Cited by 1,013Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancerRenal and related cancers

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation

Heisenberg, Carl-Philipp, Tada, Masazumi, Rauch, Gerd-Jörg, Saúde, Leonor, Concha, Miguel L., Geisler, Robert, Stemple, Derek L., Smith, James C., Wilson, Stephen W.·2000·Nature

DOI 10.1038/35011068

Open this paper in CoChat — free account

Abstract

Vertebrate gastrulation involves the specification and coordinated movement of large populations of cells that give rise to the ectodermal, mesodermal and endodermal germ layers. Although many of the genes involved in the specification of cell identity during this process have been identified, little is known of the genes that coordinate cell movement. Here we show that the zebrafish silberblick (slb) locus encodes Wnt11 and that Slb/Wnt11 activity is required for cells to undergo correct convergent extension movements during gastrulation. In the absence of Slb/Wnt11 function, abnormal extension of axial tissue results in cyclopia and other midline defects in the head. The requirement for Slb/Wnt11 is cell non-autonomous, and our results indicate that the correct extension of axial tissue is at least partly dependent on medio-lateral cell intercalation in paraxial tissue. We also show that the slb phenotype is rescued by a truncated form of Dishevelled that does not signal through the canonical Wnt pathway, suggesting that, as in flies, Wnt signalling might mediate morphogenetic events through a divergent signal transduction cascade. Our results provide genetic and experimental evidence that Wnt activity in lateral tissues has a crucial role in driving the convergent extension movements underlying vertebrate gastrulation.

Integrity signals

Registry

Crossref · 10.1038/35011068

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824
Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling
Boutros, M., Paricio, N., Strutt, D. I., & Mlodzik, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81226-x · Cited by 801
Xwnt11is a target ofXenopusBrachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway
Tada, M., & Smith, J. C. (2000) · Development · doi:10.1242/dev.127.10.2227 · Cited by 675
Self-citation
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathwaysPreprint
Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T., & Perrimon, N. (1998) · Genes & Development · doi:10.1101/gad.12.16.2610 · Cited by 659
Cell movements during epiboly and gastrulation in zebrafish
Warga, R. M., & Kimmel, C. B. (1990) · Development · doi:10.1242/dev.108.4.569 · Cited by 562
Molecular mechanisms of male germ cell differentiation
Hecht, N. B. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199807)20:7 · Cited by 434
Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus
Glinka, A., Wu, W., Onichtchouk, D., Blumenstock, C., & Niehrs, C. (1997) · Nature · doi:10.1038/39092 · Cited by 350
Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain
Barth, K. A., & Wilson, S. W. (1995) · Development · doi:10.1242/dev.121.6.1755 · Cited by 332
Self-citation
Xwnt -5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis
Moon, R. T., Campbell, R. M., Christian, J. L., McGrew, L. L., Shih, J., & Fraser, S. E. (1993) · Development · doi:10.1242/dev.119.1.97 · Cited by 330

Show all 31 references

Sorted by citations

Items 801–900 of 1,000

Furry is required for cell movements during gastrulation and functionally interacts with NDR1
Cervino, A. S., Moretti, B., Stuckenholz, C., Grecco, H. E., Davidson, L. A., & Cirio, M. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-86153-x · Cited by 7
Evolutionary Development of Marine Larvae
(2017) · Oxford University Press eBooks · doi:10.1093/oso/9780198786962.003.0002 · Cited by 7
Ingression, migration and early differentiation of cardiac progenitors
Camp, E. (2011) · Frontiers in bioscience · doi:10.2741/3863 · Cited by 7
Single Nucleotide Polymorphism (SNP) Panels for Rapid Positional Cloning in Zebrafish
Clark, M. D., Guryev, V., de Bruijn, E., Nijman, I. J., Tada, M., WILSON, C. A., Deloukas, P., Postlethwait, J. H., Cuppen, E. P. J. G., & Stemple, D. L. (2011) · Methods in cell biology · doi:10.1016/b978-0-12-374814-0.00013-6 · Cited by 7
Self-citation
XIer2 is required for convergent extension movements during Xenopus development
Hong, S., Tanegashima, K., & Dawid, I. B. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113288sh · Cited by 7
Regulation of Focal Adhesion Dynamics by Wnt5a Signaling
Matsumoto, S., & Kikuchi, A. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-510-7_17 · Cited by 7
MicroRNA targeting of the non‐canonical planar cell polarity pathway in the developing neural tube
Mukhopadhyay, P., Greene, R. M., & Pisano, M. (2020) · Cell Biochemistry and Function · doi:10.1002/cbf.3512 · Cited by 7
Chondroitin sulfate proteoglycan 4 regulates zebrafish body axis organization via Wnt/planar cell polarity pathway
Lee, Y.-H., Kawakami, K., HuangFu, W., & Liu, I. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230943 · Cited by 7
A role for planar cell polarity during early endoderm morphogenesis
Miles, L. B., Mizoguchi, T., Kikuchi, Y., & Verkade, H. M. (2017) · Biology Open · doi:10.1242/bio.021899 · Cited by 7
Bringing two hearts together
Driever, W. (2000) · Nature · doi:10.1038/35018205 · Cited by 7
Signalling pathways in a nutshell: from pathogenesis to therapeutical implications in prostate cancer
Goncharov, A. P., Elissaiou, C. D., Farzalla, E. B. A., Akhvlediani, G., Vashakidze, N., & Kharaishvili, G. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2474175 · Cited by 7
Targeting β-catenin: PROTACs and precision degraders for Wnt-driven cancers
Trapani, J. B., Caroland, K. P., Ahmed, Y. F., Robbins, D. J., Weiss, V. L., & Lee, E. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1777843 · Cited by 6
Core pathway proteins and the molecular basis of planar polarity in the zebrafish gastrula
Creighton, J. H., & Jessen, J. R. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.09.015 · Cited by 6
Activity of Wnt/PCP Regulation Pathway Classifies Patients of Low-Grade Glioma Into Molecularly Distinct Subgroups With Prognostic Difference
Zhang, M., Wang, D., Su, L., Ma, J., Wang, S., Cui, M., Hong, S., Guan, B., & Ma, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.726034 · Cited by 6
Divergent regulation of Wnt-mediated development of the dorsomedial and ventrolateral dermomyotomal lips
Krück, S., & Scaal, M. (2012) · Histochemistry and Cell Biology · doi:10.1007/s00418-012-0971-y · Cited by 6
Probing Cadherin Interactions in Zebrafish with E- and N-Cadherin Missense Mutants
Warga, R. M., & Kane, D. A. (2018) · Genetics · doi:10.1534/genetics.118.301692 · Cited by 6
NSrp70 is significant for embryonic growth and development, being a crucial factor for gastrulation and mesoderm induction
Lee, S.-H., Kim, C., Lee, H.-K., Kim, Y.-K., Ismail, T., Jeong, Y., Park, K., Park, M. J., Park, D., & Lee, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.051 · Cited by 6
Germ Layer Induction in ESC—Following the Vertebrate Roadmap
Smith, J., Wardle, F. C., Loose, M., Stanley, E. G., & Patient, R. K. (2007) · Current Protocols in Stem Cell Biology · doi:10.1002/9780470151808.sc01d01s1 · Cited by 6
Self-citation
Zebrafish Mir Antagonizes Frizzled 7-Induced Gastrulation Defects
Knowlton, M. N., & Kelly, G. M. (2004) · Zebrafish · doi:10.1089/zeb.2004.1.133 · Cited by 8
The Wnt‐signaling pathways in mammalian patterning and morphogenesis
Wang, J., Etheridge, L., & Wynshaw-Boris, A. J. (2007) · Advances in developmental biology · doi:10.1016/s1574-3349(06)17004-0 · Cited by 6
Microsurgical Manipulation of the Notochord
Alvares, L. E., Lours-Calet, C., El-Hanfy, A. S., & Dietrich, S. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-483-8_20 · Cited by 6
Prickle and Ror modulate Dishevelled-Vangl interaction to regulate non-canonical Wnt signaling during convergent extensionPreprint
Seo, H., Yu, D., Popov, I. A., Tao, J., Angermeier, A., Sha, B., Axelrod, J. D., Chang, C., & Wang, J. (2023) · eLife · doi:10.7554/elife.91199.1 · Cited by 6
Coordinating tissue development to build body and brain: Lessons from the gastrula organiser and its derivatives
Neaverson, A., & Steventon, B. (2025) · Cells and Development · doi:10.1016/j.cdev.2025.204042 · Cited by 5
Tissue rigidity phase transition shapes morphogen gradients
Autorino, C., Khoromskaia, D., Harari, L., Floris, E., Booth, H. A. F., Cartes, C. P., Petrasiunaite, V., Dorrity, M. W., Corominas‐Murtra, B., Hadjivasiliou, Z., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-01954-4 · Cited by 10
Rbm8a deficiency causes hematopoietic defects by modulating Wnt/PCP signaling
Kocere, A., Chiavacci, E., Soneson, C., Jacobson, S. T., Harrison, E., Méndez-Acevedo, K. M., Macgowan, J., Wells, H. H., Hiltabidle, M. S., Raghunath, A., et al. (2025) · Developmental Biology · doi:10.1016/j.ydbio.2025.08.021 · Cited by 2
Recent discoveries in vertebrate non‐canonical Wnt signaling: Towards a Wnt signaling network
Pandur, P. (2005) · Advances in developmental biology · doi:10.1016/s1574-3349(05)14005-8 · Cited by 5
Wnt/β-Catenin Signaling and Congenital Abnormalities of Kidney and Urinary Tract
Yu, C., Zheng, B., Zhang, L., Zhang, A., Jia, Z., & Ding, G. (2024) · Kidney Diseases · doi:10.1159/000541684 · Cited by 5
A Framework for Connecting Gene Expression to Morphogenetic Movements in Embryos
Brodland, G. W. (2011) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2011.2159604 · Cited by 5
Planar polarity in the Drosophila wing
Adler, P. N. (2005) · Advances in developmental biology · doi:10.1016/s1574-3349(05)14001-0 · Cited by 5
Winding Roots of Wnts
Korzh, V. P. (2008) · Zebrafish · doi:10.1089/zeb.2008.0532 · Cited by 5
Wnt Signaling in Early Vertebrate Development
Żyłkiewicz, E., Sokol, S. Y., & Hoppler, S. (2014) · Wiley eBooks · doi:10.1002/9781118444122.ch19 · Cited by 5
Comparative molecular and morphogenetic characterisation of larval body regions in the polychaete annelid Platynereis dumerilii
Steinmetz, P. R. H. (2006) · Publikationsserver (Universitat Marburg) · doi:10.17192/z2006.0790 · Cited by 5
A mesoderm-independent role for Nodal signaling in convergence & extension gastrulation movementsPreprint
Williams, M. K., & Solnica‐Krezel, L. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/671164 · Cited by 4
Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolutionPreprint
Uveira, J., Donati, A., Léria, M., Lechable, M., Lahaye, F., Vesque, C., Houliston, E., & Momose, T. (2025) · eLife · doi:10.7554/elife.104508 · Cited by 6
MTM-6, a Phosphoinositide Phosphatase, is Required to Promote Synapse Formation in Caenorhabditis elegans
Ericson, V. R., Spilker, K. A., Tugizova, M., & Shen, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114501 · Cited by 4
Novel Cellular and Molecular Interactions During Limb Development, Revealed from Studies on the Split Hand Foot Congenital Malformation
Conte, D., Guerrini, L., & Merlo, G. R. (2015) · InTech eBooks · doi:10.5772/60402 · Cited by 4
Dact1 induces Dishevelled oligomerization to facilitate binding partner switch and signalosome formation during convergent extension
Angermeier, A., Yu, D., Huang, Y., Marchetto, S., Borg, J., Chang, C., & Wang, J. (2025) · Nature Communications · doi:10.1038/s41467-025-57658-0 · Cited by 5
Rare missense variants in DVL1, one of the human counterparts of the Drosophila dishevelled gene, do not confer increased risk for neural tube defects
Merello, E., Kibar, Z., Allache, R., Piatelli, G., Cama, A., Capra, V., & Marco, P. D. (2013) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.23157 · Cited by 4
A novel FZD6 mutation revealed the cause of cleft lip and/or palate in a Chinese family
Zhang, J., Zhao, H., Huang, W., Song, F., Zhong, W., Zhang, M., Zhang, Y., Zhou, Z., Lin, J., & Chen, F. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.12.003 · Cited by 4
Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands
Itallie, E. S. V., Field, C. M., Mitchison, T. J., & Kirschner, M. W. (2022) · Developmental Biology · doi:10.1016/j.ydbio.2022.10.013 · Cited by 4
Single nucleotide polymorphisms of PCP pathway related genes participate in the occurrence and development of neural tube defect
Liu, Y., Dong, L., Zhi, X., Liu, Y., Zhao, L., Xu, X., Wang, L., Jie, Z., Pu, L., Gu, C., et al. (2022) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.2094 · Cited by 3
Collective cell migration due to guidance-by-followers is robust to multiple stimuli
Müller, R., Boutillon, A., Jahn, D., Starruß, J., David, N. B., & Brusch, L. (2023) · Frontiers in Applied Mathematics and Statistics · doi:10.3389/fams.2023.1163583 · Cited by 4
Cell migration under control of Wnt‐signaling in the vertebrate embryo
Köhler, A., Schambony, A., & Wedlich, D. (2007) · Advances in developmental biology · doi:10.1016/s1574-3349(06)17005-2 · Cited by 4
Getting an embryo into shape
Maurus, D., & Kühl, M. (2004) · BioEssays · doi:10.1002/bies.20163 · Cited by 4
Neural Patterning and CNS Functions of Wnt in Zebrafish
Dorsky, R. I. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-469-2_20 · Cited by 4
Morphogenetic Mechanisms of Inner Ear Development
Alsina, B., & Streit, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-42767-6_8 · Cited by 5
Cadherins in Development
Semb, H. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-68170-0_3 · Cited by 4
Planar cell polarity in the Drosophila eye: Cell fate and organization
Mlodzik, M. (2005) · Advances in developmental biology · doi:10.1016/s1574-3349(05)14002-2 · Cited by 4
Zebrafish as an Experimental Organism
Houart, C. (2001) · Encyclopedia of Life Sciences · doi:10.1038/npg.els.0002094 · Cited by 4
Vertebrate Gastrulation: The BMP Sticker Shock
Wallingford, J. B., & Harland, R. M. (2007) · Current Biology · doi:10.1016/j.cub.2007.02.010 · Cited by 4
Zebrafish Gastrulation
Concha, M. L. (2025) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-012125-115503 · Cited by 4
Self-citation
Formin Binding Protein 1 (FNBP1) regulates non-canonical Wnt signaling and vertebrate gastrulation
Zeni, C., Komiya, Y., & Habas, R. (2024) · Developmental Biology · doi:10.1016/j.ydbio.2024.06.019 · Cited by 4
Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution
Uveira, J., Donati, A., Léria, M., Lechable, M., Lahaye, F., Vesque, C., Houliston, E., & Momose, T. (2025) · eLife · doi:10.7554/elife.104508.3 · Cited by 3
Planar cell polarity emerges through polarized accumulation of Wnt11
Mii, Y., Suzuki, M., Koyama, H., Nakayama, K., Takada, R., Kobayashi, T., Tsutsumi, M., Nemoto, T., Matsuyama, M., Fujimori, T., et al. (2026) · Science Advances · doi:10.1126/sciadv.aea0326 · Cited by 3
Planar Cell Polarity Pathway in Kidney Development and Function
Rocque, B., & Torban, E. (2015) · Advances in Nephrology · doi:10.1155/2015/764682 · Cited by 4
Heparan Sulfate Clusters Regulate Distribution and Signaling of Wnt Morphogens
Mii, Y. (2020) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.2006.7e · Cited by 3
Tissue Polarity in the Retina
Mlodzik, M. (2002) · Results and problems in cell differentiation · doi:10.1007/978-3-540-45398-7_7 · Cited by 3
Vangl facilitates mesenchymal thinning during lung sacculation independently of CelsrPreprint
Paramore, S. V., Trenado-Yuste, C., Sharan, R., Devenport, D., & Nelson, C. M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.28.522148 · Cited by 3
Prickle and Ror modulate Dishevelled-Vangl interaction to regulate non-canonical Wnt signaling during convergent extension in Xenopus
Seo, H., Yu, D., Popov, I. A., Tao, J., Angermeier, A., Yang, F., Marchetto, S., Borg, J., Sha, B., Axelrod, J. D., et al. (2023) · eLife · doi:10.1101/2023.08.29.555374 · Cited by 5
Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesisPreprint
Carroll, S. H., Schäfer, S., Kawasaki, K., Tsimbal, C., Julé, A. M., Hallett, S. A., Li, E., & Liao, E. C.-W. (2024) · eLife · doi:10.7554/elife.91648 · Cited by 2
Differential sensitivity of midline development to mitosis during and after primitive streak extension
Zhao, Z., Asai, R., & Mikawa, T. (2025) · Developmental Dynamics · doi:10.1002/dvdy.70045 · Cited by 2
Quantitative live imaging reveals PRICKLE1 controls junctional neural tube morphogenesis independent of Planar Cell Polarity
Wang, J. X., Álvarez, Y. D., Tan, S. Z., Ranie, S. N., Stehbens, S. J., & White, M. D. (2026) · Nature Communications · doi:10.1038/s41467-026-71242-0 · Cited by 2
PRICKLE3 protects VANGL proteins from CK1-mediated phosphorylation and RNF43-mediated degradation
Radaszkiewicz, K. A., Radaszkiewicz, T. W., Kolarova, P., Paclíková, P., Gömöryová, K., Novotna, S., Maia, L. A., Cihalova, T., Le, Y., Bárta, T., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09422-9 · Cited by 2
Differential functions of multiple Wnts and receptors in cell polarity regulation in Caenorhabditis elegans
Sawa, H., Asakawa, M., & Negishi, T. (2026) · Genetics · doi:10.1093/genetics/iyag004 · Cited by 2
The Wnt co-receptor Arrow-LRP5/6 is required for planar cell polarity establishment in Drosophila
Weber, U., Farhadifar, R., & Mlodzik, M. (2026) · Nature Communications · doi:10.1038/s41467-026-78357-4 · Cited by 2
Functional Evaluation of Neural Tube Defect‐Related Missense Mutations Using In Silico Methods
SÜT, B. B. (2025) · Birth Defects Research · doi:10.1002/bdr2.2453 · Cited by 2
Shape Switching and Tunable Oscillations of Adaptive Droplets
Dullweber, T., Belousov, R., Autorino, C., Petridou, N. I., & Erzberger, A. (2025) · Physical Review Letters · doi:10.1103/1cq4-x499 · Cited by 2
Morphology and Gene Expression Screening with Morpholinos in Zebrafish Embryos
Tseng, L.-C., Tang, C., & Jiang, Y. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6337-9_17 · Cited by 2
Wnt Signaling in Neurite Development
Rosso, S. B., & Salinas, P. C. (2007) · Springer eBooks · doi:10.1007/978-0-387-68561-8_10 · Cited by 2
Zebrafish Rnf111 is encoded by multiple transcripts and is required for epiboly progression and prechordal plate development
Bessarab, D. A., Mathavan, S., Jones, C. M., & Dunn, N. R. (2015) · Differentiation · doi:10.1016/j.diff.2014.12.004 · Cited by 2
Phosphorylation of serine residues S252 , S268 / S269 , and S879 in p120 catenin activates migration of presomitic mesoderm in gastrulating zebrafish embryos
Kupai, A., Nakahara, H., Voss, K., Hirano, M., Rodriguez, A., Lackey, D. L., Murayama, J. F., Mathieson, C., Shan, B., Horton, E. C., et al. (2022) · Developmental Dynamics · doi:10.1002/dvdy.508 · Cited by 2
Cell Signaling and Growth Factors in Lung Development
Warburton, D., Bellusci, S., del Moral, P.-M., Langhe, S. D., Kaartinen, V., Lee, M., Tefft, D., & Shi, W. (2005) · doi:10.1002/9783527619689.ch21 · Cited by 2
Mechanisms of brain ventricle development
Lowery, L. A. (2008) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 2
Wnt Signaling during EarlyXenopusDevelopment
Fagotto, F. (2014) · Wiley eBooks · doi:10.1002/9781118492833.ch8 · Cited by 2
Gene Discovery in Nonsyndromic Cleft Lip with or without Cleft Palate
Chiquet, B. T. (2011) · Digital Commons-TMC (Texas Medical Center) · Cited by 2
Characterization of the Wnt signalling system in the coral Acropora millepora
Ukolova, S. (2023) · ResearchOnline - JCU (James Cook University) · doi:10.25903/eyhz-7977 · Cited by 2
Genetic and bioinformatic approaches to characterize ethanol teratogenesisPreprint
Sidik, A., Dixon, G., Kirby, H. G., & Eberhart, J. (2019) · bioRxiv · doi:10.1101/805556 · Cited by 1
Dynamically Evolving Cell Sizes During Early Development Enable Normal Gastrulation Movements In Zebrafish EmbryosPreprint
Menon, T., Borbora, A. S., Kumar, R., & Nair, S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/481325 · Cited by 2
Regulation of Pattern Formation by the Interaction between Growth Factors and Proteoglycans
Ueno, N., & Ohkawara, B. (2003) · Springer eBooks · doi:10.1007/978-4-431-65958-7_6 · Cited by 2
Limb Development
Mackem, S. (2005) · Wiley eBooks · doi:10.1002/9783527619689.ch15 · Cited by 2
Controlled levels of canonical Wnt signaling are required for neural crest migration
Maj, E. A. (2016) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5478 · Cited by 2
A combination of convergent extension and differential adhesion explains the shapes of elongating gastruloidsPreprint
de Jong, M. A., Adegeest, E., Bérenger-Currias, N. M. L. P., Mircea, M., Merks, R. M. H., & Semrau, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.24.541949 · Cited by 2
An active matter model captures the spatial dynamics of actomyosin oscillations during morphogenesisPreprint
Mackay, E. D., Bebbington, A., Januschke, J., Kursawe, J., Bischoff, M., & Sknepnek, R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.04.616649 · Cited by 2
Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolutionPreprint
Uveira, J., Donati, A., Léria, M., Lechable, M., Lahaye, F., Vesque, C., Houliston, E., & Momose, T. (2025) · eLife · doi:10.7554/elife.104508.1 · Cited by 2
Maternal control of embryonic dorsal organizer in vertebrates
Chen, J., & Meng, A. (2025) · Cells and Development · doi:10.1016/j.cdev.2025.204020 · Cited by 2
An Integrated Canonical and Non-Canonical Wnt Signaling Network Controls Early Anterior–Posterior Axis Formation in Sea Urchin Embryos
Fenner, J. L., Wang, B., Ka, C., Gautam, S., & Range, R. (2025) · Journal of Developmental Biology · doi:10.3390/jdb13040036 · Cited by 1
Wnt and Notch
Cohen, E. D., & Morrisey, E. E. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381510-1.00032-6 · Cited by 1
Cell Polarity in Morphogenesis—Planar Cell Polarity
Mandrekar, N., Su, B., & Habas, R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802438-6.00004-8 · Cited by 1
Three-dimensional deformation mode of multicellular epithelial tube under tension and compression tests
Okuda, S., Unoki, K., Eiraku, M., & TSUBOTA, K.-I. (2018) · Journal of Biomechanical Science and Engineering · doi:10.1299/jbse.17-00507 · Cited by 1
Neural Tube Defects
Zohn, I. E. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405945-0.00037-5 · Cited by 1
Specific CaMKIIs mediate convergent extension cell movements in early zebrafish development
McLeod, J. J. A., Rothschild, S. C., Francescatto, L., Kim, H., & Tombes, R. M. (2023) · Developmental Dynamics · doi:10.1002/dvdy.665 · Cited by 1
Dorsoventral patterning beyond the gastrulation stage: Interpretation of early dorsoventral cues and modular development mediated by zic1/zic4
Kawanishi, T., & Takeda, H. (2025) · Cells and Development · doi:10.1016/j.cdev.2025.204012 · Cited by 1
Genomics profile of ocular toxicity in zebrafish exposed to environmental contaminants
Pamanji, R., Prathiviraj, R., Bomma, Y., Venkateswaran, A. S., & Sivan, G. (2025) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2025.101544 · Cited by 1
BAC Recombineering and Transgenesis to Study Cell Polarity and Polarized Tissue Morphogenesis in Mice
Yu, D., & Wang, J. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2035-9_13 · Cited by 1
STATs in Cell Mobility and Polarity during Morphogenetic Movement
Yamashita, S., & Hirano, T. (2003) · Springer eBooks · doi:10.1007/978-94-017-3000-6_37 · Cited by 1
Correction: Sfrp5 Modulates Both Wnt and BMP Signaling and Regulates Gastrointestinal Organogensis in the Zebrafish, Danio rerio
Stuckenholz, C., Lu, L., Thakur, P. C., Choi, T. Y., Shin, D., & Bahary, N. (2013) · PLoS ONE · doi:10.1371/annotation/024a206e-293f-4a95-a188-7838a2763266 · Cited by 1
Identification and functional characterization of PTK7 ligands in Xenopus laevis
Peradziryi, H. (2011) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3158 · Cited by 1
PTK7 protein localization and stability is affected by canonical Wnt ligands
Berger, H. (2016) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5496
The transmembrane receptors Otk and Otk2 function redundantly in Drosophila Wnt signal transduction
Linnemannstöns, K. (2013) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3795 · Cited by 1
Myosin II in early Xenopus morphogenesis
Rolo, A. (2007) · doi:10.18130/v3fc9j · Cited by 1

Authors: Heisenberg, C.-P., Tada, M., Rauch, G.-J., Saúde, L., Concha, M. L., Geisler, R., Stemple, D. L., Smith, J. C., & Wilson, S. W.
Affiliations: University College London (GB)
National Institute for Medical Research (GB)
Max Planck Institute for Developmental Biology (DE)
Corresponding author: Heisenberg, Carl-Philipp
ORCID: Heisenberg, Carl-Philipp
Tada, Masazumi
Saúde, Leonor
Concha, Miguel L.
Geisler, Robert
Stemple, Derek L.
Smith, James C.
Wilson, Stephen W.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2000-05
Volume: 405
Issue: 6782
Pages: 76-81
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35011068
OpenAlex: W1974712344
Cited by: 1,013
References: 31
Citations by year: 2026: 17 · 2025: 23 · 2024: 19 · 2023: 19 · 2022: 25 · 2021: 29 · 2020: 23 · 2019: 23 · 2018: 25 · 2017: 29 · 2016: 29 · 2015: 36 · 2014: 34 · 2013: 34 · 2012: 46
FWCI: 20.38
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Health Sciences › Medicine › Oncology › Renal and related cancers
Keywords: Wnt11, convergent extension, gastrulation, zebrafish, cyclopia, midline defects, cell intercalation, Dishevelled, non-canonical Wnt signaling, cell motility, germ layer formation
MeSH terms: Animals, Cell Movement, Embryo, Nonmammalian, Gastrula, Glycoproteins, Mutation, Zebrafish, Signal Transduction, Zebrafish Proteins, Wnt Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks