Cited by 519Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase SignalingGlycogen Storage Diseases and Myoclonus

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The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

Dent, Paul, Lavoinne, Alain, Nakielny, Sara, Caudwell, F. Barry, Watt, Peter, Cohen, Philip·1990·Nature

DOI 10.1038/348302a0

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Abstract

The ability of insulin to promote the phosphorylation of some proteins and the dephosphorylation of others is paradoxical. An insulin-stimulated protein kinase is shown to activate the type-1 protein phosphatase that controls glycogen metabolism, by phosphorylating its regulatory subunit at a specific serine. Furthermore, the phosphorylation of this residue is stimulated by insulin in vivo. Increased and decreased phosphorylation of proteins by insulin can therefore be explained through the same basic underlying mechanism.

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Authors: Dent, P., Lavoinne, A., Nakielny, S., Caudwell, F. B., Watt, P., & Cohen, P.
Affiliations: University of Dundee (GB)
ORCID: Dent, Paul
Watt, Peter
Cohen, Philip
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1990-11
Volume: 348
Issue: 6299
Pages: 302-308
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/348302a0
OpenAlex: W1977182622
Cited by: 519
References: 112
Citations by year: 2025: 2 · 2024: 2 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 5
FWCI: 18.83
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (publishedVersion)
University of Brighton Repository (University of Brighton) (submittedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Glycogen Storage Diseases and Myoclonus
Keywords: insulin signaling, glycogen synthesis, skeletal muscle, glycogen phosphorylase, protein phosphatase 1, protein kinases, serine phosphorylation, protein dephosphorylation
MeSH terms: Amino Acid Sequence, Animals, Glycogen, Insulin, Kinetics, Models, Biological, Molecular Sequence Data, Muscles, Phosphorylation, Propranolol, Protein Kinases, Rabbits, GTP-Binding Proteins

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The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

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