Retinoic Acid Synthesis and Signaling during Early Organogenesis

Duester, Gregg

doi:10.1016/j.cell.2008.09.002

Cited by 1,098Developmental Biology and Gene RegulationRetinoids in leukemia and cellular processesPluripotent Stem Cells Research

Retinoic Acid Synthesis and Signaling during Early Organogenesis

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Duester, Gregg·2008·Cell

DOI 10.1016/j.cell.2008.09.002PMC PMC2632951

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Abstract

Retinoic acid, a derivative of vitamin A, is an essential component of cell-cell signaling during vertebrate organogenesis. In early development, retinoic acid organizes the trunk by providing an instructive signal for posterior neuroectoderm and foregut endoderm and a permissive signal for trunk mesoderm differentiation. At later stages, retinoic acid contributes to the development of the eye and other organs. Recent studies suggest that retinoic acid may act primarily in a paracrine manner and provide insight into the cell-cell signaling networks that control differentiation of pluripotent cells.

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The mechanisms underlying paracrine signaling remain unclear, while autocrine signaling requires CRABP2 for nuclear entry.
“The mechanisms underlying paracrine signaling remain unclear while autocrine signaling requires CRABP2 for nuclear entry28,34.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [28]
RA is the main biologically active metabolite of vitamin A.
“RA is the main biologically active metabolite of vitamin A28.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [28]
Several RA-polymer conjugates have been developed to release RA by hydrolytic cleavage of ester bonds, by enzymatic cleavage of amide bonds by proteases present in the targeted tissue, or by reducing environments such as the cell cytoplasm.
“For example, several RA-polymer conjugates have been developed to release RA by hydrolytic cleavage of ester bonds50,52, by enzymatic cleavage of amide bonds by proteases present in the targeted tissue28,65–67 or by reducing environments56 such as the cell cytoplasm.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [28]

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Authors: Duester, G.
Affiliations: Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Duester, Gregg
ORCID: Duester, Gregg
Venue: Cell
Publisher: Elsevier BV
Published: 2008-09
Volume: 134
Issue: 6
Pages: 921-931
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2008.09.002
PMC: PMC2632951
OpenAlex: W2040213004
Cited by: 1,098
References: 103
Citations by year: 2026: 42 · 2025: 60 · 2024: 48 · 2023: 45 · 2022: 47 · 2021: 52 · 2020: 59 · 2019: 74 · 2018: 54 · 2017: 61 · 2016: 57 · 2015: 73 · 2014: 82 · 2013: 86 · 2012: 77
FWCI: 4.66
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1780 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: California Institute for Regenerative Medicine
California Institute of Regenerative Medicine
National Institutes of Health (5r01ey013969-08)
National Eye Institute (R01-EY-013969, EY013969)
National Institute of General Medical Sciences (R01GM062848, GM062848)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords: retinoic acid, retinoic acid synthesis, retinoic acid signaling, organogenesis, cell-to-cell communication, paracrine signaling, foregut endoderm, pluripotent cell differentiation, eye development, vitamin A
MeSH terms: Animals, Cell Differentiation, Humans, Tretinoin, Signal Transduction, Organogenesis

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Retinoic Acid Synthesis and Signaling during Early Organogenesis

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