The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Phagocytosis and clearance of apoptotic cells is mediated by MER
Abstract
Apoptosis is fundamental to the development and maintenance of animal tissues and the immune system. Rapid clearance of apoptotic cells by macrophages is important to inhibit inflammation and autoimmune responses against intracellular antigens. Here we report a new function for Mer, a member of the Axl/Mer/Tyro3 receptor tyrosine kinase family. mer(kd) mice with a cytoplasmic truncation of Mer had macrophages deficient in the clearance of apoptotic thymocytes. This was corrected in chimaeric mice reconstituted with bone marrow from wild-type animals. Primary macrophages isolated from mer(kd) mice showed that the phagocytic deficiency was restricted to apoptotic cells and was independent of Fc receptor-mediated phagocytosis or ingestion of other particles. The inability to clear apoptotic cells adequately may be linked to an increased number of nuclear autoantibodies in mer(kd) mice. Thus, the Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells. This has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus.
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“In general, MERTK plays a key role in a variety of phagocytic events, such as microglial phagocytosis to mediate synaptic pruning (Chung et al., 2013), macrophage phagocytosis to remove apoptotic immune cells (Scott et al., 2001), and phagocytosis of apoptotic germ cells and the residual body from maturing sperm by Sertoli cells in the testes (Breucker et al., 1985).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Scott et al., 2001
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Cites
Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321
Programmed Cell Death in Animal Development
Jacobson, M. D., Weil, M., & RAFF, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,685
A receptor for phosphatidylserine-specific clearance of apoptotic cells
Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A. M., Ezekowitz, R. A. B., & Henson, P. M. (2000) · Nature · doi:10.1038/35011084 · Cited by 1,491
Phagocyte recognition of cells undergoing apoptosis
Savill, J., Fadok, V. A., Henson, P. M., & Haslett, C. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90215-7 · Cited by 981
Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat
D'Cruz, P. M. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.4.645 · Cited by 884
Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
Savill, J., Dransfield, I., Hogg, N., & Haslett, C. (1990) · Nature · doi:10.1038/343170a0 · Cited by 846
Savill, J., Hogg, N., Ren, Y., & Haslett, C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116019 · Cited by 818
O’Bryan, J. P., Frye, R. A., Cogswell, P. C., Neubauer, A., Kitch, B., Prokop, C. A., Espinosa, R., Beau, M. M. L., Earp, H. S., & Liu, E. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.10.5016 · Cited by 746
Taylor, P. R., Carugati, A., Fadok, V. A., Cook, H. T., Andrews, M., Carroll, M. C., Savill, J., Henson, P. M., Botto, M., & Walport, M. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.359 · Cited by 724
Human CD14 mediates recognition and phagocytosis of apoptotic cells
Devitt, A., Moffatt, O., Raykundalia, C., Capra, J. D., Simmons, D. L., & Gregory, C. D. (1998) · Nature · doi:10.1038/33169 · Cited by 681
Gal, A., Li, Y., Thompson, D. A., Weir, J., Orth, U., Jacobson, S. G., Apfelstedt-Sylla, E., & Vollrath, D. (2000) · Nature Genetics · doi:10.1038/81555 · Cited by 679
Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production
Mevorach, D., Zhou, J. L., Song, X., & Elkon, K. B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.387 · Cited by 567
Nagata, K., Ohashi, K., Nakano, T., Arita, H., Zong, C., Hanafusa, H., & Mizuno, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.30022 · Cited by 541
Tyro-3 family receptors are essential regulators of mammalian spermatogenesis
Lu, Q., Gore, M., Zhang, Q., Camenisch, T., Boast, S., Casagranda, F., Lai, C., Skinner, M. K., Klein, R., Matsushima, G. K., et al. (1999) · Nature · doi:10.1038/19554 · Cited by 514
Self-citationPlatt, N., Suzuki, H., Kurihara, Y., Kodama, T., & Gordon, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12456 · Cited by 428
Rosen, A., & Casciola-Rosen, L. A. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400460 · Cited by 353
Camenisch, T. D., Koller, B. H., Earp, H. S., & Matsushima, G. K. (1999) · PubMed · Cited by 321
Camenisch, T. D., Koller, B. H., Earp, H. S., & Matsushima, G. K. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3498 · Cited by 290
Self-citationCell Adhesion to Phosphatidylserine Mediated by a Product of Growth Arrest-specific Gene 6*
Nakano, T., Ishimoto, Y., Kishino, J., Umeda, M., Inoue, K., Nagata, K., Ohashi, K., Mizuno, K., & Arita, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29411 · Cited by 264
Stern, M., Savill, J., & Haslett, C. (1996) · Europe PMC (PubMed Central) · Cited by 239
GAS6 Induces Axl-mediated Chemotaxis of Vascular Smooth Muscle Cells
Fridell, Y.-W. C., Villa, J., Attar, E. C., & Liu, E. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.7123 · Cited by 195
Radiation and stress-induced apoptosis: A role for Fas/Fas ligand interactions
Reap, E. A., Roof, K. S., Maynor, K., Borrero, M., Booker, J. K., & Cohen, P. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5750 · Cited by 173
Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase.
Lai, C., Gore, M., & Lemke, G. (1994) · PubMed · Cited by 166
Cloning and developmental expression analysis of the murine c-mer tyrosine kinase.
Graham, D. K., Bowman, G. W., Dawson, T. L., Stanford, W. L., Earp, H. S., & Snodgrass, H. R. (1995) · PubMed · Cited by 135
GAS6 Mediates Adhesion of Cells Expressing the Receptor Tyrosine Kinase Axl
McCloskey, P., Fridell, Y.-W. C., Attar, E. C., Villa, J., Jin, Y., Varnum, B. C., & Liu, E. T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.37.23285 · Cited by 133
Histochemical studies on lectin binding in reactive lymphoid tissues.
Hsu, S. M., & Ree, H. J. (1983) · Journal of Histochemistry & Cytochemistry · doi:10.1177/31.4.6827084 · Cited by 86
Thymic nurse cells are sites of thymocyte apoptosis.
Aguilar, L. K., Aguilar-Córdova, E., Cartwright, J., & Belmont, J. W. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.6.2645 · Cited by 65
Recent Developments in the Understanding of Antinuclear Autoantibodies
Casiano, C. A., & Tan, E. M. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000237385 · Cited by 56
Subclass restriction of anti-Sm antibodies in MRL mice.
Eisenberg, R. A., Winfield, J. B., & Cohen, P. L. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.5.2146 · Cited by 50
Licht, R., Jacobs, C. W. M., Tax, W. J. M., & Berden, J. H. M. (1999) · Journal of Immunological Methods · doi:10.1016/s0022-1759(98)00212-9 · Cited by 49
Meryhew, N. L., Shaver, C., Messner, R. P., & Runquist, O. A. (1991) · PubMed · Cited by 19
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Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096
Antigen Presentation and T Cell Stimulation by Dendritic Cells
Guermonprez, P., Valladeau‐Guilemond, J., Zitvogel, L., Théry, C., & Amigorena, S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064828 · Cited by 1,990
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Leadbetter, E. A., Rifkin, I. R., Hohlbaum, A. M., Beaudette-Zlatanova, B. C., Shlomchik, M. J., & Marshak‐Rothstein, A. (2002) · Nature · doi:10.1038/416603a · Cited by 1,929
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Metadata
- Authors
- Scott, R. S., McMahon, E. J., Pop, S. M., Reap, E. A., Caricchio, R., Cohen, P. L., Earp, H. S., & Matsushima, G. K.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- AlphaVax (United States) (US)
- University of Pennsylvania (US)
- UNC Lineberger Comprehensive Cancer Center (US)
- Corresponding author
- Matsushima, Glenn K.
- Venue
- Nature
- Published
- 2001-05
- Volume
- 411
- Issue
- 6834
- Pages
- 207-211
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2011617127
- Cited by
- 1,215
- References
- 31
- Citations by year
- 2026: 27 · 2025: 32 · 2024: 61 · 2023: 44 · 2022: 29 · 2021: 39 · 2020: 61 · 2019: 50 · 2018: 40 · 2017: 50 · 2016: 39 · 2015: 44 · 2014: 60 · 2013: 51 · 2012: 45
- FWCI
- 21.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Research Councils UK
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- Mer receptor tyrosine kinase, efferocytosis, phagocytosis, macrophages, systemic lupus erythematosus, autoimmunity, inflammation, thymocytes
- MeSH terms
- c-Mer Tyrosine Kinase, Animals, Antibodies, Antinuclear, Cell Adhesion, Cells, Cultured, Crosses, Genetic, Cytochalasin B, Dexamethasone, Female, Flow Cytometry, Immunohistochemistry, Listeria monocytogenes, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Microscopy, Electron, Scanning, Microspheres, Mutation, Phagocytosis, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Radiation Chimera, Receptors, Fc, Thymus Gland, Bone Marrow Transplantation, Apoptosis, Macrophages, Peritoneal, Receptor Protein-Tyrosine Kinases, Mice
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