. S., Pigott, C., Thomson, J. A., & Andrews, P. W. (2002) · Journal of Anatomy · doi:10.1046/j.1469-7580.2002.00030.x · Cited by 470
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Metadata
- Authors
- Simeone, A., Acampora, D., Arcioni, L., Andrews, P. W., Boncinelli, E., & Mavilio, F.
- Venue
- Nature
- Published
- 1990-08
- Volume
- 346
- Issue
- 6286
- Pages
- 763-766
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1983678271
- Cited by
- 520
- References
- 2
- FWCI
- 23.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Simeone, A., Acampora, D., Arcioni, L., Andrews, P. W., Boncinelli, E., & Mavilio, F. (1990). Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells. Nature. https://doi.org/10.1038/346763a0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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