Hoeijmakers, Jan H. J.

Genome maintenance mechanisms for preventing cancer

Hoeijmakers, J. H. J. (2001) · Nature

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 3,939

DNA damage, aging, and Cancer

Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine

DNA Repair MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 2,239

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell

Wound Healing and TreatmentsTelomeres, Telomerase, and Senescence

Cited by 2,045

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Baar, M. P., Brandt, R. M. C., Putavet, D. A., Klein, J. D. D., Derks, K. W. J., Bourgeois, B. R. M., Stryeck, S., Rijksen, Y., van Willigenburg, H., Feijtel, D. A., et al. (2017) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,454

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

Horst, G. T. J. V. D., Muijtjens, M., Kobayashi, K., Takano, R., Kanno, S.-I., Takao, M., Wit, J. D., Verkerk, A., Eker, A. P. M., Leenen, D. V., et al. (1999) · Nature

Circadian rhythm and melatoninLight effects on plants

Cited by 1,402

Chromosomal stability and the DNA double-stranded break connection

van Gent, D. C., Hoeijmakers, J. H. J., & Kanaar, R. (2001) · Nature Reviews Genetics

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 1,219

Understanding nucleotide excision repair and its roles in cancer and ageing

Marteijn, J. A., Lans, H., Vermeulen, W., & Hoeijmakers, J. H. J. (2014) · Nature Reviews Molecular Cell Biology

DNA Repair MechanismsNuclear Structure and Function

Cited by 1,192

Molecular mechanism of nucleotide excision repair

de Laat, W. L., Jaspers, N. G. J., & Hoeijmakers, J. H. J. (1999) · Genes & Development

DNA Repair MechanismsNuclear Structure and Function

Cited by 1,122

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature

Hematopoietic Stem Cell TransplantationDNA Repair Mechanisms

Cited by 1,115

Cellular senescence drives age-dependent hepatic steatosis

Ogrodnik, M., Miwa, S., Tchkonia, T., Tiniakos, D., Wilson, C. L., Lahat, A., Day, C. P., Burt, A., Palmer, A., Anstee, Q. M., et al. (2017) · Nature Communications

Telomeres, Telomerase, and SenescenceLiver Disease Diagnosis and Treatment

Cited by 1,044

The central role of DNA damage in the ageing process

Schumacher, B., Pothof, J., Vijg, J., & Hoeijmakers, J. H. J. (2021) · Nature

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 907

Xeroderma Pigmentosum Group C Protein Complex Is the Initiator of Global Genome Nucleotide Excision Repair

Sugasawa, K., Ng, J. M. Y., Masutani, C., Iwai, S., van der Spek, P. J., Eker, A. P. M., Hanaoka, F., Bootsma, D., & Hoeijmakers, J. H. J. (1998) · Molecular Cell

DNA Repair MechanismsNuclear Structure and Function

Cited by 899

ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes

Troelstra, C., van Gool, A., de Wit, J., Vermeulen, W., Bootsma, D., & Hoeijmakers, J. H. J. (1992) · Cell

DNA Repair MechanismsNuclear Structure and Function

Cited by 729

Nucleotide excision repair and human syndromes

de Boer, J., & Hoeijmakers, J. H. J. (2000) · Carcinogenesis

DNA Repair MechanismsGenetic and rare skin diseases.

Cited by 674

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., Odijk, H., Oostendorp, R., Ahmad, A., van Leeuwen, W., et al. (2006) · Nature

Genetics, Aging, and Longevity in Model OrganismsDNA Repair Mechanisms

Cited by 669

Aging and Genome Maintenance: Lessons from the Mouse?

Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J. (2003) · Science

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 553

Premature Aging in Mice Deficient in DNA Repair and Transcription

de Boer, J., Andressoo, J. O., de Wit, J., Huijmans, J., Beems, R. B., van Steeg, H., Weeda, G., van der Horst, G. T. J., van Leeuwen, W., Themmen, A. P. N., et al. (2002) · Science

Genetics, Aging, and Longevity in Model OrganismsDNA Repair Mechanisms

Cited by 545

Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

Matsumura, H., Mohri, Y., Binh, N. T., Morinaga, H., Fukuda, M., Ito, M., Kurata, S., Hoeijmakers, J., & Nishimura, E. K. (2016) · Science

Hair Growth and DisordersSkin and Cellular Biology Research

Cited by 416

The DNA damage response to transcription stress

Lans, H., Hoeijmakers, J. H. J., Vermeulen, W., & Marteijn, J. A. (2019) · Nature Reviews Molecular Cell Biology

DNA Repair MechanismsNuclear Structure and Function

Cited by 321

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M., van der Eerden, B. C., et al. (2016) · Nature

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 315

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.

Motegi, A., Liaw, H.-J., Lee, K.-Y., Roest, H. P., Maas, A., Wu, X., Moinova, H., Markowitz, S. D., Ding, H., Hoeijmakers, J. H. J., et al. (2008) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 304

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

Schwertman, P., Lagarou, A., Dekkers, D. H. W., Raams, A., van der Hoek, A. C., Laffeber, C., Hoeijmakers, J. H. J., Demmers, J. A. A., Fousteri, M., Vermeulen, W., et al. (2012) · Nature Genetics

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 279

Nuclear genomic instability and aging

Niedernhofer, L. J., Gurkar, A. U., Wang, Y., Vijg, J., Hoeijmakers, J. H. J., & Robbins, P. D. (2018) · Annual Review of Biochemistry

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 275

The core spliceosome as target and effector of non-canonical ATM signalling

Tresini, M., Warmerdam, D. O., Kolovos, P., Snijder, L., Vrouwe, M. G., Demmers, J. A. A., van IJcken, W. F. J., Grosveld, F. G., Medema, R. H., Hoeijmakers, J. H. J., et al. (2015) · Nature

RNA Research and SplicingDNA Repair Mechanisms

Cited by 252