The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index.
Genome maintenance mechanisms for preventing cancer
Abstract
The early notion that cancer is caused by mutations in genes critical for the control of cell growth implied that genome stability is important for preventing oncogenesis. During the past decade, knowledge about the mechanisms by which genes erode and the molecular machinery designed to counteract this time-dependent genetic degeneration has increased markedly. At the same time, it has become apparent that inherited or acquired deficiencies in genome maintenance systems contribute significantly to the onset of cancer. This review summarizes the main DNA caretaking systems and their impact on genome stability and carcinogenesis.
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Claims the paper makes
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In the citing paper
“CS patients, defective in the TCR branch of NER (1, 27), present a very different clinical picture, one of developmental defects and neurodegeneration; many but not all patients are also photosensitive, some developing blistering sunburns (5, 28).”
From Why Cockayne syndrome patients do not get cancer despite their DNA repair deficiency (2016) · cites this paper as [27]
In the citing paper
“Both XP and CS patients have defects in NER.”
From Why Cockayne syndrome patients do not get cancer despite their DNA repair deficiency (2016) · cites this paper as [27]
In the citing paper
“Ultraviolet (UV) light induces DNA damage that blocks replication and transcription [1][2][3] triggering either cell death or genetic instability.”
From Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome (2014) · cites this paper as [1]
Citations
Cites
2 retracted
RETRACTED: Transcription-Coupled Repair of 8-oxoGuanine
Page, F. L., Kwoh, E. E., Avrutskaya, A. V., Gentil, A., Leadon, S. A., Sarasin, A. R., & Cooper, P. K. (2000) · Cell · doi:10.1016/s0092-8674(00)80827-2 · Cited by 280
RetractedPage, F. L., Kwoh, E. E., Avrutskaya, A. V., Gentil, A., Leadon, S. A., Sarasin, A. R., & Cooper, P. K. (2005) · Cell · doi:10.1016/j.cell.2005.11.005 · Cited by 271
RetractedOxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
The DNA damage response: putting checkpoints in perspective
Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213
A survey of telomerase activity in human cancer
Shay, J. W., & Bacchetti, S. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00062-2 · Cited by 2,794
DNA double-strand breaks: signaling, repair and the cancer connection
Khanna, K. K., & Jackson, S. P. (2001) · Nature Genetics · doi:10.1038/85798 · Cited by 2,455
Cancer-epigenetics comes of age
Jones, P. A., & Laird, P. W. (1999) · Nature Genetics · doi:10.1038/5947 · Cited by 2,358
Bootsma, D., & Hoeijmakers, J. H. J. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81408-9 · Cited by 2,285
Self-citation
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1 of the 68 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Bootsma, D., Kraemer, K. H., Cleaver, J. & Hoeijmakers, J. H. J. in The Metabolic and Molecular Basis of Inherited Disease Vol. 1 (eds Scriver, C. R., Beaudet, A. L., Sly, W. S. & Valle, D.) 677–703 (McGraw-Hill, New York, 2001).
- Digweed, M., Reis, A. & Sperling, K. Nijmegen breakage syndrome: consequences of defective DNA double strand break repair. BioEssays 21, 649–656 (1999). · DOI
Cited by
Sorted by citations
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683
The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092
Lehmann, B. D., Bauer, J. A., Chen, X., Sanders, M. E., Chakravarthy, A. B., Shyr, Y., & Pietenpol, J. A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45014 · Cited by 5,592
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
Fong, P. C., Boss, D. S., Yap, T. A., Tutt, A., Wu, P., Mergui-Roelvink, M., Mortimer, P., Swaisland, H., Lau, A., O'Connor, M. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0900212 · Cited by 3,634
A DNA damage checkpoint response in telomere-initiated senescence
Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,917
Metadata
- Authors
- Hoeijmakers, J. H. J.
- Affiliations
- Erasmus University Rotterdam (NL)
- Corresponding author
- Hoeijmakers, Jan H. J.
- Venue
- Nature
- Published
- 2001-05-01
- Volume
- 411
- Issue
- 6835
- Pages
- 366-374
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2096136751
- Semantic Scholar
- d0f61e028e7f97375defc2b754e37345af93b400
- Cited by
- 3,939
- References
- 68
- Citations by year
- 2026: 48 · 2025: 65 · 2024: 70 · 2023: 118 · 2022: 99 · 2021: 143 · 2020: 137 · 2019: 146 · 2018: 156 · 2017: 138 · 2016: 179 · 2015: 189 · 2014: 189 · 2013: 201 · 2012: 217
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- KWF Kankerbestrijding
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- genome maintenance, genome stability, carcinogenesis, DNA repair, DNA damage response, mutagenesis, cancer prevention
- MeSH terms
- Animals, DNA Damage, DNA Repair, Humans, Models, Genetic, Neoplasms, Recombination, Genetic, Syndrome, Transcription, Genetic, Telomere, Genome, Base Pair Mismatch
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