Cited by 615Immunotherapy and Immune Responsesvaccines and immunoinformatics approachesT-cell and B-cell Immunology

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Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

Pfeifer, John D., Wick, Mary Jo, Roberts, Richard L., Findlay, Kirk, Normark, Staffan J., Harding, Clifford V.·1993·Nature

DOI 10.1038/361359a0

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Abstract

Class I major histocompatibility complex (MHC) molecules present antigens that are produced within the presenting cell or penetrate from the vacuolar system into the cytosol for processing. Most studies of exogenous antigen processing have used soluble antigens, which are not efficiently presented by class I MHC molecules and do not elicit CD8 T-cell responses in vivo. But particulate antigen preparations with no known mechanism for cytosolic penetration can also elicit CD8 T-cell responses in vivo. We report here that phagocytosis of bacteria with no mechanism for cytosolic penetration also results in presentation of bacterial antigens by class I MHC molecules. Moreover, this mechanism is resistant to cycloheximide and Brefeldin A, which block the classical class I processing pathway. These results suggest a novel vacuolar class I processing pathway for exogenous phagocytic antigens.

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Influential
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Background
Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis.
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MethodSelf-citation
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Authors: Pfeifer, J. D., Wick, M. J., Roberts, R. L., Findlay, K., Normark, S. J., & Harding, C. V.
Affiliations: Washington University in St. Louis (US)
ORCID: Pfeifer, John D.
Wick, Mary Jo
Normark, Staffan J.
Harding, Clifford V.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1993-01
Volume: 361
Issue: 6410
Pages: 359-362
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/361359a0
OpenAlex: W2042470561
Cited by: 615
References: 31
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 9 · 2015: 4 · 2014: 8 · 2013: 10 · 2012: 10
FWCI: 22.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: MHC class I, antigen processing, phagocytosis, bacterial antigens, CD8+ T cells, exogenous antigen presentation, cycloheximide resistance, particulate antigen
MeSH terms: Amino Acid Sequence, Animals, Epitopes, Antigens, Bacterial, Bacterial Proteins, Escherichia coli, Macrophages, Mice, Inbred CBA, Mice, Inbred C57BL, Microscopy, Electron, Molecular Sequence Data, Ovalbumin, Phagocytosis, Recombinant Fusion Proteins, Salmonella typhimurium, T-Lymphocytes, Vacuoles, Histocompatibility Antigens Class I, T-Lymphocyte Subsets, CD8 Antigens, Escherichia coli Proteins, Mice

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Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

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