The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Phagocytic processing of bacterial antigens for class I MHC presentation to T cells
Abstract
Class I major histocompatibility complex (MHC) molecules present antigens that are produced within the presenting cell or penetrate from the vacuolar system into the cytosol for processing. Most studies of exogenous antigen processing have used soluble antigens, which are not efficiently presented by class I MHC molecules and do not elicit CD8 T-cell responses in vivo. But particulate antigen preparations with no known mechanism for cytosolic penetration can also elicit CD8 T-cell responses in vivo. We report here that phagocytosis of bacteria with no mechanism for cytosolic penetration also results in presentation of bacterial antigens by class I MHC molecules. Moreover, this mechanism is resistant to cycloheximide and Brefeldin A, which block the classical class I processing pathway. These results suggest a novel vacuolar class I processing pathway for exogenous phagocytic antigens.
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“We demonstrate that bacterial HLA-I and HLA-II peptides can be presented by both antigen-presenting cells (as has previously been shown25–28) and by melanoma cells”
From Identification of bacteria-derived HLA-bound peptides in melanoma (2021) · cites this paper as [26]
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Immunobiology of Dendritic Cells
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Metadata
- Authors
- Pfeifer, J. D., Wick, M. J., Roberts, R. L., Findlay, K., Normark, S. J., & Harding, C. V.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Nature
- Published
- 1993-01
- Volume
- 361
- Issue
- 6410
- Pages
- 359-362
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2042470561
- Cited by
- 615
- References
- 31
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 9 · 2015: 4 · 2014: 8 · 2013: 10 · 2012: 10
- FWCI
- 22.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- MHC class I, antigen processing, phagocytosis, bacterial antigens, CD8+ T cells, exogenous antigen presentation, cycloheximide resistance, particulate antigen
- MeSH terms
- Amino Acid Sequence, Animals, Epitopes, Antigens, Bacterial, Bacterial Proteins, Escherichia coli, Macrophages, Mice, Inbred CBA, Mice, Inbred C57BL, Microscopy, Electron, Molecular Sequence Data, Ovalbumin, Phagocytosis, Recombinant Fusion Proteins, Salmonella typhimurium, T-Lymphocytes, Vacuoles, Histocompatibility Antigens Class I, T-Lymphocyte Subsets, CD8 Antigens, Escherichia coli Proteins, Mice
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