The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
Open accessAbstract
Here we determine the complete genomic sequence of the gram negative, gamma-Proteobacterium Vibrio cholerae El Tor N16961 to be 4,033,460 base pairs (bp). The genome consists of two circular chromosomes of 2,961,146 bp and 1,072,314 bp that together encode 3,885 open reading frames. The vast majority of recognizable genes for essential cell functions (such as DNA replication, transcription, translation and cell-wall biosynthesis) and pathogenicity (for example, toxins, surface antigens and adhesins) are located on the large chromosome. In contrast, the small chromosome contains a larger fraction (59%) of hypothetical genes compared with the large chromosome (42%), and also contains many more genes that appear to have origins other than the gamma-Proteobacteria. The small chromosome also carries a gene capture system (the integron island) and host 'addiction' genes that are typically found on plasmids; thus, the small chromosome may have originally been a megaplasmid that was captured by an ancestral Vibrio species. The V. cholerae genomic sequence provides a starting point for understanding how a free-living, environmental organism emerged to become a significant human bacterial pathogen.
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Cites
Site‐specific integration of the conjugal Vibrio cholerae SXT element into prfC
Hochhut, B., & Waldor, M. K. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01330.x · Cited by 213
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Massé, E., & Gottesman, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032066599 · Cited by 1,154
Genomic Islands in Pathogenic and Environmental Microorganisms
Dobrindt, U., Hochhut, B., Hentschel, U., & Hacker, J. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro884 · Cited by 1,188
Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria
Crosa, J. H., & Walsh, C. T. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.223-249.2002 · Cited by 797
(2002) · PubMed · Cited by 437
Evolutionary Origins of Genomic Repertoires in Bacteria
Lerat, E., Daubin, V., Ochman, H., & Moran, N. A. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030130 · Cited by 338
Metadata
- Authors
- Heidelberg, J. F., Eisen, J. A., Nelson, W. C., Clayton, R. A., Gwinn, M. L., Dodson, R. J., Haft, D. H., Hickey, E. K., Peterson, J. D., Umayam, L., Gill, S. R., Nelson, K. E., Read, T. D., Tettelin, H., Richardson, D., Ermolaeva, M. D., Vamathevan, J., Bass, S., Qin, H., Dragoi, I., Sellers, P., McDonald, L., Utterback, T., Fleishmann, R. D., Nierman, W. C., White, O., Salzberg, S. L., Smith, H. O., Colwell, R. R., Mekalanos, J. J., Venter, J. C., & Fraser, C. M.
- Venue
- Nature
- Published
- 2000-08-01
- Volume
- 406
- Issue
- 6795
- Pages
- 477-483
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2107109782
- Cited by
- 1,870
- References
- 1
- FWCI
- 83.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Heidelberg, J. F., Eisen, J. A., Nelson, W. C., Clayton, R. A., Gwinn, M. L., Dodson, R. J., Haft, D. H., Hickey, E. K., Peterson, J. D., Umayam, L., Gill, S. R., Nelson, K. E., Read, T. D., Tettelin, H., Richardson, D., Ermolaeva, M. D., Vamathevan, J., Bass, S., Qin, H., . . . Fraser, C. M. (2000). DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature. https://doi.org/10.1038/35020000
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
