Cited by 2,685Pain Mechanisms and TreatmentsIon Channels and ReceptorsIon channel regulation and function

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

Molecular mechanisms of nociception

Julius, David, Basbaum, Allan I.·2001·Nature

Open this paper in CoChat — free account

Abstract

The sensation of pain alerts us to real or impending injury and triggers appropriate protective responses. Unfortunately, pain often outlives its usefulness as a warning system and instead becomes chronic and debilitating. This transition to a chronic phase involves changes within the spinal cord and brain, but there is also remarkable modulation where pain messages are initiated - at the level of the primary sensory neuron. Efforts to determine how these neurons detect pain-producing stimuli of a thermal, mechanical or chemical nature have revealed new signalling mechanisms and brought us closer to understanding the molecular events that facilitate transitions from acute to persistent pain.

Integrity signals

Registry

Crossref · 10.1038/35093019

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132
Self-citation
The Integrative Action of the Nervous System.
Sherrington, C. (1907) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-190734120-00021 · Cited by 4,136
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781 · cited 1×
“Moreover, because expression of neurotransmitters, their receptors and other signalling molecules are dramatically altered after tissue or nerve injur”
Background
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544
Self-citation
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,086
Self-citation
Textbook of pain
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142
Self-citation
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
Davis, J. B., Gray, J., Gunthorpe, M. J., Hatcher, J. P., Davey, P. T., Overend, P., Harries, M. H., Latcham, J., Clapham, C. M., Atkinson, K., et al. (2000) · Nature · doi:10.1038/35012076 · Cited by 1,781
A capsaicin-receptor homologue with a high threshold for noxious heat
Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. J. (1999) · Nature · doi:10.1038/18906 · Cited by 1,599
Self-citation
Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity
Samad, T. A., Moore, K. A., Sapirstein, A., Billet, S. E., Allchorne, A. J., Poole, S., Bonventre, J. V., & Woolf, C. J. (2001) · Nature · doi:10.1038/35068566 · Cited by 1,282
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
Chuang, H.-H., Prescott, E. D., Kong, H., Shields, S. D., Jordt, S. E., Basbaum, A. I., Chao, M. V., & Julius, D. J. (2001) · Nature · doi:10.1038/35082088 · Cited by 1,257
Self-citation
A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
Akopian, A. N., Sivilotti, L. G., & Wood, J. N. (1996) · Nature · doi:10.1038/379257a0 · Cited by 1,104
Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances
Hwang, S. W., Cho, H., Kwak, J., Lee, S.-Y., Kang, C.-J., Jung, J., Cho, S., Min, K. H., Suh, Y., Kim, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6155 · Cited by 1,047
Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice
Cockayne, D. A., Hamilton, S. G., Zhu, Q., Dunn, P. M., Zhong, Y., Novaković, S. D., Malmberg, A. B., Cain, G. R., Berson, A. E., Kassotakis, L., et al. (2000) · Nature · doi:10.1038/35039519 · Cited by 1,031
The Integrative Action of the Nervous System.
Freeman, F. N., & SHERRINGTON, S. C. (1907) · The Journal of Philosophy Psychology and Scientific Methods · doi:10.2307/2010953 · Cited by 906
Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ
Huang, C.-L., Feng, S., & Hilgemann, D. W. (1998) · Nature · doi:10.1038/35882 · Cited by 891
Tackling Pain at the Source: New Ideas about Nociceptors
Snider, W. D., & McMahon, S. B. (1998) · Neuron · doi:10.1016/s0896-6273(00)81003-x · Cited by 853
The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
Akopian, A. N., Souslova, V., England, S. G., Okuse, K., Ogata, N., Ure, J. M., Smith, A., Kerr, B. J., McMahon, S. B., Boyce, S., et al. (1999) · Nature Neuroscience · doi:10.1038/9195 · Cited by 828
Induction of vanilloid receptor channel activity by protein kinase C
Premkumar, L. S., & Ahern, G. P. (2000) · Nature · doi:10.1038/35050121 · Cited by 801
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
Smart, D., Gunthorpe, M. J., Jerman, J. C., Nasir, S., Gray, J., Muir, A. I., Chambers, J. K., Randall, A. D., & Davis, J. B. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703050 · Cited by 775
Messenger plasticity in primary sensory neurons following axotomy and its functional implications
Hökfelt, T. G. M., Zhang, X., & Wiesenfeld‐Hallin, Z. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90031-0 · Cited by 742
Hyperalgesia Mediated by Spinal Glutamate or Substance P Receptor Blocked by Spinal Cyclooxygenase Inhibition
Malmberg, A. B., & Yaksh, T. L. (1992) · Science · doi:10.1126/science.1381521 · Cited by 704
Acid potentiation of the capsaicin receptor determined by a key extracellular site
Jordt, S., Tominaga, M., & Julius, D. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100129497 · Cited by 635
Self-citation
Myelinated afferent fibres responding specifically to noxious stimulation of the skin
Burgess, P. R., & Perl, E. R. (1967) · The Journal of Physiology · doi:10.1113/jphysiol.1967.sp008227 · Cited by 598
PGE2 modulates the tetrodotoxin‐resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP‐protein kinase A cascade.
England, S., Bevan, S., & Docherty, R. J. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021604 · Cited by 546
A receptor for protons in the nerve cell membrane
Krishtal, O., & Pidoplichko, V. I. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90149-9 · Cited by 542
The mammalian sodium channel BNC1 is required for normal touch sensation
Price, M. P., Lewin, G. R., McIlwrath, S. L., Cheng, C., Xie, J., Heppenstall, P. A., Stucky, C. L., Mannsfeldt, A. G., Brennan, T. J., Drummond, H. A., et al. (2000) · Nature · doi:10.1038/35039512 · Cited by 508
Novel classes of responsive and unresponsive C nociceptors in human skin
Schmidt, R., Schmelz, M., Forster, C., Ringkamp, M., Torebjörk, E. H., & Handwerker, H. O. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00333.1995 · Cited by 504
NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy
Dib‐Hajj, S. D., Tyrrell, L., Black, J. A., & Waxman, S. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8963 · Cited by 502
A Modulatory Subunit of Acid Sensing Ion Channels in Brain and Dorsal Root Ganglion Cells
Lingueglia, É., de Weille, J. R., Bassilana, F., Heurteaux, C., 酒井, 秀., Waldmann, R., & Lazdunski, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29778 · Cited by 502
Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I
Kanzaki, M., Zhang, Y.-Q., Mashima, H., Lü, L., Shibata, H., & Kojima, I. (1999) · Nature Cell Biology · doi:10.1038/11086 · Cited by 497
Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses
Gu, J. G., & MacDermott, A. B. (1997) · Nature · doi:10.1038/39639 · Cited by 494
From worm to man: three subfamilies of TRP channels
Harteneck, C., Plant, T. D., & Schultz, G. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01532-5 · Cited by 486
A Novel Nociceptor Signaling Pathway Revealed in Protein Kinase C ε Mutant Mice
Khasar, S. G., Lin, Y., Martin, A., Dadgar, J., McMahon, T., Wang, D., Hundle, B. S., Aley, K. O., Isenberg, W. M., McCarter, G. C., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80837-5 · Cited by 433
A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin
Cesare, P., & McNaughton, P. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15435 · Cited by 433
Modulation of TTX-RINaby PKC and PKA and Their Role in PGE2-Induced Sensitization of Rat Sensory NeuronsIn Vitro
Gold, M. S., Levine, J. D., & Correa, A. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10345.1998 · Cited by 421
Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons
Sutherland, S. P., Benson, C. J., Adelman, J. P., & McCleskey, E. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.711 · Cited by 379
Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions
Zhang, H., He, C., Yan, X., Mirshahi, T., & Logothetis, D. E. (1999) · Nature Cell Biology · doi:10.1038/11103 · Cited by 348
Functional Attributes Discriminating Mechano-Insensitive and Mechano-Responsive C Nociceptors in Human Skin
Weidner, C., Schmelz, M., Schmidt, R., Hansson, B. S., Handwerker, H. O., & Torebjörk, H. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-10184.1999 · Cited by 348
Protons activate a cation conductance in a sub‐population of rat dorsal root ganglion neurones.
Bevan, S., & Yeats, J. C. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018419 · Cited by 340
Protons: small stimulants of capsaicin-sensitive sensory nerves
Bevan, S., & Geppetti, P. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90149-x · Cited by 300
Requirement for the PDZ Domain Protein, INAD, for Localization of the TRP Store-Operated Channel to a Signaling Complex
Chevesich, J., Kreuz, A. J., & Montell, C. (1997) · Neuron · doi:10.1016/s0896-6273(01)80049-0 · Cited by 290
Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons
Tate, S., Benn, S. C., Hick, C. A., Trezise, D. J., John, V. H., Mannion, R., Costigan, M., Plumpton, C., Grose, D., Gladwell, Z. M., et al. (1998) · Nature Neuroscience · doi:10.1038/3652 · Cited by 278
Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin
Shu, X., & Mendell, L. M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00701-6 · Cited by 272
Chapter 8. Tissue acidosis in nociception and pain
Reeh, P. W., & Steen, K. H. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61085-7 · Cited by 266
Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture
Burgess, G. M., Mullaney, I., McNeill, M., Dunn, P. M., & Rang, H. P. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-09-03314.1989 · Cited by 245
Transport and Localization of the DEG/ENaC Ion Channel BNaC1α to Peripheral Mechanosensory Terminals of Dorsal Root Ganglia Neurons
Garcı́a-Añoveros, J., Samad, T. A., Žuvela-Jelaska, L., Woolf, C. J., & Corey, D. P. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02678.2001 · Cited by 242
Substance P in Peripheral Sensory Processes
Lembeck, F., & Gamse, R. (1982) · Novartis Foundation symposium · doi:10.1002/9780470720738.ch4 · Cited by 228
H+‐Gated Cation Channelsa
Waldmann, R., Champigny, G., Lingueglia, É., de Weille, J. R., Heurteaux, C., & Lazdunski, M. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11274.x · Cited by 214
Association of somatic action potential shape with sensory receptive properties in guinea‐pig dorsal root ganglion neurones
Djouhri, L., Bleazard, L., & Lawson, S. N. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.857ba.x · Cited by 212
Involvement of Na+ channels in pain pathways
Baker, M. D., & Wood, J. N. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01585-6 · Cited by 206
Responses of Cutaneous A-Fiber Nociceptors to Noxious Cold
Simone, D. A., & Kajander, K. C. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.4.2049 · Cited by 202
Anandamide Excites Central Terminals of Dorsal Root Ganglion Neurons via Vanilloid Receptor-1 Activation
Tognetto, M., Amadesi, S., Harrison, S., Créminon, C., Trevisani, M., Carreras, M., Matera, M., Geppetti, P., & Bianchi, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01104.2001 · Cited by 196
The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat
Welch, J., Simon, S. A., & Reinhart, P. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.230146497 · Cited by 193
P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation.
Nakamura, F., & Strittmatter, S. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10465 · Cited by 179
A Clockwork Explosion!
Reppert, S. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80234-2 · Cited by 179
cAMP‐dependent phosphorylation of the tetrodotoxin‐resistant voltage‐dependent sodium channel SNS
Fitzgerald, E. M., Okuse, K., Wood, J. N., DOLPHIN, A. C., & Moss, S. J. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0433v.x · Cited by 176
Cationic channels activated by extracellular atp in rat sensory neurons
Krishtal, O., Marchenko, S. M., & Obukhov, A. G. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90203-5 · Cited by 173
DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature
Askwith, C. C., Benson, C. J., Welsh, M. J., & Snyder, P. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111155398 · Cited by 173
Noxious heat activates all capsaicin-sensitive and also a sub-population of capsaicin-insensitive dorsal root ganglion neurons
Nagy, I., & Rang, H. P. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00535-1 · Cited by 147
Regulation of Drosophila transient receptor potential‐like (TrpL) channels by phospholipase C‐dependent mechanisms
Estación, M., Sinkins, W. G., & Schilling, W. P. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0001m.x · Cited by 134
Similarities and Differences between the Responses of Rat Sensory Neurons to Noxious Heat and Capsaicin
Nagy, I., & Rang, H. P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-24-10647.1999 · Cited by 126
Cold transduction by inhibition of a background potassium conductance in rat primary sensory neurones
Reid, G., & Flonta, M. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01694-3 · Cited by 123
The organization of INAD-signaling complexes by a multivalent PDZ domain protein in Drosophila photoreceptor cells ensures sensitivity and speed of signaling
Tsunoda, S., & Zuker, C. S. (1999) · Cell Calcium · doi:10.1054/ceca.1999.0070 · Cited by 96
Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells
Petersen, M., & LaMotte, R. H. (1993) · Pain · doi:10.1016/0304-3959(93)90097-9 · Cited by 93
Do Phosphatidylinositides Modulate Vertebrate Phototransduction?
Womack, K. B., Gordon, S. E., He, F., Wensel, T. G., Lu, C.-C., & Hilgemann, D. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02792.2000 · Cited by 87
Pain
Basbaum, A. I., & Woolf, C. J. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80273-5 · Cited by 83
Self-citation
Inhibition of Rapid Heat Responses in Nociceptive Primary Sensory Neurons of Rats by Vanilloid Receptor Antagonists
Kirschstein, T., Greffrath, W., Büsselberg, D., & Treede, R. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.6.2853 · Cited by 80
Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells
Ganju, P., O’Bryan, J. P., Der, C. J., Winter, J., & James, I. F. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00209.x · Cited by 65
Anandamide and the question of its functional role for activation of capsaicin receptors
Szolcsányi, J. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01484-x · Cited by 57
Calcium signaling in cold cells studied in cultured dorsal root ganglion neurons
Suto, K., & Gotoh, H. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00063-9 · Cited by 51
Chapter 6. Visceral polymodal receptors
Gebhart, G. F. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61083-3 · Cited by 32
More sensory competence for nociceptive neurons in culture
Kress, M., & Reeh, P. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.14995 · Cited by 30

Flagged first, then by citations

Research works printed but not linked: 5

Basbaum, A. I. & Jessell, T. M. in Principles of Neuroscience (eds Kandel, E. R., Schwartz, J. H. & Jessell, T. M.) 472–491 (McGraw-Hill, New York, 2000).
Bevan, S. in Textbook of Pain (eds Wall, P. D. & Melzack, R.) 85–103 (Churchill-Livingstone, New York, 1999).
Levine, J. D. & Reichling, D. B. in Textbook of Pain (eds Wall, P. D. & Melzack, R.) 59–84 (Churchill-Livingstone, New York, 1999).
McMahon, S. B. & Bennett, D. L. H. in Textbook of Pain (eds Wall, P. D. & Melzack, R.) 105–128 (Harcourt, London, 1999).
Fields, H. L. Pain (McGraw-Hill, New York, 1987).

Sorted by citations

Origin and physiological roles of inflammation
Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618
“ATP also activates nociceptors (which are sensory receptors), thereby reporting tissue injury to the nervous syste”
Background
Cellular and Molecular Mechanisms of Pain
Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344
“Nociceptors can also be distinguished according to their differential expression of channels that confer sensitivity to heat (TRPV1), cold (TRPM8), acidic milieu (ASICs), and a host of chemical irritants (TRPA1) (Julius and Basbaum, 2001).”
Self-citation
Persistent postsurgical pain: risk factors and prevention
Kehlet, H., Jensen, T. S., & Woolf, C. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68700-x · Cited by 4,086
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
McKemy, D. D., Neuhausser, W., & Julius, D. J. (2002) · Nature · doi:10.1038/nature719 · Cited by 2,716
Self-citation
A TRP Channel that Senses Cold Stimuli and Menthol
Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,361

See all 2,685

Authors: Julius, D., & Basbaum, A. I.
Affiliations: University of California, San Francisco (US)
Corresponding author: Julius, David
ORCID: Julius, David
Basbaum, Allan I.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2001-09
Volume: 413
Issue: 6852
Pages: 203-210
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35093019
OpenAlex: W1883044208
Cited by: 2,685
References: 73
Citations by year: 2026: 63 · 2025: 66 · 2024: 95 · 2023: 91 · 2022: 100 · 2021: 103 · 2020: 94 · 2019: 138 · 2018: 119 · 2017: 113 · 2016: 109 · 2015: 114 · 2014: 147 · 2013: 144 · 2012: 117
FWCI: 8.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Bristol-Myers Squibb
National Institutes of Health
National Institute of Mental Health
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: nociception, pain, chronic pain, primary sensory neurons, pain detection, thermal pain, mechanical pain, chemical pain, acute to chronic pain transition, pain signalling, molecular mechanisms
MeSH terms: Animals, Forecasting, Humans, Neurons, Afferent, Pain, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular mechanisms of nociception

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks