Cited by 406Retinoids in leukemia and cellular processesDevelopmental Biology and Gene RegulationGenomics and Chromatin Dynamics

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Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor

Oro, Anthony E., McKeown, Michael, Evans, Ronald M.·1990·Nature

DOI 10.1038/347298a0

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Abstract

The vitamin A derivative, retinoic acid, can regulate morphogenesis and differentiation in vertebrates. Two different subfamilies of the steroid receptor superfamily of transcription factors, the retinoic acid receptors and the retinoid X receptor, mediate the effects of retinoic acid. As part of an analysis of the hormonal control of development, we have examined the Drosophila genome for retinoic acid receptor homologues. Here we describe one such gene, XR2C, which encodes a product with structural similarity to the human retinoic acid-responsive transcription factor, retinoid X receptor. This receptor-like protein is encoded by ultraspiracle (usp), a locus required both maternally and zygotically for pattern formation. The discovery that the usp product is a retinoid X receptor homologue suggests that similar chemical cues underlie morphogenic signalling in vertebrate and invertebrate systems.

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Authors: Oro, A. E., McKeown, M., & Evans, R. M.
Affiliations: Howard Hughes Medical Institute (US)
Salk Institute for Biological Studies (US)
ORCID: Oro, Anthony E.
Evans, Ronald M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1990-09
Volume: 347
Issue: 6290
Pages: 298-301
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/347298a0
OpenAlex: W1966843280
Cited by: 406
References: 22
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 2 · 2018: 8 · 2017: 5 · 2016: 1 · 2015: 9 · 2014: 9 · 2013: 8 · 2012: 10
FWCI: 9.13
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: ultraspiracle, retinoid X receptor, retinoic acid receptor, retinoic acid, steroid receptor superfamily, transcription factors, Drosophila, vertebrate-invertebrate comparison, morphogenesis, pattern formation, gene homology
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Binding Sites, Carrier Proteins, DNA, Drosophila, Humans, Molecular Sequence Data, Mutation, Nucleic Acid Hybridization, Sequence Homology, Nucleic Acid, Restriction Mapping, Receptors, Retinoic Acid

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Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor

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