Cellular and Molecular Mechanisms of Pain

Pain mechanisms: a new theory.

Melzack, R., & Wall, P. D. (1965) · Science · doi:10.1126/science.150.3699.971 · Cited by 11,108 · see citing works

The capsaicin receptor: a heat-activated ion channel in the pain pathway

Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132 · see citing works

Central sensitization: a generator of pain hypersensitivity by central neural plasticity

Latremoliere, A., & Woolf, C. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.012 · Cited by 3,913 · see citing works

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544 · see citing works

Human brain mechanisms of pain perception and regulation in health and disease

Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126 · see citing works

The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli

Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,086 · see citing works

Pain mechanisms: A new theory

Melzack, R., & Wall, P. D. (1996) · Pain Forum · doi:10.1016/s1082-3174(96)80062-6 · Cited by 2,786 · see citing works

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

McKemy, D. D., Neuhausser, W., & Julius, D. J. (2002) · Nature · doi:10.1038/nature719 · Cited by 2,716 · see citing works

Molecular mechanisms of nociception

Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685 · cited 1× · see citing works

ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures

Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,494 · see citing works

A TRP Channel that Senses Cold Stimuli and Menthol

Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,361 · see citing works

Neurotrophins and their receptors: A convergence point for many signalling pathways

Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298 · see citing works

Evidence for a central component of post-injury pain hypersensitivity

Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157 · see citing works

BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., & De Koninck, Y. (2005) · Nature · doi:10.1038/nature04223 · Cited by 1,965 · see citing works

TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents

Bautista, D. M., Jordt, S. E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., & Julius, D. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.023 · Cited by 1,921 · see citing works

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

Jordt, S., Bautista, D. M., Chuang, H.-H., McKemy, D. D., Zygmunt, P. M., Högestätt, E. D., Meng, I. D., & Julius, D. J. (2004) · Nature · doi:10.1038/nature02282 · Cited by 1,896 · see citing works

Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin

Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., & Patapoutian, A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00150-3 · Cited by 1,822 · see citing works

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

Davis, J. B., Gray, J., Gunthorpe, M. J., Hatcher, J. P., Davey, P. T., Overend, P., Harries, M. H., Latcham, J., Clapham, C. M., Atkinson, K., et al. (2000) · Nature · doi:10.1038/35012076 · Cited by 1,759 · see citing works

An SCN9A channelopathy causes congenital inability to experience pain

Cox, J. J., Reimann, F. M., Nicholas, A. K., Thornton, G., Roberts, E., Springell, K., Karbani, G., Jafri, H., Mannan, J., Raashid, Y., et al. (2006) · Nature · doi:10.1038/nature05413 · Cited by 1,605 · see citing works

A capsaicin-receptor homologue with a high threshold for noxious heat

Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. J. (1999) · Nature · doi:10.1038/18906 · Cited by 1,599 · see citing works

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

Tsuda, M., Shigemoto‐Mogami, Y., Koizumi, S., Mizokoshi, A., Kohsaka, S., Salter, M. W., & Inoue, K. (2003) · Nature · doi:10.1038/nature01786 · Cited by 1,567 · see citing works

The P2Y12 receptor regulates microglial activation by extracellular nucleotides

Haynes, S. E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M. E., Gan, W.-B., & Julius, D. (2006) · Nature Neuroscience · doi:10.1038/nn1805 · Cited by 1,542 · see citing works

The menthol receptor TRPM8 is the principal detector of environmental cold

Bautista, D. M., Siemens, J., Glazer, J. M., Tsuruda, P. R., Basbaum, A. I., Stucky, C. L., Jordt, S. E., & Julius, D. J. (2007) · Nature · doi:10.1038/nature05910 · Cited by 1,392 · see citing works

Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor

Liedtke, W., Choe, Y., Martı́-Renom, M. A., Bell, A. M., Denis, C. S., AndrejŠali, Hudspeth, A. J., Friedman, J. M., & Heller, S. (2000) · Cell · doi:10.1016/s0092-8674(00)00143-4 · Cited by 1,391 · see citing works

TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction

Kwan, K. Y., Allchorne, A. J., Vollrath, M. A., Christensen, A. P., Zhang, D.-S., Woolf, C. J., & Corey, D. P. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.042 · Cited by 1,267 · see citing works

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

Chuang, H.-H., Prescott, E. D., Kong, H., Shields, S. D., Jordt, S. E., Basbaum, A. I., Chao, M. V., & Julius, D. J. (2001) · Nature · doi:10.1038/35082088 · Cited by 1,257 · see citing works

p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia

Ji, R., Samad, T. A., Jin, S., Schmoll, R., & Woolf, C. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00908-x · Cited by 1,239 · see citing works

Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain

Coull, J. A. M., Boudreau, D., Bachand, K., Prescott, S. A., Nault, F., Attila Gabor, S. I. K., Koninck, P. D., & Koninck, Y. D. (2003) · Nature · doi:10.1038/nature01868 · Cited by 1,118 · see citing works

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

Macpherson, L. J., Dubin, A. E., Evans, M. J., Marr, F., Schultz, P. G., Cravatt, B. F., & Patapoutian, A. (2007) · Nature · doi:10.1038/nature05544 · Cited by 1,112 · see citing works

Heat-Evoked Activation of the Ion Channel, TRPV4

Güler, A. D., Lee, H., Iida, T., Shimizu, I., Tominaga, M., & Caterina, M. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06408.2002 · Cited by 1,033 · see citing works

OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity

Strotmann, R., Harteneck, C., Nunnenmacher, K., Schultz, G., & Plant, T. D. (2000) · Nature Cell Biology · doi:10.1038/35036318 · Cited by 1,023 · see citing works

Wall and Melzack's Textbook of Pain

McMahon, S. B., & Koltzenburg, M. (2005) · Cited by 1,014 · see citing works

Chronic pain and medullary descending facilitation

Porreca, F. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02157-4 · Cited by 1,007 · see citing works

A Heat-Sensitive TRP Channel Expressed in Keratinocytes

Peier, A. M., Reeve, A. J., Andersson, D. A., Moqrich, A., Earley, T. J., Hergarden, A. C., Story, G. M., Colley, S., Hogenesch, J. B., McIntyre, P., et al. (2002) · Science · doi:10.1126/science.1073140 · Cited by 968 · see citing works

Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation

Chen, L., & Huang, L.-Y. M. (1992) · Nature · doi:10.1038/356521a0 · Cited by 964 · see citing works

TRPM8 Is Required for Cold Sensation in Mice

Dhaka, A. K., Murray, A. N., Mathur, J., Earley, T. J., Petrus, M. J., & Patapoutian, A. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.024 · Cited by 934 · see citing works

TRP channel activation by reversible covalent modification

Hinman, A., Chuang, H.-H., Bautista, D. M., & Julius, D. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609598103 · Cited by 893 · see citing works

Mechanisms of sensory transduction in the skin

Lumpkin, E. A., & Caterina, M. J. (2007) · Nature · doi:10.1038/nature05662 · Cited by 860 · see citing works

Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord

Moore, K. A., Kohno, T., Karchewski, L. A., Scholz, J., Baba, H., & Woolf, C. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06724.2002 · Cited by 859 · see citing works

Tackling Pain at the Source: New Ideas about Nociceptors

Snider, W. D., & McMahon, S. B. (1998) · Neuron · doi:10.1016/s0896-6273(00)81003-x · Cited by 853 · see citing works

The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

Akopian, A. N., Souslova, V., England, S. G., Okuse, K., Ogata, N., Ure, J. M., Smith, A., Kerr, B. J., McMahon, S. B., Boyce, S., et al. (1999) · Nature Neuroscience · doi:10.1038/9195 · Cited by 816 · see citing works

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

Yang, Y., Wang, Y., Li, S., Xu, Z., Li, H., Ma, L., Fan, J., Bu, D., Liu, B., Fan, Z., et al. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.012153 · Cited by 800 · see citing works

Abnormal osmotic regulation in trpv4 -/- mice

Liedtke, W., & Friedman, J. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1735416100 · Cited by 798 · see citing works

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

Chessell, I. P., Hatcher, J. P., Bountra, C., Michel, A. D., Hughes, J. P., Green, P., Egerton, J., Murfin, M., Richardson, J. C., Peck, W. L., et al. (2005) · Pain · doi:10.1016/j.pain.2005.01.002 · Cited by 790 · see citing works

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

Trevisani, M., Siemens, J., Materazzi, S., Bautista, D. M., Nassini, R., Campi, B., Imamachi, N., Andrè, E., Patacchini, R., Cottrell, G. S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705923104 · Cited by 775 · see citing works

Attenuated Cold Sensitivity in TRPM8 Null Mice

Colburn, R. W., Lubin, M. L., Stone, D. J., Wang, Y., Lawrence, D., D’Andrea, M. R., Brandt, M. R., Liu, Y., Flores, C. M., & Qin, N. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.017 · Cited by 772 · see citing works

SCN9A Mutations in Paroxysmal Extreme Pain Disorder: Allelic Variants Underlie Distinct Channel Defects and Phenotypes

Fertleman, C. R., Baker, M. D., Parker, K. A., Moffatt, S. L., Elmslie, F., Abrahamsen, B., Östman, J., Klugbauer, N., Wood, J. N., Gardiner, R. M., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.006 · Cited by 759 · see citing works

A Diverse Family of GPCRs Expressed in Specific Subsets of Nociceptive Sensory Neurons

Dong, X., Han, S.-K., Zylka, M. J., Simon, M. I., & Anderson, D. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00483-4 · Cited by 742 · see citing works

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

Andersson, D. A., Gentry, C., Moss, S., & Bevan, S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5369-07.2008 · Cited by 722 · see citing works

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

Cavanaugh, D. J., Lee, H., Lo, L., Shields, S. D., Zylka, M. J., Basbaum, A. I., & Anderson, D. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901507106 · Cited by 706 · see citing works

Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ

Malmberg, A. B., Chen, C., Tonegawa, S., & Basbaum, A. I. (1997) · Science · doi:10.1126/science.278.5336.279 · Cited by 690 · see citing works

Nociceptor-specific gene deletion reveals a major role for Na v 1.7 (PN1) in acute and inflammatory pain

Nassar, M. A., Stirling, L. C., Forlani, G., Baker, M. D., Matthews, E. A., Dickenson, A. H., & Wood, J. N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404915101 · Cited by 685 · see citing works

Neural <i>KCNQ</i> (Kv7) channels

Brown, D. A., & Passmore, G. M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00111.x · Cited by 676 · see citing works

Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists

Yaksh, T. L. (1989) · Pain · doi:10.1016/0304-3959(89)90160-7 · Cited by 673 · see citing works

Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing

Nagata, K., Duggan, A., Kumar, G., & Garcı́a-Añoveros, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0013-05.2005 · Cited by 646 · see citing works

The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy

Tanga, F. Y., Nutile-McMenemy, N., & DeLeo, J. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501634102 · Cited by 634 · see citing works

GlyR α3: An Essential Target for Spinal PGE 2 -Mediated Inflammatory Pain Sensitization

Harvey, R. J., Depner, U. B., Wässle, H., Ahmadi, S., Heindl, C., Reinold, H., Smart, T. G., Harvey, K., Schütz, B., Abo‐Salem, O. M., et al. (2004) · Science · doi:10.1126/science.1094925 · Cited by 623 · see citing works

Upregulation of Dorsal Root Ganglion α 2 δ Calcium Channel Subunit and Its Correlation with Allodynia in Spinal Nerve-Injured Rats

Luo, Z. D., Chaplan, S. R., Higuera, E. S., Sorkin, L. S., Stauderman, K. A., Williams, M. E., & Yaksh, T. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01868.2001 · Cited by 616 · see citing works

The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice

Price, M. P., McIlwrath, S. L., Xie, J., Cheng, C., Qiao, J., Tarr, D. E. K., Sluka, K. A., Brennan, T. J., Lewin, G. R., & Welsh, M. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00547-5 · Cited by 604 · see citing works

TRPA1 acts as a cold sensor in vitro and in vivo

Karashima, Y., Talavera, K., Everaerts, W., Janssens, A., Kwan, K. Y., Vennekens, R., Nilius, B., & Voets, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808487106 · Cited by 588 · see citing works

Myelinated afferents signal the hyperalgesia associated with nerve injury

Campbell, J. N., Raja, S. N., Meyer, R. A., & Mackinnon, S. E. (1988) · Pain · doi:10.1016/0304-3959(88)90027-9 · Cited by 562 · see citing works

Up-Regulation of P2X 4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

Ulmann, L., Hatcher, J. P., Hughes, J. P., Chaumont‐Dubel, S., Green, P. J., Conquet, F., Buell, G. N., Reeve, A. J., Chessell, I. P., & Rassendren, F. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2308-08.2008 · Cited by 549 · see citing works

The receptors and coding logic for bitter taste

Mueller, K. L., Hoon, M. A., Erlenbach, I., Chandrashekar, J., Zuker, C. S., & Ryba, N. J. P. (2005) · Nature · doi:10.1038/nature03352 · Cited by 524 · see citing works

Bimodal Action of Menthol on the Transient Receptor Potential Channel TRPA1

Karashima, Y., Damann, N., Prenen, J., Talavera, K., Segal, A., Voets, T., & Nilius, B. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2221-07.2007 · Cited by 521 · see citing works

TRPV2 Is a Component of Osmotically Sensitive Cation Channels in Murine Aortic Myocytes

Muraki, K., Iwata, Y., Katanosaka, Y., Ito, T., Ohya, S., Shigekawa, M., & Imaizumi, Y. (2003) · Circulation Research · doi:10.1161/01.res.0000097263.10220.0c · Cited by 520 · see citing works

The mammalian sodium channel BNC1 is required for normal touch sensation

Price, M. P., Lewin, G. R., McIlwrath, S. L., Cheng, C., Xie, J., Heppenstall, P. A., Stucky, C. L., Mannsfeldt, A. G., Brennan, T. J., Drummond, H. A., et al. (2000) · Nature · doi:10.1038/35039512 · Cited by 508 · see citing works

Novel classes of responsive and unresponsive C nociceptors in human skin

Schmidt, R., Schmelz, M., Forster, C., Ringkamp, M., Torebjörk, E. H., & Handwerker, H. O. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00333.1995 · Cited by 504 · see citing works

Direct activation of the ion channel TRPA1 by Ca2+

Zurborg, S., Yurgionas, B., Jira, J. A., Caspani, O., & Heppenstall, P. A. (2007) · Nature Neuroscience · doi:10.1038/nn1843 · Cited by 500 · see citing works

Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

Clark, A. K., Yip, P. K., Grist, J., Gentry, C., Staniland, A. A., Marchand, F., Dehvari, M., Wotherspoon, G., Winter, J., Ullah, J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610811104 · Cited by 491 · see citing works

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

Abrahamsen, B., Zhao, J., Asante, C. O., Cendán, C. M., Marsh, S., Martı́nez-Barberá, J. P., Nassar, M. A., Dickenson, A. H., & Wood, J. N. (2008) · Science · doi:10.1126/science.1156916 · Cited by 483 · see citing works

The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord

Sivilotti, L., & Woolf, C. J. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.1.169 · Cited by 468 · see citing works

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

Caceres, A. I., Brackmann, M., Elia, M., Bessac, B. F., del Camino, D., D’Amours, M., Witek, J. S., Fanger, C. M., Chong, J. A., Hayward, N. J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900591106 · Cited by 464 · see citing works

Dissociation of the Opioid Receptor Mechanisms that Control Mechanical and Heat Pain

Scherrer, G., Imamachi, N., Cao, Y. Q., Contet, C., Mennicken, F., O’Donnell, D., Kieffer, B. L., & Basbaum, A. I. (2009) · Cell · doi:10.1016/j.cell.2009.04.019 · Cited by 463 · see citing works

Transmission of Chronic Nociception by Spinal Neurons Expressing the Substance P Receptor

Nichols, M. L., Allen, B. J., Rogers, S. D., Ghilardi, J. R., Honoré, P., Luger, N. M., Finke, M. P., Li, J., Lappi, D. A., Simone, D. A., et al. (1999) · Science · doi:10.1126/science.286.5444.1558 · Cited by 446 · see citing works

Reversal of pathological pain through specific spinal GABAA receptor subtypes

Knabl, J., Witschi, R., Hösl, K., Reinold, H., Zeilhofer, U. B., Ahmadi, S., Brockhaus, J., Sergejeva, M., Hess, A., Brune, K., et al. (2008) · Nature · doi:10.1038/nature06493 · Cited by 438 · see citing works

A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin

Cesare, P., & McNaughton, P. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15435 · Cited by 433 · see citing works

Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control

Bessac, B. F., & Jordt, S. (2008) · Physiology · doi:10.1152/physiol.00026.2008 · Cited by 431 · see citing works

A Role of TRPA1 in Mechanical Hyperalgesia is Revealed by Pharmacological Inhibition

Petrus, M. J., Peier, A. M., Bandell, M., Hwang, S. W., Huynh, T. T., Olney, N. T., Jegla, T. J., & Patapoutian, A. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-40 · Cited by 422 · see citing works

Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures

Zimmermann, K., Leffler, A., Babeș, A., Cendán, C. M., Carr, R. W., Kobayashi, J.-I., Nau, C., Wood, J. N., & Reeh, P. W. (2007) · Nature · doi:10.1038/nature05880 · Cited by 420 · see citing works

A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat

Honoré, P., Donnelly‐Roberts, D. L., Namovic, M. T., Hsieh, G. C., Zhu, C., Mikusa, J. P., Hernandez, G., Zhong, C., Gauvin, D. M., Chandran, P., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111559 · Cited by 418 · see citing works

Disinhibition Opens the Gate to Pathological Pain Signaling in Superficial Neurokinin 1 Receptor-Expressing Neurons in Rat Spinal Cord

Torsney, C., & MacDermott, A. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4584-05.2006 · Cited by 407 · see citing works

The mechano‐activated K+ channels TRAAK and TREK‐1 control both warm and cold perception

Noël, J., Zimmermann, K., Busserolles, J., Deval, E., Alloui, A., Diochot, S., Guy, N., Borsotto, M., Reeh, P. W., Eschalier, A., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.57 · Cited by 395 · see citing works

Protease‐activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

Grant, A. D., Cottrell, G. S., Amadesi, S., Trevisani, M., Nicoletti, P., Materazzi, S., Altier, C., Cénac, N., Zamponi, G. W., Bautista‐Cruz, F., et al. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.121111 · Cited by 393 · see citing works

Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons

Immke, D. C., & McCleskey, E. W. (2001) · Nature Neuroscience · doi:10.1038/nn0901-869 · Cited by 386 · see citing works

Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions

Verge, G. M., Milligan, E. D., Maier, S. F., Watkins, L. R., Naeve, G. S., & Foster, A. C. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03593.x · Cited by 386 · see citing works

Ionotropic and Metabotropic Receptors, Protein Kinase A, Protein Kinase C, and Src Contribute to C-Fiber-Induced ERK Activation and cAMP Response Element-Binding Protein Phosphorylation in Dorsal Horn Neurons, Leading to Central Sensitization

Kawasaki, Y., Kohno, T., Zhuang, Z.-Y., Brenner, G. J., Wang, H., Meer, C. V. D., Befort, K., Woolf, C. J., & Ji, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2396-04.2004 · Cited by 386 · see citing works

Neurosensory mechanotransduction

Chalfie, M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2595 · Cited by 385 · see citing works

Novel class of pain drugs based on antagonism of NGF

Hefti, F. F., Rosenthal, A., Walicke, P. A., Wyatt, S. L., Vergara, G., Shelton, D. L., & Davies, A. M. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.12.001 · Cited by 380 · see citing works

Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine

Zhuang, Z.-Y., Kawasaki, Y., Tan, P.-H., Wen, Y.-R., Huang, J., & Ji, R.-R. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.11.003 · Cited by 371 · see citing works

Functional biology of the α2δ subunits of voltage-gated calcium channels

Davies, A., Hendrich, J., Tran-Van-Minh, A., Wratten, J., Douglas, L. R., & DOLPHIN, A. C. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.03.005 · Cited by 359 · see citing works

The Perception of Pain

Melzack, R. (1961) · Scientific American · doi:10.1038/scientificamerican0261-41 · Cited by 350 · see citing works

Specificity of cold thermotransduction is determined by differential ionic channel expression

Viana, F., de la Peña, E., & Belmonte, C. (2002) · Nature Neuroscience · doi:10.1038/nn809 · Cited by 343 · see citing works

Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding

Gevaert, T., Vriens, J., Segal, A., Everaerts, W., Roskams, T., Talavera, K., Owsianik, G., Liedtke, W., Daelemans, D., Dewachter, I., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31766 · Cited by 331 · see citing works

Peripheral mechanisms of cutaneous nociception

Meyer, R. A., Ringkamp, M., Campbell, J. N., & Raja, S. N. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50006-0 · Cited by 324 · see citing works

TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons

Kwan, K. Y., Glazer, J. M., Corey, D. P., Rice, F. L., & Stucky, C. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5380-08.2009 · Cited by 322 · see citing works

A Critical Role of Toll-like Receptor 2 in Nerve Injury-induced Spinal Cord Glial Cell Activation and Pain Hypersensitivity

Kim, D., Kim, M. A., Cho, I., Kim, M. S., Lee, S., Jo, E., Choi, S., Park, K., Kim, J. S., Akira, S., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607277200 · Cited by 315 · see citing works

Parallel “Pain” Pathways Arise from Subpopulations of Primary Afferent Nociceptor

Braz, J. M., Nassar, M. A., Wood, J. N., & Basbaum, A. I. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.015 · Cited by 309 · see citing works

Warm Temperatures Activate TRPV4 in Mouse 308 Keratinocytes

Chung, M., Lee, H., & Caterina, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303251200 · Cited by 297 · see citing works

The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+ Influx and ATP Release in Primary Urothelial Cell Cultures

Mochizuki, T., Sokabe, T., Araki, I., Fujishita, K., Shibasaki, K., Uchida, K., Naruse, K., Koizumi, S., Takeda, M., & Tominaga, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.020206 · Cited by 292 · see citing works

Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats

Milligan, E. D., Zapata, V., Chacur, M., Schoeniger, D., Biedenkapp, J. C., O’Connor, K., Verge, G. M., Chapman, G. A., Green, P., Foster, A. C., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03709.x · Cited by 289 · see citing works

Molecular genetics of migraine

de Vries, B., Frants, R. R., Ferrari, M. D., & van den Maagdenberg, A. M. J. M. (2009) · Human Genetics · doi:10.1007/s00439-009-0684-z · Cited by 288 · see citing works

Spinal GABAAand GABABReceptor Pharmacology in a Rat Model of Neuropathic Pain

Malan, T. P., Mata, H. P., & Porreca, F. (2002) · Anesthesiology · doi:10.1097/00000542-200205000-00020 · Cited by 287 · see citing works

P2Y12Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury

Tozaki‐Saitoh, H., Tsuda, M., Miyata, H., Ueda, K., Kohsaka, S., & Inoue, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0323-08.2008 · Cited by 279 · see citing works

P2Y12Receptor Upregulation in Activated Microglia Is a Gateway of p38 Signaling and Neuropathic Pain

Kobayashi, K., Yamanaka, H., Fukuoka, T., Dai, Y., Obata, K., & Noguchi, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5589-07.2008 · Cited by 275 · see citing works

Nociceptors Lacking TRPV1 and TRPV2 Have Normal Heat Responses

Woodbury, C. J., Zwick, M., Wang, S., Lawson, J. J., Caterina, M. J., Koltzenburg, M., Albers, K. M., Koerber, H. R., & Davis, B. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1421-04.2004 · Cited by 272 · see citing works

Neuron–glia crosstalk gets serious: role in pain hypersensitivity

Ren, K., & Dubner, R. A. (2008) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32830edbdf · Cited by 271 · see citing works

TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP

Mandadi, S., Sokabe, T., Shibasaki, K., Katanosaka, K., Mizuno, A., Moqrich, A., Patapoutian, A., Fukumi‐Tominaga, T., Mizumura, K., & Tominaga, M. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0703-x · Cited by 268 · see citing works

A stomatin-domain protein essential for touch sensation in the mouse

Wetzel, C., Hu, J., Riethmacher, D., Benckendorff, A., Behrmann, L., Eilers, A., Moshourab, R. A., Kozlenkov, A., Łabuz, D., Caspani, O., et al. (2006) · Nature · doi:10.1038/nature05394 · Cited by 268 · see citing works

General anesthetics activate a nociceptive ion channel to enhance pain and inflammation

Matta, J. A., Cornett, P. M., Miyares, R. L., Abe, K., Sahibzada, N., & Ahern, G. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711038105 · Cited by 265 · see citing works

Transformation of the Output of Spinal Lamina I Neurons After Nerve Injury and Microglia Stimulation Underlying Neuropathic Pain

Keller, A. F., Beggs, S., Salter, M. W., & Koninck, Y. D. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-27 · Cited by 262 · see citing works

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

Bautista, D. M., Sigal, Y. M., Milstein, A. D., Garrison, J. L., Zorn, J. A., Tsuruda, P. R., Nicoll, R. A., & Julius, D. J. (2008) · Nature Neuroscience · doi:10.1038/nn.2143 · Cited by 260 · see citing works

Acid‐sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones

Drew, L., Rohrer, D. K., Price, M. P., Blaver, K. E., Cockayne, D. A., Cesare, P., & Wood, J. N. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.058693 · Cited by 256 · see citing works

Ideas about pain, a historical view

Perl, E. R. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2042 · Cited by 249 · see citing works

Sustained Currents Through ASIC3 Ion Channels at the Modest pH Changes That Occur During Myocardial Ischemia

Yagi, J., Wenk, H. N., Naves, L. A., & McCleskey, E. W. (2006) · Circulation Research · doi:10.1161/01.res.0000238388.79295.4c · Cited by 249 · see citing works

Caenorhabditis elegans TRPA-1 functions in mechanosensation

Kindt, K. S., Viswanath, V., Macpherson, L. J., Quast, K. B., Hu, H., Patapoutian, A., & Schafer, W. R. (2007) · Nature Neuroscience · doi:10.1038/nn1886 · Cited by 238 · see citing works

Protons Open Acid-Sensing Ion Channels by Catalyzing Relief of Ca2+ Blockade

Immke, D. C., & McCleskey, E. W. (2003) · Neuron · doi:10.1016/s0896-6273(02)01130-3 · Cited by 233 · see citing works

A Transient Receptor Potential Vanilloid 4-Dependent Mechanism of Hyperalgesia Is Engaged by Concerted Action of Inflammatory Mediators

Alessandri‐Haber, N., Dina, O. A., Joseph, E. K., Reichling, D. B., & Levine, J. D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5385-05.2006 · Cited by 228 · see citing works

Role of voltage-gated calcium channels in ascending pain pathways

Zamponi, G. W., Lewis, R. J., Todorovic, S. M., Arnerić, S. P., & Snutch, T. P. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.021 · Cited by 226 · see citing works

Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex

Liu, X. J., Gingrich, J. R., Vargas‐Caballero, M., Dong, Y., Sengar, A. S., Beggs, S., Wang, S., Ding, H. K., Frankland, P. W., & Salter, M. W. (2008) · Nature Medicine · doi:10.1038/nm.1883 · Cited by 222 · see citing works

The Effect of Menthol on the Thermoreceptors

Hensel, H., & Zotterman, Y. (1951) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1951.tb00824.x · Cited by 221 · see citing works

Neuropathic Pain Develops Normally in Mice Lacking both Nav1.7 and Nav1.8

Nassar, M. A., Levato, A., Stirling, L. C., & Wood, J. N. (2005) · Molecular Pain · doi:10.1186/1744-8069-1-24 · Cited by 210 · see citing works

Glycine Inhibitory Dysfunction Turns Touch into Pain through PKCgamma Interneurons

Miraucourt, L. S., Dallel, R., & Voisin, D. L. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001116 · Cited by 208 · see citing works

Induction of CX3CL1 Expression in Astrocytes and CX3CR1 in Microglia in the Spinal Cord of a Rat Model of Neuropathic Pain

Lindia, J. A., McGowan, E., Jochnowitz, N., & Abbadie, C. (2005) · Journal of Pain · doi:10.1016/j.jpain.2005.02.001 · Cited by 207 · see citing works

Thermal hyperalgesia as a marker of oxaliplatin neurotoxicity: A prospective quantified sensory assessment study

Attal, N., Bouhassira, D., Gautron, M., Vaillant, J.-N., Mitry, E., Lepère, C., Rougier, P. R., & Guirimand, F. (2009) · Pain · doi:10.1016/j.pain.2009.03.024 · Cited by 196 · see citing works

Distinct Mechanosensitive Properties of Capsaicin-Sensitive and -Insensitive Sensory Neurons

Drew, L., Wood, J. N., & Cesare, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-j0001.2002 · Cited by 193 · see citing works

Variable Threshold of Trigeminal Cold-Thermosensitive Neurons Is Determined by a Balance between TRPM8 and Kv1 Potassium Channels

Madrid, R., de la Peña, E., Donovan-Rodríguez, T., Belmonte, C., & Viana, F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4778-08.2009 · Cited by 185 · see citing works

In vivo silencing of the CaV3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy

Messinger, R. B., Naik, A. K., Jagodic, M. M., Nelson, M. T., Lee, W. Y., Choe, W. J., Orestes, P., Latham, J. R., Todorovic, S. M., & Jevtović‐Todorović, V. (2009) · Pain · doi:10.1016/j.pain.2009.06.012 · Cited by 183 · see citing works

Cold current in thermoreceptive neurons

Reid, G., & Flonta, M. (2001) · Nature · doi:10.1038/35097164 · Cited by 180 · see citing works

Innocuous, Not Noxious, Input Activates PKCγ Interneurons of the Spinal Dorsal Horn via Myelinated Afferent Fibers

Neumann, S., Braz, J. M., Skinner, K., Llewellyn‐Smith, I. J., & Basbaum, A. I. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1259-08.2008 · Cited by 175 · see citing works

Sodium Channel Blockade May Contribute to the Analgesic Efficacy of Antidepressants

Dick, I. E., Brochu, R. M., Purohit, Y., Kaczorowski, G. J., Martin, W. J., & Priest, B. T. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.10.001 · Cited by 174 · see citing works

Mechanosensitive currents in the neurites of cultured mouse sensory neurones

Hu, J., & Lewin, G. R. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.117648 · Cited by 174 · see citing works

Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

Materazzi, S., Nassini, R., Andrè, E., Campi, B., Amadesi, S., Trevisani, M., Bunnett, N. W., Patacchini, R., & Geppetti, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802354105 · Cited by 171 · see citing works

Functional role of unmyelinated tactile afferents in human hairy skin: sympathetic response and perceptual localization

Olausson, H., Cole, J. D., Rylander, K., McGlone, F. P., Lamarre, Y., Wallin, B. G., Krämer, H. H., Wessberg, J., Elam, M., Bushnell, M. C., et al. (2007) · Experimental Brain Research · doi:10.1007/s00221-007-1175-x · Cited by 169 · see citing works

NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders

Estación, M., Dib‐Hajj, S. D., Benke, P. J., Morsche, R. H. M. T., Eastman, E. M., Macala, L. J., Drenth, J. P. H., & Waxman, S. G. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3443-08.2008 · Cited by 166 · see citing works

Autoimmunity and Anti-TNF-α Agents

Atzeni, F., Turiel, M., CAPSONI, F., Doria, A., Meroni, P. L., & Sarzi‐Puttini, P. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.100 · Cited by 159 · see citing works

TRPV1 Unlike TRPV2 Is Restricted to a Subset of Mechanically Insensitive Cutaneous Nociceptors Responding to Heat

Lawson, J. J., McIlwrath, S. L., Woodbury, C. J., Davis, B. M., & Koerber, H. R. (2008) · Journal of Pain · doi:10.1016/j.jpain.2007.12.001 · Cited by 158 · see citing works

The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function

Page, A. J., Brierley, S. M., Martin, C. M., Martínez‐Salgado, C., Wemmie, J. A., Brennan, T. J., Symonds, E. L., Omari, T. I., Lewin, G. R., Welsh, M. J., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.061 · Cited by 154 · see citing works

Inflammatory mediators and modulators of pain

McMahon, S. B., Bennett, D., & Bevan, S. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50008-4 · Cited by 152 · see citing works

Loss of Neurons from Laminas I-III of the Spinal Dorsal Horn Is Not Required for Development of Tactile Allodynia in the Spared Nerve Injury Model of Neuropathic Pain

Polgár, E., Hughes, D. I., Arham, A. Z., & Todd, A. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1490-05.2005 · Cited by 151 · see citing works

TRESK two‐pore‐domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones

Dobler, T., Springauf, A., Tovornik, S., Weber, M., Schmitt, A. G., Sedlmeier, R., Wischmeyer, E., & Döring, F. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.145649 · Cited by 151 · see citing works

Noxious heat activates all capsaicin-sensitive and also a sub-population of capsaicin-insensitive dorsal root ganglion neurons

Nagy, I., & Rang, H. P. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00535-1 · Cited by 147 · see citing works

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

Honoré, P., Chandran, P., Hernandez, G., Gauvin, D. M., Mikusa, J. P., Zhong, C., Joshi, S. K., Ghilardi, J. R., Sevcik, M. A., Fryer, R. M., et al. (2009) · Pain · doi:10.1016/j.pain.2008.11.004 · Cited by 146 · see citing works

Cutaneous Nociception Evoked by 15-delta PGJ2 via Activation of Ion Channel TRPA1

Cruz‐Orengo, L., Dhaka, A. K., Heuermann, R. J., Young, T. J., Montana, M. C., Cavanaugh, E. J., Kim, D., & Story, G. M. (2008) · Molecular Pain · doi:10.1186/1744-8069-4-30 · Cited by 132 · see citing works

Localization of mechanosensitive channel TRPV4 in mouse skin

Suzuki, M., Watanabe, Y., Oyama, Y., Mizuno, A., Kusano, E., Hirao, A., & Ookawara, S. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.041 · Cited by 124 · see citing works

Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing

Roza, C., Puel, J., Kress, M., Baron, A., Diochot, S., Lazdunski, M., & Waldmann, R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.066001 · Cited by 123 · see citing works

Alkylamides that produce tingling paresthesia activate tactile and thermal trigeminal neurons

Bryant, B. P., & Mezine, I. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01878-8 · Cited by 123 · see citing works

Glia in pathological pain: A role for fractalkine

Milligan, E. D., Sloane, E. M., & Watkins, L. R. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.04.011 · Cited by 123 · see citing works

Mechanosensitive Ion Channels in Cultured Sensory Neurons of Neonatal Rats

Cho, H., Shin, J.-E., Shin, C. Y., Lee, S.-Y., & Oh, U. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01238.2002 · Cited by 117 · see citing works

Pungent Qualities of Sanshool-Related Compounds Evaluated by a Sensory Test and Activation of Rat TRPV1

SUGAI, E., Morimitsu, Y., Iwasaki, Y., Morita, A., Watanabe, T., & Kubota, K. (2005) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.69.1951 · Cited by 117 · see citing works

Intrathecal Ziconotide for Neuropathic Pain: A Review

Rauck, R. L., Wallace, M. S., Burton, A. W., Kapural, L., & North, J. M. (2009) · Pain Practice · doi:10.1111/j.1533-2500.2009.00303.x · Cited by 104 · see citing works

Voltage-gated calcium channels and pain

Cao, Y. Q. (2006) · Pain · doi:10.1016/j.pain.2006.10.019 · Cited by 99 · see citing works

TRPA1 Is Differentially Modulated by the Amphipathic Molecules Trinitrophenol and Chlorpromazine

Hill, K., & Schaefer, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609600200 · Cited by 94 · see citing works

Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons

Bhattacharya, M. R. C., Bautista, D. M., Wu, K. C., Haeberle, H., Lumpkin, E. A., & Julius, D. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810801105 · Cited by 85 · see citing works

A high‐threshold heat‐activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium

Leffler, A., Babeș, R.-M., Nau, C., Reeh, P. W., & Babeș, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05643.x · Cited by 82 · see citing works

Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons

Kirschstein, T., Büsselberg, D., & Treede, R. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00533-8 · Cited by 79 · see citing works

Immune and glial regulation of pain

Watkins, L. R. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.12.001 · Cited by 78 · see citing works

Long-Term Potentiation at C-Fibre Synapses by Low-Level Presynaptic Activity in vivo

Drdla-Schutting, R., & Sandkühler, J. (2008) · Molecular Pain · doi:10.1186/1744-8069-4-18 · Cited by 73 · see citing works

Understanding Sensory Nerve Mechanotransduction through Localized Elastomeric Matrix Control

Lin, Y., Cheng, C., LeDuc, P. R., & Chen, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004293 · Cited by 70 · see citing works

Chapter 4 Genetics and Molecular Pathophysiology of Nav1.7‐Related Pain Syndromes

Dib‐Hajj, S. D., Yang, Y., & Waxman, S. G. (2008) · Advances in genetics · doi:10.1016/s0065-2660(08)01004-3 · Cited by 69 · see citing works

Heat Sensitization in Skin and Muscle Nociceptors Expressing Distinct Combinations of TRPV1 and TRPV2 Protein

Rau, K. K., Jiang, N., Johnson, R. D., & Cooper, B. Y. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00840.2006 · Cited by 63 · see citing works

Science of pain

Basbaum, A. I., & Bushnell, M. C. (2009) · Elsevier eBooks · Cited by 58 · see citing works

Marked Attenuation of Inflammatory Mediator-Induced C-Fiber Sensitization for Mechanical and Hypotonic Stimuli in TRPV4 −/− Mice

Chen, X., Alessandri‐Haber, N., & Levine, J. D. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-31 · Cited by 58 · see citing works

NaV1.7 Gain-of-function Mutations As A Continuum: A1632E Displays Physiological Changes Associated With Erythromelalgia And Paroxysmal Extreme Pain Disorder Mutations And Produces Symptoms Of Both Disorders

Estación, M., Dib‐Hajj, S. D., Benke, P. J., Morsche, R. H. M. T., Eastman, E. M., Macala, L. J., Drenth, J. P. H., & Waxman, S. G. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.12.960 · Cited by 53 · see citing works

A novel mechanosensitive channel identified in sensory neurons

Cho, H., Koo, J. Y., Kim, S., Park, S. P., Yang, Y., & Oh, U. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04802.x · Cited by 34 · see citing works

Voltage-gated calcium channels in chronic pain: emerging role of alternative splicing

Swayne, L. A., & Bourinet, E. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0390-4 · Cited by 32 · see citing works

Mechanosensitive whole-cell currents in cultured rat somatosensory neurons

Takahashi, A., & Gotoh, H. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02366-0 · Cited by 22 · see citing works

Immune System, Pain and Analgesia

Rittner, H. L., Machelska, H., & Stein, C. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00172-9 · Cited by 17 · see citing works

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

Coste, B., Mathur, J., Schmidt, M., Earley, T. J., Ranade, S., Petrus, M. J., Dubin, A. E., & Patapoutian, A. (2010) · Science · doi:10.1126/science.1193270 · Cited by 3,316 · see citing works

Inflammation 2010: New Adventures of an Old Flame

Medzhitov, R. M. (2010) · Cell · doi:10.1016/j.cell.2010.03.006 · Cited by 1,854 · see citing works

The Sensory Neurons of Touch

Abraira, V. E., & Ginty, D. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.051 · Cited by 1,648 · see citing works

Neuroinflammation and Central Sensitization in Chronic and Widespread Pain

Ji, R.-R., Nackley, A., Huh, Y., Terrando, N., & Maixner, W. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002130 · Cited by 1,630 · see citing works

Nociceptors: the sensors of the pain pathway

Dubin, A. E., & Patapoutian, A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42843 · Cited by 1,418 · see citing works

Macrophage-mediated inflammation in metabolic disease

Chawla, A., Nguyen, K. D., & Goh, Y. P. S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3071 · Cited by 1,314 · see citing works

Pain regulation by non-neuronal cells and inflammation

Ji, R.-R., Chamessian, A., & Zhang, Y.-Q. (2016) · Science · doi:10.1126/science.aaf8924 · Cited by 1,314 · see citing works

Glia and pain: Is chronic pain a gliopathy?

Ji, R., Berta, T., & Nedergaard, M. (2013) · Pain · doi:10.1016/j.pain.2013.06.022 · Cited by 1,193 · see citing works

TRP Channels and Pain

Julius, D. J. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155833 · Cited by 1,152 · see citing works

Emerging targets in neuroinflammation-driven chronic pain

Ji, R., Xu, Z., & Gao, Y. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4334 · Cited by 1,102 · see citing works

TRPV1 structures in distinct conformations reveal activation mechanisms

Cao, E., Liao, M., Cheng, Y., & Julius, D. J. (2013) · Nature · doi:10.1038/nature12823 · Cited by 1,034 · see citing works

Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation

Pinho-Ribeiro, F. A., Verri, W. A., Jr., & Chiu, I. M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.10.001 · Cited by 1,031 · see citing works

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

Wilson, S. R., Thé, L., Batia, L. M., Beattie, K., Katibah, G. E., McClain, S. P., Pellegrino, M., Estandian, D., & Bautista, D. M. (2013) · Cell · doi:10.1016/j.cell.2013.08.057 · Cited by 989 · see citing works

Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms

Jensen, T. S., & Finnerup, N. B. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70102-4 · Cited by 976 · see citing works

Pathological pain and the neuroimmune interface

Grace, P. M., Hutchinson, M. R., Maier, S. F., & Watkins, L. R. (2014) · Nature reviews. Immunology · doi:10.1038/nri3621 · Cited by 951 · see citing works

Transition from acute to chronic pain after surgery

Glare, P., Aubrey, K. R., & Myles, P. S. (2019) · The Lancet · doi:10.1016/s0140-6736(19)30352-6 · Cited by 914 · see citing works

Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

Inoue, K., & Tsuda, M. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.2 · Cited by 908 · see citing works

Migraine pathophysiology: Anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain

Noseda, R., & Burstein, R. (2013) · Pain · doi:10.1016/j.pain.2013.07.021 · Cited by 892 · see citing works

Molecular Background of Leak K + Currents: Two-Pore Domain Potassium Channels

Enyedi, P., & Czirják, G. (2010) · Physiological Reviews · doi:10.1152/physrev.00029.2009 · Cited by 871 · see citing works

Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms

von Hehn, C. A., Baron, R., & Woolf, C. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.008 · Cited by 804 · see citing works

The Role of Voltage-Gated Sodium Channels in Pain Signaling

Bennett, D. L., Clark, A. J., Huang, J., Waxman, S. G., & Dib-Hajj, S. D. (2019) · Physiological Reviews · doi:10.1152/physrev.00052.2017 · Cited by 730 · see citing works

Nociception, pain, negative moods, and behavior selection

Baliki, M. N., & Apkarian, A. V. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.005 · Cited by 731 · see citing works

Stress, Inflammation, and Defense of Homeostasis

Chovatiya, R., & Medzhitov, R. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.030 · Cited by 704 · see citing works

Wireless magnetothermal deep brain stimulation

Chen, R., Romero, G., Christiansen, M. G., Mohr, A. C., & Anikeeva, P. (2015) · Science · doi:10.1126/science.1261821 · Cited by 690 · see citing works

Structural plasticity and reorganisation in chronic pain

Kuner, R., & Flor, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.162 · Cited by 700 · see citing works

Emerging Targets in Photopharmacology

Lerch, M. M., Hansen, M. J., van Dam, G. M., Szymański, W., & Feringa, B. L. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201601931 · Cited by 674 · see citing works

TFOS DEWS II pain and sensation report

Belmonte, C., Nichols, J. J., Cox, S. M., Brock, J. A., Begley, C. G., Bereiter, D. A., Dartt, D. A., Galor, A., Hamrah, P., Ivanusic, J. J., et al. (2017) · The Ocular Surface · doi:10.1016/j.jtos.2017.05.002 · Cited by 665 · see citing works

General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation

Yam, M. F., Loh, Y. C., Tan, C. S., Adam, S. K., Manan, N. A., & Basir, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082164 · Cited by 694 · see citing works

Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues

Hernández–Gea, V., Ghiassi–Nejad, Z., Rozenfeld, R., Gordon, R., Fiel, M. I., Yue, Z., Czaja, M. J., & Friedman, S. L. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.12.044 · Cited by 654 · see citing works

Metabotropic glutamate receptors: From the workbench to the bedside

Nicoletti, F., Bockaert, J., Collingridge, G. L., Conn, P. J., Ferraguti, F., Schoepp, D. D., Wroblewski, J. T., & Pin, J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.10.022 · Cited by 654 · see citing works

The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases

Russo, R. C., Garcia, C. C., Teixeira, M. M., & Amaral, F. A. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.894886 · Cited by 652 · see citing works

Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets

Larouche, J. A., Sheoran, S., Maruyama, K., & Martino, M. M. (2018) · Advances in Wound Care · doi:10.1089/wound.2017.0761 · Cited by 643 · see citing works

Host Responses in Tissue Repair and Fibrosis

Duffield, J. S., Lupher, M., Thannickal, V. J., & Wynn, T. A. (2012) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-163930 · Cited by 624 · see citing works

A subpopulation of nociceptors specifically linked to itch

Han, L., Ma, C., Liu, Q., Weng, H.-J., Cui, Y., Tang, Z., Kim, Y., Nie, H., Qu, L., Patel, K., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3289 · Cited by 614 · see citing works

Regulation of Macrophage Polarization and Wound Healing

Ferrante, C., & Leibovich, S. (2012) · Advances in wound care · doi:10.1089/wound.2011.0307 · Cited by 578 · see citing works

What is this thing called pain?

Woolf, C. J. (2010) · Journal of Clinical Investigation · doi:10.1172/jci45178 · Cited by 610 · see citing works

The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine

Iyengar, S., Ossipov, M. H., & Johnson, K. W. (2017) · Pain · doi:10.1097/j.pain.0000000000000831 · Cited by 592 · see citing works

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

Vriens, J., Owsianik, G., Hofmann, T., Philipp, S. E., Stäb, J., Chen, X. F., Benoit, M., Xue, F., Janssens, A., Kerselaers, S., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.051 · Cited by 577 · see citing works

Mu Opioids and Their Receptors: Evolution of a Concept

Pasternak, G. W., & Pan, Y. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007138 · Cited by 582 · see citing works

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

Guan, Z., Kuhn, J., Wang, X., Colquitt, B. M., Solórzano, C., Vaman, S., Guan, A. K., Evans-Reinsch, Z., Braz, J. M., Devor, M. G., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4189 · Cited by 554 · see citing works

Molecular mechanisms of mechanotransduction in mammalian sensory neurons

Delmas, P., Hao, J., & Rodat‐Despoix, L. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn2993 · Cited by 538 · see citing works

Structure and Function of TMEM16 Proteins (Anoctamins)

Pedemonte, N., & Galietta, L. J. V. (2014) · Physiological Reviews · doi:10.1152/physrev.00039.2011 · Cited by 523 · see citing works

An artificial nociceptor based on a diffusive memristor

Yoon, J. H., Wang, Z., Kim, K. M., Wu, H., Ravichandran, V., Xia, Q., Hwang, C. S., & Yang, J. J. (2018) · Nature Communications · doi:10.1038/s41467-017-02572-3 · Cited by 524 · see citing works

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

Yu, X., Liu, H., Hamel, K. A., Morvan, M. G., Yu, S. W., Leff, J., Guan, Z., Braz, J. M., & Basbaum, A. I. (2020) · Nature Communications · doi:10.1038/s41467-019-13839-2 · Cited by 508 · see citing works

Endogenous and Exogenous Opioids in Pain

Corder, G. F., Castro, D. C., Bruchas, M. R., & Scherrer, G. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061522 · Cited by 511 · see citing works

miR-29 Is a Major Regulator of Genes Associated with Pulmonary Fibrosis

Cushing, L., Kuang, P. P., Qian, J., Shao, F., Wu, J., Little, F. F., Thannickal, V. J., Cardoso, W. V., & Lü, J. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0323oc · Cited by 503 · see citing works

The emergence of transcriptional identity in somatosensory neurons

Sharma, N., Flaherty, K., Lezgiyeva, K., Wagner, D. E., Klein, A. M., & Ginty, D. D. (2020) · Nature · doi:10.1038/s41586-019-1900-1 · Cited by 498 · see citing works

Pain and immunity: implications for host defence

Baral, P., Udit, S., & Chiu, I. M. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0147-2 · Cited by 487 · see citing works

Opioid Receptors

Stein, C. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-062613-093100 · Cited by 493 · see citing works

Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

Wu, C., Asokan, S. B., Berginski, M. E., Haynes, E. M., Sharpless, N. E., Griffith, J. D., Gomez, S. M., & Bear, J. E. (2012) · Cell · doi:10.1016/j.cell.2011.12.034 · Cited by 473 · see citing works

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

Meseguer, V., Alpizar, Y. A., Luis, E., Tajada, S., Denlinger, B., Fajardo, O., Manenschijn, J.-A., Fernández-Peña, C., Talavera, A., Kichko, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms4125 · Cited by 479 · see citing works

Emerging Diversity in Lipid–Protein Interactions

Corradi, V., Sejdiu, B. I., Galloso, H. M., Abdizadeh, H., Noskov, S. Y., Marrink, ‪. J., & Tieleman, D. P. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00451 · Cited by 458 · see citing works

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Makvandi, P., Kirkby, M., Hutton, A. R. J., Shabani, M., Yiu, C. K. Y., Baghbantaraghdari, Z., Jamaledin, R., Carlotti, M., Mazzolai, B., Mattoli, V., et al. (2021) · Nano-Micro Letters · doi:10.1007/s40820-021-00611-9 · Cited by 461 · see citing works

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

Skaper, S. D., Facci, L., Zusso, M., & Giusti, P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00072 · Cited by 461 · see citing works

Peripheral thermosensation in mammals

Vriens, J., Nilius, B., & Voets, T. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3784 · Cited by 453 · see citing works

Transmitting Pain and Itch Messages: A Contemporary View of the Spinal Cord Circuits that Generate Gate Control

Braz, J. M., Solórzano, C., Wang, X., & Basbaum, A. I. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.018 · Cited by 446 · see citing works

Vagal Sensory Neuron Subtypes that Differentially Control Breathing

Chang, R. B., Strochlic, D. E., Williams, E. K., Umans, B. D., & Liberles, S. D. (2015) · Cell · doi:10.1016/j.cell.2015.03.022 · Cited by 434 · see citing works

The mechanosensory neurons of touch and their mechanisms of activation

Handler, A., & Ginty, D. D. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00489-x · Cited by 445 · see citing works

An Overview of Animal Models of Pain: Disease Models and Outcome Measures

Gregory, N. S., Bozer, A. L. H., Robinson, C. R., Dougherty, P. M., Fuchs, P. N., & Sluka, K. A. (2013) · Journal of Pain · doi:10.1016/j.jpain.2013.06.008 · Cited by 441 · see citing works

Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection

Pinho-Ribeiro, F. A., Baddal, B., Haarsma, R., O’Seaghdha, M., Yang, N. J., Blake, K. J., Portley, M. K., Verri, W. A., Jr., Dale, J. B., Wessels, M. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.04.006 · Cited by 437 · see citing works

Chemotherapy-induced peripheral neuropathy: What do we know about mechanisms?

Carozzi, V., Canta, A., & Chiorazzi, A. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.10.014 · Cited by 436 · see citing works

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

Baral, P., Umans, B. D., Li, L., Wallrapp, A., Bist, M., Kirschbaum, T., Wei, Y., Zhou, Y., Kuchroo, V. K., Burkett, P. R., et al. (2018) · Nature Medicine · doi:10.1038/nm.4501 · Cited by 430 · see citing works

Porous Implants Modulate Healing and Induce Shifts in Local Macrophage Polarization in the Foreign Body Reaction

Sussman, E. M., Halpin, M. C., Muster, J., Moon, R. T., & Ratner, B. D. (2014) · Annals of Biomedical Engineering · doi:10.1007/s10439-013-0933-0 · Cited by 416 · see citing works

The transition of acute postoperative pain to chronic pain: an integrative overview of research on mechanisms

Chapman, C. R., & Vierck, C. J. (2017) · The Journal of Pain · doi:10.1016/j.jpain.2016.11.004 · Cited by 423 · see citing works

Targeting Astrocyte Signaling for Chronic Pain

Gao, Y., & Ji, R. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.016 · Cited by 424 · see citing works

Interleukin-6: an emerging regulator of pathological pain

Zhou, Y., Liu, Z., Liu, Z., Chen, S., Li, M., Shahveranov, A., Ye, D., & Tian, Y. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0607-6 · Cited by 418 · see citing works

TRPA1: A Gatekeeper for Inflammation

Bautista, D. M., Pellegrino, M., & Tsunozaki, M. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183811 · Cited by 411 · see citing works

Inflammatory mechanisms in tendinopathy – towards translation

Millar, N., Murrell, G., & Mcinnes, I. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.213 · Cited by 383 · see citing works

Structures of human Na v 1.7 channel in complex with auxiliary subunits and animal toxins

Shen, H., Liu, D., Wu, K. K., Lei, J., & Yan, N. (2019) · Science · doi:10.1126/science.aaw2493 · Cited by 408 · see citing works

Neuromodulation by the immune system: a focus on cytokines

Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389 · see citing works

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data

Reif, D. M., Martin, M. T., Tan, S. W., Houck, K. A., Judson, R., Richard, A. M., Knudsen, T. B., Dix, D. J., & Kavlock, R. J. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.1002180 · Cited by 405 · see citing works

Cell Adhesion by Integrins

Bachmann, M., Kukkurainen, S., Hytönen, V. P., & Wehrle‐Haller, B. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2018 · Cited by 400 · see citing works

Pain regulation by gut microbiota: molecular mechanisms and therapeutic potential

Guo, R., Chen, L., Xing, C., & Liu, T. (2019) · British Journal of Anaesthesia · doi:10.1016/j.bja.2019.07.026 · Cited by 416 · see citing works

Therapeutic options for targeting inflammatory osteoarthritis pain

Conaghan, P. G., Cook, A. D., Hamilton, J. A., & Tak, P. P. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0221-y · Cited by 405 · see citing works

Acute and Residual Soccer Match-Related Fatigue: A Systematic Review and Meta-analysis

Silva, J. R., Rumpf, M., Hertzog, M., Castagna, C., Farooq, A., Girard, O., & Hader, K. (2017) · Sports Medicine · doi:10.1007/s40279-017-0798-8 · Cited by 403 · see citing works

Black mamba venom peptides target acid-sensing ion channels to abolish pain

Diochot, S., Baron, A., Salinas, M., Douguet, D., Scarzello, S., Gay, A.-S., Debayle, D., Friend, V., Alloui, A., Lazdunski, M., et al. (2012) · Nature · doi:10.1038/nature11494 · Cited by 402 · see citing works

Activation of central trigeminovascular neurons by cortical spreading depression

Zhang, X., Levy, D., Kainz, V., Noseda, R., Jakubowski, M., & Burstein, R. (2010) · Annals of Neurology · doi:10.1002/ana.22329 · Cited by 400 · see citing works

Etiology and Pharmacology of Neuropathic Pain

Alles, S. R. A., & Smith, P. A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014399 · Cited by 395 · see citing works

Epigenetic mechanisms of chronic pain

Descalzi, G., Ikegami, D., Ushijima, T., Nestler, E. J., Zachariou, V., & Narita, M. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.02.001 · Cited by 390 · see citing works

Allergic host defences

Palm, N. W., Rosenstein, R. K., & Medzhitov, R. M. (2012) · Nature · doi:10.1038/nature11047 · Cited by 390 · see citing works

Opioid-induced hyperalgesia: Cellular and molecular mechanisms

Roeckel, L.-A., Coz, G.-M. L., Gavériaux‐Ruff, C., & Simonin, F. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.029 · Cited by 389 · see citing works

Chronic pain-related remodeling of cerebral cortex - 'pain memory': a possible target for treatment of chronic pain.

Lithwick, A., Lev, S., & Binshtok, A. (2013) · Pain Management · doi:10.2217/pmt.12.74 · Cited by 420 · see citing works

Exopolysaccharide Produced by Probiotic Strain Lactobacillus paraplantarum BGCG11 Reduces Inflammatory Hyperalgesia in Rats

Dinić, M., Pecikoza, U. B., Đokić, J., Stepanović-Petrović, R. M., Milenković, M., Stevanović, M. M., Filipović, N., Begović, J., Golić, N., & Lukić, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00001 · Cited by 386 · see citing works

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice

Murthy, S. E., Loud, M. C., Daou, I., Marshall, K. L., Schwaller, F., Kühnemund, J., Francisco, A. G., Keenan, W. T., Dubin, A. E., Lewin, G. R., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat9897 · Cited by 384 · see citing works

Peripheral and Central Mechanisms of Itch

Dong, X., & Dong, X. (2018) · Neuron · doi:10.1016/j.neuron.2018.03.023 · Cited by 382 · see citing works

Optochemical Genetics

Fehrentz, T., Schönberger, M., & Trauner, D. H. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201103236 · Cited by 376 · see citing works

Mechanisms of low back pain: a guide for diagnosis and therapy

Allegri, M., Montella, S., Salici, F., Valente, A., Marchesini, M., Compagnone, C., Baciarello, M., Manferdini, M. E., & Fanelli, G. C. (2016) · F1000Research · doi:10.12688/f1000research.8105.2 · Cited by 378 · see citing works

The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

Lee, Y. C., Nassikas, N. J., & Clauw, D. J. (2011) · Arthritis Research &amp; Therapy · doi:10.1186/ar3306 · Cited by 377 · see citing works

Discogenic Low Back Pain: Anatomy, Pathophysiology and Treatments of Intervertebral Disc Degeneration

Isa, I. L. M., Teoh, S. L., Nor, N. H. M., & Mokhtar, S. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010208 · Cited by 376 · see citing works

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

Cho, H., Yang, Y. D., Lee, J., Lee, B., Kim, T., Jang, Y., Back, S. K., Na, H. S., Harfe, B. D., Wang, F., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3111 · Cited by 374 · see citing works

Nuclear calcium signalling in the regulation of brain function

Bading, H. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3531 · Cited by 374 · see citing works

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

Zamponi, G. W. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.5 · Cited by 371 · see citing works

Breaking barriers to novel analgesic drug development

Yekkirala, A. S., Roberson, D. P., Bean, B. P., & Woolf, C. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.87 · Cited by 366 · see citing works

Potential cellular and molecular causes of hypertrophic scar formation

van der Veer, W. M., Bloemen, M. C. T., Ulrich, M. M. W., Molema, G., van Zuijlen, P. P. M., Middelkoop, E., & Niessen, F. B. (2008) · Burns · doi:10.1016/j.burns.2008.06.020 · Cited by 356 · see citing works

Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?

Mollanazar, N. K., Smith, P. K., & Yosipovitch, G. (2015) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8488-5 · Cited by 354 · see citing works

Pain and Nociception: Mechanisms of Cancer-Induced Bone Pain

Falk, S., & Dickenson, A. H. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.51.7219 · Cited by 352 · see citing works

A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins

François, A., Low, S. A., Sypek, E. I., Christensen, A. J., Sotoudeh, C., Beier, K. T., Ramakrishnan, C., Ritola, K., Sharif‐Naeini, R., Deisseroth, K. A., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.008 · Cited by 354 · see citing works

A neural circuit for comorbid depressive symptoms in chronic pain

Zhou, W., Jin, Y., Meng, Q., Zhu, X., Bai, T., Tian, Y., Mao, Y., Wang, L., Xie, W., Zhong, H., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0468-2 · Cited by 343 · see citing works

Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense

Lai, N. Y., Musser, M. A., Pinho-Ribeiro, F. A., Baral, P., Jacobson, A. R., Ma, P., Potts, D. E., Chen, Z., Paik, D., Soualhi, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.11.014 · Cited by 349 · see citing works

Emerging roles of resolvins in the resolution of inflammation and pain

Ji, R., Xu, Z., Strichartz, G. R., & Serhan, C. N. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.08.005 · Cited by 345 · see citing works

Leading Edge Review Cellular and Molecular Mechanisms of Pain

Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. J. (2014)

Mechanisms of Physiologic Pain

Chan, S. F., Hayek, S. M., & Veizi, E. (2018) · Springer eBooks · doi:10.1007/978-3-319-64922-1_3

Molecular mechanisms of pain: a basis for chronic pain and therapeutic approaches based on the cell and the gene.

Riley, J. P., & Boulis, N. M. (2006) · PubMed · Cited by 12 · see citing works

Molecular mechanisms of nociception

Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685 · see citing works

Genetic Analysis of Pain Mechanisms

Robinson, D. A., & Zhuo, M. (2002) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v12.i4.30 · Cited by 2 · see citing works